Alterations of DNA mismatch repair proteins and microsatellite instability levels in gastric cancer cell lines

Laboratory Investigation

Volumn 84, Issue 7, 2004, Pages 915-922

  Yao, Yuan ^a   Tao, Hong ^a   Kim, Jae J ^b   Burkhead, Benjamin ^a   Carloni, Emilia ^c   Gasbarrini, Antonio ^c   Sepulveda, Antonia R ^a,d  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b Samsung Medical Center   (South Korea)

^c CATHOLIC UNIVERSITY   (Italy)

^d UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Gastric cancer cell lines; Microsatellite instability; Mismatch repair genes; Mutations; Stomach cancer

Indexed keywords

DNA; MISMATCH REPAIR PROTEIN PMS1; MISMATCH REPAIR PROTEIN PMS2; PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH6; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CARCINOGENESIS; DNA METHYLATION; GENE MUTATION; HUMAN; HUMAN CELL; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; MUTATION RATE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; STOMACH CANCER; WESTERN BLOTTING;

BASE PAIR MISMATCH; CARRIER PROTEINS; CELL LINE, TUMOR; DNA METHYLATION; DNA REPAIR; DNA-BINDING PROTEINS; HUMANS; MICROSATELLITE REPEATS; MUTATION; MUTS HOMOLOG 2 PROTEIN; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; STOMACH NEOPLASMS;

EID: 3042598659     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1038/labinvest.3700117     Document Type: Article

References (42)

1. Kolodner RD, Marsischky GT. Eukaryotic DNA mismatch repair. Curr Opin Genet Dev 1999;9:89-96.
2. Lipkin SM, Wang V, Jacoby R, et al. MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability. Nat Genet 2000;24:27-35.
3. Leung WK, Kim JJ, Wu L, et al. Identification of a second MutL DNA mismatch repair complex (hPMS1 and hMLH1) in human epithelial cells. J Biol Chem 2000;275:15728-15732.
4. Liu T, Yan H, Kuismanen S, et al. The role of hPMS1 and hPMS2 in predisposing to colorectal cancer. Cancer Res 2001;61:7798-7802.
5. Raschle M, Marra G, Nystrom-Lahti M, et al. Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1. J Biol Chem 1999;274:32368-32375.
6. Park K, Kim SJ, Bang YJ, et al. Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-beta. Proc Natl Acad Sci USA 1994;91:8772-8776.
7. Oliveira C, Seruca R, Seixas M, et al. The clinicopathological features of gastric carcinomas with microsatellite instability may be mediated by mutations of different "target genes": a study of the TGFbeta RII, IGFII R, and BAX genes. Am J Pathol 1998;153:1211-1219.
8. Abe T, Ouyang H, Migita T, et al. The somatic mutation frequency of the transforming growth factor beta receptor type II gene varies widely among different cancers with microsatellite instability. Eur J Surg Oncol 1996;22:474-477.
9. Myeroff LL, Parsons R, Kim SJ, et al. A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability. Cancer Res 1995;55:5545-5547.
10. Ohue M, Tomita N, Monden T, et al. Mutations of the transforming growth factor beta type II receptor gene and microsatellite instability in gastric cancer. Int J Cancer 1996;68:203-206.
11. Ottini L, Falchetti M, D'Amico C, et al. Mutations at coding mononucleotide repeats in gastric cancer with the microsatellite mutator phenotype. Oncogene 1998;16:2767-2772.
12. Leung WK, Kim JJ, Kim JG, et al. Microsatellite instability in gastric intestinal metaplasia in patients with and without gastric cancer. Am J Pathol 2000;156:537-543.
13. Arzimanoglou II, Gilbert F, Barber HR. Microsatellite instability in human solid tumors. Cancer 1998;82;1808-1820.
14. Duval A, Hamelin R. Genetic instability in human mismatch repair deficient cancers. Ann Genet 2002;45:71-75.
15. Boland CR, Thibodeau SN, Hamilton SR, et al. A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 1998;58:5248-5257.
16. Boland CR. Molecular genetics of hereditary non-polyposis colorectal cancer. Ann NY Acad Sci 2000;910:50-59. discussion 59-61.
17. Fleisher AS, Esteller M, Wang S, et al. Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability. Cancer Res 1999;59:1090-1095.
18. Herman JG, Umar A, Polyak K, et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci USA 1998;95:6870-6875.
19. Liu B, Parsons R, Papadopoulos N, et al. Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nat Med 1996;2:169-174.
20. Tomlinson I, Halford S, Aaltonen L, et al. Does MSI-low exist? J Pathol 2002;197:6-13.
21. Pinto M, Oliveira C, Machado JC, et al. MSI-L gastric carcinomas share the hMLH1 methylation status of MSI-H carcinomas but not their clinicopathological profile. Lab Invest 2000;80:1915-1923.
22. Ferlay JBF, Pisani P, Parkin DM. GLOBOCAN 2000: Cancer Incidence, Mortality, and Prevalence Worldwide. Version: 1.0 ed. International Agency for Research on Cancer Press, 2001.
23. Parkin DM, Bray F, Ferlay J, et al. Estimating the world cancer burden: Globocan 2000. Int J Cancer 2001;94:153-156.
24. Jemal A, Thomas A, Murray T, et al. Cancer statistics, 2002. CA Cancer J Clin 2002;52:23-47.
25. Semba S, Yokozaki H, Yamamoto S, et al. Microsatellite instability in precancerous lesions and adenocarcinomas of the stomach. Cancer 1996;77(Suppl 8):1620-1627.
26. Bae SI, Park JG, Kim YI, et al. Genetic alterations in gastric cancer cell lines and their original tissues. Int J Cancer 2000;87:512-516.
27. Park JG, Yang HK, Kim WH, et al. Establishment and characterization of human gastric carcinoma cell lines. Int J Cancer 1997;70:443-449.
28. Yokozaki H. Molecular characteristics of eight gastric cancer cell lines established in Japan. Pathol Int 2000;50:767-777.
29. Ochiai A, Yasui W, Tahara E. Growth-promoting effect of gastrin on human gastric carcinoma cell line TMK-1. Jpn J Cancer Res 1985;76:1064-1071.
30. Dietmaier W, Wallinger S, Bocker T, et al. Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression. Cancer Res 1997;57:4749-4756.
31. Kane M, Loda M, Gaida G, et al. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch-repair defective human tumor cell lines. Cancer Res 1997;57:808-811.
32. Liu B, Parsons RE, Hamilton SR, et al. hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds. Cancer Res 1994;54:4590-4594.
33. Umar A, Boyer JC, Thomas DC, et al. Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability. J Biol Chem 1994;269:14367-14370.
34. Parsons R, Guo-Min L, Longley M, et al. Mismatch repair deficiency in phenotypically normal human cells. Science 1995;268:738-740.
35. Reitmair AH, Risley R, Bristow RG, et al. Mutator phenotype in Msh2-deficient murine embryonic fibroblasts. Cancer Research 1997;57:3765-3771.
36. Hoang JM, Cottu PH, Thuille B, et al. BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines. Cancer Res 1997;57:300-303.
37. Wheeler JM, Loukola A, Aaltonen LA, et al. The role of hypermethylation of the hMLH1 promoter region in HNPCC versus MSI+ sporadic colorectal cancers. J Med Genet 2000;37:588-592.
38. Shin K, Yang Y, Park J. Absence or decreased levels of the hMLH1 protein in human gastric carcinoma cell lines: implication of hMLH1 in alkylation tolerance. J Cancer Res Clin Oncol 1998;124:421-426.
39. Shin KH, Park JG. Microsatellite instability is associated with genetic alteration but not with low levels of expression of the human mismatch repair proteins hMSH2 and hMLH1. Eur J Cancer 2000;36:925-931.
40. Kang YH, Bae SI, Kim WH. Comprehensive analysis of promoter methylation and altered expression of hMLH1 in gastric cancer cell lines with microsatellite instability. J Cancer Res Clin Oncol 2002;128:119-124.
41. Carethers JM, Hawn MT, Chauhan DP, et al. Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N-nitro-N- nitroso-guanidine. J Clin Invest 1996;98:199-206.
42. Renault B, Calistri D, Buonsanti G, et al. Microsatellite instability and mutations of p53 and TGF-beta RII genes in gastric cancer. Hum Genet 1996;98:601-607.