Individual 5-FU dose adaptation in metastatic colorectal cancer: Results of a phase II study using a bimonthly pharmacokinetically intensified LV5FU2 regimen

Cancer Chemotherapy and Pharmacology

Volumn 52, Issue 4, 2003, Pages 282-290

  Ychou, Marc ^a   Duffour, Jacqueline ^a   Kramar, Andrew ^a   Debrigode, Charles ^b   Gourgou, Sophie ^a   Bressolle, Françoise ^a   Pinguet, Frédéric ^a  

^a CENTRE VAL D AURELLE   (France)

^b DEPARTMENT OF NEUROLOGY   (France)

Author keywords

5 fluorouracil; Antineoplastic protocols; Colorectal neoplasms; Pharmacokinetics

Indexed keywords

FLUOROURACIL; FOLINIC ACID;

ADULT; AGED; ALOPECIA; APLASIA; AREA UNDER THE CURVE; ARTICLE; BAYES THEOREM; BLOOD TOXICITY; BOLUS INJECTION; CANCER COMBINATION CHEMOTHERAPY; CARDIOTOXICITY; CLINICAL PROTOCOL; CLINICAL TRIAL; COLORECTAL CANCER; COMPUTER PROGRAM; CONTINUOUS INFUSION; DIARRHEA; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG FATALITY; DRUG TOLERABILITY; FEMALE; GASTROINTESTINAL TOXICITY; HAND FOOT SYNDROME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INFECTION; MAJOR CLINICAL STUDY; MALE; METASTASIS; MUCOSA INFLAMMATION; NAUSEA; NEUTROPENIA; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; SKIN DISEASE; SURVIVAL RATE; THORAX DISEASE; THROMBOCYTOPENIA; VOMITING;

ADENOCARCINOMA; ADULT; AGED; ANTIMETABOLITES, ANTINEOPLASTIC; AREA UNDER CURVE; COLORECTAL NEOPLASMS; DISEASE-FREE SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLUOROURACIL; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; SURVIVAL ANALYSIS;

EID: 0242361685     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-003-0658-0     Document Type: Article

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