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Volumn 19, Issue 8, 2008, Pages 524-535

Allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway in HL60 and U937 cells

Author keywords

Allicin; Apoptosis; Garlic; GSH; HL60; U937

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ACETYLCYSTEINE; ALLICIN; BUTHIONINE SULFOXIMINE; CASPASE 3; CASPASE 9; CYCLOSPORIN A; CYTOCHROME C; GLUTATHIONE;

EID: 46749116520     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2007.06.009     Document Type: Article
Times cited : (88)

References (55)
  • 1
    • 74049134817 scopus 로고
    • Chemical investigation on alliin, the specific principle of garlic
    • Stoll A., and Seebeck E. Chemical investigation on alliin, the specific principle of garlic. Adv Enzymol 11 (1951) 377-400
    • (1951) Adv Enzymol , vol.11 , pp. 377-400
    • Stoll, A.1    Seebeck, E.2
  • 3
    • 0035058201 scopus 로고    scopus 로고
    • The effects of allicin and enalapril in fructose-induced hyperinsulinemic hyperlipidemic hypertensive rats
    • Elkayam A., Mirelman D., Peleg E., Wilchek M., Miron T., Rabinkov A., et al. The effects of allicin and enalapril in fructose-induced hyperinsulinemic hyperlipidemic hypertensive rats. Am J Hypertens 14 (2001) 377-381
    • (2001) Am J Hypertens , vol.14 , pp. 377-381
    • Elkayam, A.1    Mirelman, D.2    Peleg, E.3    Wilchek, M.4    Miron, T.5    Rabinkov, A.6
  • 4
    • 0029552949 scopus 로고
    • Alteration of lipid profile in hyperlipidemic rabbits by allicin, an active constituent of garlic
    • Eilat S., Oestraicher Y., Rabinkov A., Ohad D., Mirelman D., Battler A., et al. Alteration of lipid profile in hyperlipidemic rabbits by allicin, an active constituent of garlic. Coron Artery Dis 6 (1995) 985-990
    • (1995) Coron Artery Dis , vol.6 , pp. 985-990
    • Eilat, S.1    Oestraicher, Y.2    Rabinkov, A.3    Ohad, D.4    Mirelman, D.5    Battler, A.6
  • 5
    • 0033452902 scopus 로고    scopus 로고
    • Allicin-induced decrease in formation of fatty streaks (atherosclerosis) in mice fed a cholesterol-rich diet
    • Abramovitz D., Gavri S., Harats D., Levkovitz H., Mirelman D., Miron T., et al. Allicin-induced decrease in formation of fatty streaks (atherosclerosis) in mice fed a cholesterol-rich diet. Coron Artery Dis 10 (1999) 515-519
    • (1999) Coron Artery Dis , vol.10 , pp. 515-519
    • Abramovitz, D.1    Gavri, S.2    Harats, D.3    Levkovitz, H.4    Mirelman, D.5    Miron, T.6
  • 7
    • 4544226878 scopus 로고    scopus 로고
    • Allicin inhibits spontaneous and TNF-alpha induced secretion of proinflammatory cytokines and chemokines from intestinal epithelial cells
    • Lang A., Lahav M., Sakhnini E., Barshack I., Fidder H.H., Avidan B., et al. Allicin inhibits spontaneous and TNF-alpha induced secretion of proinflammatory cytokines and chemokines from intestinal epithelial cells. Clin Nutr 23 (2004) 1199-1208
    • (2004) Clin Nutr , vol.23 , pp. 1199-1208
    • Lang, A.1    Lahav, M.2    Sakhnini, E.3    Barshack, I.4    Fidder, H.H.5    Avidan, B.6
  • 8
    • 0030029823 scopus 로고    scopus 로고
    • Therapeutic actions of garlic constituents
    • Agarwal K.C. Therapeutic actions of garlic constituents. Med Res Rev 16 (1996) 111-124
    • (1996) Med Res Rev , vol.16 , pp. 111-124
    • Agarwal, K.C.1
  • 9
    • 0034434470 scopus 로고    scopus 로고
    • Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation
    • Hirsch K., Danilenko M., Giat J., Miron T., Rabinkov A., Wilchek M., et al. Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation. Nutr Cancer 38 (2000) 245-254
    • (2000) Nutr Cancer , vol.38 , pp. 245-254
    • Hirsch, K.1    Danilenko, M.2    Giat, J.3    Miron, T.4    Rabinkov, A.5    Wilchek, M.6
  • 10
    • 0035119745 scopus 로고    scopus 로고
    • Possible mechanism by which allyl sulfides suppress neoplastic cell proliferation
    • Knowles L.M., and Milner J.A. Possible mechanism by which allyl sulfides suppress neoplastic cell proliferation. J Nutr 131 (2001) 1061S-1066S
    • (2001) J Nutr , vol.131
    • Knowles, L.M.1    Milner, J.A.2
  • 11
    • 0141829813 scopus 로고    scopus 로고
    • Effects of allicin on both telomerase activity and apoptosis in gastric cancer SGC-7901 cells
    • Sun L., and Wang X. Effects of allicin on both telomerase activity and apoptosis in gastric cancer SGC-7901 cells. World J Gastroenterol 9 (2003) 1930-1934
    • (2003) World J Gastroenterol , vol.9 , pp. 1930-1934
    • Sun, L.1    Wang, X.2
  • 12
    • 1642456598 scopus 로고    scopus 로고
    • Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells
    • Oommen S., Anto R.J., Srinivas G., and Karunagaran D. Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells. Eur J Pharmacol 485 (2004) 97-103
    • (2004) Eur J Pharmacol , vol.485 , pp. 97-103
    • Oommen, S.1    Anto, R.J.2    Srinivas, G.3    Karunagaran, D.4
  • 13
    • 19344369098 scopus 로고    scopus 로고
    • Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA
    • Park S.Y., Cho S.J., Kwon H.C., Lee K.R., Rhee D.K., and Pyo S. Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA. Cancer Lett 224 (2005) 123-132
    • (2005) Cancer Lett , vol.224 , pp. 123-132
    • Park, S.Y.1    Cho, S.J.2    Kwon, H.C.3    Lee, K.R.4    Rhee, D.K.5    Pyo, S.6
  • 14
    • 0037473080 scopus 로고    scopus 로고
    • Ajoene-induced cell death in human promyeloleukemic cells does not require JNK but is amplified by the inhibition of ERK
    • Antlsperger D.S.M., Dirsch V.M., Ferreira D., Su J.L., Kuo M.L., and Vollmar A.M. Ajoene-induced cell death in human promyeloleukemic cells does not require JNK but is amplified by the inhibition of ERK. Oncogene 22 (2003) 582-589
    • (2003) Oncogene , vol.22 , pp. 582-589
    • Antlsperger, D.S.M.1    Dirsch, V.M.2    Ferreira, D.3    Su, J.L.4    Kuo, M.L.5    Vollmar, A.M.6
  • 15
    • 25144489068 scopus 로고    scopus 로고
    • Overview of cell death signaling pathways
    • Jin Z., and El-Deiry W.S. Overview of cell death signaling pathways. Cancer Biol Ther 4 (2005) 139-163
    • (2005) Cancer Biol Ther , vol.4 , pp. 139-163
    • Jin, Z.1    El-Deiry, W.S.2
  • 16
    • 0030963602 scopus 로고    scopus 로고
    • Cytosol-to-membrane redistribution of Bax and Bcl-X1 during apoptosis
    • Hsu Y.T., Wolter K.G., and Youle R.J. Cytosol-to-membrane redistribution of Bax and Bcl-X1 during apoptosis. Proc Natl Acad Sci U S A 94 (1997) 3668-3672
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 3668-3672
    • Hsu, Y.T.1    Wolter, K.G.2    Youle, R.J.3
  • 17
  • 18
    • 0033973286 scopus 로고    scopus 로고
    • The mode of action of allicin: its ready permeability through phospholipid membranes may contribute to its biological activity
    • Miron T., Rabinkov A., Mirelman D., Wilchek M., and Weiner L. The mode of action of allicin: its ready permeability through phospholipid membranes may contribute to its biological activity. Biochim Biophys Acta 1463 (2000) 20-30
    • (2000) Biochim Biophys Acta , vol.1463 , pp. 20-30
    • Miron, T.1    Rabinkov, A.2    Mirelman, D.3    Wilchek, M.4    Weiner, L.5
  • 19
    • 0034639280 scopus 로고    scopus 로고
    • S-allylmercaptoglutathione: the reaction product of allicin with glutathione possesses SH-modifying and antioxidant properties
    • Rabinkov A., Miron T., Mirelman D., Wilchek M., Glozman S., Yavin E., et al. S-allylmercaptoglutathione: the reaction product of allicin with glutathione possesses SH-modifying and antioxidant properties. Biochim Biophys Acta 1499 (2000) 144-153
    • (2000) Biochim Biophys Acta , vol.1499 , pp. 144-153
    • Rabinkov, A.1    Miron, T.2    Mirelman, D.3    Wilchek, M.4    Glozman, S.5    Yavin, E.6
  • 20
    • 0037165535 scopus 로고    scopus 로고
    • Antioxidant functions of selected allium thiosulfinates and S-alk(en)yl-l-cysteine sulfoxides
    • Xiao H., and Parkin K.L. Antioxidant functions of selected allium thiosulfinates and S-alk(en)yl-l-cysteine sulfoxides. J Agric Food Chem 50 (2002) 2488-2493
    • (2002) J Agric Food Chem , vol.50 , pp. 2488-2493
    • Xiao, H.1    Parkin, K.L.2
  • 21
    • 33750507938 scopus 로고    scopus 로고
    • Kinetic and mechanistic studies of allicin as an antioxidant
    • Okada Y., Tanaka K., Sato E., and Okajima H. Kinetic and mechanistic studies of allicin as an antioxidant. Org Biomol Chem 4 (2006) 4113-4117
    • (2006) Org Biomol Chem , vol.4 , pp. 4113-4117
    • Okada, Y.1    Tanaka, K.2    Sato, E.3    Okajima, H.4
  • 22
  • 23
    • 0000817158 scopus 로고
    • Garlic chemistry-stability of S-(2-propenyl) 2-propene-1-sulfinothioate (allicin) in blood, solvents, and simulated physiological fluids
    • Freeman F., and Kodera Y. Garlic chemistry-stability of S-(2-propenyl) 2-propene-1-sulfinothioate (allicin) in blood, solvents, and simulated physiological fluids. J Agric Food Chem 43 (1995) 2332-2338
    • (1995) J Agric Food Chem , vol.43 , pp. 2332-2338
    • Freeman, F.1    Kodera, Y.2
  • 24
    • 0028343378 scopus 로고
    • The pharmacokinetics of the S35 labeled garlic constituents alliin, allicin and vinyldithiine
    • Lachmann G., Lorenz D., Radeck W., and Steiper M. The pharmacokinetics of the S35 labeled garlic constituents alliin, allicin and vinyldithiine. Arzneimittelforschung 44 (1994) 734-743
    • (1994) Arzneimittelforschung , vol.44 , pp. 734-743
    • Lachmann, G.1    Lorenz, D.2    Radeck, W.3    Steiper, M.4
  • 25
    • 2442638335 scopus 로고    scopus 로고
    • Inhibition of tumor growth by a novel approach: in situ allicin generation using targeted alliinase delivery
    • Miron T., Mironchik M., Mirelman D., Wilchek M., and Rabinkov A. Inhibition of tumor growth by a novel approach: in situ allicin generation using targeted alliinase delivery. Mol Cancer Ther 2 (2003) 1295-1301
    • (2003) Mol Cancer Ther , vol.2 , pp. 1295-1301
    • Miron, T.1    Mironchik, M.2    Mirelman, D.3    Wilchek, M.4    Rabinkov, A.5
  • 26
    • 14844286972 scopus 로고    scopus 로고
    • Apoptotic killing of B-chronic lymphocytic leukemia tumor cells by allicin generated in situ using a rituximab-alliinase conjugate
    • Arditti F., Rabinkov A., Miron T., Reisner Y., Berrebi A., Wilchek M., et al. Apoptotic killing of B-chronic lymphocytic leukemia tumor cells by allicin generated in situ using a rituximab-alliinase conjugate. Mol Cancer Ther 4 (2005) 325-331
    • (2005) Mol Cancer Ther , vol.4 , pp. 325-331
    • Arditti, F.1    Rabinkov, A.2    Miron, T.3    Reisner, Y.4    Berrebi, A.5    Wilchek, M.6
  • 27
    • 0035371184 scopus 로고    scopus 로고
    • Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
    • Schafer F.Q., and Buettner G.R. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med 30 (2001) 1191-1212
    • (2001) Free Radic Biol Med , vol.30 , pp. 1191-1212
    • Schafer, F.Q.1    Buettner, G.R.2
  • 28
    • 0036890251 scopus 로고    scopus 로고
    • Extracellular thiol/disulfide redox state affects proliferation rate in a human colon carcinoma (Caco2) cell line
    • Jonas C.R., Ziegler T.R., Gu L.H., and Jones D.P. Extracellular thiol/disulfide redox state affects proliferation rate in a human colon carcinoma (Caco2) cell line. Free Radic Biol Med 33 (2002) 1499-1506
    • (2002) Free Radic Biol Med , vol.33 , pp. 1499-1506
    • Jonas, C.R.1    Ziegler, T.R.2    Gu, L.H.3    Jones, D.P.4
  • 29
    • 0025118967 scopus 로고
    • Molecular and cellular aspects of thiol-disulfide exchange
    • Gilbert H.F. Molecular and cellular aspects of thiol-disulfide exchange. Adv Enzymol Relat Areas Mol Biol 63 (1990) 69-172
    • (1990) Adv Enzymol Relat Areas Mol Biol , vol.63 , pp. 69-172
    • Gilbert, H.F.1
  • 30
    • 84981838512 scopus 로고
    • Allium compounds V. The synthesis of natural alliin and its three optical active isomers
    • Stoll A., and Seebeck E. Allium compounds V. The synthesis of natural alliin and its three optical active isomers. Helv Chim Acta 34 (1951) 481-487
    • (1951) Helv Chim Acta , vol.34 , pp. 481-487
    • Stoll, A.1    Seebeck, E.2
  • 31
    • 33644933461 scopus 로고    scopus 로고
    • A method for continuous production of allicin using immobilized alliinase
    • Miron T., SivaRaman H., Rabinkov A., Mirelman D., and Wilchek M. A method for continuous production of allicin using immobilized alliinase. Anal Biochem 351 (2006) 152-154
    • (2006) Anal Biochem , vol.351 , pp. 152-154
    • Miron, T.1    SivaRaman, H.2    Rabinkov, A.3    Mirelman, D.4    Wilchek, M.5
  • 32
    • 15744396281 scopus 로고    scopus 로고
    • A potent apoptosis-inducing activity of a sesquiterpene lactone, arucanolide, in HL60 cells: a crucial role of apoptosis-inducing factor
    • Nakagawa Y., Iinuma M., Matsuura N., Yi K., Naoi M., Nakayama T., et al. A potent apoptosis-inducing activity of a sesquiterpene lactone, arucanolide, in HL60 cells: a crucial role of apoptosis-inducing factor. J Pharmacol Sci 97 (2005) 242-252
    • (2005) J Pharmacol Sci , vol.97 , pp. 242-252
    • Nakagawa, Y.1    Iinuma, M.2    Matsuura, N.3    Yi, K.4    Naoi, M.5    Nakayama, T.6
  • 33
    • 18944408104 scopus 로고    scopus 로고
    • Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha
    • Grinberg M., Schwarz M., Zaltsman Y., Eini T., Niv H., Pietrokovski S., et al. Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha. Mol Cell Biol 25 (2005) 4579-4590
    • (2005) Mol Cell Biol , vol.25 , pp. 4579-4590
    • Grinberg, M.1    Schwarz, M.2    Zaltsman, Y.3    Eini, T.4    Niv, H.5    Pietrokovski, S.6
  • 34
    • 29744466425 scopus 로고
    • Determination of serum proteins by means of the biuret reaction
    • Gornall A., Bardawill C., and David M. Determination of serum proteins by means of the biuret reaction. J Biol Chem 177 (1949) 751-766
    • (1949) J Biol Chem , vol.177 , pp. 751-766
    • Gornall, A.1    Bardawill, C.2    David, M.3
  • 35
    • 0022272493 scopus 로고
    • Determination of glutathione and glutathione disulfide in biological samples
    • Anderson M.E. Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol 113 (1985) 548-555
    • (1985) Methods Enzymol , vol.113 , pp. 548-555
    • Anderson, M.E.1
  • 36
    • 0018416496 scopus 로고
    • Ellman's reagent: 5,5′-dithiobis(2-nitrobenzoic acid) - a reexamination
    • Riddles P.W., Blakeley R.L., and Zerner B. Ellman's reagent: 5,5′-dithiobis(2-nitrobenzoic acid) - a reexamination. Anal Biochem 94 (1979) 75-81
    • (1979) Anal Biochem , vol.94 , pp. 75-81
    • Riddles, P.W.1    Blakeley, R.L.2    Zerner, B.3
  • 38
    • 0031953857 scopus 로고    scopus 로고
    • Influence of heat shock on cell volume regulation: protection from hypertonic challenge in a human monocyte cell line
    • Oehler R., Zellner M., Hefel B., Weingartmann G., Spittler A., Struse H.M., et al. Influence of heat shock on cell volume regulation: protection from hypertonic challenge in a human monocyte cell line. FASEB J 12 (1998) 553-560
    • (1998) FASEB J , vol.12 , pp. 553-560
    • Oehler, R.1    Zellner, M.2    Hefel, B.3    Weingartmann, G.4    Spittler, A.5    Struse, H.M.6
  • 39
    • 17144421250 scopus 로고    scopus 로고
    • Analysis of cytosolic and lysosomal pH in apoptotic cells by flow cytometry
    • Nilsson C., Kagedal K., Johansson U., and Ollinger K. Analysis of cytosolic and lysosomal pH in apoptotic cells by flow cytometry. Methods Cell Sci 25 (2003) 185-194
    • (2003) Methods Cell Sci , vol.25 , pp. 185-194
    • Nilsson, C.1    Kagedal, K.2    Johansson, U.3    Ollinger, K.4
  • 40
    • 0014827630 scopus 로고
    • Mosquito control with active principle of garlic, Allium sativum
    • Amonkar S.V., and Reeves E.L. Mosquito control with active principle of garlic, Allium sativum. J Econ Entomol 63 (1970) 1172-1175
    • (1970) J Econ Entomol , vol.63 , pp. 1172-1175
    • Amonkar, S.V.1    Reeves, E.L.2
  • 41
    • 0028793659 scopus 로고
    • Anticancer drugs acting against signaling pathways
    • Powis G. Anticancer drugs acting against signaling pathways. Curr Opin Oncol 7 (1995) 554-559
    • (1995) Curr Opin Oncol , vol.7 , pp. 554-559
    • Powis, G.1
  • 42
    • 0033230043 scopus 로고    scopus 로고
    • Glutathione and its role in cellular functions
    • Sies H. Glutathione and its role in cellular functions. Free Radic Biol Med 27 (1999) 16-21
    • (1999) Free Radic Biol Med , vol.27 , pp. 16-21
    • Sies, H.1
  • 43
    • 0035024022 scopus 로고    scopus 로고
    • Thiols in cellular redox signalling and control
    • Moran L.K., Gutteridge J.M., and Quinlan G.J. Thiols in cellular redox signalling and control. Curr Med Chem 8 (2001) 763-772
    • (2001) Curr Med Chem , vol.8 , pp. 763-772
    • Moran, L.K.1    Gutteridge, J.M.2    Quinlan, G.J.3
  • 44
    • 0029007943 scopus 로고
    • Glutathione metabolism
    • Meister A. Glutathione metabolism. Methods Enzymol 251 (1995) 3-7
    • (1995) Methods Enzymol , vol.251 , pp. 3-7
    • Meister, A.1
  • 45
    • 33750011601 scopus 로고    scopus 로고
    • Mitochondrial glutathione transport: physiological, pathological and toxicological implications
    • Lash L.H. Mitochondrial glutathione transport: physiological, pathological and toxicological implications. Chem Biol Interact 163 (2006) 54-67
    • (2006) Chem Biol Interact , vol.163 , pp. 54-67
    • Lash, L.H.1
  • 46
    • 0019992090 scopus 로고
    • Bleb formation in hepatocytes during drug metabolism is caused by disturbances in thiol and calcium ion homeostasis
    • Jewell S.A., Bellomo G., Thor H., Orrenius S., and Smith M. Bleb formation in hepatocytes during drug metabolism is caused by disturbances in thiol and calcium ion homeostasis. Science 217 (1982) 1257-1259
    • (1982) Science , vol.217 , pp. 1257-1259
    • Jewell, S.A.1    Bellomo, G.2    Thor, H.3    Orrenius, S.4    Smith, M.5
  • 47
    • 0029033862 scopus 로고
    • Mitochondrial changes associated with glutathione deficiency
    • Meister A. Mitochondrial changes associated with glutathione deficiency. Biochim Biophys Acta 1271 (1995) 35-42
    • (1995) Biochim Biophys Acta , vol.1271 , pp. 35-42
    • Meister, A.1
  • 48
    • 0016282960 scopus 로고
    • Role of tubulin-SH groups in polymerization to microtubules. Functional-SH groups in tubulin for polymerization
    • Kuriyama R., and Sakai H. Role of tubulin-SH groups in polymerization to microtubules. Functional-SH groups in tubulin for polymerization. J Biochem (Tokyo) 76 (1974) 651-654
    • (1974) J Biochem (Tokyo) , vol.76 , pp. 651-654
    • Kuriyama, R.1    Sakai, H.2
  • 49
    • 0036257468 scopus 로고    scopus 로고
    • Antitumor activity of Z-ajoene, a natural compound purified from garlic: antimitotic and microtubule-interaction properties
    • Li M., Ciu J.R., Ye Y., Min J.M., Zhang L.H., Wang K., et al. Antitumor activity of Z-ajoene, a natural compound purified from garlic: antimitotic and microtubule-interaction properties. Carcinogenesis 23 (2002) 573-579
    • (2002) Carcinogenesis , vol.23 , pp. 573-579
    • Li, M.1    Ciu, J.R.2    Ye, Y.3    Min, J.M.4    Zhang, L.H.5    Wang, K.6
  • 50
    • 0142188703 scopus 로고    scopus 로고
    • Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH(2)-terminal kinase 1 activation
    • Xiao D., Pinto J.T., Soh J.W., Deguchi A., Gundersen G.G., Palazzo A.F., et al. Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH(2)-terminal kinase 1 activation. Cancer Res 63 (2003) 6825-6837
    • (2003) Cancer Res , vol.63 , pp. 6825-6837
    • Xiao, D.1    Pinto, J.T.2    Soh, J.W.3    Deguchi, A.4    Gundersen, G.G.5    Palazzo, A.F.6
  • 51
    • 0017334231 scopus 로고
    • Relationship between tubulin SH groups and bound guanine nucleotides
    • Nishida E., and Kobayashi T. Relationship between tubulin SH groups and bound guanine nucleotides. J Biochem (Tokyo) 81 (1977) 343-347
    • (1977) J Biochem (Tokyo) , vol.81 , pp. 343-347
    • Nishida, E.1    Kobayashi, T.2
  • 52
    • 0032078217 scopus 로고    scopus 로고
    • Caspases: key mediators of apoptosis
    • Thornberry N.A. Caspases: key mediators of apoptosis. Chem Biol 5 (1998) R97-R103
    • (1998) Chem Biol , vol.5
    • Thornberry, N.A.1
  • 53
    • 1042269473 scopus 로고    scopus 로고
    • Allicin stimulates lymphocytes and elicits an antitumor effect: a possible role of p21(ras)
    • Patya M., Zahalka M.A., Vanichkin A., Rabinkov A., Miron T., Mirelman D., et al. Allicin stimulates lymphocytes and elicits an antitumor effect: a possible role of p21(ras). Int Immunol 16 (2004) 275-281
    • (2004) Int Immunol , vol.16 , pp. 275-281
    • Patya, M.1    Zahalka, M.A.2    Vanichkin, A.3    Rabinkov, A.4    Miron, T.5    Mirelman, D.6
  • 54
    • 14044273000 scopus 로고    scopus 로고
    • Antiapoptotic response to induced GSH depletion: involvement of heat shock proteins and NF-kappaB activation
    • Filomeni G., Aquilano K., Rotilio G., and Ciriolo M.R. Antiapoptotic response to induced GSH depletion: involvement of heat shock proteins and NF-kappaB activation. Antioxid Redox Signal 7 (2005) 446-455
    • (2005) Antioxid Redox Signal , vol.7 , pp. 446-455
    • Filomeni, G.1    Aquilano, K.2    Rotilio, G.3    Ciriolo, M.R.4
  • 55
    • 0037109064 scopus 로고    scopus 로고
    • Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore
    • McStay G.P., Clarke S.J., and Halestrap A.P. Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore. Biochem J 367 (2002541) 548
    • Biochem J , vol.367 , pp. 548
    • McStay, G.P.1    Clarke, S.J.2    Halestrap, A.P.3


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