Molecular mechanism of macrophage activation by exopolysaccharides from liquid culture of Lentinus edodes

Journal of Microbiology and Biotechnology

Volumn 18, Issue 2, 2008, Pages 355-364

  Lee, Ji Yeon ^a   Kim, Joo Young ^a   Lee, Yong Gyu ^a   Rhee, Man Hee ^b   Hong, Eock Ki ^a   Cho, Jae Youl ^a  

^a Kangwon National University   (South Korea)

^b Kyungpook National University   (South Korea)

Author keywords

Lentinus edodes; Macrophage functions; Mushroom derived glucan; Pattern recognition receptors; Signaling cascade

Indexed keywords

BETA GLUCAN; CHEMOKINE RECEPTOR CCR3; DECTIN 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LENTINUS EDODES EXTRACT; MITOGEN ACTIVATED PROTEIN KINASE; NATURAL PRODUCT; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 2; CYTOKINE; MEMBRANE PROTEIN; NERVE PROTEIN; NFKB1 PROTEIN, MOUSE; POLYSACCHARIDE; TLR2 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FUNGUS CULTURE; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; LENTINUS EDODES; LIQUID CULTURE; MACROPHAGE ACTIVATION; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PHAGOCYTOSIS; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; ANIMAL; CHEMISTRY; CULTURE MEDIUM; DRUG EFFECT; GENE EXPRESSION; GENETICS; IMMUNOLOGY; MACROPHAGE; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

BASIDIOMYCOTA; LENTINULA EDODES;

ANIMALS; CELL LINE, TUMOR; CULTURE MEDIA; CYTOKINES; GENE EXPRESSION; MACROPHAGE ACTIVATION; MACROPHAGES; MEMBRANE PROTEINS; MICE; NERVE TISSUE PROTEINS; NF-KAPPA B P50 SUBUNIT; NITRIC OXIDE; POLYSACCHARIDES; SHIITAKE MUSHROOMS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2;

EID: 46449123505     PISSN: 10177825     EISSN: 17388872     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Akamatsu, S., A. Watanabe, M. Tamesada, R. Nakamura, S. Hayashi, D. Kodama, M. Kawase, and K. Yagi. 2004. Hepatoprotective effect of extracts from Lentinus edodes mycelia on dimethylnitrosamine-induced liver injury. Biol. Pharm. Bull. 27: 1957-1960.
2. Allavena, P., M. Chieppa, P. Monti, and L. Piemonti. 2004. From pattern recognition receptor to regulator of homeostasis: The double-faced macrophage mannose receptor. Crit. Rev. Immunol. 24: 179-192.
3. Borchers, A. T., J. S. Stern. R. M. Hackman, C. L. Keen, and M. E. Gershwin. 1999. Mushrooms, tumors, and immunity. Proc. Soc. Exp. Biol. Med. 221: 281-293.
4. Brown, G. D. 2006. Dectin-1: A signalling non-TLR pattern-recognition receptor. Nat. Rev. Immunol. 6: 33-43.
5. Brown, G. D., P. R. Taylor, D. M. Reid, J. A. Willment, D. L. Williams, L. Martinez-Pomares, S. Y. Wong, and S. Gordon. 2002. Dectin-1 is a major beta-glucan receptor on macrophages. J. Exp. Med. 196: 407-412.
6. Brown, G. D., J. Herre, D. L. Williams, J. A. Willment, A. S. Marshall, and S. Gordon. 2003. Dectin-1 mediates the biological effects of beta-glucans. J. Exp, Med. 197: 1119-1124.
7. Cho, H. J., J. Y. Cho, M. H. Rhee, H. S. Kim, H. S. Lee, and H. J. Park. 2007. Inhibitory effects of cordycepin (3′-deoxydenosine). a component of Cordyceps militaris, on human platelet aggregation induced by thapsigargin. J. Microbiol. Biotechnol. 17: 1134-1138.
8. Clio, J. Y.. K. U. Baik J. H. Jung, and M. H. Park. 2000. In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa. Eur. J. Pharmacol. 398: 399-407.
9. Cutolo, M. 1999. Macrophages as effectors of the immunoendocrinologic interactions in autoimmune rheumatic diseases. Ann. NY Acad Sci. 876: 32-41; discussion 41-42.
10. Dai, Q. and S. B. Pruett. 2006. Ethanol suppresses LPS-induced Toll-like receptor 4 clustering, reorganization of the actin cytoskeleton, and associated TNF-alpha production. Alcohol. Clin. Exp. Res. 30: 1436-1444.
11. Dillon, S., S. Agrawal, K. Banerjce, J. Letterio, T. L. Denning, K. Oswald-Richter, D. J. Kasprowicz, K. Kellar, J. Pare, T van Dyke, S. Ziegler, D. Unutmaz, and B. Pulendran. 2006. Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance. J. Clin. Invest. 116: 916-928.
12. Dong, Q., L. M. Jia, and J. N. Fang. 2006. A beta-D-glucan isolated front the fruiting bodies of Hericium erinaceus and its aqueous conformation. Carbohydr Res. 341: 791-795.
13. Doyle, S. L. and L. A. O'Neill. 2006, Toll-like receptors: From the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity. Biochem. Pharmacol. 72: 1102-1113.
14. Duperrier, K., A. Eljaafari, C. Dezutter-Dambuyant, C. Bardin, C. Jacquet, K. Yoneda, D. Schmitt, L. Gebuhrer, and D. Rigal. 2000. Distinct subsets of dendritic cells resembling dermal DCs can be gerterated in vivo from monocytes, in the presence of different serum supplements. J. Immunol. Methods 238: 119-131.
15. Evans, S. E., P. Y. Hahn, F. McCann, T. J. Kottom, Z. V. Pavlovic, and A. H. Limper. 2005. Pneumocystis cell wall beta-glucans stimulate alveolar epithelial cell chentokine generation through nuclear factor-kappaB-dependent mechanisms. Am. J. Respir. Cell Mol. Biol. 32: 490-497.
16. Fang, N., Q. Li, S. Yu, J. Zhang, L. He, M. J. Ronis, and T. M. Badger. 2006. Inhibition of growth and induction of apoptosis in human cancer cell lines by an ethyl acetate fraction from shiitake mushrooms. J. Altern. Complement Med. 12: 125-132.
17. Fishman, P., S. Bar-Yehuda. L. Madi, L. Rath-Wolfson, A. Ochaion, S. Cohen, and E. Baharav. 2006. - The P13K-NF-kappaB signal transduction pathway is involved in mediating the anti-inflammatory effect of IB-MECA in adjuvant-induced arthritis. Arthritis Res. Ther. 8: R33.
18. Gordon. S. 2002. Pattern recognition receptors: Doubling kip for the innate immune response. Cell 111: 927-930.
19. Gordon, S. B. and R. C. Read. 2002. Macrophage defences against respiratory tract infections. Br. Med. Bull. 61: 45-61.
20. Hahn, P. Y., S. E. Evans, T. J. Kottom, J. E. Standing, R. E. Pagano, and A. H. Limper. 2003. Pneumocystis carinii cell wall beta-glucan induces release of macrophage inflammatory protein-2 from alveolar epithelial cells via a lactosylceramide-mediated mechanism. J. Biol. Chem. 278: 2043-2050.
21. Hardy, K. and N. H. Hunt. 2004. Effects of a redox-active agent on lymphocyte activation and early gene expression patterns. Free Radic. Biol. Med. 37: 1550-1563.
22. Herre, J., S. Gordon, and G. D. Brown. 2004. Dectin-1 and its role in the recognition of beta-glucans by macrophages. Mol. Immunol. 40: 869-876.
23. Hoebe, K., Z. Jiang, P. Georgel, K. Tabeta, E. Janssen, X. Du, and B. Beutler. 2006. TLR signaling pathways: Opportunities for activation and blockade in pursuit of therapy. Curr. Pharm. Des. 12: 4123-4134.
24. Hsu, T. C. M. R. Young, J. Cmarik. and N. H. Colburn. 2000. Activator protein 1 (AP-I)- and nuclear factor KappaB (NF-kappaB)-dependent transcriptional events in carcinogenesis. Free Radic. Biol. Med. 28: 1338-1348.
25. Jung, K. K., H. S. Lee, J. Y. Cho, W. C. Shin, M. H. Rhee, T. G. Kim, J. H. Kang, S. H. Kim, S. Hong, and S. Y. Kang. 2006. Inhibitor effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia. Life Sci. 79: 2022-2031.
26. Kataoka, K., T. Muta, S. Yamazaki, and K. Takeshige. 2002. Activation of macrophages by linear (1→3)-beta-D-glucans. Implications for the recognition of fungi by innate immunity. J. Biol. Chem. 277: 36825-36831.
27. Kupfahl, C., G. Geginat, and H. Hof. 2006. Lentinan has a stimulatory effect on innate and adaptive immunity against murine Listeria monocytogenes infection. Int. Immunopharmacol. 6: 686-696.
28. Kweon, M. H., W. J. Lim, H. C. Yang, and H. C. Sung. 2000. Characterization of two glucans activating an alternative complement pathway from the fruiting bodies of mushroom Pleurotus ostreatus. J. Microbiol. Biotechnol. 10: 267-271.
29. Lull, C., H. J. Wichers, and H. F. Savelkoul. 2005. Antiinflammatory and immunomodulating properties of fungal metabolites. Mediators Inflamm. 2005: 63-80.
30. Mayell, M. 2001. Maitake extracts and their therapeutic potential. Altern. Med. Rev. 6: 48-60.
31. Morand, E. F. and M. Leech. 2005. Macrophage migration inhibitory factor in rheumatoid arthritis. Front. Biosci. 10: 12-22.
32. Nair, P. K., S. J. Melnick, R. Ramachandran, E. Escalon, and C. Ramachandran. 2006, Mechanism of macrophage activation by (1,4)-alpha-D-glucan isolated from Tinospora cordifolia. Int. Immunopharmacol. 6: 1815-1824.
33. Olsson, S. and R. Sundler. 2007. The macrophage beta-glucan receptor mediates arachidonate release induced by zymosan: Essential role for Sre family kinases. Mol. Immunol. 44: 1509-1515.
34. Olynych, T. J., D. L. Jakeman, and J. S. Marshall. 2006. Fungal zymosan induces leukotriene production by human mast cells through a dectin-1-dependent mechanism. J. Allergy Clin. Immunol. 118: 837-843.
35. Park, S. K., G. Y. Kim, J. Y. Lim, J. Y. Kwak, Y. S. Bae, J. D. Lee. Y. H. Oh S. C. Ahn. and Y. M. Park. 2003. Acidic polysacharides isolated from Phellinus linteus induce phenotypic and functional maturation of murine, dendritic cells. Biochem. Biophys. Res. Commun. 312: 449-458.
36. Rogers, N. C., E. C. Slack, A. D. Edwards, M. A. Nolte, O. Schulz, E. Schweighoffer, D. L. Williams, S. Gordon, V. L. Tybulewicz, G. D. Brown, and C, Reis e Sousa. 2005. Syk-dependent cytokine induction by dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity, 22: 507-517.
37. Sato, M., H. Sano, D. Iwaki, K. Kudo, M. Konishi, H., Takahashi, T. Takahashi, H. Imaizumi, Y. Asai, and Y. Kuroki, 2003. Direct binding of Toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A. J. Immunol. 171: 417-425.
38. Schaefer, L., A. Babelova, E. Kiss, H. J. Hausser, M. Baliova, M. Krzyzankova, G. Marsche, M. F. Young, D. Mihalik, M. Gotte, E. Malle, R. M. Schaefer, and H. J. Grone. 2005. The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J. Clin. Invest. 115: 2223-2233.
39. Schroder, N. W., B. Opitz, N. Lamping, K. S. Michelsen, L., Zahringer, U. B. Gobel, and R. R. Schumann. 2000. Involvement of lipopolysaccharide binding protein, CD14, and Toll-like receptors in the initiation of innate immune responses by Treponema glycolipids. J. Immunol. 165: 2683-2693.
40. Son, C. G., J. W. Shin, J. H. Cho, C. K. Cho, C. H., Yun, W. Chung, and S. H. Han. 2006. Macrophage activation and nitric oxide production by water soluble components of Hericium erinaceum. Int. Immunopharmacol. 6: 1363-1369.
41. Sorensen, H. R., A. S. Meyer, and S. Pedersen, 2003. Enzymatic hydrolysis of water-soluble wheat arabinoxylan, 1. Synergy between alpha-t-arabinofuranosidases, endo-1,4-beta-xylanases, and beta-xylosidase activities. Biotechnol. Bioeng. 81: 726-731.
42. Stuhlmuller, B., U. Ungethum, S. Scholze, L. Martinez, M. Backhaus, H. G. Kraetsch, R. W. Kinne, and G. R. Burmester. 2000. Identification of known and novel genes in activated monocytes from patients with rheumatoid arthritis. Arthritis Rheum. 43: 775-790.
43. Taylor, P. R., S. V. Tsoni, J. A. Wi?ment, K. M. Dennehy, M. Rosas, H. Findon, K. Haynes, C. Steele, M. Botto, S. Gordon, and G. D. Brown. 2007. Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat. Immunol. 8: 31-38.
44. Trinchieri, G. and A. Sher. 2007. Cooperation of Toll-like receptor signals in innate immune defence. Nat. Rev. Immunol. 7: 179-190.
45. Wu, M. J., T. L. Cheng, S. Y. Cheng, T. W. Lian, L. Wang, and S. Y. Chiou. 2006. Immunomodulatory properties of Grifola frondosa in submerged culture. J. Agric. Food Chem. 54: 2906-2914.
46. Yadav, M. and J. S. Schorey. 2006. The beta-glucan receptor dectin-1 functions together with TLR2 to mediate macrophage activation by mycobacteria. Blood 108: 3168-3175.
47. Yrlid, U., M. Svensson, C. Johansson, and M. J. Wick. 2000. Salmonella infection of bone marrow-derived macrophages and ? cells: Influence on antigen presentation and initiating an immune response. FEMS Immunol. Med. Microbiol. 27: 313-320.
48. Zhao, M. W., W. Q. Liang, D. B. Zhang, N. Wang, C. G. Wang, and Y. J. Pan. 2007. Cloning and characterization of squalene ? (SQS) gene from Ganoderma lucidum. J. Microbiol. Biotechnol. 17: 1106-1112.
49. Zheng, R., S. Jie, D. Hanchuan, and W. Moucheng. 2005. Characterization and immunomodulating activities of polysaccharide from Lentinus edodes. Int. Immunopharmacol. 5: 811-820.