Leptin modulates the negative inotropic effect of interleukin-1β in cardiac myocytes

Molecular and Cellular Biochemistry

Volumn 315, Issue 1-2, 2008, Pages 179-184

  Radin, Judith M ^a   Holycross, Bethany J ^b   Dumitrescu, Cristian ^b   Kelley, Robert ^b   Altschuld, Ruth A ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Cardiac myocytes; Ceramide; Interleukin 1 ; Leptin

Indexed keywords

CALCIUM ION; CERAMIDE; FURA 2 ACETOXYMETHYL ESTER; HYDROLASE INHIBITOR; INTERLEUKIN 1BETA; LEPTIN; MANUMYCIN A; N OLEOYL ETHANOLAMINE; SPHINGOLIPID; SPHINGOMYELIN PHOSPHODIESTERASE INHIBITOR;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CELL ISOLATION; CELL STIMULATION; CONTROLLED STUDY; ELECTROSTIMULATION; FLUORESCENCE ANALYSIS; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE RELAXATION; HEART PROTECTION; HEART VENTRICLE; INOTROPISM; MALE; NONHUMAN; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; CALCIUM SIGNALING; CERAMIDES; FURA-2; INTERLEUKIN-1BETA; LEPTIN; MALE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 46749134244     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-008-9805-6     Document Type: Article

References (25)

1. Blum A, Miller H (2001) Pathophysiological role of cytokines in congestive heart failure. Annu Rev Med 52:15-27. doi: 10.1146/ annurev.med.52.1.15
2. Long CS (2001) The role of interleukin-1 in the failing heart. Heart Fail Rev 6:81-94. doi: 10.1023/A:1011428824771
3. Favory R, Lancel S, Marchetti P, Mordon S, Chopin C, Formstecher P et al (2004) Endotoxin-induced myocardial dysfunction: Evidence for a role of sphingosine production. Crit Care Med 32:495-501. doi: 10.1097/ 01.CCM.0000109452.36271.FA
4. Schreur KD, Liu S (1997) Involvement of ceramide in inhibitory effect of IL-1 beta on L-type calcium current in adult rat ventricular myocytes. Am J Physiol Heart Circ Physiol 272:H2591-H2598
5. Sweeney G (2002) Leptin signaling. Cell Signal 12:655-663. doi: 10.1016/ S0898-6568(02)00006-2
6. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R et al (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271. doi: 10.1016/0092-8674(95)90151-5
7. Hoggard N, Mercer JG, Rayner DV, Moar K, Trayhurn P, Williams LM (1997) Localization of leptin receptor mRNA splice variants in murine peripheral tissues by RT-PCR and in situ hybridization. Biochem Biophys Res Commun 232:383-387. doi: 10.1006/bbrc.1997.6245
8. Nickola MW, Wold LE, Colligan PB, Wang G-J, Samson WK, Ren J (2000) Leptin attenuates cardiac contraction in rat ventricular myocytes. Role of NO. Hypertension 36:501-505
9. Faggioni R, Moser A, Feingold KR, Grunfeld C (2000) Reduced leptin levels in starvation increase susceptibility to endotoxic shock. Am J Pathol 156:1781-1787
10. Faggioni R, Fantuzzi G, Gabay C, Moser A, Dinarello CA, Feingold KR et al (1999) Leptin deficiency enhances sensitivity to endotoxin-induced lethality. Am J Physiol 276:R136-R142
11. Wimsatt DK, Hohl CM, Brierley GP, Altschuld RA (1990) Calcium accumulation and release by the sarcoplasmic reticulum of digitonin-lysed adult mammalian ventricular cardiomyocytes. J Biol Chem 265:14849-14857
12. Hohl CM, Altschuld RA (1991) Response of isolated adult canine cardiac myocytes to prolonged hypoxia and reoxygenation. Am J Physiol 260:C383-C391
13. Bergman MR, Holycross BJ (1996) Pharmacological modulation of myocardial tumor necrosis factor α production by phosphodiesterase inhibitors. J Pharmacol Exp Ther 279:247-254
14. 2-adrenergic receptor stimulation in dogs susceptible to lethal arrhythmias. J Appl Physiol 91:1627-1637
15. 2+ transients in rat and canine cardiomyocytes. J Mol Cell Cardiol 29:1037-1043. doi: 10.1006/ jmcc.1996.0348
16. Dasgupta S, Hogan EL (2001) Chromatographic resolution and quantitative assay of CNS tissue sphingoids and sphingolipids. J Lipid Res 42:301-307
17. Bishcel MD, Austin JH (1963) A modified benzidine method for the chromatographic detection of sphingolipids and acid polysaccharides. Biochim Biophys Acta 70:598-600. doi: 10.1016/0006-3002(63)90800-X
18. Huwiler A, Kolter T, Pfeilschifter J, Sandhoff K (2000) Physiology and pathophysiology of sphingolipid metabolism and signaling. Biochim Biophys Acta 1485:63-99
19. ++ influx. Am J Physiol Heart Circ Physiol 285:H735-H744
20. Relling DP, Hintz KK, Ren J (2003) Acute exposure of ceramide enhances cardiac contractile function in isolated ventricular myocytes. Br J Pharmacol 140:1163-1168. doi: 10.1038/sj.bjp.0705510
21. Viani P, Giussani P, Brioschi L, Bassi R, Anelli V, Tettamanti G et al (2003) Ceramide in nitric oxide inhibition of glioma cell growth. Evidence for the involvement of ceramide traffic. J Biol Chem 278:9592-9601. doi: 10.1074/jbc.M207729200
22. Franzen R, Fabbro D, Aschrafi A, Pfeilschifter J, Huwiler A (2002) Nitric oxide induces degradation of the neutral ceramidase in rat renal mesangial cells and is couterrregulated by protein kinase C. J Biol Chem 277:46184-46190. doi: 10.1074/jbc.M204034200
23. Zhang Y, Scarpace PJ (2006) The role of leptin in leptin resistance and obesity. Physiol Behav 88:249-256. doi: 10.1016/j.physbeh.2006.05.038
24. Zhou YT, Grayburn P, Karim A, Shimabukuro M, Higa M, Baetens D et al (2000) Lipotoxic heart disease in obese rats: Implications for human obesity. Proc Natl Acad Sci USA 97:1784-1789. doi: 10.1073/pnas.97.4.1784
25. Chabowski A, Zmijewska M, Gorski J, Bonen A, Kaminski K, Winnicka MM (2007) Effect of IL-6 deficiency on myocardial expression of fatty acid transporters and intracellular lipid deposits. J Physiol Pharmacol 58:73-82