The use of enzyme mixtures for complex biosyntheses

Current Opinion in Biotechnology

Volumn 15, Issue 5, 2004, Pages 449-455

  Bhattacharya, Sanjoy K ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; PENICILLIN G;

BIOSYNTHESIS; BIOTECHNOLOGICAL PRODUCTION; ENZYME SYNTHESIS; GENOMICS; METABOLISM; MICROORGANISM; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MODEL; MUTAGENESIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROCESS DESIGN; PROTEIN FOLDING; PROTEIN SYNTHESIS; PROTEOMICS; REVIEW; SITE DIRECTED MUTAGENESIS; SYNTHESIS;

BIOTECHNOLOGY; ENZYMES; GENOMICS; MULTIENZYME COMPLEXES; PROTEIN BIOSYNTHESIS; PROTEOMICS; SYSTEMS BIOLOGY;

EID: 4644334606     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.copbio.2004.08.012     Document Type: Review

References (45)

1. O. Kirk, T.V. Borchert, and C.C. Fuglsang Industrial enzyme applications Curr Opin Biotechnol 13 2002 345 351 This paper provides an account of recent developments in protein engineering and important tools for the development of new biocatalysts. The paper describes the production of new enzymes tailor-made for entirely new areas of application where enzymes have not previously been used.
2. F.B. Oppermann-Sanio, and A. Steinbuchel Occurrence, functions and biosynthesis of polyamides in microorganisms and biotechnological production Naturwissenschaften 89 2002 11 22 The current knowledge on the occurrence, biosynthesis, physiological functions, biodegradation and putative applications of polyamide are summarized. Prospects for novel polyamide production processes are presented.
3. P.G. Rieger, H.M. Meier, M. Gerle, U. Vogt, T. Groth, and H.J. Knackmuss Xenobiotics in the environment: present and future strategies to obviate the problem of biological persistence J Biotechnol 94 2002 101 123 An interdisciplinary approach for the potential design of environmentally benign substances is presented with examples for new commodity chemicals that better fit the naturally existing catabolic prospects.
4. T. Velkov, and A. Lawen Non-ribosomal peptide synthetases as technological platforms for the synthesis of highly modified peptide bioeffectors -cyclosporin synthetase as a complex example Biotechnol Annu Rev 9 2003 151 197
5. T. Asami, T. Nakano, H. Nakashita, K. Sekimata, Y. Shimada, and S. Yoshida The influence of chemical genetics on plant science: shedding light on functions and mechanism of action of brassinosteroids using biosynthesis inhibitors Plant Growth Regul 22 2003 336 349
6. M.C. Jewett, and J.R. Swartz Rapid expression and purification of 100 nmol quantities of active protein using cell-free protein synthesis Biotechnol Prog 20 2004 102 109
7. M.C. Jewett, and J.R. Swartz Mimicking the Escherichia coli cytoplasmic environment activates long-lived and efficient cell-free protein synthesis Biotechnol Bioeng 86 2004 19 26 The 'Cytomim' system, which closely replicates the physiological conditions of the cytoplasm of E. coli, is described using chloramphenicol acetyltransferase (CAT) expression as an example. It provides a stable energy supply for protein expression without the need for the exogenous addition of expensive high-energy phosphate compounds.
8. K.G. Knapp, and J.R. Swartz Cell-free production of active E. coli thioredoxin reductase and glutathione reductase FEBS Lett 559 2004 66 70
9. D.M. Kim, and J.R. Swartz Efficient production of a bioactive, multiple disulfide-bonded protein using modified extracts of Escherichia coli Biotechnol Bioeng 85 2004 122 129
10. G. Yin, and J.R. Swartz Enhancing multiple disulfide bonded protein folding in a cell-free system Biotechnol Bioeng 86 2004 188 195
11. X. Zhan, J. Gao, C. Jain, M.J. Cieslewicz, J.R. Swartz, and G. Georgiou Genetic analysis of disulfide isomerization in Escherichia coli: expression of DsbC is modulated by RNase E-dependent mRNA processing J Bacteriol 186 2004 654 660
12. G. Perugino, A. Trincone, M. Rossi, and M. Moracci Oligosaccharide synthesis by glycosynthases Trends Biotechnol 22 2004 31 37 A comprehensive account of syntheses of oligosaccharides using a number of thermophilic and hyperthermophilic bacterial glycosynthases have been described.
13. R.N. Patel Microbial/enzymatic synthesis of chiral pharmaceutical intermediates Curr Opin Drug Discov Dev 6 2003 902 920
14. R.V. Ulijn, L. De Martin, P.J. Halling, B.D. Moore, and A.E. Janssen Enzymatic synthesis of β-lactam antibiotics via direct condensation J Biotechnol 99 2002 215 222
15. C.G. Schroen, V.A. Nierstrasz, R. Bosma, Z.J. Dijkstra, E.J. VandeSandt, H.H. Beeftink, and J. Tramper Process design for enzymatic adipyl-7-ADCA hydrolysis Biotechnol Prog 18 2002 745 751
16. J. Oh, S.-G. Lee, B.-G. Kim, J.K. Sohng, K. Liou, and H.C. Lee One-pot enzymatic production of dTDP-4-keto-6-deoxy-d-glucose from dTMP and glucose-1-phosphate Biotechnol Bioeng 84 2003 452 458
17. B. Shen Accessing natural products by combinatorial biosynthesis Sci STKE 2004 2004 PE14
18. T. Fukui, H. Abe, and Y. Doi Engineering of Ralstonia eutropha for production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from fructose and solid-state properties of the copolymer Biomacromolecules 3 2002 618 624
19. C.T. Nomura, K. Taguchi, S. Taguchi, and Y. Doi Coexpression of genetically engineered 3-ketoacyl-ACP synthase III (fabH) and polyhydroxyalkanoate synthase (phaC) genes leads to short-chain-length-medium- chain-length polyhydroxyalkanoate copolymer production from glucose in Escherichia coli JM109 Appl Environ Microbiol 70 2004 999 1007
20. Y. Ohtsubo, M. Shimura, M. Delawary, K. Kimbara, M. Takagi, T. Kudo, A. Ohta, and Y. Nagata Novel approach to the improvement of biphenyl and polychlorinated biphenyl degradation activity: promoter implantation by homologous recombination Appl Environ Microbiol 69 2003 146 153
21. T. Weber, K. Welzel, S. Pelzer, A. Vente, and W. Wohlleben Exploiting the genetic potential of polyketide producing streptomycetes J Biotechnol 106 2003 221 232
22. K. Watanabe, C. Khosla, R.M. Stroud, and S.C. Tsai Crystal structure of an acyl-ACP dehydrogenase from the FK520 polyketide biosynthetic pathway: insights into extender unit biosynthesis J Mol Biol 334 2003 435 444
23. M.T. Mazur, C.T. Walsh, and N.L. Kelleher Site-specific observation of acyl intermediate processing in thiotemplate biosynthesis by Fourier transform mass spectrometry: the polyketide module of yersiniabactin synthetase Biochemistry 42 2003 13393 13400
24. J. Kennedy, S. Murli, and J.T. Kealey 6-Deoxyerythronolide B analogue production in Escherichia coli through metabolic pathway engineering Biochemistry 42 2003 14342 14348
25. S. Murli, J. Kennedy, L.C. Dayem, J.R. Carney, and J.T. Kealey Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production J Ind Microbiol Biotechnol 30 2003 500 509
26. O.A. Trivedi, P. Arora, V. Sridharan, R. Tickoo, D. Mohanty, and R.S. Gokhale Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria Nature 428 2004 441 445 Using the example of mycobacteria, where several unique complex lipids are produced by the combined action of fatty acid synthases and polyketide synthases, the authors illustrate how the metabolic repertoire is augmented by generating hybrid metabolites from a limited set of gene products.
27. G.H. Hakimelahi, P.C. Li, A.A. Moosavi-Movahedi, J. Chamani, G.A. Khodarahmi, T.W. Ly, F. Valiyev, M.K. Leong, S. Hakimelahi, K.S. Shia, and I. Chao Application of the Barton photochemical reaction in the synthesis of 1-dethia-3-aza-1-carba-2-oxacephem: a novel agent against resistant pathogenic microorganisms Org Biomol Chem 1 2003 2461 2467
28. I. Hirao, T. Ohtsuki, T. Fujiwara, T. Mitsui, T. Yokogawa, T. Okuni, H. Nakayama, K. Takio, T. Yabuki, and T. Kigawa An unnatural base pair for incorporating amino acid analogs into proteins Nat Biotechnol 20 2002 177 182
29. D. Kiga, K. Sakamoto, K. Kodama, T. Kigawa, T. Matsuda, T. Yabuki, M. Shirouzu, Y. Harada, H. Nakayama, and K. Takio An engineered Escherichia coli tyrosyl-tRNA synthetase for site-specific incorporation of an unnatural amino acid into proteins in eukaryotic translation and its application in a wheat germ cell-free system Proc Natl Acad Sci USA 99 2002 9715 9720
30. M.K. Hellerstein New stable isotope-mass spectrometric techniques for measuring fluxes through intact metabolic pathways in mammalian systems: introduction of moving pictures into functional genomics and biochemical phenotyping Metab Eng 6 2004 85 100
31. S. Cho, S.G. Park, H. Lee do, and B.C. Park Protein-protein interaction networks: from Interactions to Networks J Biochem Mol Biol 37 2004 45 52
32. F. Hayes Transposon-based strategies for microbial functional genomics and proteomics Annu Rev Genet 37 2003 3 29 An account of transposon-based approaches is provided. They are simple yet highly effective mutagens for both functional genomic and proteomic studies of microorganisms as well as for the dissection of individual proteins and protein complexes.
33. S. Kim, S.W. Lee, E.C. Choi, and S.Y. Choi Aminoacyl-tRNA synthetases and their inhibitors as a novel family of antibiotics Appl Microbiol Biotechnol 61 2003 278 288
34. S. Bhattacharya, S. Chakrabarti, A. Nayak, and S.K. Bhattacharya Metabolic networks of microbial systems Microb Cell Fact 2 2003 1 9 A comprehensive account of the properties of metabolic networks. This article is also a single source for information pertaining to many databases and tools used in the study of protein networks.
35. P. Pharkya, E.V. Nikolaev, and C.D. Maranas Review of the BRENDA Database Metab Eng 5 2003 71 73
36. I. Schomburg, A. Chang, C. Ebeling, M. Gremse, C. Heldt, G. Huhn, and D. Schomburg BRENDA, the enzyme database: updates and major new developments Nucleic Acids Res 32 2004 D431 D433 Provides a detailed description of the BRENDA database and its potential applications.
37. st century Biologists Science 303 2004 788 790
38. V. Spirin, and L.A. Mirny Protein complexes and functional modules in molecular networks Proc Natl Acad Sci USA 100 2003 12123 12128 An informative narrative of protein complexes and network modules. This paper also contains information about protein complexes and functional modules that could be used for applied purposes.
39. H. Kitano Systems biology: a brief overview Science 295 2002 1662 1664 A comprehensive overview of systems level biology. This paper summarizes, with examples, the new outlook in the modern era of biology and systems level approaches.
40. N. Nagradova Interdomain communications in bifunctional enzymes: how are different activities coordinated? IUBMB Life 55 2003 459 466
41. K. Schneider, K. Hovel, K. Witzel, B. Hamberger, D. Schomburg, E. Kombrink, and H.P. Stuible The substrate specificity-determining amino acid code of 4-coumarate:CoA ligase Proc Natl Acad Sci USA 100 2003 8601 8606
42. J.A. Morgan, and D.S. Clark Salt-activation of nonhydrolase enzymes for use in organic solvents Biotechnol Bioeng 85 2004 456 459
43. S. Chakrabarti, S. Bhattacharya, and S.K. Bhattacharya Biochemical engineering: cues from cells Trends Biotechnol 21 2003 204 209 Uses the generation of RuBP as an example to describe novel uses of enzymes and enzyme mixtures.
44. W.J. Strock Stocks rise in fourth quarter. Indexes for chemical drug and biotech firms were up from third quarter and from 2002 Chem Eng News 82 2004 21 22
45. 2 fixation: a general description. In Recent Research Advances in Biotechnology and Bioengineering. Edited by Bhattacharya SK, Mal, TK and Chakrabarti S. Trivandrum, Kerala, India: Research Signpost; 2002: 109-120. A detailed account of the abatement of carbon dioxide pollution at source has been described and economic analyses presented. The fixation of carbon dioxide is done by Rubisco and is recyclable with respect to the acceptor. The acceptor recycling involves complex enzymatic conversions.