Further evidence for shared genetic effects between psychotic bipolar disorder and P50 suppression: A combined twin and family study

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 147, Issue 5, 2008, Pages 619-627

  Hall, Mei Hua ^a   Schulze, Katja ^b   Sham, Pak ^c   Kalidindi, Sridevi ^b   McDonald, Colm ^d   Bramon, Elvira ^b   Levy, Deborah L ^a   Murray, Robin M ^b   Rijsdijk, Frühling ^b  

^a MCLEAN HOSPITAL   (United States)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

Bipolar disorder; Endophenotype; P50 ERPs; Twin modelling

Indexed keywords

ADULT; ARTICLE; BIPOLAR DISORDER; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; EVOKED AUDITORY RESPONSE; FAMILIAL DISEASE; FEMALE; GENETIC SUSCEPTIBILITY; GENETIC TRAIT; HEREDITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOZYGOTIC TWINS; NEUROPSYCHOLOGICAL TEST; P50 CONDITIONING TESTING; PHENOTYPE; PRIORITY JOURNAL; PSYCHOSIS; SENSORY SYSTEM; STATISTICAL ANALYSIS; TWINS;

ADULT; BIPOLAR DISORDER; DISEASES IN TWINS; ELECTROENCEPHALOGRAPHY; EVOKED POTENTIALS, AUDITORY; FEMALE; HUMANS; MALE; PSYCHOTIC DISORDERS; TWINS; TWINS, MONOZYGOTIC;

EID: 46949087544     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30653     Document Type: Article

References (47)

1. Adler LE, Pachtman E, Franks RD, Pecevich M, Waldo MC, Freedman R. 1982. Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia. Biol Psychiatry 17(6):639-654.
2. Adler LE, Hoffer LJ, Griffith J, Waldo MC, Freedman R. 1992. Normalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics. Biol Psychiatry 32(7):607-616.
3. Adler LE, Hoffer LD, Wiser A, Freedman R. 1993. Normalization of auditory physiology by cigarette smoking in schizophrenic patients. Am J Psychiatry 150(12):1856-1861.
4. Boomsma D, Busjahn A, Peltonen L. 2002. Classical twin studies and beyond. Nat Rev Genet 3(11):872-882.
5. Boutros NN, Korzyuko O, Oliwa G, Feingold A, Campbell D, McClain-Furmanski D, Struve F, Jansen BH. 2004a. Morphological and latency abnormalities of the mid-latency auditory evoked responses in schizophrenia: A preliminary report. Schizophr Res 70(2-3):303-313.
6. Boutros NN, Korzyukov O, Jansen B, Feingold A, Bell M. 2004b. Sensory gating deficits during the mid-latency phase of information processing in medicated schizophrenia patients. Psychiatry Res 126(3):203-215.
7. Bramon E, Rabe-Hesketh S, Sham P, Murray RM, Frangou S. 2004. Meta-analysis of the P300 and P50 waveforms in schizophrenia. Schizophr Res 70(2-3):315-329.
8. Breen G, Prata D, Osborne S, Munro J, Sinclair M, Li T, Staddon S, Dempster D, Sainz R, Arroyo B, et al. 2006. Association of the dysbindin gene with bipolar affective disorder. Am J Psychiatry 163(9):1636-1638.
9. Clementz BA, Blumenfeld LD. 2001. Multichannel electroencephalographic assessment of auditory evoked response suppression in schizophrenia. Exp Brain Res 139(4):377-390.
10. Clementz BA, Blumenfeld LD, Cobb S. 1997. The gamma band response may account for poor P50 suppression in schizophrenia. Neuroreport 8(18):3889-3893.
11. Clementz BA, Geyer MA, Braff DL. 1998. Poor P50 suppression among schizophrenia patients and their first-degree biological relatives. Am J Psychiatry 155(12):1691-1694.
12. Craddock N, Owen MJ. 2005. The beginning of the end for the Kraepelinian dichotomy. Br J Psychiatry 186:364-366.
13. DePaulo JR Jr. 2004. Genetics of Bipolar Disorder: Where Do We Stand? Am J Psychiatry 161(4):595-597.
14. Falconer DS, Mackay TFC. 1996. Introduction to quantitative genetics. 4th ed. Harlow: Longman.
15. First MB, Spitzer RL, Gibbon M, Williams JBW. 1997. Structured Clinical Interview for DSM-IV Axis I Disorders (SCID). New York: New York State Psychiatric Institute, Biometrics Research.
16. Freedman R, Adler LE, Waldo MC, Pachtman E, Franks RD. 1983. Neurophysiological evidence for a defect in inhibitory pathways in schizophrenia: Comparison of medicated and drug-free patients. Biol Psychiatry 18(5):537-551.
17. Freedman R, Adler LE, Myles-Worsley M, Nagamoto HT, Miller C, Kisley M, McRae K, Cawthra E, Waldo M. 1996. Inhibitory gating of an evoked response to repeated auditory stimuli in schizophrenic and normal subjects. Human recordings, computer simulation, and an animal model. Arch Gen Psychiatry 53(12):1114-1121.
18. Freedman R, Coon H, Myles-Worsley M, Orr-Urtreger A, Olincy A, Davis A, Polymeropoulos M, Holik J, Hopkins J, Hoff M, et al. 1997. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc Natl Acad Sci USA 94(2):587-592.
19. Freedman R, Adler LE, Leonard S. 1999. Alternative phenotypes for the complex genetics of schizophrenia. Biol Psychiatry 45(5):551-558.
20. Gottesman II, Gould TD. 2003. The endophenotype concept in psychiatry: Etymology and strategic intentions. Am J Psychiatry 160(4):636-645.
21. Hall MH, Schulze K, Rijsdijk F, Picchioni M, Ettinger U, Bramon E, Freedman R, Murray RM, Sham P. 2006. Heritability and reliability of P300, P50 and duration mismatch negativity. Behav Genet 36(6):845-857.
22. Hall M-H, Rijsdijk FV, Kalidindi S, Schulze K, Kravariti E, Kane F, Sham P, Bramon E, Murray R. 2007a. Genetic overlap between bipolar illness and event-related potentials. Psychol Med 37(5):667-678.
23. Hall M-H, Rijsdijk FV, Picchioni M, Schulze K, Ettinger U, Toulopoulou T, Murray R, Sham P. 2007b. Substantial shared genetic influences on schizophrenia and event-related potentials. Am J Psychiatry 164:804-812.
24. Hasler G, Drevets WC, Gould TD, Gottesman II, Manji HK. 2006. Toward constructing an endophenotype strategy for bipolar disorders. Biol Psychiatry 60(2):93-105.
25. Jasper H. 1958. Report to the committee on methods of clinical examination in electroencephalography. Electroencephalogr Clin Neurophysiol 10:371-375.
26. Johannesen JK, Kieffaber PD, O'Donnell BF, Shekhar A, Evans JD, Hetrick WP. 2005. Contributions of subtype and spectral frequency analyses to the study of P50 ERP amplitude and suppression in schizophrenia. Schizophr Res 78(2-3):269-284.
27. Lander ES. 1988. Splitting schizophrenia. Nature 336(6195):105-106.
28. Lenox R, Gould TD, Manji HK. 2002. Endophenotypes in bipolar disorder. Am J Med Genet 114:391-406.
29. Louchart-de la Chapelle S, Nkam I, Houy E, Belmont A, Menard JF, Roussignol AC, Siwek O, Mezerai M, Guillermou M, Fouldrin G, et al. 2005. A concordance study of three electrophysiological measures in schizophrenia. Am J Psychiatry 162(3):466-474.
30. Matthysse S, Parnas J. 1992. Extending the phenotype of schizophrenia: Implications for linkage analysis. J Psychiatr Res 26(4):329-344.
31. McDonald C, Marshall N, Sham PC, Bullmore ET, Schulze K, Chapple B, Bramon E, Filbey F, Quraishi S, Walshe M, et al. 2006. Regional brain morphometry in patients with schizophrenia or bipolar disorder and their unaffected relatives. Am J Psychiatry 163(3):478-487.
32. McGuffin P, Rijsdijk F, Andrew M, Sham P, Katz R, Cardno A. 2003. The heritability of bipolar affective disorder and the genetic relationship to unipolar depression. Arch Gen Psychiatry 60(5):497-502.
33. McQueen MB, Devlin B, Faraone SV, Nimgaonkar VL, Sklar P, Smoller JW, Abou Jamra R, Albus M, Bacanu S-A, Baron M, et al. 2005. Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. Am J Hum Genet 77(4):582-595.
34. Myles-Worsley M, Ord L, Blailes F, Ngiralmau H, Freedman R. 2004. P50 sensory gating in adolescents from a pacific island isolate with elevated risk for schizophrenia. Biol Psychiatry 55(7):663-667.
35. Neale MC, Kendler KS. 1995. Models of comorbidity for multifactorial disorders. Am J Hum Genet 57(4):935-953.
36. Neale MC, Boker SM, Xie G, Maes HH. 1999. MX; statistical modeling. 5th edition. Richmond, VA: Department of Psychiatry.
37. Olincy A, Martin L. 2005. Diminished suppression of the P50 auditory evoked potential in bipolar disorder subjects with a history of psychosis. Am J Psychiatry 162(1):43-49.
38. Posthuma D, de Geus EJ, Neale MC, Hulshoff Pol HE, Baare WEC, Kahn RS, Boomsma D. 2000. Multivariate genetic analysis of brain structure in an extended twin design. Behav Genet 30(4):311-319.
39. Preston GA, Weinberger DR. 2005. Intermediate phenotypes in schizophrenia: A selective review. Dialogues Clin Neurosci 7(2):165-179.
40. Price GW, Michie PT, Johnston J, Innes-Brown H, Kent A, Clissa P, Jablensky AV. 2006. A multivariate electrophysiological endophenotype, from a unitary cohort, shows greater research utility than any single feature in the Western Australian Family Study of Schizophrenia. Biol Psychiatry 60(1):1-10.
41. Rijsdijk FV, van Haren NE, Picchioni MM, McDonald C, Toulopoulou T, Pol HE, Kahn RS, Murray R, Sham PC. 2005. Brain MRI abnormalities in schizophrenia: Same genes or same environment? Psychol Med 35(10):1399-1409.
42. Schulze KK, Hall MH, McDonald C, Marshall N, Walshe M, Murray RM, Bramon E. 2007. P50 auditory evoked potential suppression in bipolar disorder patients with psychotic features and their unaffected relatives. Biol Psychiatry. 62(2):121-128.
43. Segurado R, Detera-Wadleigh SD, Levinson DF, Lewis CM, Gill M, Nurnberger JI Jr, Craddock N, DePaulo JR, Baron M, Gershon ES, et al. 2003. Genome scan meta-analysis of schizophrenia and bipolar disorder. Part III. Bipolar disorder. Am J Hum Genet 73(1):49-62.
44. Shastry BS. 2005. Bipolar disorder: An update. Neurochem Int 46(4):273-279.
45. Siegel C, Waldo M, Mizner G, Adler LE, Freedman R. 1984. Deficits in sensory gating in schizophrenic patients and their relatives. Evidence obtained with auditory evoked responses. Arch Gen Psychiatry 41(6):607-612.
46. Smith DA, Boutros NN, Schwarzkopf SB. 1994. Reliability of P50 auditory event-related potential indices of sensory gating. Psychophysiology 31(5):495-502.
47. Spitzer RL, Endicott J. 1978. Schedule for affective disorders and schizophrenia - Lifetime version. New York: New York State Psychiatric Institute.