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Volumn 15, Issue 4, 2008, Pages 381-390

B-cell lymphoma 6 and the molecular pathogenesis of diffuse large B-cell lymphoma

Author keywords

B cell lymphoma 6; Non Hodgkin lymphoma; Transcription therapy; Transcriptional repression

Indexed keywords

ANTINEOPLASTIC AGENT; APTAMER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 6; STAT PROTEIN;

EID: 47149096182     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0b013e328302c7df     Document Type: Review
Times cited : (69)

References (51)
  • 1
    • 0029904294 scopus 로고    scopus 로고
    • BCL-6 expression during B-cell activation
    • Allman D, Jain A, Dent A, et al. BCL-6 expression during B-cell activation. Blood 1996; 87:5257-5268.
    • (1996) Blood , vol.87 , pp. 5257-5268
    • Allman, D.1    Jain, A.2    Dent, A.3
  • 2
    • 0030901289 scopus 로고    scopus 로고
    • Control of inflammation, cytokine expression, and germinal center formation by BCL-6
    • Dent AL, Shaffer AL, Yu X, et al. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 1997; 276:589-592.
    • (1997) Science , vol.276 , pp. 589-592
    • Dent, A.L.1    Shaffer, A.L.2    Yu, X.3
  • 3
    • 17144439800 scopus 로고    scopus 로고
    • The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation
    • Ye BH, Cattoretti G, Shen Q, et al. The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat Genet 1997; 16:161-170.
    • (1997) Nat Genet , vol.16 , pp. 161-170
    • Ye, B.H.1    Cattoretti, G.2    Shen, Q.3
  • 4
    • 0034036293 scopus 로고    scopus 로고
    • BCL-6 in the pathogenesis of non-Hodgkin's lymphoma
    • Ye BH. BCL-6 in the pathogenesis of non-Hodgkin's lymphoma. Cancer Invest 2000; 18:356-365.
    • (2000) Cancer Invest , vol.18 , pp. 356-365
    • Ye, B.H.1
  • 5
    • 4644302712 scopus 로고    scopus 로고
    • The human BCL6 transgene promotes the development of lymphomas in the mouse
    • Baron BW, Anastasi J, Montag A, et al. The human BCL6 transgene promotes the development of lymphomas in the mouse. Proc Natl Acad Sci USA 2004; 101:14198-14203.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 14198-14203
    • Baron, B.W.1    Anastasi, J.2    Montag, A.3
  • 6
    • 19344368745 scopus 로고    scopus 로고
    • Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice
    • Cattoretti G, Pasqualucci L, Ballon G, et al. Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice. Cancer Cell 2005; 7:445-455.
    • (2005) Cancer Cell , vol.7 , pp. 445-455
    • Cattoretti, G.1    Pasqualucci, L.2    Ballon, G.3
  • 7
    • 11144277489 scopus 로고    scopus 로고
    • Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells
    • Polo JM, Dell'Oso T, Ranuncolo SM, et al. Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells. Nat Med 2004; 10:1329-1335.
    • (2004) Nat Med , vol.10 , pp. 1329-1335
    • Polo, J.M.1    Dell'Oso, T.2    Ranuncolo, S.M.3
  • 8
    • 10344247666 scopus 로고    scopus 로고
    • The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells
    • Phan RT, Dalla-Favera R. The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells. Nature 2004; 432:635-639.
    • (2004) Nature , vol.432 , pp. 635-639
    • Phan, R.T.1    Dalla-Favera, R.2
  • 9
    • 39149099085 scopus 로고    scopus 로고
    • Two levels of protection for the Bcell genome during somatic hypermutation
    • Liu M, Duke JL, Richter DJ, et al. Two levels of protection for the Bcell genome during somatic hypermutation. Nature 2008; 451:841-845.
    • (2008) Nature , vol.451 , pp. 841-845
    • Liu, M.1    Duke, J.L.2    Richter, D.J.3
  • 10
    • 0035913362 scopus 로고    scopus 로고
    • Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas
    • Pasqualucci L, Neumeister P, Goossens T, et al. Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature 2001; 412:341-346.
    • (2001) Nature , vol.412 , pp. 341-346
    • Pasqualucci, L.1    Neumeister, P.2    Goossens, T.3
  • 11
    • 37549068541 scopus 로고    scopus 로고
    • AID is required for germinal center- derived lymphomagenesis
    • Pasqualucci L, BhagatG, Jankovic M, et al. AID is required for germinal center- derived lymphomagenesis. Nat Genet 2008; 40:108-112.
    • (2008) Nat Genet , vol.40 , pp. 108-112
    • Pasqualucci, L.1    Bhagat, G.2    Jankovic, M.3
  • 12
    • 34250762588 scopus 로고    scopus 로고
    • Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR
    • Ranuncolo SM, Polo JM, Dierov J, et al. Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR. Nat Immunol 2007; 8:705-714.
    • (2007) Nat Immunol , vol.8 , pp. 705-714
    • Ranuncolo, S.M.1    Polo, J.M.2    Dierov, J.3
  • 13
    • 44449102037 scopus 로고    scopus 로고
    • Ranuncolo SM, Polo JM, MelnickA. BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells. Blood Cells Mol Dis 2008 [Epub ahead of print].
    • Ranuncolo SM, Polo JM, MelnickA. BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells. Blood Cells Mol Dis 2008 [Epub ahead of print].
  • 14
    • 27144462049 scopus 로고    scopus 로고
    • BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells
    • Phan RT, Saito M, Basso K, et al. BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells. Nat Immunol 2005; 6:1054-1060.
    • (2005) Nat Immunol , vol.6 , pp. 1054-1060
    • Phan, R.T.1    Saito, M.2    Basso, K.3
  • 15
    • 44849126092 scopus 로고    scopus 로고
    • Sequential transcription factor targeting for diffuse large B-cell lymphomas
    • Cerchietti L, Polo J, DaSilva G, et al. Sequential transcription factor targeting for diffuse large B-cell lymphomas. Cancer Res 2008; 68:3361-3369.
    • (2008) Cancer Res , vol.68 , pp. 3361-3369
    • Cerchietti, L.1    Polo, J.2    DaSilva, G.3
  • 16
    • 33847206141 scopus 로고    scopus 로고
    • In vivo imaging of germinal centres reveals a dynamic open structure
    • Schwickert TA, Lindquist RL, Shakhar G, et al. In vivo imaging of germinal centres reveals a dynamic open structure. Nature 2007; 446:83-87.
    • (2007) Nature , vol.446 , pp. 83-87
    • Schwickert, T.A.1    Lindquist, R.L.2    Shakhar, G.3
  • 17
    • 33846635838 scopus 로고    scopus 로고
    • Imaging of germinal center selection events during affinity maturation
    • Allen CD, Okada T, Tang HL, Cyster JG. Imaging of germinal center selection events during affinity maturation. Science 2007; 315:528-531.
    • (2007) Science , vol.315 , pp. 528-531
    • Allen, C.D.1    Okada, T.2    Tang, H.L.3    Cyster, J.G.4
  • 18
    • 66549094752 scopus 로고    scopus 로고
    • A 'survival of the fittest' mechanism for weeding out potentially lymphomagenic B-cells during germinal center B-cell differentiation
    • Ci W, Polo JM, Dell'Oso T, Melnick A. A 'survival of the fittest' mechanism for weeding out potentially lymphomagenic B-cells during germinal center B-cell differentiation. Blood 2007; 110:171a-172a.
    • (2007) Blood , vol.110
    • Ci, W.1    Polo, J.M.2    Dell'Oso, T.3    Melnick, A.4
  • 19
    • 34548706562 scopus 로고    scopus 로고
    • Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells
    • Phan RT, Saito M, Kitagawa Y, et al. Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells. Nat Immunol 2007; 8:1132-1139.
    • (2007) Nat Immunol , vol.8 , pp. 1132-1139
    • Phan, R.T.1    Saito, M.2    Kitagawa, Y.3
  • 20
    • 34247387876 scopus 로고    scopus 로고
    • KuoTC, Shaffer AL, Haddad J Jr, et al. Repression of BCL-6 is required for the formation of human memory B cells in vitro. J Exp Med 2007; 204:819-830.
    • KuoTC, Shaffer AL, Haddad J Jr, et al. Repression of BCL-6 is required for the formation of human memory B cells in vitro. J Exp Med 2007; 204:819-830.
  • 21
    • 3142728530 scopus 로고    scopus 로고
    • Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation
    • Tunyaplin C, Shaffer AL, Angelin-Duclos CD, et al. Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation. J Immunol 2004; 173:1158-1165.
    • (2004) J Immunol , vol.173 , pp. 1158-1165
    • Tunyaplin, C.1    Shaffer, A.L.2    Angelin-Duclos, C.D.3
  • 22
    • 10244261528 scopus 로고    scopus 로고
    • Tracking CD40 signaling during germinal center development
    • Basso K, Klein U, Niu H, et al. Tracking CD40 signaling during germinal center development. Blood 2004; 104:4088-4096.
    • (2004) Blood , vol.104 , pp. 4088-4096
    • Basso, K.1    Klein, U.2    Niu, H.3
  • 23
    • 34548237299 scopus 로고    scopus 로고
    • A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma
    • Saito M, Gao J, Basso K, et al. A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma. Cancer Cell 2007; 12:280-292.
    • (2007) Cancer Cell , vol.12 , pp. 280-292
    • Saito, M.1    Gao, J.2    Basso, K.3
  • 24
    • 34548617140 scopus 로고    scopus 로고
    • IRF4 negatively regulates proliferation of germinal center B cell-derived Burkitt's lymphoma cell lines and induces differentiation toward plasma cells
    • Teng Y, Takahashi Y, Yamada M, et al. IRF4 negatively regulates proliferation of germinal center B cell-derived Burkitt's lymphoma cell lines and induces differentiation toward plasma cells. Eur J Cell Biol 2007; 86:581-589.
    • (2007) Eur J Cell Biol , vol.86 , pp. 581-589
    • Teng, Y.1    Takahashi, Y.2    Yamada, M.3
  • 25
    • 10844275574 scopus 로고    scopus 로고
    • BCL-6 negatively regulates expression of the NF-kappaB1 p105/p50 subunit
    • Li Z, Wang X, Yu RY, et al. BCL-6 negatively regulates expression of the NF-kappaB1 p105/p50 subunit. J Immunol 2005; 174:205-214.
    • (2005) J Immunol , vol.174 , pp. 205-214
    • Li, Z.1    Wang, X.2    Yu, R.Y.3
  • 26
    • 40349091558 scopus 로고    scopus 로고
    • BCL6 represses NFkappaB activity in diffuse large B-cell lymphomas
    • Perez-Rosado A, Artiga M, Vargiu P, et al. BCL6 represses NFkappaB activity in diffuse large B-cell lymphomas. J Pathol 2008; 214:498-507.
    • (2008) J Pathol , vol.214 , pp. 498-507
    • Perez-Rosado, A.1    Artiga, M.2    Vargiu, P.3
  • 27
    • 33847674920 scopus 로고    scopus 로고
    • Transcriptional signature with differ- ential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas
    • Polo JM, Juszczynski P, Monti S, et al. Transcriptional signature with differ- ential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas. Proc Natl Acad Sci USA 2007; 104:3207-3212.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 3207-3212
    • Polo, J.M.1    Juszczynski, P.2    Monti, S.3
  • 28
    • 0034598746 scopus 로고    scopus 로고
    • Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
    • Alizadeh AA, Eisen MB, Davis RE, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000; 403:503-511.
    • (2000) Nature , vol.403 , pp. 503-511
    • Alizadeh, A.A.1    Eisen, M.B.2    Davis, R.E.3
  • 29
    • 19944428834 scopus 로고    scopus 로고
    • Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling
    • Lam LT, Davis RE, Pierce J, et al. Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling. Clin Cancer Res 2005; 11:28-40.
    • (2005) Clin Cancer Res , vol.11 , pp. 28-40
    • Lam, L.T.1    Davis, R.E.2    Pierce, J.3
  • 30
    • 43549097394 scopus 로고    scopus 로고
    • Cooperative signaling through the STAT3 and NF-{kappa}B pathways in subtypes of diffuse large B cell lymphoma
    • Lam LT, Wright G, Davis RE, et al. Cooperative signaling through the STAT3 and NF-{kappa}B pathways in subtypes of diffuse large B cell lymphoma. Blood 2008; 111:3701-3713.
    • (2008) Blood , vol.111 , pp. 3701-3713
    • Lam, L.T.1    Wright, G.2    Davis, R.E.3
  • 31
    • 38949165127 scopus 로고    scopus 로고
    • Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas
    • Ding BB, Yu JJ, Yu RY, et al. Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas. Blood 2008; 111:1515-1523.
    • (2008) Blood , vol.111 , pp. 1515-1523
    • Ding, B.B.1    Yu, J.J.2    Yu, R.Y.3
  • 32
    • 0034684672 scopus 로고    scopus 로고
    • Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6
    • Reljic R, Wagner SD, Peakman LJ, Fearon DT. Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6. J Exp Med 2000; 192:1841-1848.
    • (2000) J Exp Med , vol.192 , pp. 1841-1848
    • Reljic, R.1    Wagner, S.D.2    Peakman, L.J.3    Fearon, D.T.4
  • 33
    • 33846187999 scopus 로고    scopus 로고
    • STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas
    • Walker SR, Nelson EA, Frank DA. STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas. Oncogene 2007; 26:224-233.
    • (2007) Oncogene , vol.26 , pp. 224-233
    • Walker, S.R.1    Nelson, E.A.2    Frank, D.A.3
  • 34
    • 33645053774 scopus 로고    scopus 로고
    • Mad1 is a transcriptional repressor of Bcl-6
    • Lee SC, Bottaro A, Chen L, Insel RA. Mad1 is a transcriptional repressor of Bcl-6. Mol Immunol 2006; 43:1965-1971.
    • (2006) Mol Immunol , vol.43 , pp. 1965-1971
    • Lee, S.C.1    Bottaro, A.2    Chen, L.3    Insel, R.A.4
  • 35
    • 0034661112 scopus 로고    scopus 로고
    • Huynh KD, Fischle W, Verdin E, Bardwell VJ. BCoR, a novel corepressor involved in BCL-6 repression. Genes Dev 2000; 14:1810-1823.
    • Huynh KD, Fischle W, Verdin E, Bardwell VJ. BCoR, a novel corepressor involved in BCL-6 repression. Genes Dev 2000; 14:1810-1823.
  • 36
    • 9144242434 scopus 로고    scopus 로고
    • Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain
    • Ahmad KF, Melnick A, Lax S, et al. Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain. Mol Cell 2003; 12:1551-1564.
    • (2003) Mol Cell , vol.12 , pp. 1551-1564
    • Ahmad, K.F.1    Melnick, A.2    Lax, S.3
  • 37
    • 34547909260 scopus 로고    scopus 로고
    • HDAC3: Taking the SMRT-N-CoRrect road to repression
    • Karagianni P, Wong J. HDAC3: taking the SMRT-N-CoRrect road to repression. Oncogene 2007; 26:5439-5449.
    • (2007) Oncogene , vol.26 , pp. 5439-5449
    • Karagianni, P.1    Wong, J.2
  • 38
    • 38949165374 scopus 로고    scopus 로고
    • Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer
    • Ghetu AF, Corcoran CM, Cerchietti L, et al. Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer. Mol Cell 2008; 29:384-391.
    • (2008) Mol Cell , vol.29 , pp. 384-391
    • Ghetu, A.F.1    Corcoran, C.M.2    Cerchietti, L.3
  • 39
    • 33748641974 scopus 로고    scopus 로고
    • Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets
    • Gearhart MD, Corcoran CM, Wamstad JA, Bardwell VJ. Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. Mol Cell Biol 2006; 26:6880-6889.
    • (2006) Mol Cell Biol , vol.26 , pp. 6880-6889
    • Gearhart, M.D.1    Corcoran, C.M.2    Wamstad, J.A.3    Bardwell, V.J.4
  • 40
    • 34249715325 scopus 로고    scopus 로고
    • Proteomics analysis of Ring1B/ Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor
    • Sanchez C, Sanchez I, Demmers JA, et al. Proteomics analysis of Ring1B/ Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. Mol Cell Proteomics 2007; 6:820-834.
    • (2007) Mol Cell Proteomics , vol.6 , pp. 820-834
    • Sanchez, C.1    Sanchez, I.2    Demmers, J.A.3
  • 41
    • 34548256410 scopus 로고    scopus 로고
    • BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms
    • Parekh S, Polo JM, Shaknovich R, et al. BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms. Blood 2007; 110:2067-2074.
    • (2007) Blood , vol.110 , pp. 2067-2074
    • Parekh, S.1    Polo, J.M.2    Shaknovich, R.3
  • 42
    • 5344280456 scopus 로고    scopus 로고
    • MTA3and Mi-2/NuRD complex regulate cell fate during B-lymphocyte differentiation
    • FujitaN, Jaye DL, Geigerman C, et al. MTA3and Mi-2/NuRD complex regulate cell fate during B-lymphocyte differentiation. Cell 2004; 119:75-86.
    • (2004) Cell , vol.119 , pp. 75-86
    • Fujita, N.1    Jaye, D.L.2    Geigerman, C.3
  • 43
    • 34548393739 scopus 로고    scopus 로고
    • The BCL6-associated transcriptional co-repressor, MTA3, is selectively expressed by germinal centre B cells and lymphomas of putative germinal centre derivation
    • Jaye DL, Iqbal J, Fujita N, et al. The BCL6-associated transcriptional co-repressor, MTA3, is selectively expressed by germinal centre B cells and lymphomas of putative germinal centre derivation. J Pathol 2007; 213:106-115.
    • (2007) J Pathol , vol.213 , pp. 106-115
    • Jaye, D.L.1    Iqbal, J.2    Fujita, N.3
  • 44
    • 0842285672 scopus 로고    scopus 로고
    • ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein
    • Chevallier N, Corcoran CM, Lennon C, et al. ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein. Blood 2004; 103: 1454-1463.
    • (2004) Blood , vol.103 , pp. 1454-1463
    • Chevallier, N.1    Corcoran, C.M.2    Lennon, C.3
  • 45
    • 41149139718 scopus 로고    scopus 로고
    • CtBP is an essential corepressor for BCL6 autoregulation
    • Mendez LM, Polo JM, Yu JJ, et al. CtBP is an essential corepressor for BCL6 autoregulation. Mol Cell Biol 2008; 28:2175-2186.
    • (2008) Mol Cell Biol , vol.28 , pp. 2175-2186
    • Mendez, L.M.1    Polo, J.M.2    Yu, J.J.3
  • 46
    • 0034278508 scopus 로고    scopus 로고
    • BCL-6 regulates chemokine gene transcription in macrophages
    • Toney LM, Cattoretti G, Graf JA, et al. BCL-6 regulates chemokine gene transcription in macrophages. Nat Immunol 2000; 1:214-220.
    • (2000) Nat Immunol , vol.1 , pp. 214-220
    • Toney, L.M.1    Cattoretti, G.2    Graf, J.A.3
  • 47
    • 33645735686 scopus 로고    scopus 로고
    • A peptide aptamer to antagonize BCL-6 function
    • Chattopadhyay A, Tate SA, Beswick RW, et al. A peptide aptamer to antagonize BCL-6 function. Oncogene 2006; 25:2223-2233.
    • (2006) Oncogene , vol.25 , pp. 2223-2233
    • Chattopadhyay, A.1    Tate, S.A.2    Beswick, R.W.3
  • 48
    • 77952582485 scopus 로고    scopus 로고
    • Design and development of small molecules for specific targeted therapy of diffuse large B-cell lymphoma
    • Da Silva G, Ghetu AF, Cerchietti L, et al. Design and development of small molecules for specific targeted therapy of diffuse large B-cell lymphoma. Blood 2007; 110:245-246a.
    • (2007) Blood , vol.110
    • Da Silva, G.1    Ghetu, A.F.2    Cerchietti, L.3
  • 49
    • 46749154664 scopus 로고    scopus 로고
    • Parekh S, Prive GG, MelnickA. Therapeutic targeting of the BCL6 oncogene for diffuse large B-cell lymphomas. Leuk Lymphoma 2008; iFirst:1-9.
    • Parekh S, Prive GG, MelnickA. Therapeutic targeting of the BCL6 oncogene for diffuse large B-cell lymphomas. Leuk Lymphoma 2008; iFirst:1-9.
  • 50
    • 35548935663 scopus 로고    scopus 로고
    • Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma
    • Iqbal J, Greiner TC, Patel K, et al. Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma. Leukemia 2007; 21:2332-2343.
    • (2007) Leukemia , vol.21 , pp. 2332-2343
    • Iqbal, J.1    Greiner, T.C.2    Patel, K.3
  • 51
    • 20144382754 scopus 로고    scopus 로고
    • Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response
    • Monti S, Savage KJ, Kutok JL, et al. Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response. Blood 2005; 105:1851-1861.
    • (2005) Blood , vol.105 , pp. 1851-1861
    • Monti, S.1    Savage, K.J.2    Kutok, J.L.3


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