Arachidonic acid relaxes human pulmonary arteries through K + channels and nitric oxide pathways

European Journal of Pharmacology

Volumn 501, Issue 1-3, 2004, Pages 127-135

  Guerard, Pascal ^a,d   Goirand, Fraņoise ^a   Fichet, Nicolas ^a   Bernard, Alain ^b   Rochette, Luc ^a   Morcillo, Esteban J ^c   Dumas, Monique ^a   Bardou, Marc ^a  

^a Faculty of Medicine   (France)

^b HÔPITAL DU BOCAGE   (France)

^c UNIVERSITY OF VALENCIA   (Spain)

^d Bd Jeanne d'Arc BP 87900 21079 D   (France)

Author keywords

Arachidonic acid; Cyclooxygenase; Cytochrome P450; Human pulmonary arteries; K + channels; NO (Nitric oxide)

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 17 OCTADECYNOIC ACID; 4 AMINOPYRIDINE; ADENOSINE TRIPHOSPHATE; APAMIN; ARACHIDONIC ACID; CALCIUM CHANNEL BLOCKING AGENT; CHARYBDOTOXIN; CYTOCHROME P450 INHIBITOR; GLIBENCLAMIDE; INDOMETACIN; KETOCONAZOLE; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PAPAVERINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; PROSTAGLANDIN SYNTHASE INHIBITOR; THROMBOXANE A2;

ARTERY CONSTRICTION; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; MAJOR CLINICAL STUDY; METABOLITE; MUSCLE RELAXATION; PRIORITY JOURNAL; PULMONARY ARTERY;

ARACHIDONIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; NITRIC OXIDE; POTASSIUM CHANNELS; PULMONARY ARTERY; SIGNAL TRANSDUCTION; VASODILATION;

EID: 4644300360     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.08.007     Document Type: Article

References (46)

1. A.S. Adeagbo, and K.U. Malik Contribution of K+ channels to arachidonic acid-induced endothelium-dependent vasodilation in rat isolated perfused mesenteric arteries J. Pharmacol. Exp. Ther. 258 1991 452 458
2. E. Adelroth, M.M. Morris, F.E. Hargreave, and P.M. O'Byrne Airway responsiveness to leukotrienes C4 and D4 and to methacholine in patients with asthma and normal controls N. Engl. J. Med. 315 1986 480 484
3. S.L. Archer, F.S. Gragasin, X. Wu, S. Wang, S. McMurtry, D.H. Kim, M. Platonov, A. Koshal, K. Hashimoto, W.B. Campbell, J.R. Falck, and E.D. Michelakis Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12-epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BK(Ca) channels Circulation 107 2003 769 776
4. M. Bardou, F. Goirand, S. Marchand, C. Rouget, P. Devillier, J.P. Dumas, E.J. Morcillo, L. Rochette, and M. Dumas Hypoxic vasoconstriction of rat main pulmonary artery: role of endogenous nitric oxide, potassium channels, and phosphodiesterase inhibition J. Cardiovasc. Pharmacol. 38 2001 325 334
5. M. Bardou, F. Goirand, A. Bernard, P. Guerard, M. Gatinet, P. Devillier, J.P. Dumas, E.J. Morcillo, L. Rochette, and M. Dumas Relaxant Effects of Selective Phosphodiesterase Inhibitors on U46619 Precontracted Human Intralobar Pulmonary Arteries and Role of Potassium Channels J. Cardiovasc. Pharmacol. 40 2002 153 161
6. E.K. Birks, M. Bousamra, K. Presberg, J.A. Marsh, R.M. Effros, and E.R. Jacobs Human pulmonary arteries dilate to 20-HETE, an endogenous eicosanoid of lung tissue Am. J. Physiol. 272 1997 L823 L829
7. J. Capdevila, L. Gil, M. Orellana, L.J. Marnett, J.I. Mason, P. Yadagiri, and J.R. Falck Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism Arch. Biochem. Biophys. 261 1988 257 263
8. B. Cryer, and M. Feldman Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs Am. J. Med. 104 1998 413 421
9. L. Daffonchio, M. Fano, and C. Omini Rat pulmonary artery responses to some mediators of anaphylaxis: modifications by indomethacin Pharmacol. Res. Commun. 16 1984 679 688
10. J.M. Drazen Asthma therapy with agents preventing leukotriene synthesis or action Proc. Assoc. Am. Physicians 111 1999 547 559
11. M. Dumas, J.P. Dumas, L. Rochette, C. Advenier, and J.F. Giudicelli Role of potassium channels and nitric oxide in the effects of iloprost and prostaglandin E1 on hypoxic vasoconstriction in the isolated perfused lung of the rat Br. J. Pharmacol. 120 1997 405 410
12. D.M. Eckman, N. Hopkins, C. McBride, and K.D. Keef Endothelium-dependent relaxation and hyperpolarization in guinea-pig coronary artery: role of epoxyeicosatrienoic acid Br. J. Pharmacol. 124 1998 181 189
13. C.O. Feddersen, S. Chang, J. Czartalomna, and N.F. Voelkel Arachidonic acid causes cyclooxygenase-dependent and-independent pulmonary vasodilation J. Appl. Physiol. 68 1990 1799 1808
14. B. Fisslthaler, R. Popp, L. Kiss, M. Potente, D.R. Harder, I. Fleming, and R. Busse Cytochrome P450 2C is an EDHF synthase in coronary arteries Nature 401 1999 493 497
15. G.A. FitzGerald, and C. Patrono The coxibs, selective inhibitors of cyclooxygenase-2 N. Engl. J. Med. 345 2001 433 442
16. M. Fuloria, T.K. Smith, and J.L. Aschner Role of 5,6-epoxyeicosatrienoic acid in the regulation of newborn piglet pulmonary vascular tone Am. J. Physiol., Lung Cell. Mol. Physiol. 283 2002 L383 L389
17. L.M. Gambone, P.A. Murray, and N.A. Flavahan Synergistic interaction between endothelium-derived NO and prostacyclin in pulmonary artery: potential role for K+ ATP channels Br. J. Pharmacol. 121 1997 271 279
18. M.H. Holmqvist, J. Cao, M.H. Knoppers, M.E. Jurman, P.S. Distefano, K.J. Rhodes, Y. Xie, and W.F. An Kinetic modulation of Kv4-mediated A-current by arachidonic acid is dependent on potassium channel interacting proteins J. Neurosci. 21 2001 4154 4161
19. M.J. Holtzman Arachidonic acid metabolism. Implications of biological chemistry for lung function and disease Am. Rev. Respir. Dis. 143 1991 188 203
20. A.L. Hyman, A.A. Mathe, H.L. Lippton, and P.J. Kadowitz Prostaglandins and the lung Med. Clin. North Am. 65 1981 789 808
21. C.J. Kerkhof, E.N. Bakker, and P. Sipkema Role of cytochrome P-450 4A in oxygen sensing and NO production in rat cremaster resistance arteries Am. J. Physiol. 277 1999 H1546 H1552
22. L. Kiss, H. Schutte, K. Mayer, H. Grimm, W. Padberg, W. Seeger, and F. Grimminger Synthesis of arachidonic acid-derived lipoxygenase and cytochrome P450 products in the intact human lung vasculature Am. J. Respir. Crit. Care Med. 161 2000 1917 1923
23. P.L. Li, and W.B. Campbell Epoxyeicosatrienoic acids activate K+ channels in coronary smooth muscle through a guanine nucleotide binding protein Circ. Res. 80 1997 877 884
24. P. Lumley, B.P. White, and P.P. Humphrey GR32191, a highly potent and specific thromboxane A2 receptor blocking drug on platelets and vascular and airways smooth muscle in vitro Br. J. Pharmacol. 97 1989 783 794
25. A.W. Miller, P.V. Katakam, H.C. Lee, C.D. Tulbert, D.W. Busija, and N.L. Weintraub Arachidonic acid-induced vasodilation of rat small mesenteric arteries is lipoxygenase-dependent J. Pharmacol. Exp. Ther. 304 2003 139 144
26. J.A. Mitchell, S. Larkin, and T.J. Williams Cyclooxygenase-2: regulation and relevance in inflammation Biochem. Pharmacol. 50 1995 1535 1542
27. H. Miura, and D.D. Gutterman Human coronary arteriolar dilation to arachidonic acid depends on cytochrome P-450 monooxygenase and Ca2+-activated K+ channels Circ. Res. 83 1998 501 507
28. M. Nishiyama, H. Hashitani, H. Fukuta, Y. Yamamoto, and H. Suzuki Potassium channels activated in the endothelium-dependent hyperpolarization in guinea-pig coronary artery J. Physiol. (Lond.) 510 1998 455 465
29. Y. Qiu, and J. Quilley Vascular effects of arachidonic acid in the rat perfused heart. Role of the endothelium, cyclooxygenase, cytochrome P450, and K(+) channels J. Lipid Res. 40 1999 2177 2184
30. J. Quilley, and J.C. McGiff Is EDHF an epoxyeicosatrienoic acid? Trends Pharmacol. Sci. 21 2000 121 124
31. P. Russell, C. Wright, K. Kapeller, G. Barer, and P. Howard Attenuation of chronic hypoxic pulmonary hypertension in rats by cyclooxygenase products and by nitric oxide Eur. Respir. J. 6 1993 1501 1506
32. N. Satake, M. Shibata, and S. Shibata The involvement of KCa, KATP and KV channels in vasorelaxing responses to acetylcholine in rat aortic rings Gen. Pharmacol. 28 1997 453 457
33. R. Schubert, V.N. Serebryakov, H. Engel, and H.H. Hopp Iloprost activates KCa channels of vascular smooth muscle cells: role of cAMP-dependent protein kinase Am. J. Physiol. 271 1996 C1203 C1211
34. R. Schubert, V.N. Serebryakov, H. Mewes, and H.H. Hopp Iloprost dilates rat small arteries: role of K(ATP)-and K(Ca)-channel activation by cAMP-dependent protein kinase Am. J. Physiol. 272 1997 H1147 H1156
35. C.G. Sobey, D.D. Heistad, and F.M. Faraci Potassium channels mediate dilatation of cerebral arterioles in response to arachidonate Am. J. Physiol. 275 1998 H1606 H1612
36. A.H. Stephenson, R.S. Sprague, N.L. Weintraub, L. McMurdo, and A.J. Lonigro Inhibition of cytochrome P-450 attenuates hypoxemia of acute lung injury in dogs Am. J. Physiol. 270 1996 H1355 H1362
37. A.H. Stephenson, R.S. Sprague, and A.J. Lonigro 5,6-Epoxyeicosatrienoic acid reduces increases in pulmonary vascular resistance in the dog Am. J. Physiol. 275 1998 H100 H109
38. J.Z. Tan, G. Kaley, and G.H. Gurtner Nitric oxide and prostaglandins mediate vasodilation to 5,6-EET in rabbit lung Adv. Exp. Med. Biol. 407 1997 561 566
39. L. Walch, C. Labat, J.P. Gascard, V. de Montpreville, C. Brink, and X. Norel Prostanoid receptors involved in the relaxation of human pulmonary vessels Br. J. Pharmacol. 126 1999 859 866
40. M.H. Wang, E. Brand-Schieber, B.A. Zand, X. Nguyen, J.R. Falck, N. Balu, and M.L. Schwartzman Cytochrome P450-derived arachidonic acid metabolism in the rat kidney: characterization of selective inhibitors J. Pharmacol. Exp. Ther. 284 1998 966 973
41. N. Weissmann, W. Seeger, J. Conzen, L. Kiss, and F. Grimminger Effects of arachidonic acid metabolism on hypoxic vasoconstriction in rabbit lungs Eur. J. Pharmacol. 356 1998 231 237
42. S.N. Wu Large-conductance Ca2+-activated K+ channels:physiological role and pharmacology Curr. Med. Chem. 10 2003 649 661
43. X.J. Yuan, M.L. Tod, L.J. Rubin, and M.P. Blaustein Inhibition of cytochrome P-450 reduces voltage-gated K+ currents in pulmonary arterial myocytes Am. J. Physiol. 268 1995 C259 C270
44. D. Zhu, E.K. Birks, C.A. Dawson, M. Patel, J.R. Falck, K. Presberg, R.J. Roman, and E.R. Jacobs Hypoxic pulmonary vasoconstriction is modified by P-450 metabolites Am. J. Physiol, Heart Circ. Physiol. 279 2000 H1526 H1533
45. D. Zhu, M. Bousamra 2nd, D.C. Zeldin, J.R. Falck, M. Townsley, D.R. Harder, R.J. Roman, and E.R. Jacobs Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries Am. J. Physiol., Lung Cell. Mol. Physiol. 278 2000 L335 L343
46. A.P. Zou, Y.H. Ma, Z.H. Sui, P.R. Ortiz de Montellano, J.E. Clark, B.S. Masters, and R.J. Roman Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid omega-hydroxylase, on renal function in rats J. Pharmacol. Exp. Ther. 268 1994 474 481