Folate intake, serum folate, serum total homocysteine levels and methylenetetrahydrofolate reductase C677T polymorphism in young Japanese women

Journal of Nutritional Science and Vitaminology

Volumn 50, Issue 4, 2004, Pages 238-245

  Hiraoka, Mami ^a  

^a KAGAWA NUTRITION UNIVERSITY   (Japan)

Author keywords

Folate; Homocysteine; MTHFR; Polymorphism; RDA

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYTOSINE; FOLIC ACID; HOMOCYSTEINE; THYMINE;

ADULT; ARTICLE; BINDING ASSAY; BREAD; CALCULATION; CHEMOLUMINESCENCE; DATA BASE; DIET SUPPLEMENTATION; DIETARY INTAKE; DOCUMENTATION; FEMALE; FOOD COMPOSITION; FOOD INTAKE; GENETIC POLYMORPHISM; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; JAPAN; NORMAL HUMAN; PROTEIN BINDING; TEA; VEGETABLE;

EID: 4644313710     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.50.238     Document Type: Article

References (42)

1. Brody T, Barry S. 2001. Folic acid. In: Handbook of Vitamins, third edition revised and expanded (Rucker RB, Suttie JW, McCormick DB, Machlin LJ, eds), p 437. Marcel Dekker, New York.
2. 6 from diet and supplements in relation to risk of coronary heart disease among women. JAMA 279: 359-364.
3. Ma J, Stampfer MJ, Giovannucci E, Artigas C, Hunter DJ, Fuchs C, Willett WC, Selhub J, Hennekens CH, Rozen R. 1997. Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res 57: 1098-1102.
4. Scott JM, Kirke PN, Weir DG. 1995. Folate and neural tube defects. In: Folate in Health and Disease (Bailey LB, ed). p 329-360. Marcel Dekker, New York.
5. Resources Council, Science and Technology Agency. 2000. Standard Tables of Food Composition in Japan. Fifth revised edition. National Printing Bureau, Tokyo (in Japanese).
6. Ministry of Health, Labor and Welfare. 1999. Recommended Dietary Allowances-Dietary Reference Intakes, Sixth Revision. Daiichi-Shuppan, Tokyo (in Japanese).
7. Milen DB, Johnson LAK, Mahalko JR, Sandstead HH. 1983. Folate status of adult males living in a metabolic unit: Possible relationships with iron nutrition. Am J Clin Nutr 37: 768-773.
8. National Research Council. 1989. Folate. In: Recommended Dietary Allowances, 10th Ed, National Academy Press, Washington, DC.
9. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJH, den Heijer M, Kluijtmans LAJ, van den Heuvel L, Rozen R. 1995. A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase. Nat Genet 10: 111-113.
10. van der Put NMJ, Steegers-Theunissen RPM, Frosst P, Trijbels FJM, Eskes TKAB, van den Heuvel LP, Mariman ECM, den Heyer M, Rozen R, Blom HJ. 1995. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet 346: 1070-1071.
11. Jacques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg IH, Selhub J, Rozen R. 1996. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 93: 7-9.
12. Brattström L, Wilcken DEL, Öhrvik J, Brudin L. 1998. Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease. The result of a meta-analysis. Circulation 98: 2520-2526.
13. Nelen WLDM, Blom HJ, Thomas CMG, Steegers EAP, Boers GHJ, Eskes TKAB. 1998. Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages. J Nutr 128: 1336-1341.
14. Bailey LB, Gregory III JF. 1999. Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: Metabolic significance, risks and impact on folate requirement. J Nutr 129: 919-922.
15. Morita H, Kurihara H, Tsubaki S, Sugiyama T, Hamada C. Kurihara Y, Shindo T, Oh-hashi Y, Kitamura K, Yazaki Y. 1998. Methylenetetrahydrofolate reductase gene polymorphism and ischemic stroke in Japanese. Arterioscler Thromb Vase Biol 18: 1465-1469.
16. Wu Y, Tomon M, Sumino K. 2001. Methylenetetrahydrofolate reductase gene polymorphism and ischemic stroke: Sex difference in Japanese. Kobe J Med Sci 47: 255-262.
17. 12, folate, and β-carotene in young women. J Nutr Sci Vitaminol 47: 20-27.
18. Kondo A, Kimura K, Isobe Y, Kamihira O, Matsuura O, Gotoh M, Okai I. 2003. Folic acid reduces risks of having fetus affected with neural tube defects: Dietary food folate and plasma folate concentration. Nippon Hinyokika Gakkai Zasshi 94: 551-559 (in Japanese).
19. Imaeda N, Goto C, Tokudome Y, Ikeda M, Maki S, Tokudome S. 2002. Folate intake and food sources in Japanese female dietitians. Environ Health Prev Med 7: 156-161.
20. Bowes ADP. 1994. Bowes and Church's food values of portions commonly used, 16th ed. (Pennington JAT. ed) JB Lippincott C., Philadelphia.
21. Holland B, Welch AA, Unwin ID, Buss DH, Paul AA, Southgate DAT. 1991. McCance and Widdowson's the Composition of Foods, 5th ed. Royal Society of Chemistry. Ministry of Agriculture, Fisheries, and Food, Cambridge.
22. Tietz NW. 1994. Tietz Textbook of Clinical Chemistry, 2nd ed. (Burtis CA, Ashwood ER, ed) W.B. Saunders Company, Philadelphia.
23. Pfeiffer CM, Huff DL, Gunter EW. 1999. Rapid and accurate HPLC assay for plasma total homocysteine and cysteine in a clinical laboratory setting. Clin Chem 45: 290-292.
24. Ministry of Health. Labor and Welfare. 2003. Nutrition Status Based on the National Nutrition Survey in 2001. Daiichi-Shuppan, Tokyo (in Japanese).
25. Deharveng G, Charrondière UR. Slimani N, Southgate DAT. Riboli E. 1999. Comparison of nutrients in the food composition tables available in the nine European countries participating in EPIC. Eur J Clin Nutr 53: 60-79.
26. Pfeiffer CM, Rogers LM, Gregory III JF. 1997. Determination of folate in cereal-grain food products using trienzyme extraction and combined affinity and reversed-phase liquid chromatography. J Agric Food Chem 45: 407-413.
27. Tamura T, Mizuno Y, Johnston KE, Jacob RA. 1997. Food folate assay with protease, α-amylase, and folate conjugase treatments. J Agric Food Chem 45: 135-139.
28. Martin JI, Landen WO Jr, Soliman AGM, Eitenmiller RR. 1990. Application of a tri-enzyme extraction for total folate determination in foods. J Assoc Off Anal Chem 73: 805-808.
29. 12, Pantothenic Acid, Biotin and Choline. National Academy Press, Washington, DC.
30. 12, and total antioxidant status in vegetarians. Clin Chem 47: 1094-1101.
31. Selhub J, Jacques PF, Wilson PWF, Rush D, Rosenberg IH. 1993. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 270: 2693-2698.
32. Welch GN, Loscalzo J. 1998. Homocysteine and atherothrombosis. N Engl J Med 338: 1042-1050.
33. Jacobsen DW 1998. Homocysteine and vitamins in cardiovascular disease. Clin Chem 44: 1833-1843.
34. Kang SS, Wong PW, Malinow MR. 1992. Hyperhomocyst(e)inemia as a risk factor for occlusive vascular disease. Annu Rev Nutr 12: 279-298.
35. Rasmussen LB, Oveson L, Bülow I, Knudsen N, Laurberg P, Perrild H. 2000. Folate intake, lifestyle factors, and homocysteine concentrations in younger and older women. Am J Clin Nutr 72: 1156-1163.
36. Moriyama Y, Okamura T, Kajinami K, Iso H, Inazu A, Kawashiri M, Mizuno M, Takeda Y, Sakamoto Y, Kimura H, Suzuki H, Mabuchi H. 2002. Effects of serum B vitamins on elevated plasma homocysteine levels associated with the mutation of methylenetetrahydrofolate reductase gene In Japanese. Atherosclerosis 164: 321-328.
37. Kobashi G, Yamada H, Asano T, Nagano S, Hata A, Kishi R, Fujimoto S, Kondo K. 2000. Absence of association between a common mutation in the methylenetetrahydrofolate reductase gene and preeclampsia in Japanese women. Am J Med Genet 93: 122-125.
38. Rosenberg N, Murata M, Ikeda Y, Opare-Sem O, Zivelin A, Geffen E, Seligsohn U. 2002. The frequent 5.10-methylenetetrahydrofolate reductase C677T polymorphism is associated with a common haplotype in Whites, Japanese, and Africans. Am J Hum Genet 70: 758-762.
39. de Bree A, Vershuren WMM, Bjørke-Monsen AL, van der Put NMJ, Heil SG, Trijbels FJM, Blom HJ. 2003. Effect of the methylenetetrahydrofolate reductase 677C→T mutation on the relations among folate intake and plasma folate and homocysteine concentrations in a general population sample. Am J Clin Nutr 77: 687-693.
40. Guttormsen AB, Ueland PM, Nesthus I, Nygård O, Schneede J, Vollset SE, Refsum H. 1996. Determinations and vitamin responsiveness of intermediate hyperhomocysteinemia (>40 μmol/liter). J Clin Invest 98: 2174-2183.
41. Silaste ML, Rantala M, Sämpi M, Alfthan G, Aro A, Kesäniemi YA. 2001. Polymorphisms of key enzymes in homocysteine metabolism affect diet responsiveness of plasma homocysteine in healthy women. J Nutr 131: 2643-2647.
42. Hiraoka M, Kato K, Saito Y, Yasuda K, Kagawa Y. 2004. Gene-nutrient and gene-gene interactions of controlled folate intake by Japanese women. Biochem Biophys Res Commun 316: 1210-1216.