P50 sensory gating in adolescents from a Pacific Island isolate with elevated risk for schizophrenia

Biological Psychiatry

Volumn 55, Issue 7, 2004, Pages 663-667

  Myles Worsley, Marina ^a   Ord, Lisa ^a   Blailes, Francisca ^b   Ngiralmau, Hilda ^b   Freedman, Robert ^c  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b Republic of Palau Ministry of Health   (Palau)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

Genetics; High risk offspring; P50 sensory gating; Prodrome; Schizophrenia

Indexed keywords

ADOLESCENT; ARTICLE; AUDITORY STIMULATION; CONTROLLED STUDY; EVOKED AUDITORY RESPONSE; FEMALE; GENETIC PREDISPOSITION; GENETIC RISK; HIGH RISK POPULATION; HUMAN; HUMAN EXPERIMENT; MALE; PALAU; PRIORITY JOURNAL; PROGENY; RELATIVE; RISK FACTOR; SCHIZOPHRENIA;

ADOLESCENT; ATTENTION; AUDITORY CORTEX; ELECTROENCEPHALOGRAPHY; EVOKED POTENTIALS, AUDITORY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETICS, POPULATION; HUMANS; MALE; NEURAL INHIBITION; OCEANIC ANCESTRY GROUP; PALAU; PHENOTYPE; PSYCHIATRIC STATUS RATING SCALES; REACTION TIME; RISK; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SCHIZOTYPAL PERSONALITY DISORDER; SIGNAL PROCESSING, COMPUTER-ASSISTED;

EID: 1642417429     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2003.12.006     Document Type: Article

References (26)

1. Adler L.E., Pachtman E., Franks R.D., Pacevich M., Waldo M., Freedman R. Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia. Biol Psychiatry. 17:1982;639-654.
2. Adler L.E., Hoffer L.J., Griffith J., Waldo M.C., Freedman R. Normalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics. Biol Psychiatry. 32:1992;607-616.
3. Braff D.L., Geyer M.A. Sensorimotor gating and schizophrenia Human and animal model studies. Arch Gen Psychiatry. 47:1990;181-188.
4. Cadenhead K.S., Light G.A., Geyer M.A., Braff D.L. Sensory gating deficits assessed by the P50 event-related potential in subjects with schizotypal personality disorder. Am J Psychiatry. 157:2000;55-59.
5. Clementz B.A., Geyer M.A., Braff D.L. Poor P50 suppression among schizophrenia patients and their first-degree biological relatives. Am J Psychiatry. 155:1998;1691-1694.
6. Cornblatt B., Obuchowski M., Schnur D., O'Brien J.D. Hillside study of risk and early detection in schizophrenia. Br J Psychiatry. 172:1998;26-32.
7. Erlenmeyer-Kimling L., Adamo U.H., Rock D., Roberts S.A., Bassett A.S., Squires-Wheeler E., et al. The New York High Risk Project Prevalence and comorbidity of axis I disorders in the offspring of schizophrenic parents at 25-year follow-up. Arch Gen Psychiatry. 54:1997;1096-1102.
8. Escher S., Romme M., Buiks A., Delespaul P., Van Os J. Independent course of childhood auditory hallucinations A sequential 3-year follow-up study. Br J Psychiatry. 181:2002;10-18.
9. Freedman R., Adler L.E., Waldo M.C., Pachtman E., Franks R.D. Neurophysiological evidence for a defect in inhibitory pathways in schizophrenia Comparison of medicated and drug-free patients. Biol Psychiatry. 18:1983;537-551.
10. Freedman R., Adler L., Gerhardt G., Waldo M., Baker N., Rose G., et al. Neurobiological studies of sensory gating in schizophrenia. Schizophr Bull. 13:1987;669-677.
11. Freedman R., Coon H., Myles-Worsley M., Orr-Urtreger A., Olincy A., Davis A., et al. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc Natl Acad Sci U S A. 94:1997;587-592.
12. Freedman R., Adler L.E., Leonard S. Alternative phenotypes for the complex genetics of schizophrenia. Biol Psychiatry. 45:1999;551-558.
13. Gottesman I.I., Gould T.D. The endophenotype concept in psychiatry Etymology and strategic intentions. Am J Psychiatry. 160:2003;1-10.
14. Gottesman I.I., Shields J. Schizophrenia and Genetics: A Twin Study VantagePoint. 1972;Academic Press, Orlando, Florida.
15. Gottesman I.I., Shields J., Hanson D.R. Schizophrenia: The Epigenetic Puzzle. 1982;Cambridge University Press, New York.
16. McGorry P.D., Edwards J., Mihalopoulos C., Harrigan S.M., Jackson H.J. EPPIC An evolving system of early detection and optimal management. Schizophr Bull. 22:1996;305-326.
17. Myles-Worsley M. P50 sensory gating in multiplex schizophrenia families from a Pacific Island isolate. Am J Psychiatry. 159:2002;2007-2012.
18. Myles-Worsley M., Coon H., Byerley W., Waldo M., Young D., Freedman R. Developmental and genetic influences on the P50 sensory gating phenotype. Biol Psychiatry. 39:1996;289-295.
19. Myles-Worsley M., Coon H., Tiobech J., Collier J., Dale P., Wender P., et al. A genetic epidemiological study of schizophrenia in Palau, Micronesia Prevalence and familiality. Am J Med Genet. 88:1999;4-10.
20. Phillips L., Yung A.R., McGorry P.D. Identification of young people at risk of psychosis Validation of Personal Assessment and Crisis Evaluation Clinic intake criteria. Aust N Z J Psychiatry. 34:2000;164-169.
21. Siegel C., Waldo M., Mizner G., Adler L.E., Freedman R. Deficits in sensory gating in schizophrenic patients and their relatives Evidence obtained with auditory evoked responses. Arch Gen Psychiatry. 41:1984;607-612.
22. Waldo M., Carey G., Myles-Worsley M., Cawthra E., Adler L.E., Nagamoto H.T., et al. Co-distribution of a sensory gating deficit and schizophrenia in multi-affected families. Psychiatry Res. 39:1991;257-268.
23. Yee C.M., Nuechterlein K.H., Morris S.E., White P.M. P50 suppression in recent-onset schizophrenia Clinical correlates and risperidone effects. J Abnorm Psychol. 107:1998;691-698.
24. Ysaol J., Chilton J.I., Callaghan P. A survey of betel nut chewing in Palau. Isla. 4:1996;244-255.
25. Yung A., McGorry P. The prodromal phase of first-episode psychosis Past and current conceptualizations. Schizophr Bull. 22:1996;353-370.
26. Yung A., Phillips L., Yuen H.P., Francey S.M., McFarlane C., Hallgren M., McGorry P. Psychosis prediction 12-month follow up of a high-risk ("prodromal") group. Schizophr Res. 60:2003;21-32.