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Volumn 144, Issue 1, 2008, Pages 7-14

Heparan sulphate biosynthesis and disease

Author keywords

Glycosyltransferase; Heparan sulphate; Hereditary multiple exostoses; Proteoglycan; Tumour suppressor gene

Indexed keywords

GROWTH FACTOR; HEPARAN SULFATE; MORPHOGEN; PROTEOGLYCAN;

EID: 46849088581     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvn040     Document Type: Short Survey
Times cited : (110)

References (56)
  • 1
    • 33746614761 scopus 로고    scopus 로고
    • Interactions between heparan sulfate and proteins: The concept of specificity
    • Kreuger, J., Spillmann, D., Li, J.P., and Lindahl, U. (2006) Interactions between heparan sulfate and proteins: the concept of specificity. J. Cell Biol. 174, 323-327
    • (2006) J. Cell Biol , vol.174 , pp. 323-327
    • Kreuger, J.1    Spillmann, D.2    Li, J.P.3    Lindahl, U.4
  • 2
    • 33947714581 scopus 로고    scopus 로고
    • Tinkering with heparan sulfate sulfation to steer development
    • Gorsi, B. and Stringer, S.E. (2007) Tinkering with heparan sulfate sulfation to steer development. Trends Cell Biol. 17, 173-177
    • (2007) Trends Cell Biol , vol.17 , pp. 173-177
    • Gorsi, B.1    Stringer, S.E.2
  • 3
    • 34247610845 scopus 로고    scopus 로고
    • Heparan sulphate proteoglycans fine-tune mammalian physiology
    • Bishop, J.R., Schuksz, M., and Esko, J.D. (2007) Heparan sulphate proteoglycans fine-tune mammalian physiology. Nature 446, 1030-1037
    • (2007) Nature , vol.446 , pp. 1030-1037
    • Bishop, J.R.1    Schuksz, M.2    Esko, J.D.3
  • 4
    • 33846157731 scopus 로고    scopus 로고
    • Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development
    • Pan, Y., Woodbury, A., Esko, J.D., Grobe, K., and Zhang, X. (2006) Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development. Development 133, 4933-4944
    • (2006) Development , vol.133 , pp. 4933-4944
    • Pan, Y.1    Woodbury, A.2    Esko, J.D.3    Grobe, K.4    Zhang, X.5
  • 5
    • 0034643323 scopus 로고    scopus 로고
    • Specificities of heparan sulphate proteoglycans in developmental processes
    • Perrimon, N. and Bernfield, M. (2000) Specificities of heparan sulphate proteoglycans in developmental processes. Nature 404, 725-728
    • (2000) Nature , vol.404 , pp. 725-728
    • Perrimon, N.1    Bernfield, M.2
  • 6
    • 33846012847 scopus 로고    scopus 로고
    • Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members
    • MacArthur, J.M., Bishop, J.R., Stanford, K.I., Wang, L., Bensadoun, A., Witztum, J.L., and Esko, J.D. (2007) Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members. J. Clin. Invest. 117, 153-164
    • (2007) J. Clin. Invest , vol.117 , pp. 153-164
    • MacArthur, J.M.1    Bishop, J.R.2    Stanford, K.I.3    Wang, L.4    Bensadoun, A.5    Witztum, J.L.6    Esko, J.D.7
  • 7
    • 0001524698 scopus 로고
    • Hereditary Multiple Exostosis
    • Solomon, L. (1964) Hereditary Multiple Exostosis. Am. J. Hum. Genet. 16, 351-363
    • (1964) Am. J. Hum. Genet , vol.16 , pp. 351-363
    • Solomon, L.1
  • 9
    • 0028917663 scopus 로고
    • Hereditary multiple exostosis and chondrosarcoma: Linkage to chromosome II and loss of heterozygosity for EXT-linked markers on chromosomes II and 8
    • Hecht, J.T., Hogue, D., Strong, L.C., Hansen, M.F., Blanton, S.H., and Wagner, M. (1995) Hereditary multiple exostosis and chondrosarcoma: linkage to chromosome II and loss of heterozygosity for EXT-linked markers on chromosomes II and 8. Am. J. Hum. Genet. 56, 1125-1131
    • (1995) Am. J. Hum. Genet , vol.56 , pp. 1125-1131
    • Hecht, J.T.1    Hogue, D.2    Strong, L.C.3    Hansen, M.F.4    Blanton, S.H.5    Wagner, M.6
  • 10
    • 0032481245 scopus 로고    scopus 로고
    • Structure, chromosomal location, and expression profile of EXTR1 and EXTR2, new members of the multiple exostoses gene family
    • Saito, T., Seki, N., Yamauchi, M., Tsuji, S., Hayashi, A., Kozuma, S., and Hori, T. (1998) Structure, chromosomal location, and expression profile of EXTR1 and EXTR2, new members of the multiple exostoses gene family. Biochem. Biophys. Res. Commun. 243, 61-66
    • (1998) Biochem. Biophys. Res. Commun , vol.243 , pp. 61-66
    • Saito, T.1    Seki, N.2    Yamauchi, M.3    Tsuji, S.4    Hayashi, A.5    Kozuma, S.6    Hori, T.7
  • 12
    • 0031051305 scopus 로고    scopus 로고
    • Identification and localization of the gene for EXTL, a third member of the multiple exostoses gene family
    • Wise, C.A., Clines, G.A., Massa, H., Trask, B.J., and Lovett, M. (1997) Identification and localization of the gene for EXTL, a third member of the multiple exostoses gene family. Genome Res. 7, 10-16
    • (1997) Genome Res , vol.7 , pp. 10-16
    • Wise, C.A.1    Clines, G.A.2    Massa, H.3    Trask, B.J.4    Lovett, M.5
  • 14
    • 84896762510 scopus 로고    scopus 로고
    • Biosynthetic pathways for differential expression of functional chondroitin sulfate and heparan sulfate
    • Yarema, K.J, ed, pp, CRC Press Taylor & Francis Group, Boca Raton, FL
    • Mizumoto, S., Uyama, T., Mikami, T., Kitagawa, H., and Sugahara, K. (2005) Biosynthetic pathways for differential expression of functional chondroitin sulfate and heparan sulfate. Handbook of Carbohydrate Engineering (Yarema, K.J., ed.) pp. 289-324, CRC Press (Taylor & Francis Group), Boca Raton, FL.
    • (2005) Handbook of Carbohydrate Engineering , pp. 289-324
    • Mizumoto, S.1    Uyama, T.2    Mikami, T.3    Kitagawa, H.4    Sugahara, K.5
  • 15
    • 0033794318 scopus 로고    scopus 로고
    • Recent advances in the study of the biosynthesis and functions of sulfated glycosaminoglycans
    • Sugahara, K. and Kitagawa, H. (2000) Recent advances in the study of the biosynthesis and functions of sulfated glycosaminoglycans. Curr. Opin. Struct. Biol. 10, 518-527
    • (2000) Curr. Opin. Struct. Biol , vol.10 , pp. 518-527
    • Sugahara, K.1    Kitagawa, H.2
  • 16
  • 17
    • 0032500662 scopus 로고    scopus 로고
    • The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate
    • Lind, T., Tufaro, F., McCormick, C., Lindahl, U., and Lidholt, K. (1998) The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate. J. Biol. Chem. 273, 26265-26268
    • (1998) J. Biol. Chem , vol.273 , pp. 26265-26268
    • Lind, T.1    Tufaro, F.2    McCormick, C.3    Lindahl, U.4    Lidholt, K.5
  • 19
    • 0034681139 scopus 로고    scopus 로고
    • The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate
    • McCormick, C., Duncan, G., Goutsos, K.T., and Tufaro, F. (2000) The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate. Proc. Natl. Acad. Sci. USA 97, 668-673
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 668-673
    • McCormick, C.1    Duncan, G.2    Goutsos, K.T.3    Tufaro, F.4
  • 20
    • 0142149173 scopus 로고    scopus 로고
    • In vitro heparan sulfate polymerization: Crucial roles of core protein moieties of primer substrates in addition to the EXT1-EXT2 interaction
    • Kim, B.T., Kitagawa, H., Tanaka, J., Tamura, J., and Sugahara, K. (2003) In vitro heparan sulfate polymerization: crucial roles of core protein moieties of primer substrates in addition to the EXT1-EXT2 interaction. J. Biol. Chem. 278, 41618-41623
    • (2003) J. Biol. Chem , vol.278 , pp. 41618-41623
    • Kim, B.T.1    Kitagawa, H.2    Tanaka, J.3    Tamura, J.4    Sugahara, K.5
  • 21
    • 0033553525 scopus 로고    scopus 로고
    • The tumor suppressor EXT-like gene EXTL2 encodes an alpha1,4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate
    • Kitagawa, H., Shimakawa, H., and Sugahara, K. (1999) The tumor suppressor EXT-like gene EXTL2 encodes an alpha1,4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate. J. Biol. Chem. 274, 13933-13937
    • (1999) J. Biol. Chem , vol.274 , pp. 13933-13937
    • Kitagawa, H.1    Shimakawa, H.2    Sugahara, K.3
  • 22
    • 0035912848 scopus 로고    scopus 로고
    • Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/heparin biosynthesis
    • Kim, B.T., Kitagawa, H., Tamura, J., Saito, T., Kusche-Gullberg, M., Lindahl, U., and Sugahara, K. (2001) Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/heparin biosynthesis. Proc. Natl. Acad. Sci. USA 98, 7176-7181
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 7176-7181
    • Kim, B.T.1    Kitagawa, H.2    Tamura, J.3    Saito, T.4    Kusche-Gullberg, M.5    Lindahl, U.6    Sugahara, K.7
  • 23
    • 0026577602 scopus 로고
    • A single mutation affects both N-acetylglucosaminyltransferase and glucuronosyltransferase activities in a Chinese hamster ovary cell mutant defective in heparan sulfate biosynthesis
    • Lidholt, K., Weinke, J.L., Kiser, C.S., Lugemwa, F.N., Bame, K.J., Cheifetz, S., Massague, J., Lindahl, U., and Esko, J.D. (1992) A single mutation affects both N-acetylglucosaminyltransferase and glucuronosyltransferase activities in a Chinese hamster ovary cell mutant defective in heparan sulfate biosynthesis. Proc. Natl. Acad. Sci. USA 89, 2267-2271
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 2267-2271
    • Lidholt, K.1    Weinke, J.L.2    Kiser, C.S.3    Lugemwa, F.N.4    Bame, K.J.5    Cheifetz, S.6    Massague, J.7    Lindahl, U.8    Esko, J.D.9
  • 24
    • 0028127188 scopus 로고
    • Two N-acetylglucosaminyltransferases catalyze the biosynthesis of heparan sulfate
    • Fritz, T.A., Gabb, M.M., Wei, G., and Esko, J.D. (1994) Two N-acetylglucosaminyltransferases catalyze the biosynthesis of heparan sulfate. J. Biol. Chem. 269, 28809-28814
    • (1994) J. Biol. Chem , vol.269 , pp. 28809-28814
    • Fritz, T.A.1    Gabb, M.M.2    Wei, G.3    Esko, J.D.4
  • 27
    • 0034663225 scopus 로고    scopus 로고
    • Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice
    • Lin, X., Wei, G., Shi, Z., Dryer, L., Esko, J.D., Wells, D.E., and Matzuk, M.M. (2000) Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice. Dev. Biol. 224, 299-311
    • (2000) Dev. Biol , vol.224 , pp. 299-311
    • Lin, X.1    Wei, G.2    Shi, Z.3    Dryer, L.4    Esko, J.D.5    Wells, D.E.6    Matzuk, M.M.7
  • 28
    • 28844450108 scopus 로고    scopus 로고
    • Mice deficient in Ext2 lack heparan sulfate and develop exostoses
    • Stickens, D., Zak, B.M., Rougier, N., Esko, J.D., and Werb, Z. (2005) Mice deficient in Ext2 lack heparan sulfate and develop exostoses. Development 132, 5055-5068
    • (2005) Development , vol.132 , pp. 5055-5068
    • Stickens, D.1    Zak, B.M.2    Rougier, N.3    Esko, J.D.4    Werb, Z.5
  • 30
    • 0035895926 scopus 로고    scopus 로고
    • rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate
    • Kitagawa, H., Egusa, N., Tamura, J.I., Kusche-Gullberg, M., Lindahl, U., and Sugahara, K. (2001) rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate. J. Biol. Chem. 276, 4834-4838
    • (2001) J. Biol. Chem , vol.276 , pp. 4834-4838
    • Kitagawa, H.1    Egusa, N.2    Tamura, J.I.3    Kusche-Gullberg, M.4    Lindahl, U.5    Sugahara, K.6
  • 32
    • 2542627320 scopus 로고    scopus 로고
    • Abrogation of heparan sulfate synthesis in Drosophila disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways
    • Bornemann, D.J., Duncan, J.E., Staatz, W., Selleck, S., and Warrior, R. (2004) Abrogation of heparan sulfate synthesis in Drosophila disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways. Development 131, 1927-1938
    • (2004) Development , vol.131 , pp. 1927-1938
    • Bornemann, D.J.1    Duncan, J.E.2    Staatz, W.3    Selleck, S.4    Warrior, R.5
  • 33
    • 1342341864 scopus 로고    scopus 로고
    • Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans
    • Takei, Y., Ozawa, Y., Sato, M., Watanabe, A., and Tabata, T. (2004) Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans. Development 131, 73-82
    • (2004) Development , vol.131 , pp. 73-82
    • Takei, Y.1    Ozawa, Y.2    Sato, M.3    Watanabe, A.4    Tabata, T.5
  • 34
    • 2342440335 scopus 로고    scopus 로고
    • Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation
    • Han, C., Belenkaya, T.Y., Khodoun, M., Tauchi, M., Lin, X., and Lin, X. (2004) Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation. Development 131, 1563-1575
    • (2004) Development , vol.131 , pp. 1563-1575
    • Han, C.1    Belenkaya, T.Y.2    Khodoun, M.3    Tauchi, M.4    Lin, X.5    Lin, X.6
  • 36
    • 0037134509 scopus 로고    scopus 로고
    • Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: Chain initiation and elongation
    • Kim, B.T., Kitagawa, H., Tamura Ji, J., Kusche-Gullberg, M., Lindahl, U., and Sugahara, K. (2002) Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: chain initiation and elongation. J. Biol. Chem. 277, 13659-13665
    • (2002) J. Biol. Chem , vol.277 , pp. 13659-13665
    • Kim, B.T.1    Kitagawa, H.2    Tamura Ji, J.3    Kusche-Gullberg, M.4    Lindahl, U.5    Sugahara, K.6
  • 37
    • 2942538442 scopus 로고    scopus 로고
    • Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification
    • Koziel, L., Kunath, M., Kelly, O.G., and Vortkamp, A. (2004) Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification. Dev. Cell 6, 801-813
    • (2004) Dev. Cell , vol.6 , pp. 801-813
    • Koziel, L.1    Kunath, M.2    Kelly, O.G.3    Vortkamp, A.4
  • 38
  • 39
    • 0242494082 scopus 로고    scopus 로고
    • Mammalian brain morphogenesis and midline axon guidance require heparan sulfate
    • Inatani, M., Irie, F., Plump, A.S., Tessier-Lavigne, M., and Yamaguchi, Y. (2003) Mammalian brain morphogenesis and midline axon guidance require heparan sulfate. Science 302, 1044-1046
    • (2003) Science , vol.302 , pp. 1044-1046
    • Inatani, M.1    Irie, F.2    Plump, A.S.3    Tessier-Lavigne, M.4    Yamaguchi, Y.5
  • 40
    • 0033924650 scopus 로고    scopus 로고
    • EXT genes are differentially expressed in bone and cartilage during mouse embryogenesis
    • Stickens, D., Brown, D., and Evans, G.A. (2000) EXT genes are differentially expressed in bone and cartilage during mouse embryogenesis. Dev. Dyn. 218, 452-464
    • (2000) Dev. Dyn , vol.218 , pp. 452-464
    • Stickens, D.1    Brown, D.2    Evans, G.A.3
  • 41
    • 1542318326 scopus 로고    scopus 로고
    • Indian hedgehog and syndecans-3 coregulate chondrocyte proliferation and function during chick limb skeletogenesis
    • Shimo, T., Gentili, C., Iwamoto, M., Wu, C., Koyama, E., and Pacifici, M. (2004) Indian hedgehog and syndecans-3 coregulate chondrocyte proliferation and function during chick limb skeletogenesis. Dev. Dyn. 229, 607-617
    • (2004) Dev. Dyn , vol.229 , pp. 607-617
    • Shimo, T.1    Gentili, C.2    Iwamoto, M.3    Wu, C.4    Koyama, E.5    Pacifici, M.6
  • 43
    • 0036558290 scopus 로고    scopus 로고
    • Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites
    • Li, J., Shworak, N.W., and Simons, M. (2002) Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites. J. Cell Sci. 115, 1951-1959
    • (2002) J. Cell Sci , vol.115 , pp. 1951-1959
    • Li, J.1    Shworak, N.W.2    Simons, M.3
  • 44
    • 33745949315 scopus 로고    scopus 로고
    • FGF2 binding, signaling, and angiogenesis are modulated by heparanase in metastatic melanoma cells
    • Reiland, J., Kempf, D., Roy, M., Denkins, Y., and Marchetti, D. (2006) FGF2 binding, signaling, and angiogenesis are modulated by heparanase in metastatic melanoma cells. Neoplasia 8, 596-606
    • (2006) Neoplasia , vol.8 , pp. 596-606
    • Reiland, J.1    Kempf, D.2    Roy, M.3    Denkins, Y.4    Marchetti, D.5
  • 46
    • 2342495787 scopus 로고    scopus 로고
    • Amyloid beta-peptide interactions with neuronal and glial cell plasma membrane: Binding sites and implications for Alzheimer's disease
    • Verdier, Y., Zarandi, M., and Penke, B. (2004) Amyloid beta-peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for Alzheimer's disease. J. Pept. Sci. 10, 229-248
    • (2004) J. Pept. Sci , vol.10 , pp. 229-248
    • Verdier, Y.1    Zarandi, M.2    Penke, B.3
  • 49
    • 0031817009 scopus 로고    scopus 로고
    • Evidence that glypican is a receptor mediating beta-amyloid neurotoxicity in PC12 cells
    • Schulz, J.G., Megow, D., Reszka, R., Villringer, A., Einhaupl, K.M., and Dirnagl, U. (1998) Evidence that glypican is a receptor mediating beta-amyloid neurotoxicity in PC12 cells. Eur. J. Neurosci. 10, 2085-2093
    • (1998) Eur. J. Neurosci , vol.10 , pp. 2085-2093
    • Schulz, J.G.1    Megow, D.2    Reszka, R.3    Villringer, A.4    Einhaupl, K.M.5    Dirnagl, U.6
  • 50
    • 0033572813 scopus 로고    scopus 로고
    • Interactions of Alzheimer amyloid-beta peptides with glycosaminoglycans effects on fibril nucleation and growth
    • McLaurin, J., Franklin, T., Zhang, X., Deng, J., and Fraser, P.E. (1999) Interactions of Alzheimer amyloid-beta peptides with glycosaminoglycans effects on fibril nucleation and growth. Eur. J. Biochem. 266, 1101-1110
    • (1999) Eur. J. Biochem , vol.266 , pp. 1101-1110
    • McLaurin, J.1    Franklin, T.2    Zhang, X.3    Deng, J.4    Fraser, P.E.5
  • 54
    • 4444370179 scopus 로고    scopus 로고
    • How does parkin ligate ubiquitin to Parkinson's disease?
    • Kahle, P.J. and Haass, C. (2004) How does parkin ligate ubiquitin to Parkinson's disease? EMBO Rep. 5, 681-685
    • (2004) EMBO Rep , vol.5 , pp. 681-685
    • Kahle, P.J.1    Haass, C.2
  • 56
    • 0032004972 scopus 로고    scopus 로고
    • Inducible inactivation of hepatic LRP gene by cremediated recombination confirms role of LRP in clearance of chylomicron remnants
    • Rohlmann, A., Gotthardt, M., Hammer, R.E., and Herz, J. (1998) Inducible inactivation of hepatic LRP gene by cremediated recombination confirms role of LRP in clearance of chylomicron remnants. J. Clin. Invest. 101, 689-695
    • (1998) J. Clin. Invest , vol.101 , pp. 689-695
    • Rohlmann, A.1    Gotthardt, M.2    Hammer, R.E.3    Herz, J.4


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