Miniaturization of scorpion β-toxins uncovers a putative ancestral surface of interaction with voltage-gated sodium channels

Journal of Biological Chemistry

Volumn 283, Issue 22, 2008, Pages 15169-15176

  Cohen, Lior ^a   Lipstein, Noa ^a   Karbat, Izhar ^a   Ilan, Nitza ^a   Gilles, Nicolas ^b   Kahn, Roy ^a   Gordon, Dalia ^a   Gurevitz, Michael ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b CEA SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALS; METABOLITES; SCAFFOLDS; SODIUM;

BIOACTIVE SURFACES; BREVETOXINS; NON-TOXIC; NOVEL SURFACES; RECEPTOR SITES; SECONDARY STRUCTURES; SODIUM CHANNEL;

TOXIC MATERIALS;

ALPHA TOXIN; ALPHA TOXIN LQH2; ANTITOXIN; ANTITOXIN BJ XTRIT; ANTITOXIN CSS4; BETA TOXIN; BREVETOXIN; INSECT VENOM; SCORPION VENOM; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL; SODIUM CHANNEL;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; SEQUENCE ALIGNMENT; AMINO ACID SEQUENCE; ANIMAL; CELL CULTURE; CYTOLOGY; GENE DELETION; GENETICS; LOCUST; METABOLISM; MOLECULAR EVOLUTION; NERVE CELL; RAT; SURFACE PROPERTY; WISTAR RAT;

HEXAPODA; MAMMALIA; SCORPIONES;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; EVOLUTION, MOLECULAR; LOCUSTA MIGRATORIA; NEURONS; PROTEIN BINDING; RATS; RATS, WISTAR; SCORPION VENOMS; SEQUENCE DELETION; SODIUM CHANNELS; SURFACE PROPERTIES;

EID: 47249163404     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801229200     Document Type: Article

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