Simulation of the regulation of EGFR endocytosis and EGFR-ERK signaling by endophilin-mediated RhoA-EGFR crosstalk

FEBS Letters

Volumn 582, Issue 15, 2008, Pages 2283-2290

  Ung, Choong Yong ^a   Li, Hu ^a   Ma, Xiao Hua ^a   Jia, Jia ^a   Li, Bao Wen ^a   Low, Boon Chuan ^a   Chen, Yu Zong ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

EGFR endocytosis; ERK activation; Pathway simulation; RhoA; ROCK

Indexed keywords

ENDOPHILIN; ENDOPHILIN A1; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ARTICLE; CARCINOGENESIS; CELL MOTILITY; CROSS LINKING; CYTOSKELETON; ENDOCYTOSIS; ENZYME ACTIVATION; GENE OVEREXPRESSION; MATHEMATICAL MODEL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SIMULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CELL TRANSFORMATION, NEOPLASTIC; COMPUTER SIMULATION; ENDOCYTOSIS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; LUNG NEOPLASMS; MODELS, BIOLOGICAL; MUTATION; PROTO-ONCOGENE PROTEINS C-CBL; RECEPTOR, EPIDERMAL GROWTH FACTOR; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION;

EID: 46549089054     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2008.05.026     Document Type: Article

References (55)

1. Sternberg P.W., and Alberola-Ila J. Conspiracy theory: RAS and RAF do not act alone. Cell 95 (1998) 447-450
2. Henson E.S., and Gibson S.B. Surviving cell death through epidermal growth factor (EGF) signal transduction pathways: implications for cancer therapy. Cell Signal. 18 (2006) 2089-2097
3. Schubbert S., Bollag G., and Shannon K. Deregulated Ras signaling in developmental disorders: new tricks for an old dog. Curr. Opin. Genet. Dev. 17 (2007) 15-22
4. Perona R. Cell signalling: growth factors and tyrosine kinase receptors. Clin. Trans. Oncol. 8 (2006) 77-82
5. Kosaka T., Yatabe Y., Endoh H., Kuwano H., Takahashi T., and Mitsudomi T. Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications. Cancer Res. 64 (2004) 8919-8923
6. Haslekas C., Breen K., Pedersen K.W., Johannessen L.E., Stang E., and Madshus I.H. The inhibitory effect of ErbB2 on epidermal growth factor-induced formation of clathrin-coated pits correlates with retention of epidermal growth factor receptor-ErbB2 oligomeric complexes at the plasma membrane. Mol. Biol. Cell 16 (2005) 5832-5842
7. Lerdrup M., Hommelgaard A.M., Grandal M., and van Deurs B. Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way. J. Cell Sci. 119 (2006) 85-95
8. Shtiegman K., et al. Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling. Oncogene 26 (2007) 6968-6978
9. Kirisits A., Pils D., and Krainer M. Epidermal growth factor receptor degradation: an alternative view of oncogenic pathways. Int. J. Biochem. Cell. Biol. 39 (2007) 2173-2182
10. Shen F., Lin Q., Gu Y., Childress C., and Yang W. Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation. Mol. Biol. Cell 18 (2007) 732-742
11. Tanos B., and Pendergast A.M. Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor. J. Biol. Chem. 281 (2006) 32714-32723
12. Kaneko T., et al. Rho mediates endocytosis of epidermal growth factor receptor through phosphorylation of endophilin A1 by Rho-kinase. Genes Cell 10 (2005) 973-987
13. Carter R.E., and Sorkin A. Endocytosis of functional epidermal growth factor receptor-green fluorescent protein chimera. J. Biol. Chem. 273 (1998) 35000-35007
14. Marshall C.J. Signal transduction. Taking the Rap. Nature 392 (1998) 553-554
15. York R.D., Yao H., Dillon T., Ellig C.L., Eckert S.P., McCleskey E.W., and Stork P.J. Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature 392 (1998) 622-626
16. Dhillon A.S., Hagan S., Rath O., and Kolch W. MAP kinase signalling pathways in cancer. Oncogene 26 (2007) 3279-3290
17. Budzyn K., Marley P.D., and Sobey C.G. Targeting Rho and Rho-kinase in the treatment of cardiovascular disease. Trends Pharmacol. Sci. 27 (2006) 97-104
18. Shimokawa H., and Rashid M. Development of Rho-kinase inhibitors for cardiovascular medicine. Trends Pharmacol. Sci. 28 (2007) 296-302
19. Peters S.L., Schmidt M., and Michel M.C. Rho kinase: a target for treating urinary bladder dysfunction?. Trends Pharmacol. Sci. 27 (2006) 492-497
20. Haglund K., Sigismund S., Polo S., Szymkiewicz I., Di Fiore P.P., and Dikic I. Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation. Nat. Cell Biol. 5 (2003) 461-466
21. Hall A. Rho GTPases and the control of cell behaviour. Biochem. Soc. Trans. 33 (2005) 891-895
22. Welsh C.F., Roovers K., Villanueva J., Liu Y., Schwartz M.A., and Assoian R.K. Timing of cyclin D1 expression within G1 phase is controlled by Rho. Nat. Cell Biol. 3 (2001) 950-957
23. Bijian K., Takano T., Papillon J., Le Berre L., Michaud J.L., Kennedy C.R., and Cybulsky A.V. Actin cytoskeleton regulates extracellular matrix-dependent survival signals in glomerular epithelial cells. Am. J. Physiol. Renal. Physiol. 289 (2005) F1313-F1323
24. Guo F., and Zheng Y. Rho family GTPases cooperate with p53 deletion to promote primary mouse embryonic fibroblast cell invasion. Oncogene 23 (2004) 5577-5585
25. Xia M., and Land H. Tumor suppressor p53 restricts Ras stimulation of RhoA and cancer cell motility. Nat. Struct. Mol. Biol. 14 (2007) 215-223
26. Orton R.J., Sturm O.E., Vyshemirsky V., Calder M., Gilbert D.R., and Kolch W. Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway. Biochem. J. 392 (2005) 249-261
27. Schoeberl B., Eichler-Jonsson C., Gilles E.D., and Muller G. Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors. Nat. Biotechnol. 20 (2002) 370-375
28. Brightman F.A., and Fell D.A. Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells. FEBS Lett. 482 (2000) 169-174
29. Kholodenko B.N., Demin O.V., Moehren G., and Hoek J.B. Quantification of short term signaling by the epidermal growth factor receptor. J. Biol. Chem. 274 (1999) 30169-30181
30. Kiyatkin A., Aksamitiene E., Markevich N.I., Borisov N.M., Hoek J.B., and Kholodenko B.N. Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops. J. Biol. Chem. 281 (2006) 19925-19938
31. Sasagawa S., Ozaki Y., Fujita K., and Kuroda S. Prediction and validation of the distinct dynamics of transient and sustained ERK activation. Nat. Cell Biol. 7 (2005) 365-373
32. Yamada S., Taketomi T., and Yoshimura A. Model analysis of difference between EGF pathway and FGF pathway. Biochem. Biophys. Res. Commun. 314 (2004) 1113-1120
33. Tang Y., Olufemi L., Wang M.T., and Nie D. Role of Rho GTPases in breast cancer. Front. Biosci. 13 (2008) 759-776
34. Vishnubhotla R., Sun S., Huq J., Bulic M., Ramesh A., Guzman G., Cho M., and Glover S.C. ROCK-II mediates colon cancer invasion via regulation of MMP-2 and MMP-13 at the site of invadopodia as revealed by multiphoton imaging. Lab. Invest. 87 (2007) 1149-1158
35. Mayawala K., Gelmi C.A., and Edwards J.S. MAPK cascade possesses decoupled controllability of signal amplification and duration. Biophys. J. 87 (2004) L01-L02
36. Tourkova I.L., Shurin G.V., Wei S., and Shurin M.R. Small rho GTPases mediate tumor-induced inhibition of endocytic activity of dendritic cells. J. Immunol. 178 (2007) 7787-7793
37. Barandier C., Ming X.F., Rusconi S., and Yang Z. PKC is required for activation of ROCK by RhoA in human endothelial cells. Biochem. Biophys. Res. Commun. 304 (2003) 714-719
38. Kubo T., Hata K., Yamaguchi A., and Yamashita T. Rho-ROCK inhibitors as emerging strategies to promote nerve regeneration. Curr. Pharm. Des. 13 (2007) 2493-2499
39. Karandikar M., Xu S., and Cobb M.H. MEKK1 binds raf-1 and the ERK2 cascade components. J. Biol. Chem. 275 (2000) 40120-40127
40. Kofahl B., and Klipp E. Modelling the dynamics of the yeast pheromone pathway. Yeast 21 (2004) 831-850
41. Gallagher E.D., Gutowski S., Sternweis P.C., and Cobb M.H. RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity. J. Biol. Chem. 279 (2004) 1872-1877
42. Oda K., Matsuoka Y., Funahashi A., and Kitano H. A comprehensive pathway map of epidermal growth factor receptor signaling. Mol. Syst. Biol. 1 (2005) 0010
43. Yarden Y., and Sliwkowski M.X. Untangling the ErbB signalling network. Nat. Rev. Mol. Cell Biol. 2 (2001) 127-137
44. Ceresa B.P., and Schmid S.L. Regulation of signal transduction by endocytosis. Curr. Opin. Cell. Biol. 12 (2000) 204-210
45. Lua B.L., and Low B.C. Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain. J. Cell Sci. 118 (2005) 2707-2721
46. Wang L., and Zheng Y. Cell type-specific functions of Rho GTPases revealed by gene targeting in mice. Trends Cell Biol. 17 (2007) 58-64
47. Faried A., et al. RhoA and RhoC proteins promote both cell proliferation and cell invasion of human oesophageal squamous cell carcinoma cell lines in vitro and in vivo. Eur. J. Cancer 42 (2006) 1455-1465
48. Takeda N., Kondo M., Ito S., Ito Y., Shimokata K., and Kume H. Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin. Am. J. Respir. Cell Mol. Biol. 35 (2006) 722-729
49. Kholodenko B.N. Cell-signalling dynamics in time and space. Nat. Rev. Mol. Cell Biol. 7 (2006) 165-176
50. Zhang B., Chernoff J., and Zheng Y. Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA. J. Biol. Chem. 273 (1998) 8776-8782
51. MathWorks, T. (2007) Matlabed (Eds.), The MathWorks Inc., Natick, MA.
52. Saito T., et al. Differential activation of epidermal growth factor (EGF) receptor downstream signaling pathways by betacellulin and EGF. Endocrinology 145 (2004) 4232-4243
53. Russell M., Lange-Carter C.A., and Johnson G.L. Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1). J. Biol. Chem. 270 (1995) 11757-11760
54. Pomerance M., Multon M.C., Parker F., Venot C., Blondeau J.P., Tocque B., and Schweighoffer F. Grb2 interaction with MEK-kinase 1 is involved in regulation of Jun-kinase activities in response to epidermal growth factor. J. Biol. Chem. 273 (1998) 24301-24304
55. Christerson L.B., Gallagher E., Vanderbilt C.A., Whitehurst A.W., Wells C., Kazempour R., Sternweis P.C., and Cobb M.H. p115 Rho GTPase activating protein interacts with MEKK1. J. Cell Physiol. 192 (2002) 200-208