메뉴 건너뛰기




Volumn 45, Issue 1, 2008, Pages 79-85

Melatonin enhances pro-inflammatory cytokine levels and protects against Chagas disease

Author keywords

interferon; Cytokines; Immune response; Macrophage; Melatonin; Trypanosoma cruzi

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; MELATONIN; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

EID: 47249088637     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2008.00558.x     Document Type: Article
Times cited : (33)

References (68)
  • 2
    • 34249826035 scopus 로고    scopus 로고
    • Trypanosoma cruzi: Populations bearing opposite virulence induce differential expansion of circulating CD3+CD4-CD8- T cells and cytokine serum levels in young and adult rats
    • Nagib PR, Dutra WO, Chiari E et al. Trypanosoma cruzi: populations bearing opposite virulence induce differential expansion of circulating CD3+CD4-CD8- T cells and cytokine serum levels in young and adult rats. Exp Parasitol 2007 116 : 366 374.
    • (2007) Exp Parasitol , vol.116 , pp. 366-374
    • Nagib, P.R.1    Dutra, W.O.2    Chiari, E.3
  • 3
    • 0026805989 scopus 로고
    • The microbicidal activity of interferon-γ-treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-α
    • Gazzinelli RT, Oswald IP, Hienry S et al. The microbicidal activity of interferon-γ-treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-α. Eur J Immunol 1992 22 : 2501 2506.
    • (1992) Eur J Immunol , vol.22 , pp. 2501-2506
    • Gazzinelli, R.T.1    Oswald, I.P.2    Hienry, S.3
  • 4
    • 0026691581 scopus 로고
    • Activation of human macrophages for the killing of intracellular Trypanosoma cruzi by TNF-α and IFN-γ through a nitric oxide-dependent mechanism
    • Muñoz-Fernandez MA, Fernandez MA, Fresno M. Activation of human macrophages for the killing of intracellular Trypanosoma cruzi by TNF-α and IFN-γ through a nitric oxide-dependent mechanism. Immunol Lett 1992 33 : 35 40.
    • (1992) Immunol Lett , vol.33 , pp. 35-40
    • Muñoz-Fernandez, M.A.1    Fernandez, M.A.2    Fresno, M.3
  • 5
    • 0028051548 scopus 로고
    • Nitric oxide is involved in control of Trypanosoma cruzi-induced parasitemia and directly kills the parasite in vitro
    • Vespa GN, Cunha FQ, Silva JS. Nitric oxide is involved in control of Trypanosoma cruzi-induced parasitemia and directly kills the parasite in vitro. Infect Immun 1994 62 : 5177 5182.
    • (1994) Infect Immun , vol.62 , pp. 5177-5182
    • Vespa, G.N.1    Cunha, F.Q.2    Silva, J.S.3
  • 6
    • 0028807425 scopus 로고
    • Tumor necrosis factor mediates resistance to Trypanosoma cruzi infection in mice by inducing nitric oxide production in infected interferon-activated macrophages
    • Silva JS, Vespa GNR, Cardoso MAG et al. Tumor necrosis factor mediates resistance to Trypanosoma cruzi infection in mice by inducing nitric oxide production in infected interferon-activated macrophages. Infect Immun 1995 63 : 4862 4867.
    • (1995) Infect Immun , vol.63 , pp. 4862-4867
    • Silva, J.S.1    Vespa, G.N.R.2    Cardoso, M.A.G.3
  • 7
    • 0029119310 scopus 로고
    • Role of nitric oxide in resistance and histopathology during experimental infection with Trypanosoma cruzi
    • Petray P, Castanos Velez E, Grinstein S et al. Role of nitric oxide in resistance and histopathology during experimental infection with Trypanosoma cruzi. Immunol Lett 1995 47 : 121 126.
    • (1995) Immunol Lett , vol.47 , pp. 121-126
    • Petray, P.1    Castanos Velez, E.2    Grinstein, S.3
  • 8
    • 0035081911 scopus 로고    scopus 로고
    • Stage-dependent role of nitric oxide in control of Trypanosoma cruzi infection
    • Saeftel M, Fleischer B, Hoerauf A. Stage-dependent role of nitric oxide in control of Trypanosoma cruzi infection. Infect Immun 2001 69 : 2252 2259.
    • (2001) Infect Immun , vol.69 , pp. 2252-2259
    • Saeftel, M.1    Fleischer, B.2    Hoerauf, A.3
  • 9
    • 0031913243 scopus 로고    scopus 로고
    • Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in interferon receptor or inducible nitric oxide synthase
    • Holscher C, Kohler G, Muller U et al. Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in interferon receptor or inducible nitric oxide synthase. Infect Immun 1998 66 : 1208 1215.
    • (1998) Infect Immun , vol.66 , pp. 1208-1215
    • Holscher, C.1    Kohler, G.2    Muller, U.3
  • 10
    • 0035149345 scopus 로고    scopus 로고
    • Pivotal role of interleukin-12 and interferon axis in controlling tissue parasitism and inflammation in the heart and central nervous system during Trypanosoma cruzi infection
    • Michailowsky V, Silva NM, Rocha CD et al. Pivotal role of interleukin-12 and interferon axis in controlling tissue parasitism and inflammation in the heart and central nervous system during Trypanosoma cruzi infection. Am J Pathol 2001 159 : 1723 1733.
    • (2001) Am J Pathol , vol.159 , pp. 1723-1733
    • Michailowsky, V.1    Silva, N.M.2    Rocha, C.D.3
  • 11
    • 8444241078 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis can be prevented and cured by infection with Trypanosoma cruzi
    • Dokoro CE, Vallochi AL, Rios LS et al. Experimental autoimmune encephalomyelitis can be prevented and cured by infection with Trypanosoma cruzi. J Autoimmun 2004 23 : 103 115.
    • (2004) J Autoimmun , vol.23 , pp. 103-115
    • Dokoro, C.E.1    Vallochi, A.L.2    Rios, L.S.3
  • 12
    • 0033902040 scopus 로고    scopus 로고
    • Signaling of immune system cells by glycosylphosphatidylinositol (GPI) anchor and related structures derived from parasitic protozoa
    • Ropert C, Gazzinelli RT. Signaling of immune system cells by glycosylphosphatidylinositol (GPI) anchor and related structures derived from parasitic protozoa. Curr Opin Microbiol 2000 3 : 395 403.
    • (2000) Curr Opin Microbiol , vol.3 , pp. 395-403
    • Ropert, C.1    Gazzinelli, R.T.2
  • 13
    • 0642281742 scopus 로고    scopus 로고
    • Pathophysiology of the heart in Chagas' disease: Current status and new developments
    • Higuchi ML, Benvenutti LA, Reis MM et al. Pathophysiology of the heart in Chagas' disease: current status and new developments. Cardiovasc Res 2003 15 : 96 107.
    • (2003) Cardiovasc Res , vol.15 , pp. 96-107
    • Higuchi, M.L.1    Benvenutti, L.A.2    Reis, M.M.3
  • 14
    • 0037372978 scopus 로고    scopus 로고
    • Evidence that development of severe cardiomyopathy in human Chagas disease is due to a Th1 specific response
    • Gomes JAS, Bahia-Oliveira LMG, Rocha MOC et al. Evidence that development of severe cardiomyopathy in human Chagas disease is due to a Th1 specific response. Infect Immun 2003 71 : 1185 1193.
    • (2003) Infect Immun , vol.71 , pp. 1185-1193
    • Gomes, J.A.S.1    Bahia-Oliveira, L.M.G.2    Rocha, M.O.C.3
  • 15
    • 1842613609 scopus 로고    scopus 로고
    • Elevated concentrations of CCL2 and tumor necrosis factor-alpha in chagasic cardiomyopathy
    • Talvani A, Rocha MOC, Barcelos LS et al. Elevated concentrations of CCL2 and tumor necrosis factor-alpha in chagasic cardiomyopathy. Clin Infect Dis 2004 38 : 943 950.
    • (2004) Clin Infect Dis , vol.38 , pp. 943-950
    • Talvani, A.1    Rocha, M.O.C.2    Barcelos, L.S.3
  • 16
    • 0029967256 scopus 로고    scopus 로고
    • Interleukin-12-mediated resistance to Trypanosoma cruzi is dependent on tumor necrosis factor alpha and gamma interferon
    • Hunter CA, Slifer T, Araujo F. Interleukin-12-mediated resistance to Trypanosoma cruzi is dependent on tumor necrosis factor alpha and gamma interferon. Infect Immun 1996 64 : 2381 2386.
    • (1996) Infect Immun , vol.64 , pp. 2381-2386
    • Hunter, C.A.1    Slifer, T.2    Araujo, F.3
  • 17
    • 0030010929 scopus 로고    scopus 로고
    • Interleukin-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes
    • Aliberti JC, Cardoso MA, Martins GA et al. Interleukin-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes. Infect Immun 1996 64 : 1961 1967.
    • (1996) Infect Immun , vol.64 , pp. 1961-1967
    • Aliberti, J.C.1    Cardoso, M.A.2    Martins, G.A.3
  • 18
    • 0023770735 scopus 로고
    • In vivo administration of recombinant IFN-g induces macrophage activation, and prevents acute disease, immune suppression, and death in experimental Trypanosoma cruzi infections
    • Reed SG. In vivo administration of recombinant IFN-g induces macrophage activation, and prevents acute disease, immune suppression, and death in experimental Trypanosoma cruzi infections. J Immunol 1988 140 : 4342 4347.
    • (1988) J Immunol , vol.140 , pp. 4342-4347
    • Reed, S.G.1
  • 19
    • 33747756473 scopus 로고    scopus 로고
    • Type I IFNs stimulate nitric oxide production and resistance to Trypanosoma cruzi infection
    • Costa VM, Torres KC, Mendonca RZ et al. Type I IFNs stimulate nitric oxide production and resistance to Trypanosoma cruzi infection. J Immunol 2006 177 : 3193 3200.
    • (2006) J Immunol , vol.177 , pp. 3193-3200
    • Costa, V.M.1    Torres, K.C.2    Mendonca, R.Z.3
  • 20
    • 43949157849 scopus 로고
    • The syntax of immune-neuroendocrine communication
    • Blalock JE. The syntax of immune-neuroendocrine communication. Immunol Today 1994 15 : 504 511.
    • (1994) Immunol Today , vol.15 , pp. 504-511
    • Blalock, J.E.1
  • 21
    • 0002563594 scopus 로고
    • Psychoneuroimmunology: Brain and immunity
    • Black PH. Psychoneuroimmunology: brain and immunity. Sci Am 1995 2 : 16 25.
    • (1995) Sci Am , vol.2 , pp. 16-25
    • Black, P.H.1
  • 22
    • 0036230531 scopus 로고    scopus 로고
    • Minireview: Neuro-immuno-endocrine modulation of the hypothalamic- pituitary-adrenal (HPA) axis by gp130 signaling molecules
    • Chesnokova V, Melmed S. Minireview: neuro-immuno-endocrine modulation of the hypothalamic-pituitary-adrenal (HPA) axis by gp130 signaling molecules. Endocrinology 2002 143 : 1571 1574.
    • (2002) Endocrinology , vol.143 , pp. 1571-1574
    • Chesnokova, V.1    Melmed, S.2
  • 23
    • 27644466592 scopus 로고    scopus 로고
    • A review of the multiple actions of melatonin on the immune system
    • Carrillo-Vico A, Guerrero JM, Lardone PJ et al. A review of the multiple actions of melatonin on the immune system. Endocrine 2005 27 : 189 200.
    • (2005) Endocrine , vol.27 , pp. 189-200
    • Carrillo-Vico, A.1    Guerrero, J.M.2    Lardone, P.J.3
  • 24
    • 0031570820 scopus 로고    scopus 로고
    • Melatonin enhances IL-2, IL-6, and IFN-gamma production by human circulating CD4+ cells: A possible nuclear receptor-mediated mechanism involving T helper type 1 lymphocytes and monocytes
    • Garcia-Maurino S, Gonzalez-Haba MG, Calvo JR et al. Melatonin enhances IL-2, IL-6, and IFN-gamma production by human circulating CD4+ cells: a possible nuclear receptor-mediated mechanism involving T helper type 1 lymphocytes and monocytes. J Immunol 1997 159 : 574 581.
    • (1997) J Immunol , vol.159 , pp. 574-581
    • Garcia-Maurino, S.1    Gonzalez-Haba, M.G.2    Calvo, J.R.3
  • 25
    • 0028075016 scopus 로고
    • Activation of human monocytes by the pineal hormone melatonin
    • Morrey KM, Mclachlan JA, Serkin CD et al. Activation of human monocytes by the pineal hormone melatonin. J Immunol 1994 153 : 2671 2680.
    • (1994) J Immunol , vol.153 , pp. 2671-2680
    • Morrey, K.M.1    McLachlan, J.A.2    Serkin, C.D.3
  • 26
    • 0031940492 scopus 로고    scopus 로고
    • Differential expression of the melatonin receptor in human monocytes
    • Barjavel MJ, Mamdouh Z, Raghbate N et al. Differential expression of the melatonin receptor in human monocytes. J Immunol 1998 160 : 1191 1197.
    • (1998) J Immunol , vol.160 , pp. 1191-1197
    • Barjavel, M.J.1    Mamdouh, Z.2    Raghbate, N.3
  • 27
    • 0031739212 scopus 로고    scopus 로고
    • Circadian secretions of IL-2, IL-12, IL-6 and IL-10 in relation to the light/dark rhythm of the pineal hormone melatonin in healthy humans
    • Lissoni P, Rovelli F, Brivio F et al. Circadian secretions of IL-2, IL-12, IL-6 and IL-10 in relation to the light/dark rhythm of the pineal hormone melatonin in healthy humans. Nat Immunity 1998 16 : 1 5.
    • (1998) Nat Immunity , vol.16 , pp. 1-5
    • Lissoni, P.1    Rovelli, F.2    Brivio, F.3
  • 28
    • 34147197385 scopus 로고    scopus 로고
    • Melatonin treatment reduces the severity of experimental Trypanosoma cruzi infection
    • Santello FH, Frare EO, Dos Santos CD et al. Melatonin treatment reduces the severity of experimental Trypanosoma cruzi infection. J Pineal Res 2007 42 : 359 363.
    • (2007) J Pineal Res , vol.42 , pp. 359-363
    • Santello, F.H.1    Frare, E.O.2    Dos Santos, C.D.3
  • 29
    • 1642439258 scopus 로고    scopus 로고
    • Effect of zinc and melatonin supplementation on cellular immunity in rats with toxoplasmosis
    • Avunduk AM, Avunduk MC, Baltaci AK et al. Effect of zinc and melatonin supplementation on cellular immunity in rats with toxoplasmosis. Biol Trace Elem Res 2003 96 : 237 245.
    • (2003) Biol Trace Elem Res , vol.96 , pp. 237-245
    • Avunduk, A.M.1    Avunduk, M.C.2    Baltaci, A.K.3
  • 30
    • 33846905545 scopus 로고    scopus 로고
    • Melatonin decreases nitric oxide production and lipid peroxidation and increases interleukin-1 beta in the brain of mice infected by the Venezuelan equine encephalomyelitis virus
    • Valero N, Marinaespina L, Bonilla E, Mosquera J. Melatonin decreases nitric oxide production and lipid peroxidation and increases interleukin-1 beta in the brain of mice infected by the Venezuelan equine encephalomyelitis virus. J Pineal Res 2007 42 : 107 112.
    • (2007) J Pineal Res , vol.42 , pp. 107-112
    • Valero, N.1    Marinaespina, L.2    Bonilla, E.3    Mosquera, J.4
  • 31
    • 0000582767 scopus 로고
    • Sobre uma cepa de Trypanosoma cruzi altamente virulenta para o camundongo branco
    • Silva LHP, Nussenzweig V. Sobre uma cepa de Trypanosoma cruzi altamente virulenta para o camundongo branco. Folia Clin Biol 1953 20 : 191 201.
    • (1953) Folia Clin Biol , vol.20 , pp. 191-201
    • Silva, L.H.P.1    Nussenzweig, V.2
  • 32
    • 73649161135 scopus 로고
    • Therapeutic activity and criterion of cure in mice experimentally infected with Trypanosoma cruzi
    • Brener Z. Therapeutic activity and criterion of cure in mice experimentally infected with Trypanosoma cruzi. Rev Inst Med Trop São Paulo 1962 4 : 389 396.
    • (1962) Rev Inst Med Trop São Paulo , vol.4 , pp. 389-396
    • Brener, Z.1
  • 33
    • 84979132832 scopus 로고
    • Bemerkungen zu der Abhandlung der H.H.Weselsky und Benedikt Uber einige Azoverbindungen'
    • Griess P. Bemerkungen zu der Abhandlung der H.H.Weselsky und Benedikt Uber einige Azoverbindungen'. Chem Ber 1879 12 : 426.
    • (1879) Chem Ber , vol.12 , pp. 426
    • Griess, P.1
  • 34
    • 17444393621 scopus 로고    scopus 로고
    • The importance of aberrant T-cell responses in Chagas disease
    • Dos Reis GA, Freire-De-Lima CG, Nunes MP et al. The importance of aberrant T-cell responses in Chagas disease. Trends Parasitol 2005 21 : 237 243.
    • (2005) Trends Parasitol , vol.21 , pp. 237-243
    • Dos Reis, G.A.1    Freire-De-Lima, C.G.2    Nunes, M.P.3
  • 35
    • 33748057802 scopus 로고    scopus 로고
    • CD8+ T-cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes
    • Martin DL, Weatherly DB, Laucella SA et al. CD8+ T-cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes. PLoS Pathog 2006 2 : e77.
    • (2006) PLoS Pathog , vol.2
    • Martin, D.L.1    Weatherly, D.B.2    Laucella, S.A.3
  • 36
    • 23044488575 scopus 로고    scopus 로고
    • Molecular basis of Trypanosoma cruzi and Leishmania interaction with their host(s): Exploitation of immune and defense mechanisms by the parasite leading to persistence and chronicity, features reminiscent of immune system evasion strategies in cancer diseases
    • Ouaissi A, Ouaissi M. Molecular basis of Trypanosoma cruzi and Leishmania interaction with their host(s): exploitation of immune and defense mechanisms by the parasite leading to persistence and chronicity, features reminiscent of immune system evasion strategies in cancer diseases. Arch Immunol Ther Exp (Warsz) 2005 53 : 102 114.
    • (2005) Arch Immunol Ther Exp (Warsz) , vol.53 , pp. 102-114
    • Ouaissi, A.1    Ouaissi, M.2
  • 37
    • 12444258695 scopus 로고    scopus 로고
    • Antigen-specific T cells maintain an effector memory phenotype during persistent Trypanosoma cruzi infection
    • Martin DL, Tarleton RL. Antigen-specific T cells maintain an effector memory phenotype during persistent Trypanosoma cruzi infection. J Immunol 2005 174 : 1594 1601.
    • (2005) J Immunol , vol.174 , pp. 1594-1601
    • Martin, D.L.1    Tarleton, R.L.2
  • 38
    • 0020773414 scopus 로고
    • Circadian rhythms of pineal function in rats
    • Binkley SA. Circadian rhythms of pineal function in rats. Endocr Rev 1983 4 : 255 270.
    • (1983) Endocr Rev , vol.4 , pp. 255-270
    • Binkley, S.A.1
  • 39
    • 0021712814 scopus 로고
    • Effects of melatonin on human mood and performance
    • Lieberman HR, Waldhauser F, Garfield G et al. Effects of melatonin on human mood and performance. Brain Res 1984 323 : 201 207.
    • (1984) Brain Res , vol.323 , pp. 201-207
    • Lieberman, H.R.1    Waldhauser, F.2    Garfield, G.3
  • 40
    • 0019781433 scopus 로고
    • The mammalian pineal gland: Structure and function
    • Reiter RJ. The mammalian pineal gland: structure and function. Am J Ana 1981 162 : 287 313.
    • (1981) Am J Ana , vol.162 , pp. 287-313
    • Reiter, R.J.1
  • 41
    • 0025187950 scopus 로고
    • Regulatory sites in the melatonin system of mammals
    • Krause DN, Dubocovich ML. Regulatory sites in the melatonin system of mammals. Trends Neurosci 1990 13 : 464 470.
    • (1990) Trends Neurosci , vol.13 , pp. 464-470
    • Krause, D.N.1    Dubocovich, M.L.2
  • 42
    • 0000329353 scopus 로고
    • Entrainment of vertebrate circadian rhythms by melatonin
    • Amstrong SM. Entrainment of vertebrate circadian rhythms by melatonin. Adv Pineal Res 1991 5 : 259 266.
    • (1991) Adv Pineal Res , vol.5 , pp. 259-266
    • Amstrong, S.M.1
  • 43
    • 0345130053 scopus 로고    scopus 로고
    • Characterization of membrane melatonin receptor in mouse peritoneal macrophages: Inhibition of adenylyl cyclase by a pertussis toxin-sensitive G protein
    • Garcia-Perganeda A, Guerrero JM, Raffi-El-Idrissi M et al. Characterization of membrane melatonin receptor in mouse peritoneal macrophages: inhibition of adenylyl cyclase by a pertussis toxin-sensitive G protein. J Neuroimmunol 1999 95 : 85 94.
    • (1999) J Neuroimmunol , vol.95 , pp. 85-94
    • Garcia-Perganeda, A.1    Guerrero, J.M.2    Raffi-El-Idrissi, M.3
  • 44
    • 0242320500 scopus 로고    scopus 로고
    • Expression of membrane and nuclear melatonin receptor mRNA and protein in the mouse immune system
    • Carrillo-Vico A., Garcia-Perganeda A., Naji L et al. Expression of membrane and nuclear melatonin receptor mRNA and protein in the mouse immune system. Cell Mol Life Sci 2003 60 : 2272 2278.
    • (2003) Cell Mol Life Sci , vol.60 , pp. 2272-2278
    • Carrillo-Vico, A.1    Garcia-Perganeda, A.2    Naji, L.3
  • 45
    • 0015789507 scopus 로고
    • The role of antibodies and host cells in the resistance of mice against infection by Coxsakie B3 virus
    • Rager-Zisman B, Allison AC. The role of antibodies and host cells in the resistance of mice against infection by Coxsakie B3 virus. J Gen Virol 1973 19 : 329 338.
    • (1973) J Gen Virol , vol.19 , pp. 329-338
    • Rager-Zisman, B.1    Allison, A.C.2
  • 46
    • 0016684725 scopus 로고
    • Depressed specific cell mediated immunity to herpes simplex virus type 1 in patients with recurrent herpes labialis
    • Thong HY, Vincent MM, Hensen SA et al. Depressed specific cell mediated immunity to herpes simplex virus type 1 in patients with recurrent herpes labialis. Infect Immun 1975 12 : 76 80.
    • (1975) Infect Immun , vol.12 , pp. 76-80
    • Thong, H.Y.1    Vincent, M.M.2    Hensen, S.A.3
  • 47
    • 0023810955 scopus 로고
    • Pineal melatonin, its fundamental immuno-regulatory role in aging and cancer
    • Maestroni GJM, Conti A, Pierpaoli W. Pineal melatonin, its fundamental immuno-regulatory role in aging and cancer. Ann N Y Acad Sci 1988 521 : 140 148.
    • (1988) Ann N Y Acad Sci , vol.521 , pp. 140-148
    • Maestroni, G.J.M.1    Conti, A.2    Pierpaoli, W.3
  • 48
    • 0029163629 scopus 로고
    • Protective effects of melatonin in mice infected with encephalitis viruses
    • Ben-Nathan D, Maestroni GJM, Lustig S et al. Protective effects of melatonin in mice infected with encephalitis viruses. Arch Virol 1995 140 : 223 230.
    • (1995) Arch Virol , vol.140 , pp. 223-230
    • Ben-Nathan, D.1    Maestroni, G.J.M.2    Lustig, S.3
  • 49
    • 0032923093 scopus 로고    scopus 로고
    • Prevention of immune dysfunction and vitamin e loss by dehydroepiandrosterone and melatonin supplementation during murine retrovirus infection
    • Zhang Z, Araghi-Niknam M, Liang B et al. Prevention of immune dysfunction and vitamin E loss by dehydroepiandrosterone and melatonin supplementation during murine retrovirus infection. Immunology 1999 96 : 291 297.
    • (1999) Immunology , vol.96 , pp. 291-297
    • Zhang, Z.1    Araghi-Niknam, M.2    Liang, B.3
  • 50
    • 0344131940 scopus 로고    scopus 로고
    • Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats
    • Crespo E, Macias M, Pozo D et al. Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats. FASEB J 1999 13 : 1537 1546.
    • (1999) FASEB J , vol.13 , pp. 1537-1546
    • Crespo, E.1    MacIas, M.2    Pozo, D.3
  • 51
    • 0036790693 scopus 로고    scopus 로고
    • Melatonin reduces colon immunological injury in rats by regulating activity of macrophages
    • Mei Q, Yu JP, Xu JM et al. Melatonin reduces colon immunological injury in rats by regulating activity of macrophages. Acta Pharmacol Sin 2002 23 : 882 886.
    • (2002) Acta Pharmacol Sin , vol.23 , pp. 882-886
    • Mei, Q.1    Yu, J.P.2    Xu, J.M.3
  • 52
    • 4644220884 scopus 로고    scopus 로고
    • Effect of melatonin on the generation of nitric oxide in murine macrophages
    • Zhanga S, Lib W, Gaob Q et al. Effect of melatonin on the generation of nitric oxide in murine macrophages. Eur J Pharmacol 2004 501 : 25 30.
    • (2004) Eur J Pharmacol , vol.501 , pp. 25-30
    • Zhanga, S.1    Lib, W.2    Gaob, Q.3
  • 53
    • 0032033419 scopus 로고    scopus 로고
    • Cytokines induce the development of functionally heterogeneous T helper cell subsets
    • O'garra A. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 1998 8 : 275 283.
    • (1998) Immunity , vol.8 , pp. 275-283
    • O'Garra, A.1
  • 54
    • 0034129629 scopus 로고    scopus 로고
    • Signaling and transcription in T helper development
    • Murphy KM, Ouyang W, Farrar JD et al. Signaling and transcription in T helper development. Annu Rev Immunol 2000 18 : 451 494.
    • (2000) Annu Rev Immunol , vol.18 , pp. 451-494
    • Murphy, K.M.1    Ouyang, W.2    Farrar, J.D.3
  • 55
    • 0037313578 scopus 로고    scopus 로고
    • Interleukin-12 and the regulation of innate resistance and adaptive immunity
    • Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003 3 : 133 146.
    • (2003) Nat Rev Immunol , vol.3 , pp. 133-146
    • Trinchieri, G.1
  • 56
    • 0034571173 scopus 로고    scopus 로고
    • The molecular basis of T helper 1 and T helper 2 cell differentiation
    • O'garra A, Arai N. The molecular basis of T helper 1 and T helper 2 cell differentiation. Trends Cell Biol 2000 10 : 542 550.
    • (2000) Trends Cell Biol , vol.10 , pp. 542-550
    • O'Garra, A.1    Arai, N.2
  • 57
    • 0038638583 scopus 로고    scopus 로고
    • An epigenetic view of helper T cell differentiation
    • Ansel KM, Lee DU, Rao A. An epigenetic view of helper T cell differentiation. Nat Immunol 2003 4 : 616 623.
    • (2003) Nat Immunol , vol.4 , pp. 616-623
    • Ansel, K.M.1    Lee, D.U.2    Rao, A.3
  • 58
    • 0029105296 scopus 로고
    • A review of the evidence supporting melatonin's role as an antioxidant
    • Reiter RJ, Melchiorri D, Sewerynek E et al. A review of the evidence supporting melatonin's role as an antioxidant. J Pineal Res 1995 18 : 1 11.
    • (1995) J Pineal Res , vol.18 , pp. 1-11
    • Reiter, R.J.1    Melchiorri, D.2    Sewerynek, E.3
  • 60
    • 33845529120 scopus 로고    scopus 로고
    • The potential of melatonin in reducing morbidity-mortality after craniocerebral trauma
    • Maldonado MD, Murillo-Cabezas F, Terron MP et al. The potential of melatonin in reducing morbidity-mortality after craniocerebral trauma. J Pineal Res 2007 42 : 1 11.
    • (2007) J Pineal Res , vol.42 , pp. 1-11
    • Maldonado, M.D.1    Murillo-Cabezas, F.2    Terron, M.P.3
  • 61
    • 33847607366 scopus 로고    scopus 로고
    • Chronic melatonin treatment reduces the age-dependent inflammatory process in senescence-accelerated mice
    • Rodríguez MI, Escames G, López LC et al. Chronic melatonin treatment reduces the age-dependent inflammatory process in senescence- accelerated mice. J Pineal Res 2007 42 : 272 279.
    • (2007) J Pineal Res , vol.42 , pp. 272-279
    • Rodríguez, M.I.1    Escames, G.2    López, L.C.3
  • 62
    • 33845536018 scopus 로고    scopus 로고
    • One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species?
    • Tan DX, Manchester LC, Terron MP et al. One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J Pineal Res 2007 42 : 28 42.
    • (2007) J Pineal Res , vol.42 , pp. 28-42
    • Tan, D.X.1    Manchester, L.C.2    Terron, M.P.3
  • 63
    • 33748042003 scopus 로고    scopus 로고
    • Inhibition of neuronal nitric oxide synthase activity by N1-acetyl-5-methoxykynuramine, a brain metabolite of melatonin
    • León J, Escames G, Rodríguez MI, López LC et al. Inhibition of neuronal nitric oxide synthase activity by N1-acetyl-5- methoxykynuramine, a brain metabolite of melatonin. J Neurochem 2006 98 : 2023 2033.
    • (2006) J Neurochem , vol.98 , pp. 2023-2033
    • León, J.1    Escames, G.2    Rodríguez, M.I.3    López, L.C.4
  • 64
    • 0019814668 scopus 로고
    • The half-life of melatonin elimination from rat plasma
    • Gibbs FP, Vriend J. The half-life of melatonin elimination from rat plasma. Endocrinology 1981 109 : 1796 1798.
    • (1981) Endocrinology , vol.109 , pp. 1796-1798
    • Gibbs, F.P.1    Vriend, J.2
  • 65
    • 0037082351 scopus 로고    scopus 로고
    • Melatonin reduces oxidative damage and increases survival of mice infected with Schistosoma mansoni
    • El-Sokkary GH, Omar HM, Hassanein AF et al. Melatonin reduces oxidative damage and increases survival of mice infected with Schistosoma mansoni. Free Radic Biol Med 2002 32 : 319 332.
    • (2002) Free Radic Biol Med , vol.32 , pp. 319-332
    • El-Sokkary, G.H.1    Omar, H.M.2    Hassanein, A.F.3
  • 66
    • 34848850220 scopus 로고    scopus 로고
    • Human malarial parasite, Plasmodium falciparum, displays capacitative calcium entry: 2-aminoethyl diphenylborinate blocks the signal transduction pathway of melatonin action on the P. falciparum cell cycle
    • Beraldo FH, Mikoshiba K, Garcia CR. Human malarial parasite, Plasmodium falciparum, displays capacitative calcium entry: 2-aminoethyl diphenylborinate blocks the signal transduction pathway of melatonin action on the P. falciparum cell cycle. J Pineal Res 2007 43 : 360 364.
    • (2007) J Pineal Res , vol.43 , pp. 360-364
    • Beraldo, F.H.1    Mikoshiba, K.2    Garcia, C.R.3
  • 67
    • 34848826062 scopus 로고    scopus 로고
    • Melatonin inhibits free radical-mediated mitochondrial-dependent hepatocyte apoptosis and liver damage induced during malarial infection
    • Guha M, Maity P, Choubey V, Mitra K et al. Melatonin inhibits free radical-mediated mitochondrial-dependent hepatocyte apoptosis and liver damage induced during malarial infection. J Pineal Res 2007 43 : 372 381.
    • (2007) J Pineal Res , vol.43 , pp. 372-381
    • Guha, M.1    Maity, P.2    Choubey, V.3    Mitra, K.4
  • 68
    • 0026032553 scopus 로고
    • Functional diversity of T lymphocytes due to secretion of different cytokine patterns
    • Street NE, Mosmann TR. Functional diversity of T lymphocytes due to secretion of different cytokine patterns. FASEB J 1991 5 : 171 177.
    • (1991) FASEB J , vol.5 , pp. 171-177
    • Street, N.E.1    Mosmann, T.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.