Enzymatic synthesis of β-lactam antibiotics via direct condensation

Journal of Biotechnology

Volumn 99, Issue 3, 2002, Pages 215-222

  Ulijn, R V ^a,c   De Martin, L ^a   Halling, P J ^a   Moore, B D ^a   Janssen, A E M ^b  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Lactam antibiotics; Biocatalysis; Peptides; Product precipitation; Solid to solid

Indexed keywords

CONDENSATION; DEGRADATION; HYDROLYSIS; PRECIPITATION (CHEMICAL); SYNTHESIS (CHEMICAL);

SYNTHETIC REACTIONS;

ANTIBIOTICS;

AMOXICILLIN; AMPICILLIN; BETA LACTAM ANTIBIOTIC; CEFALEXIN; CEFALOGLYCIN; CEFALOTIN; CEFAMANDOLE; PENICILLIN G; SODIUM CHLORIDE; ZINC ION; ANTIINFECTIVE AGENT; PENICILLIN AMIDASE;

ADDITION REACTION; ARTICLE; DRUG DEGRADATION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME SYNTHESIS; FEASIBILITY STUDY; POLYMERIZATION; PRECIPITATION; PRIORITY JOURNAL; BIOSYNTHESIS; CATALYSIS; CHEMISTRY; ENZYME ACTIVATION; ENZYME STABILITY; ENZYMOLOGY; ESCHERICHIA COLI; EVALUATION; METABOLISM; QUALITY CONTROL; SYNTHESIS;

AMOXICILLIN; ANTI-BACTERIAL AGENTS; CATALYSIS; ENZYME ACTIVATION; ENZYME STABILITY; ESCHERICHIA COLI; FEASIBILITY STUDIES; PENICILLIN AMIDASE; PENICILLIN G; PRECIPITATION; QUALITY CONTROL;

EID: 0037073197     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1656(02)00211-0     Document Type: Article

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