Hypercapnic acidosis does not modulate the severity of bacterial pneumonia-induced lung injury

Critical Care Medicine

Volumn 33, Issue 11, 2005, Pages 2606-2612

  O'Croinin, Donall F ^a   Hopkins, Natalie O ^a   Moore, Michael M ^a   Boylan, John F ^b   McLoughlin, Paul ^a   Laffey, John G ^c,d  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

^c NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^d UNIVERSITY HOSPITAL GALWAY   (Ireland)

Author keywords

Acute lung injury; Acute respiratory distress syndrome; Hypercarbia; Pneumonia; Rat; Sepsis

Indexed keywords

ACIDOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ESCHERICHIA COLI; HYPERCAPNIA; LABORATORY TEST; LUNG INJURY; LUNG VENTILATION; MALE; MEDICAL RESEARCH; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROSPECTIVE STUDY; RAT;

EID: 27944478961     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000186761.41090.C6     Document Type: Article

References (45)

1. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome: The Acute Respiratory Distress Syndrome Network. N Engl J Med 2000; 342:1301-1308
2. Amato MB, Barbas CS, Medeiros DM, et al: Effect of a protective- ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med 1998; 338:347-354
3. Laffey JG, Tanaka M, Engelberts D, et al: Therapeutic hypercapnia reduces pulmonary and systemic injury following in vivo lung reperfusion. Am J Respir Crit Care Med 2000; 162:2287-2294
4. Shibata K, Cregg N, Engelberts D, et al: Hypercapnic acidosis may attenuate acute lung injury by inhibition of endogenous xanthine oxidase. Am J Respir Crit Care Med 1998; 158:1578-1584
5. Sinclair SE, Kregenow DA, Lamm WJ, et al: Hypercapnic acidosis is protective in an in vivo model of ventilator-induced lung injury. Am J Respir Crit Care Med 2002; 166:403-408
6. Laffey JG, Jankov RP, Engelberts D, et al: Effects of therapeutic hypercapnia on mesenteric ischemia-reperfusion injury. Am J Respir Crit Care Med 2003; 168:1383-1390
7. Laffey JG, Honan D, Hopkins N, et al: Hypercapnic acidosis attenuates endotoxin-induced acute lung injury. Am J Respir Crit Care Med 2004; 169:46-56
8. Broccard AF, Hotchkiss JR, Vannay C, et al: Protective effects of hypercapnic acidosis on ventilator-induced lung injury. Am J Respir Crit Care Med 2001; 164:802-806
9. Laffey JG, Engelberts D, Duggan M, et al: Carbon dioxide attenuates pulmonary impairment resulting from hyperventilation. Crit Care Med 2003; 31:2634-2640
10. Allen DB, Maguire JJ, Mahdavian M, et al: Wound hypoxia and acidosis limit neutrophil bacterial killing mechanisms. Arch Surg 1997; 132:991-996
11. Coakley RJ, Taggart C, McElvaney NG, et al: Cytosolic pH and the inflammatory microenvironment modulate cell death in human neutrophils after phagocytosis. Blood 2002; 100:3383-3391
12. Coakley RJ, Taggart C, Greene C, et al: Ambient pC02 modulates intracellular pH, intracellular oxidant generation, and interleukin-8 secretion in human neutrophils. J Leukoc Biol 2002; 71:603-610
13. Laffey JG, Kavanagh BP: Carbon dioxide and the critically ill: Too little of a good thing? Lancet 1999; 354:1283-1286
14. Swenson ER: Therapeutic hypercapnic acidosis: Pushing the envelope. Am J Respir Crit Care Med 2004; 169:8-9
15. West MA, Hackam DJ, Baker J, et al: Mechanism of decreased in vitro murine macrophage cytokine release after exposure to carbon dioxide: Relevance to laparoscopic surgery. Ann Surg 1997; 226:179-190
16. Hickling KG: Lung-protective ventilation in acute respiratory distress syndrome: Protection by reduced lung stress or by therapeutic hypercapnia? Am J Respir Crit Care Med 2000; 162:2021-2022
17. Zilberberg MD, Epstein SK: Acute lung injury in the medical ICU: Comorbid conditions, age, etiology, and hospital outcome. Am J Respir Crit Care Med 1998; 157:1159-1164
18. Goh AY, Chan PW, Lum LC, et al: Incidence of acute respiratory distress syndrome: A comparison of two definitions. Arch Dis Child 1998; 79:256-259
19. Paret G, Ziv T, Augarten A, et al: Acute respiratory distress syndrome in children: A 10 year experience. Isr Med Assoc J 1999; 1:149-153
20. Valta P, Uusaro A, Nunes S, et al: Acute respiratory distress syndrome: Frequency, clinical course, and costs of care. Crit Care Med 1999; 27:2367-2374
21. TenHoor T, Mannino DM, Moss M: Risk factors for ARDS in the United States: Analysis of the 1993 National Mortality Followback Study. Chest 2001; 119:1179-1184
22. Redding GJ: Current concepts in adult respiratory distress syndrome in children. Curr Opin Pediatr 2001; 13:261-266
23. Fein AM, Lippmann M, Holtzman H, et al: The risk factors, incidence, and prognosis of ARDS following septicemia. Chest 1983; 83:40-42
24. Weinberg PF, Matthay MA, Webster RO, et al: Biologically active products of complement and acute lung injury in patients with the sepsis syndrome. Am Rev Respir Dis 1984; 130:791-796
25. Martin MA, Silverman HJ: Gram-negative sepsis and the adult respiratory distress syndrome. Clin Infect Dis 1992; 14:1213-1228
26. Markowicz P, Wolff M, Djedaini K, et al: Multicenter prospective study of ventilator-associated pneumonia during acute respiratory distress syndrome: Incidence, prognosis, and risk factors. ARDS Study Group. Am J Respir Crit Care Med 2000; 161:1942-8
27. Laffey JG, O'Croinin D, McLoughlin P, et al: Permissive hypercapnia: Role in protective lung ventilatory strategies. Intensive Care Med 2004; 30:347-356
28. Song GW, Robertson B, Curstedt T, et al: Surfactant treatment in experimental Escherichia coli pneumonia. Acta Anaesthesiol Scand 1996; 40:1154-1160
29. Freeman BD, Correa R, Karzai W, et al: Controlled trials of rG-CSF and CD11b-directed MAb during hyperoxia and E. coli pneumonia in rats. J Appl Physiol 1996; 80:2066-2076
30. Karzai W, von Specht BU, Parent C, et al: G-CSF during Escherichia coli versus Staphylococcus aureus pneumonia in rats has fundamentally different and opposite effects. Am J Respir Crit Care Med 1999; 159:1377-1382
31. Zeni F, Parent C, Correa R, et al: ICAM-1 and CD11b inhibition worsen outcome in rats with E. coli pneumonia. J Appl Physiol 1999; 87:299-307
32. Russo TA, Bartholomew LA, Davidson BA, et al: Total extracellular surfactant is increased but abnormal in a rat model of Gram-negative bacterial pneumonia. Am J Physiol Lung Cell Mol Physiol 2002; 283:L655-L663
33. Tsukimoto K, Arcos JP, Schaffartzik W, et al: Effect of common dead space on VA/Q distribution in the dog. J Appl Physiol 1990; 68:2488-2493
34. Howell K, Preston RJ, McLoughlin P: Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation. J Physiol 2003; 547:133-145
35. Hopkins N, Cadogan E, Giles S, et al: Chronic airway infection leads to angiogenesis in the pulmonary circulation. J Appl Physiol 2001; 91:919-928
36. Moreland JG, Fuhrman RM, Wohlford-Lenane CL, et al: TNF-alpha and IL-1 beta are not essential to the inflammatory response in LPS-induced airway disease. Am J Physiol Lung Cell Mol Physiol 2001; 280:L173-L180
37. Calkins CM, Bensard DD, Heimbach JK, et al: L-arginine attenuates lipopolysaccharide-induced lung chemokine production. Am J Physiol Lung Cell Mol Physiol 2001; 280:L400-L408
38. Simchowitz L, Cragoe EJ Jr: Regulation of human neutrophil chemotaxis by intracellular pH. J Biol Chem 1986; 261:6492-6500
39. Demaurex N, Downey GP, Waddell TK, et al: Intracellular pH regulation during spreading of human neutrophils. J Cell Biol 1996; 133:1391-1402
40. Rotstein OD, Fiegel VD, Simmons RL, et al: The deleterious effect of reduced pH and hypoxia on neutrophil migration in vitro. J Surg Res 1988; 45:298-303
41. Zhu WH, Loh TT: Effects of Na+/H+ antiport and intracellular pH in the regulation of HL-60 cell apoptosis. Biochim Biophys Acta 1995; 1269:122-128
42. Beutler B: Endotoxin, toll-like receptor 4, and the afferent limb of innate immunity. Curr Opin Microbiol 2000; 3:23-28
43. Lien E, Ingalls RR: Toll-like receptors. Crit Care Med 2002; 30:S1-S11
44. Monick MM, Hunninghake GW: Activation of second messenger pathways in alveolar macrophages by endotoxin. Eur Respir J 2002; 20:210-222
45. Warrell DA, Cox TM, Firth JD Jr (Eds): Oxford Textbook of Medicine. Oxford, Oxford University Press, 2003