Altered expression of mismatch repair proteins associated with acquisition of microsatellite instability in a clonal model of human T lymphocyte aging

Rejuvenation Research

Volumn 11, Issue 3, 2008, Pages 565-572

  Neri, Simona ^a   Pawelec, Graham ^b   Facchini, Andrea ^a,c   Ferrari, Cinzia ^a   Mariani, Erminia ^a,c  

^a RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ENZYME; MESSENGER RNA; MISMATCH REPAIR PROTEIN; PMS1 ENZYME; PMS2 ENZYME; PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH3; PROTEIN MSH6;

ADULT; AGED; ARTICLE; CELL AGING; CELL DIVISION; CONTROLLED STUDY; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; WESTERN BLOTTING;

EUKARYOTA;

EID: 46449095981     PISSN: 15491684     EISSN: None     Source Type: Journal    
DOI: 10.1089/rej.2007.0639     Document Type: Article

References (31)

1. Brentnall TA, Chen R, Lee JG, Kimmey MB, Bronner MP, Haggitt RC, Kowdley KV, Hecker LM, Byrd DR. Microsatellite instability and k-ras mutations associated with pancreatic adenocarcinoma and pancreatitis. Cancer Res 1995;55:42564-4267.
2. Guo HH, Loeb LA. Tumbling down a different pathway to genetic instability. J Clin Invest 2003;112:1887-1894.
3. Coolbaugh-Murphy MI, Xu J, Ramagli LS, Brown BW, Siciliano MJ. Microsatellite instability (MSI) increases with age in normal somatic cells. Mech Ageing Dev 2005;126:1051-1059.
4. Ben Yehuda A, Globerson A, Krichevsky S, Bar On H, Kidron M, Friedlander Y, Friedman G, Ben Yehuda D. Ageing and the mismatch repair system. Mech Ageing Dev 2000;121:173-179.
5. Krichevsky S, Pawelec G, Gural A, Effros RB, Globerson A, Yehuda DB, Yehuda AB. Age related microsatellite instability in T cells from healthy individuals. Exp Gerontol 2004;39:507-515.
6. Neri S, Gardini A, Facchini A, Olivieri F, Franceschi C, Ravaglia G, Mariani E. Mismatch repair system and aging: microsatellite instability in peripheral blood cells from differently aged participants. J Gerontol A Biol Sci Med Sci 2005;60:285-292.
7. Pawelec G. Immunity and ageing in man. Exp Gerontol 2006;41:1239-1242.
8. Neri S, Cattini L, Facchini A, Pawelec G, Mariani E. Microsatellite instability in in vitro ageing of T lymphocyte clones. Exp Gerontol 2004;39:499-505.
9. Annet K, Duggan O, Freeburn R, Hyland P, Pawelec G, Barnett Y. An investigation of DNA mismatch repair capacity under normal culture conditions and under conditions of supra-physiological challenge in human CD4+T cell clones from donors of different ages. Exp Gerontol 2005;40:976-981.
10. Neri S, Pawelec G, Facchini A, Mariani E. Microsatellite instability and compromized mismatch repair expression during in vitro passaging of monoclonal human T lymphocytes. Rejuvenation Res 2007;10:145-156.
11. Iyer RR, Pluciennik A, Burdett V, Modrich PL. DNA Mismatch repair: functions and mechanisms. Chem Rev 2006;106:302-323.
12. Jun SH, Kim TG, Ban C. DNA mismatch repair system. Classical and fresh roles. FEBS J 2006;273:1609-1619.
13. Kolodner RD, Marsischky GT. Eukaryotic DNA mismatch repair. Curr Opin Genet Dev1999;9:89-96.
14. Chang DK, Ricciardiello L, Goel A, Chang CL, Boland CR. Steady-state regulation of the human DNA mismatch repair system. J Biol Chem 2000;275:18424-18431.
15. Pawelec G, Mariani E, Solana R, Forsey R, Larbi A, Neri S, Dela Rosa O, Barnett Y, Tolson J, Fülöp T: Human T cell clones in long-term culture as models for the impact of chronic antigenic stress in ageing. In: Conn PM (ed.): Handbook of Models of Human Aging. New York: 2006, Elsevier, pp. 781-792.
16. Pawelec G, Barnett Y, Mariani E, Solana R. Human CD4+T cell clone longevity in tissue culture: lack of influence of donor age or cell origin. Exp Gerontol 2002;37:265-269.
17. Hyland P, Barnett C, Pawelec G, Barnett Y. Age-related accumulation of oxidative DNA damage and alterations in levels of p16 (INK4α/CDKN2α) , p21(WAF1/CIP1/SDI1) and p27 (KIP1) in human CD4+ T cell clones in vitro. Mech Ageing Dev 2001;122:1151-1167.
18. Plevova P, Sedlakova E, Zapletalova J, Krepelova A, Skypalova P, Kolar Z. Expression of the hMLH1 and hMSH2 proteins in normal tissues: relationship to cancer predisposition in hereditary non-polyposis colon cancer. Virchows Arch 2005;446:112-119.
19. Marra G, Chang CL, Laghi LA, Chauhan DP, Young D, Boland CR. Expression of human MutS homolog 2 (hMSH2) protein in resting and proliferating cells. Oncogene 1996;13:2189-2196.
20. Genschel J, Littman SJ, Drummond JT, Modrich P. Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha. J Biol Chem 1998;273:19895-19901.
21. Drummond JT, Genschel J, Wolf E, Modrich P. DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair. Proc Natl Acad Sci USA 1997;94:10144-10149.
22. Marra G, Iaccarino I, Lettieri T, Roscilli G, Delmastro P, Jiricny J. Mismatch repair deficiency associated with overexpression of the MSH3 gene. Proc Natl Acad Sci USA 1998;95:8568-8573.
23. Yao Y, Tao H, Kim JJ, Burkhead B, Carloni E, Gasbarrini A, Sepulveda AR. Alterations of DNA mismatch repair proteins and microsatellite instability levels in gastric cancer cell lines. Lab Invest 2004;84:915-922.
24. Yanagisawa Y, Ito E, Iwahashi Y, Akiyama Y, Yuasa Y, Maruyama K. Isolation and characterization of the 5′ region of the human mismatch repair gene hPMS1. Biochem Biophys Res Commun 1998;243:738-743.
25. Nicolaides NC, Kinzler KW, Vogelstein B. Analysis of the 5′ region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene. Genomics 1995;29: 329-334.
26. Iwahashi Y, Ito E, Yanagisawa Y, Akiyama Y, Yuasa Y, Onodera T, Maruyama K. Promoter analysis of the human mismatch repair gene hMSH2.Gene 1998;213:141-147.
27. Ito E, Yanagisawa Y, Iwahashi Y, Suzuki Y, Nagasaki H, Akiyama Y, Sugano S, Yuasa Y, Maruyama K. A core promoter and a frequent single-nucleo-tide polymorphism of the mismatch repair gene hMLH1. Biochem Biophys Res Commun 1999;256:488-494.
28. Quaresima B, Faniello MC, Baudi F, Cuda G, Grandinetti C, Tassone P, Costanzo F, Venuta S. Transcriptional regulation of the mismatch repair gene hMLH1. Gene 2001;275:261-265.
29. Warnick CT, Dabbas B, Ford CD, Strait KA. Identification of a p53 response element in the promoter region of the hMSH2 gene required for expression in A2780 ovarian cancer cells. J Biol Chem 2001;276:27363-27370.
30. Humbert O, Achour I, Lautier D, Laurent G, Salles B. hMSH2 expression is driven by AP1-dependent regulation through phorbol-ester exposure. Nucleic Acids Res 2003;31:5627-5634.
31. Christmann M, Tomicic MT, Kaina B. Phosphorylation of mismatch repair proteins MSH2 and MSH6 affecting MutSα mismatch-binding activity. Nucleic Acids Res 2002;30:1959-1966.