Evaluation of the autoinduction of ifosfamide metabolism by a population pharmacokinetic approach using NONMEM

British Journal of Clinical Pharmacology

Volumn 49, Issue 6, 2000, Pages 555-561

  Kerbusch, T ^a   Huitema, A D R ^a   Ouwerkerk, J ^b   Keizer, H J ^b   Mathot R A A ^a   Schellens, J H M ^a   Beijnen, J H ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Autoinduction; Ifosfamide; NONMEM; Population pharmacokinetics

Indexed keywords

ANTICOAGULANT AGENT; ANTIEMETIC AGENT; BICARBONATE; DRUG METABOLIZING ENZYME; GLUCOCORTICOID; HISTAMINE H2 RECEPTOR ANTAGONIST; IFOSFAMIDE; MESNA; TRICYCLIC ANTIDEPRESSANT AGENT;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTINUOUS INFUSION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG METABOLISM; ENZYME METABOLISM; FEMALE; HUMAN; MALE; MODEL; NEUROTOXICITY; PRIORITY JOURNAL; SOFT TISSUE SARCOMA;

ADULT; AGED; ALGORITHMS; ANTINEOPLASTIC AGENTS, ALKYLATING; AREA UNDER CURVE; COMPUTER SIMULATION; FEMALE; HUMANS; IFOSFAMIDE; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; PHARMACOKINETICS; POPULATION; SARCOMA; SOFT TISSUE NEOPLASMS; SOFTWARE;

EID: 0034081715     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.2000.00217.x     Document Type: Article

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