Population pharmacokinetics and pharmacodynamics for treatment optimization in clinical oncology

Clinical Pharmacokinetics

Volumn 47, Issue 8, 2008, Pages 487-513

  Zandvliet, Anthe S ^a   Schellens, Jan H M ^b,c   Beijnen, Jos H ^c   Huitema, Alwin D R ^a  

^a SLOTERVAART HOSPITAL   (Netherlands)

^b ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Alkylating agents, pharmacokinetics; Antimetabolites, pharmacokinetics; Antineoplastics, pharmacokinetics; Aromatase inhibitors, pharmacokinetics; Camptothecins, pharmacokinetics; Cyclin dependent kinase 1 inhibitors, pharmacokinetics

Indexed keywords

2' DEOXY 2' METHYLIDENECYTIDINE; 5 CHLORO 2,4 DIHYDROXYPYRIDINE PLUS OXONATE POTASSIUM PLUS TEGAFUR; 5' DEOXY 5 FLUOROCYTIDINE; 6 [4 DEOXY 4 (2,4 TETRADECADIENOYLGLYCYLAMINO) GLYCERO BETA MANNOHEPTOPYRANOSYLAMINO] 9H PURINE; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; 7 ETHYL 10 HYDROXYCAMPTOTHECIN GLUCURONIDE; 9 AMINOCAMPTOTHECIN; ALEMTUZUMAB; ANTINEOPLASTIC AGENT; APAZIQUONE; ASPARAGINASE; BUTHIONINE SULFOXIMINE; CAPECITABINE; CARBOPLATIN; CISPLATIN; CRYPTOPHYCIN 52; DEGARELIX; DOCETAXEL; DOXIFLURIDINE; ETOPOSIDE; FLUOROURACIL; IFOSFAMIDE; INDISULAM; IRINOTECAN; MELPHALAN; METHOTREXATE; NEDAPLATIN; OXALIPLATIN; PACLITAXEL; PEMETREXED; SAM 486A; TOPOTECAN; TRASTUZUMAB; TRIPTORELIN; UNINDEXED DRUG; VINFLUNINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; AREA UNDER THE CURVE; BLOOD TOXICITY; BONE MARROW SUPPRESSION; CANCER PATIENT; CHILDHOOD CANCER; CLINICAL TRIAL; DIARRHEA; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG ELIMINATION; DRUG EXPOSURE; DRUG HALF LIFE; DRUG MONITORING; DRUG SAFETY; DRUG TOLERABILITY; DRUG TRANSFORMATION; HAND FOOT SYNDROME; HUMAN; LEUKOPENIA; LUNG NON SMALL CELL CANCER; NEUTROPENIA; OSTEOSARCOMA; PHARMACOGENETICS; PRIORITY JOURNAL; PROSTATE CANCER; REVIEW; THROMBOCYTOPENIA;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG MONITORING; HUMANS; MODELS, BIOLOGICAL; NEOPLASMS;

EID: 47049112936     PISSN: 03125963     EISSN: 03125963     Source Type: Journal    
DOI: 10.2165/00003088-200847080-00001     Document Type: Review

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