Total extracellular surfactant is increased but abnormal in a rat model of gram-negative bacterial pneumonia

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 283, Issue 3 27-3, 2002, Pages

  Russo, Thomas A ^a   Bartholomew, Lori A ^b   Davidson, Bruce A ^a,b   Helinski, Jadwiga D ^a,b   Carlino, Ulrike B ^a   Knight III, Paul R ^a,b   Beers, Michael F ^c   Atochina, Elena N ^c   Notter, Robert H ^d   Holm, Bruce A ^b  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Escherichia coli; Phospholipid; Pulmonary injury; Surfactant dysfunction

Indexed keywords

LUNG SURFACTANT EXTRACT; SURFACTANT; SURFACTANT PROTEIN A; SURFACTANT PROTEIN B; SURFACTANT PROTEIN C; SURFACTANT PROTEIN D;

ANIMAL MODEL; ARTICLE; CAPILLARY LEAK SYNDROME; CONTROLLED STUDY; ESCHERICHIA COLI; GRAM NEGATIVE INFECTION; LIPID COMPOSITION; LUNG FUNCTION; LUNG INJURY; LUNG LAVAGE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN CONTENT; RAT; WESTERN BLOTTING;

EID: 0036723676     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00071.2002     Document Type: Article

References (57)

1. P. carinii induces selective alterations in component expression and biophysical activity of lung surfactant
2. Changes in fatty acids in phospholipids of the bronchoalveolar fluid in bacterial pneumonia and adult respiratory distress syndrome
3. Decreased surfactant protein A in patients with bacterial pneumonia
4. A rapid method of total lipid extraction and purification
5. Microdetermination of phosphorus
6. Nosocomial pneumonia in the 1990's: Update of epidemiology and risk factors
7. An overview of nosocomial infections, including the role of the microbiology laboratory
8. Novel phospholipase A activity secreted by Legionella species
9. Pulmonary surfactant in health and human lung diseases: State of the art
10. Extracellular metabolism of pulmonary surfactant: The role of a new serine protease
11. Inhibition of surfactant subtype convertase in radiation model of adult respiratory distress syndrome
12. Surfactant subtypes in mice: Characterization and quantitation
13. Epidemiology of hospital-acquired infection
14. Surfactant alterations in severe pneumonia, acute respiratory distress syndrome, and cardiogenic lung edema
15. Surfactant protein A and D
16. Changes in subphase surfactant aggregates in rabbits injured by free fatty acid
17. Inhibition of pulmonary surfactant by oleic acid: Mechanisms and characteristics
18. Evidence of lung surfactant abnormality in respiratory failure
19. Surfactant: A review of its functions and relevance in adult respiratory disorders
20. Inhibition of pulmonary surfactant function by phospholipases
21. Effects of hemoglobin and cell membrane lipids on pulmonary surfactant activity
22. Surface property changes from interactions of albumin with natural lung surfactant and extracted lung lipids
23. Multiple mechanisms of lung surfactant inhibition
24. Pathogens causing nosocomial infections
25. Surfactant and acute lung injury
26. Acid aspiration increases sensitivity to increased ambient oxygen concentrations
27. Surfactant content in children with inflammatory lung disease
28. Altered surfactant function and metabolism in rabbits with acute lung injury
29. Surfactant and the adult respiratory distress syndrome
30. Protein measurement with the Folin phenol reagent
31. Subfractionation of lung surfactant: Implications for metabolism and surface activity
32. Surfactant protein A and surfactant protein D in health and disease
33. Component-specific surface and physiological activity in bovine-derived lung surfactants
34. Molecular comparison of nonhemolytic and hemolytic phospholipase C from Pseudomonas aeruginosa
35. Proteolytic inactivation of dog lung surfactant-associated proteins by neutrophil elastase
36. Pulmonary surfactant subtype metabolism is altered after short-term ozone exposure
37. Surface properties, morphology and protein composition of pulmonary surfactant subtypes
38. Effect of pulmonary pathogens on surfactant
39. The O4-specific antigen moiety of lipopolysaccharide but not the K54 group 2 capsule is important for urovirulence in an extraintestinal isolate of Escherichia coli
40. Capsular polysaccharide and O-specific antigen divergently modulate pulmonary neutrophil influx in an Escherichia coli model of gram-negative pneumonitis in rats
41. Generation of isogenic K54 capsule-deficient Escherichia coli strains through TnphoA-mediated gene disruption
42. Proposal for a new inclusive designation for extraintestinal pathogenic isolates of Escherichia coli: ExPEC
43. The presence of K54 capsular polysaccharide increases the pathogenicity of Escherichia coli in vivo
44. Effect of endotoxins on rabbit alveolar phospholipids
45. Surfactant treatment in experimental Escherichia coli pneumonia
46. Surfactant abnormality after endotoxin-induced injury in guinea pigs
47. Characterizing alterations in the pulmonary surfactant system in a rat model of Pseudomonas aeruginosa pneumonia
48. Pulmonary surfactant subfractions in patients with the acute respiratory distress syndrome
49. Surface-area cycling of different surfactant preparations: SP-A and SP-B are essential for large aggregate integrity
50. Additivity of protein and non-protein inhibitors of lung surfactant activity
51. Hospital-acquired pneumonia: Overview of the current state of the art for prevention and control
52. Clearance and recycling of pulmonary surfactant
53. Immunomodulatory functions of surfactant
54. Protein composition of rabbit alveolar surfactant subfractions
55. Metabolism and turnover of lung surfactant