Overexpression of dominant-negative Ikaros 6 protein is restricted to a subset of B common adult acute lymphoblastic leukemias that express high levels of the CD34 antigen

Hematology Journal

Volumn 4, Issue 2, 2003, Pages 104-109

  Tonnelle, Cécile ^a   Imbert, Marie Christine ^a   Sainty, Danielle ^a   Granjeaud, Samuel ^b   N'Guyen, Catherine ^b   Chabannon, Christian ^a  

^a INSTITUT PAOLI CALMETTES   (France)

^b Aix Marseille university   (France)

Author keywords

Hematopoiesis; Ikaros; Leukemia; Transcription factors

Indexed keywords

CD34 ANTIGEN; IKAROS 6; ISOPROTEIN; MEMBRANE ANTIGEN; MESSENGER RNA; PROTEIN HYDROLYSATE; REGULATOR PROTEIN; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; DIMERIZATION; DNA BINDING MOTIF; DNA MICROARRAY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENE OVEREXPRESSION; HEMATOPOIESIS; HUMAN; HUMAN CELL; LYMPHOCYTE SUBPOPULATION; MALE; PHENOTYPE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING; STEM CELL; WESTERN BLOTTING;

ADOLESCENT; ADULT; AGED; ANTIGENS, CD34; COHORT STUDIES; CYTOGENETIC ANALYSIS; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION PROFILING; HUMANS; IKAROS TRANSCRIPTION FACTOR; IMMUNOPHENOTYPING; LEUKEMIA, B-CELL, ACUTE; MALE; MIDDLE AGED; PROTEIN ISOFORMS; RNA, NEOPLASM; TRANSCRIPTION FACTORS;

EID: 0038677916     PISSN: 14664860     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.thj.6200235     Document Type: Article

References (33)

1. Nichogiannopoulou A, Trevisan M, Friedrich C, Georgopoulos K. Ikaros in hemaopoietic lineages determination and homeostasis. Semin Immunol 1998; 10: 119-125.
2. Brown KE, Guest SS, Smale ST, Hahm K, Merkenschlager M, Fisher AG. Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin. Cell 1997, 91:845-854.
3. Koipally J, Renold A, Kim J, Georgopoulos K. Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. Embo J 1999; 18:3090-3100.
4. Molnar A, Wu P, Largespada DA, Vortkamp A, Scherer S, Copeland NG et al. The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse. J Immunol 1996; 156: 585-592.
5. Hansen JD, Strassburger P, Du Pasquier L. Conservation of a master hematopoietic switch gene during vertebrate evolution: isolation and characterization of Ikaros from teleost and aphibian species. Eur J Immunol 1997; 27: 3049-3058.
6. Hahm K, Ernst P, Lo K, Kim GS, Turck C, Smale ST. The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene. Mol Cell Biol 1994; 14: 7111-7123.
7. Klug CA, Morrison SJ, Masek M, Hahm K, Smale ST, Weissman IL. Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes. Proc Natl Acad Sci USA 1998; 95: 657-662.
8. Galy A, Christopherson I, Ferlazzo G, Liu G, Spits H, Georgopoulos K. Distinct signals control the hematopoiesis of lymphoid-related dendritic cells. Blood 2000; 95: 128-137.
9. Tonnelle C, Bardin F, Maroc C, Imbert AM, Campa F, Dalloul A et al. Forced expression of the Ikaros 6 isoform in human placental blood CD34 + cells impairs their ability to differentiate towards the B lymphoid lineage. Blood 2001; 98: 2673-2680.
10. Tucker SN, Jessup HK, Fujii H, Wilson CB. Enforced expression of the Ikaros isoform IK5 decreases the numbers of extrathymic intraepithelial lymphocytes and natural killer 1.1 + T cells. Blood 2002; 99: 513-519.
11. Payne KJ, Nicolas JH, Zhu JY, Barsky LW, Crooks GM. Cutting edge: predominant expression of a novel Ikaros isoform in normal human hemopoiesis. J Immunol 2001; 167: 1867-1870.
12. Georgopoulos K, Bigby M, Wang JH, Molnar A, Wu P, Winandy S et al. The Ikaros gene is required for the development of all lymphoid lineages. Cell 1994; 79: 143-56.
13. Wang J, Nichogiannopoulou. A, Wu L, Sun L, Sharpe AH, Bigby M et al. Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation. Immunity 1996; 5: 537-549.
14. Winandy S, Wu P, Georgopoulos K. A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma. Cell 1995; 83: 289-299.
15. Hosokawa Y, Maeda Y, Ichinohasama R, Miura I, Tanikawai M, Seto M. The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphoma. Blood 2000; 95: 2719-2721.
16. Sun L, Heerema N, Crotty L, Wu X, Navara C, Vassilev A et al. Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia. Proc Natl Acad Sci USA 1999; 96: 680-685.
17. Sun L, Crotty ML, Sensel M, Sather H, Navara C, Nachman J et al. Expression of dominant-negative Ikaros isoforms in T-cell acute lymphoblastic leukemia. Clin Cancer-Res 1999; 5: 2112-2120.
18. Sun L, Goodman PA, Wood CM, Crotty ML, Sensel M, Sather H et al. Expression of aberrantly spliced oncogenic ikaros isoforms in childhood acute lymphoblastic leukemia. J Clin Oncol 1999; 17: 3753-3766.
19. Takanashi M, Yagi T, Imamura T, Tabata Y, Morimoto A, Hibi S et al. Expression of the Ikaros gene family in childhood acute lymphoblastic leukaemia. Br J Haematol 2002; 117: 525-530.
20. Yagi T, Hibi S, Takanashi M, Kano G, Tabata Y, Imamura T et al. High frequency of Ikaros isoform 6 expression in acute myelomonocytic and monocytic leukemias: implications for up-regulation of the antiapoptotic protein Bcl-XL in leukemogenesis. Blood 2002; 99: 1350-1355.
21. Nakayama H, Ishimaru F, Avitahl N, Sezaki N, Fujii N, Nakase K et al. Decreases in Ikaros activity correlate with blast crisis in patients with chronic myelogenous leukemia. Cancer Res 1999; 59: 3931-3934.
22. Olivero S, Maroc C, Beillard E, Gabert J, Nietfeld W, Chabannon C et al. Detection of different Ikaros isoforms in human leukemias, using real time quantitative PCR. Br J Haematol 2000; 110: 1-6.
23. Nishii K, Katayama N, Miwa H, Shikami M, Usui E, Masuya M et al. Non-DNA-binding Ikaros isoform. gene expressed in adult B-precursor acute lymphoblastic leukemia. Leukemia 2002; 16: 1285-1292.
24. Bene MC, Castoldi G, Knapp W, Ludwig WD, Matutes E, Orfao A et al. Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL). Leukemia 1995; 9: 1783-1786.
25. Lemmers B, Arnoulet C, Fossat C, Chambost H, Sainty D, Gabert J et al. Fine characterization of childhood and adult acute lymphoblastic leukemia (ALL) by a proB and preB surrogate light chain-specific mAb and a proposal for a new B cell ALL classification. Leukemia 2000; 14: 2103-11.
26. Fiere D, Lepage E, Sebban C, Boucheix C, Gisselbrecht C, Vernant JP et al. Adult acute lymphoblastic leukemia: a multicentric randomized trial testing bone marrow transplantation as postremission therapy. The French Group on Therapy for Adult Acute Lymphoblastic Leukemia. J Clin Oncol 1993; 11: 1990-2001.
27. Boucheix C, David B, Sebban C, Racadot E, Bene MC, Bernard A et al. Immunophenotype of adult acute lymphoblastic leukemia, clinical parameters, and outcome: an analysis of a prospective trial including 562 tested patients (LALA87). French Group on Therapy for Adult Acute Lymphoblastic Leukemia. Blood 1994; 84: 1603-1612.
28. Tonnelle C, Calmels B, Maroc C, Gabert J, Chabannon C. Ikaros gene expression and leukemia. Leukemia Lymphoma 2002; 43: 29-35.
29. Bertucci F, Houlgatte R, Benziane A, Granjeaud S, Adelaïde J, Tagett R et al. Gene expression profiling of primary breast cacinomas using arrays of candidate genes. Hum Mol Genet 2000; 9: 1981-1991.
30. Nakase K, Ishimaru F, Avitahl N, Dansako H, Matsuo K, Fujii K et al. Dominant negative isoform of the Ikaros gene in patients with adult B-cell acute lymphoblastic leukemia. Cancer Res 2000; 60: 4062-4065.
31. Armstrong SA, Staunton JE, Silverman LB, Pieters R, den Boer ML, Minden MD et al. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet 2002; 30: 41-47.
32. Molnar A, Georgopoulos K. The Ikaros gene encodes a family of functionnally diverse zinc finger DNA-binding proteins. Mol Cell Biol 1994; 14: 8292-8303.
33. Sabbattini P, Lundgren M, Georgiou A, Chow C, Warnes G, Dillon N. Binding of Ikaros to the lambda5 promoter silences transcription through a mechanism that does not require heterochromatin formation. EMBO J 2001; 20: 2812-2822.