Controlled trials of rG-CSF and CD11b-directed MAb during hyperoxia and E. coli pneumonia in rats

Journal of Applied Physiology

Volumn 80, Issue 6, 1996, Pages 2066-2076

  Freeman, Bradley D ^a   Correa, Rosaly ^a   Karzai, Waheedulla ^a   Natanson, Charles ^a   Patterson, Mary ^a   Banks, Steve ^a   Fitz, Yvonne ^a   Danner, Robert L ^a   Wilson, Laura ^a   Eichacker, Peter Q ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

CD11b CD18; Escherichia coli; monoclonal antibody 1b6; oxygen toxicity; recombinant granulocyte colony stimulating factor

Indexed keywords

RECOMBINANT COLONY STIMULATING FACTOR 1;

ANIMAL EXPERIMENT; ARTICLE; BACTERIAL PNEUMONIA; CONTROLLED STUDY; ESCHERICHIA COLI; HYPEROXIA; IMMUNOCOMPETENCE; LUNG TOXICITY; NEUTROPHIL; NONHUMAN; OXYGEN TOXICITY; PRIORITY JOURNAL; RAT;

EID: 8944251133     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1996.80.6.2066     Document Type: Article

References (56)

1. Abraham, E., and P. Stevens. Effects of granulocyte colony-stimulating factor in modifying mortality from Pseudomonas aeruginosa pneumonia after hemorrhage. Crit. Care Med. 20: 8: 1127-1133, 1992.
2. Abraham, E., R. Wunderink, H. Silverman, T. M. Perl, S. Nasraway, H. E. Levy, R. Bone, R. P. Wenzel, R. Balk, R. Allred, J. E. Pennington, and J. C. Wherry. Efficacy and safety of monoclonal antibodies to human tumor necrosis factor-alpha in patients with sepsis syndrome. J. Am. Med. Assoc. 273: 934-941, 1995.
3. Arfos, K, E., C. Lundberg, L. Lindbom, K. Lundberg, P. G. Beatty, and J. M. Harlan. A monoclonal antibody to the membrane glycoprotein complex CD18 inhibits polymorphonuclear leukocyte accumulation and plasma leakage in vitro. Blood 69: 338-340, 1987.
4. Bersten, A., and W. J. Sibbald. Acute lung injury in septic shock. Crit. Care Clin. 5: 49-77, 1989.
5. Bone, R. C., C. J. Fisher, T. P. Clemmer, G. J. Slotman, C. A. Metz, and R. A. Balk. A controlled trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N. Engl. J. Med. 317: 653-658, 1987.
6. Cairo, M. S., D. Mauss, S. Kommareddy, K. Norris, C. Van De Ven, and H. E. Modanlou. Prophylactic or simultaneous administration of recombinant human granulocyte colony stimulating factor in the treatment of group B streptococcal sepsis in neonatal rats. Pediatr. Res. 27: 6: 612-615, 1990.
7. Chen, H., M. Chopp, R. L. Zhang, G. Bodzin, Q. Chen, J. R. Rusche, and R. F. Todd. Anti-CD11b monoclonal antibody reduces ischemic cell damage after transient focal cerebral ischemia in rats. Ann. Neurol. 35: 458-463, 1994.
8. Clark, S. C., and R. Kamen. The human hematopoietic colony-stimulating factors. Science Wash. DC 236: 1229-1237, 1987.
9. Cox, D. R., and D. Oakes. Analysis of Survival Data. London: Chapman and Hall, 1984.
10. Daifuku, R., J. Andresen, and G. Morstyn. Recombinant methionyl human granulocyte colony-stimulating factor for the prevention and treatment of non-neutropenic infectious diseases. J. Antimicrob. Chemother. 32, Suppl. A: 91-97, 1993.
11. Davies, K. A, V. J. Toothill, J. Savill, N, Hotchin, J. D. Peters, J. D. Pearson, C. Haslett, M. Burke, S. K. A. Law, N. F. G. Mercer, M. J. Walport, and A. D. B. Webster. A 19-year-old man with leukocyte adhesion deficiency. In vitro and in vivo studies of leucocyte function. Clin. Exp. Immunol. 84: 223-231, 1991.
12. Detmers, P. A., S. K. Lo, E. Olsen-Egbert, A. Walz, M. Baggiolini, and Z. A. Cohn. Neutrophil-activating protein 1/interleukin 8 stimulates the binding activity of the leukocyte adhesion receptor CD11b/CD18 on human neutrophils. J. Exp. Med. 171: 1155-1162, 1990.
13. Dhinaut, J.-F. A., A. Tenaillon, Y. Le Tulzo, B. Schlemmer, J.-P. Solet, M. Wolff, L. Holzapfel, F. Zeni, D. Dreyfuss, J.-P. Mira, F. De Vathaie, and P. Guinot. Platelet-activating factor receptor antagonist BN 52021 in the treatment of severe sepsis: a randomized, double-blind, placebo-controlled, multicenter clinical trial. Crit. Care Med. 22: 1720-1728, 1994.
14. Doerschuk, C. M., R. K. Winn, H. O. Coxson, and J. M. Harlan. CD18-dependent and -independent mechanisms of neutrophil emigration in the pulmonary and systemic microcirculation of rabbits. J. Immunol. 14: 2327-2333, 1990.
15. Eichacker, P. Q., A. Farese, W. D. Hoffman, S. M. Banks, T. Mouginis, D. Richmond, G. C. Kuo, T. J. MacVittie, and C. Natanson. Leukocyte CD11b/18 antigen-directed monoclonal antibody improves early survival and decreases hypoxemia in dogs challenged with tumor necrosis factor. Am. Rev. Respir. Dis. 145: 1023-1029, 1992.
16. Eichacker, P. Q., W. D. Hoffman, A. Farese, S. M. Banks, G. C. Kuo, T. J. MacVittie, and C. Natanson. TNF but not IL-1 in dogs causes lethal lung injury and multiple organ dysfunction similar to human sepsis. J. Appl. Physiol. 71: 1979-1989, 1991.
17. Eichacker, P. Q., W. D. Hoffman, A. Farese, R. L. Danner, A. F. Suffredini, Y. Waisman, S. M. Banks, T. Mouginis, L. Wilson, R. Rothlein, R. J. Elin, J. M. Hosseini, T. J. MacVittie, and C. Natanson. Leukocyte CD18 monoclonal antibody worsens endotoxemia and cardiovascular injury in canines with septic shock. J. Appl. Physiol. 74: 1885-1892, 1993.
18. Eichacker, P. Q., Y. Waisman, C. Natanson, A. Farese, W. D. Hoffman, S. M. Banks, and T. J. MacVittie. Cardiopulmonary effects of granulocyte colony-stimulating factor in a canine model of bacterial sepsis. J. Appl. Physiol. 77: 2366-2373, 1994.
19. Fink, M. S., B. P. O'Sullivan, M. J. Menconi, W. P. Steffan, H. Wang, M. E. Youseft, and J. M. Belleisle. Effect of granulocyte colony-stimulating factor on systemic and pulmonary responses to endotoxin in pigs. J. Trauma 34: 571-578, 1993.
20. Fisher, C. J., J.-F. Dhainaut, S. M. Opal, J. P. Pribble, R. A. Balk, G. J. Slotman, T. J. Iberti, E. C. Rackow, M. J. Shapiro, R. L. Greenman, H. D. Reines, M. P. Shelly, B. W. Thompson, J. F. LaBrecque, M. A. Catalane, W. A. Knaus, and J. C. Sadoff. Recombinant human interleukin-1 receptor antagonist in the treatment of patients with sepsis syndrome. J. Am. Med. Assoc. 271: 1836-1843, 1994.
21. Hawkins, H. K., S. C. Heffelfinger, and D. C. Anderson. Leukocyte adhesion deficiency: clinical and postmortem observations. Pediatr. Pathol. 12: 119-130, 1992.
22. Hebert, J. C., M. O'Reilly, and R. L. Gamelli. Protective effect of recombinant human granulocyte colony-stimulating factor against pneumococcal infections in splenectomized mice. Arch. Surg. 125: 1075-1078, 1990.
23. Horgan, M. J., S. D. Wright, and A. B. Malik. Antibody against leukocyte integrin (CD18) prevents reperfusion-induced lung vascular injury. Am. J. Physiol. 259 (Lung Cell. Mol. Physiol. 3): L315-L319, 1990.
24. Jaeschke, H., A. Farhood, and C. W. Smith. Neutrophil-induced liver cell injury in endotoxin shock is a CD11b/CD18-dependent mechanism. Am. J. Physiol. 261 (Gastrointest. Liver Physiol. 24): G1051-G1056, 1991.
25. Kanazawa, M., A. Ishizaka, N. Hasegawa, Y. Suzuki, and T. Yokoyama. Granulocyte colony-stimulating factor does not enhance endotoxin-induced acute lung injury in guinea pigs. Am. Rev. Respir. Dis. 145: 1030-1035, 1992.
26. Keeney, S. E., M. J. Mathews, A. K. Haque, H. E. Rudloff, and F. C. Schmalstieg. Oxygen-induced lung injury in the guinea pig proceeds through CD18-independent mechanisms. Am. J. Respir. Crit. Care Med. 149: 311-319, 1994.
27. King, J., B. P. Deboisblanc, C. M. Mason, J. M. Onofrio, G. Lipscomb, D. E. Mercante, W. R. Summer, and S. Nelson. Effect of granulocyte colony-stimulating factor on acute lung injury in the rat. Am. J. Respir. Crit. Care Med, 151: 302-309, 1995.
28. Koizumi, T., K. Kubo, S. Shinozaki, S. Koyama. T. Kobayashi, and M. Sekiguchi. Granulocyte colony-stimulating factor does not exacerbate endotoxin-induced lung injury in sheep. Am. Rev. Respir. Dis. 148: 132-137, 1993.
29. Mileski, W. J., J. F. Raymond, R. K. Winn, J. H. Harlan, and C. L. Rice. Inhibition of leukocyte adherence and aggregation for treatment of severe cold injury in rabbits. J. Appl. Physiol. 74: 1432-1436, 1993.
30. Mileski, W. J., R. K. Winn, N. B. Vedder, T. H. Pohlman, J. M. Harlan, and C. L. Rice. Inhibition of CD18-dependent neutrophil adherence reduces organ injury after hemorrhagic shock in primates. Surgery St. Louis 108: 206-212, 1990.
31. Mulligan, M. S., C. W. Smith, D. C. Anderson, R. F. Todd, M. Miyasaka, T. Tamatani, T. B. Issekutz, and P. A. Ward. Role of leukocyte adhesion molecules in complement-induced lung injury. J. Immunol. 150: 2401-2406, 1993.
32. Mulligan, M. S., G. P. Wilson, R. F. Todd, C. W. Smith, D. C. Anderson, J. Varani, T. B. Issekutz, M. Myasaka, T. Tamatani, J. R. Rusche, A, A, Vaporciyan, and P. A. Ward. Role of β1, β2 integrins and ICAM-1 in lung injury after deposition of IgG and IgA immune complexes. J. Immunol. 150: 2407-2417, 1993.
33. Natanson, C., M. P. Fink, H. K. Ballantyne, T. J. MacVittie, J. J. Conklin, and J. E. Parillo. Gram-negative bacteremia produces both severe systolic and diastolic cardiac dysfunction in a canine model that simulates human septic shock. J. Clin. Invest. 78: 259-270, 1986.
34. Natanson, C., W. D. Huffman, A. F. Suffredini, P. Q. Eichacker, and R. L. Danner. Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis. Ann. Intern. Med. 120: 771-783, 1994.
35. National Institutes of Health. Guide for the Care and Use of Laboratory Animals. Bethesda, MD: Institute of Laboratory Resources, National Research Council, Department of Health, Education, and Welfare Publication no. (NIH) 85-23, revised 1985, Office of Science and Health Reports, DRR/NIH.
36. Nelson, S., W. Summer, G. Bagby, C. Nakamura, L. Stewart, G. Lipscomb, and J. Anderson. Granulocyte colony-stimulating factor enhances pulmonary host defenses in normal and ethanol-treated rats. J. Infect. Dis. 164: 901-906, 1991.
37. 111In-neutrophils in rabbit skin in allergic and non-allergic inflammatory reactions in vivo. Inhibition by neutrophil pretreatment in vitro with a monoclonal antibody recognizing the CD18 antigen. J. Immunol. 142: 3193-3198, 1989.
38. Novales, J. S., A. M. Salva, H. D. Modanlur, D. L. Kaplan, J. D. Castillo, J. E. Andresen, and E. S. Medlock. Maternal administration of granulocyte colony-stimulating factor improves neonatal rat survival after lethal group B streptococcal infection. Blood 81: 4: 923-927, 1993.
39. Polak-Wyss, A. Protective effect of human granulocyte colony stimulating factor (hG-CSF) on Cryptococcus and Aspergillus infections in normal and immunosuppressed mice. Mycoses 34: 205-215, 1990.
40. Quezado, Z. M. N., C. Natanson, W. D. Hoffman, M. J. N. Quezado, B. D. Freeman, S. M. Banks, and P. Q. Eichacker. Granulocyte colony stimulating factor (GCSF) improves endotoxin clearance but not cardiopulmonary injury in canine endotoxin shock (Abstract). Am. J. Respir. Crit. Care Med. 151: A320, 1995.
41. Rangel-Frausto, M. S., D. Pittet, M. Costigan, T. Hwang, C. S. Davis, and R. P. Wenzel. The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. J. Am. Med. Assoc. 273: 117-123, 1995.
42. Rinaldo, J. E., and J. W. Christman. Mechanisms and mediators of the adult respiratory distress syndrome. Clin. Chest Med. 11: 621-632, 1990.
43. Rosen, H., S. Gordon, and R. J. North. Exacerbation of murine Listeriosis by a monoclonal antibody specific for the type 3 complement receptor of myelomonocytic cells. Absence of monocytes at infective foci allows Listeria to multiply in nonphagocytic cells. J. Exp. Med. 170: 27-37, 1989.
44. Saez-Llorens, X., H. S. Jafari, C. Severien, F. Parras, K. D. Olsen, E. J. Hansen, I. I. Singer, and G. H. McCracken. Enhanced attenuation of meningeal inflammation and brain edema by concomitant administration of anti-CD18 monoclonal antibodies and dexamethasone in experimental Haemophilus meningitis. J. Clin. Invest. 88: 2003-2011, 1991.
45. Sharar, S. R., R. K. Winn, C. E. Murray, J. M. Harlan, and C. L. Rice. A CD18 monoclonal antibody increases the incidence and severity of subcutaneous abscess formation after high-dose Staphylococcus aureus injection in rabbits. Surgery St. Louis 110: 213-220, 1991.
46. Siegel, S. Nonparametric Statistics for the Behavioral Sciences. New York: McGraw-Hill, 1956.
47. Simpson, P. J., R. F. Todd, J. C. Fantone, J. K. Mickelson, and B. R. Lucchesi. Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-mol, anti-CD11b) that inhibits leukocyte adhesion. J. Clin. Invest. 81: 624-629, 1988.
48. Smith, C. W., S. D. Marlin, R. Rothlein, C. Toman, and D. C. Anderson. Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro. J. Clin. Invest. 83: 2008-2017, 1989.
49. Snedecor, G. W., and W. G. Cochran. Statistical Methods. Ames: Iowa State Univ. Press, 1989.
50. Terashima, T., M. Kanazawa, K. Sayama, A. Ishizaka, T. Urano, F. Sakamaki, H. Nakamura, Y. Waki, and S. Tasaka. Granulocyte colony-stimulating factor exacerbates acute lung injury induced by intratracheal endotoxin in guinea pigs. Am. J. Respir. Crit. Care Med. 149: 1295-1303, 1994.
51. Toda, H., A. Murata, N. Matsuura, K. Uda, Y. Oka, N. Tanaka, and T. Mori. Therapeutic efficacy of granulocyte colony stimulating factor against rat cecal ligation and puncture model. Stem Cells 11: 228-234, 1993.
52. Tuomanen, E. I, K. Saukkonen, S. Sande, C. Cioffe, and S. D. Wright. Reduction of inflammation, tissue damage, and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of leukocytes. J. Exp. Med. 170: 959-968, 1989.
53. Vedder, N. B., R. K. Winn, C. L. Rice, E. Y. Chi, K. E. Arfors, and J. M. Harlan. A monoclonal antibody to the adherence-promoting leukocyte glycoprotein, CD18, reduces organ injury and improves survival from hemorrhagic shock and resuscitation in rabbits. J. Clin. Invest. 81: 939-944, 1988.
54. Wegner, C. D., W. W. Wolyniec, A. M. LaPlante, K. Marschman, K. Lubbe, N. EHaynes, R. Rothlein, and L. G. Letts. Intercellular adhesion molecule-1 contributes to pulmonary oxygen toxicity in mice: role of leukocytes revised. Lung 170: 267-279, 1992.
55. Weise, S. J. Tissue destruction by neutrophils. N. Engl. J. Med. 320: 365-376, 1989.
56. Zimmerman, J. J., and T. V. Ringer. Inflammatory host responses in sepsis. Crit. Care Clin. 8: 163-189, 1992.