Osteopontin: A bridge between bone and the immune system

Journal of Clinical Investigation

Volumn 112, Issue 2, 2003, Pages 147-149

  Gravallese, Ellen M ^a  

^a HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; OSTEOPONTIN; MESSENGER RNA; SIALOGLYCOPROTEIN; SPP1 PROTEIN, MOUSE;

CELL INFILTRATION; CHRONIC INFLAMMATION; IMMUNE SYSTEM; INFLAMMATORY CELL; MOLECULAR BIOLOGY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; ANIMAL; C57BL MOUSE; DISEASE MODEL; INFLAMMATION; METABOLISM; MOUSE; NOTE; PHYSIOLOGY;

ANIMALS; ARTHRITIS, RHEUMATOID; DISEASE MODELS, ANIMAL; EPITOPES; INFLAMMATION; MICE; MICE, INBRED C57BL; OSTEOPONTIN; RNA, MESSENGER; SIALOGLYCOPROTEINS;

EID: 0043245084     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200319190     Document Type: Review

References (14)

1. Kong, Y.Y., et al. 1999. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 397:315-323.
2. Simonet, W.S., et al. 1997. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell. 89:309-319.
3. Pettit, A.R., and Gravallese, E.M. 2003. Osteoprotegerin. In Targeted therapies in rheumatology. P.E. Lipsky and J.S. Smolen, editors. Martin Dunitz. London, United Kingdom/New York, New York, USA. 359-377.
4. Yamamoto, N., et al. 2003. Essential role of the cryptic epitope SLAYGLR within osteopontin in a murine model of rheumatoid arthritis. J. Clin. Invest. 112:181-188. doi:10.1172/JCI200317778.
5. Denhardt, D.T., and Noda, M. 1998. Osteopontin expression and function: role in bone remodeling. J. Cell. Biochem. Suppl. 30/31:92-102.
6. Murry, C.E., Giachelli, C.M., Schwartz, S.M., and Vracko, R. 1994. Macrophages express osteopontin during repair of myocardial necrosis. Am. J. Pathol. 145:1450-1462.
7. Chellaiah, M.A., et al. 2003. Osteopontin deficiency produces osteoclast dysfunction due to reduced CD44 surface expression. Mol. Biol. Cell. 14:173-189.
8. Weber, G.F., Ashkar, S., Glimcher, M.J., and Cantor, H. 1996. Receptor-ligand interaction between CD44 and osteopontin (Eta-1). Science. 71:509-512.
9. Jansson, M., Panoutsakopoulou, V., Baker, J., Klein, L., and Cantor, H. 2002. Attenuated experimental autoimmune encephalomyelitis in Era-1/osteopontin-deficient mice. J. Immunol. 168:2096-2099.
10. Petrow, P.K., et al. 2000. Expression of osteopontin messenger RNA and protein in rheumatoid arthritis: effects of osteopontin on the release of collagenase 1 from articular chondrocytes and synovial fibroblasts. Arthritis Rheum. 43:1597-1605.
11. Ohshima, S., et al. 2002. Expression of osteopontin at sites of bone erosion in a murine experimental arthritis model of collagen-induced arthritis: possible involvement of osteopontin in bone destruction in arthritis. Arthritis Rheum. 46:1094-1101.
12. Ihara, H., et al. 2001. Parathyroid hormone-induced bone resorption does not occur in the absence of osteopontin. J. Biol. Chem. 276:13065-13071.
13. Yumoto, K., et al. 2002. Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice. Proc Natl. Acad. Sci. U. S. A. 99:4556-4561.
14. Blom, T., Franzen, A., Heinegard, D., and Holmdahl, R. 2003. Technical comments: comment on "The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease." Science. 299:1845a.