The involvement of K(Ca), K(ATP) and K(V) channels in vasorelaxing responses to acetylcholine in rat aortic rings

General Pharmacology

Volumn 28, Issue 3, 1997, Pages 453-457

  Satake, N ^a   Shibata, M ^b   Shibata, S ^a  

^a UNIVERSITY OF HAWAII   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

acetylcholine; K channels; NO dependent and independent pathways; rat aortic rings; relaxation

Indexed keywords

4 AMINOPYRIDINE; ACETYLCHOLINE; ADENOSINE TRIPHOSPHATE; CALCIUM; CYCLIC GMP; CYTOCHROME P450; CYTOCHROME P450 INHIBITOR; DOCEBENONE; GLIBENCLAMIDE; GUANYLATE CYCLASE; GUANYLATE CYCLASE INHIBITOR; IBERIOTOXIN; INDOMETACIN; ISOPRENALINE; LIPOXYGENASE; LIPOXYGENASE INHIBITOR; METHYLENE BLUE; METYRAPONE; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; OXYGENASE INHIBITOR; PHENYLEPHRINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; PROSTAGLANDIN SYNTHASE INHIBITOR; UNSPECIFIC MONOOXYGENASE; PEPTIDE;

ANIMAL TISSUE; AORTA; ARACHIDONIC ACID METABOLISM; ARTERY DILATATION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTRIC POTENTIAL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE RELAXATION; VASCULAR ENDOTHELIUM; ANIMAL; BIOSYNTHESIS; COMPARATIVE STUDY; DRUG EFFECT; IN VITRO STUDY; PHYSIOLOGY; VASCULAR SMOOTH MUSCLE; VASODILATATION; WISTAR RAT;

4-AMINOPYRIDINE; ACETYLCHOLINE; ANIMALS; CYCLIC GMP; GLYBURIDE; MALE; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; PEPTIDES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; RATS; RATS, WISTAR; VASODILATION;

EID: 0030615191     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(96)00238-8     Document Type: Article

References (22)

1. Chen G. and Suzuki H. (1989) Some electrical properties of the endothelium-dependent hyperpolarization recorded from rat arterial smooth muscle cells. J. Physiol. 410, 91-106.
2. Chen G., Suzuki H. and Weston A. H. (1988) Acetylcholine releases endothelium-derived hyperpolarizing factor and EDRF from rat blood vessels. Br. J. Pharmac. 95, 1165-1174.
3. Escalante B., Sessa W. C., Falck J. R., Yadagiri P. and Laniado Schwartzman M. (1989) Vasoactivity of 20-hydroxyeicosatetraenoic acid is dependent on metabolism of cyclooxygenase. J. Pharmac. Exp. Ther. 248, 229-232.
4. Furchgott R. F. and Zawadzki J. V. (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288, 373-376.
5. Galvez A., Gimenez-Gallego G., Reuben J. P., Contancin L., Fiedenbaum P., Kaczorowski G. J. and Garcia M. L. (1990) Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Bathus tamulus. J. Biol. Chem. 265, 11083-11090.
6. Garland C. J. and McPherson G. A. (1992) Evidence that nitric oxide does not mediate the hyperpolarization and relaxation to acetylcholine in the rat small mesenteric artery. Br. J. Pharmacol. 105, 429-435.
7. Hwa J. J., Ghibaudi L., Williams P. and Chatterjee M. (1994) Comparison of acetylcholine-dependent relaxation in large and small arteries of rat mesenteric vascular bed. Am. J. Physiol. 266(Heart Circ. Physiol. 35), H952-H958.
8. Ignarro L. J., Buga G. M., Wood K. S., Byrns R. E. and Chaudhuri G. (1987) Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. USA 84, 9265-9269.
9. Ignarro L. J. and Kadowitz P. J. (1985) The pharmacological and physiological role of cyclic GMP in vascular smooth muscle relaxation. Annu. Rev. Pharmac. Toxicol. 25, 171-191.
10. Hildebrandt A. G. (1972) The binding of metyrapone to cytochrome P-450 and its inhibitory actions on microsomal hepatic mixed function oxidation reactions. Biochem. Soc. Symp. 34, 79-102.
11. w-Nitro-L-arginine: A potent inhibitor of endothetium-derived relaxing factor formation. Eur. J. Pharmac. 176, 219-223.
12. Komori K., Lorenz R. R. and Vanhoutte P. M. (1988) Nitric oxide, acetylcholine, and electrical and mechanical properties of canine arterial smooth muscle. Am. J. Physiol. 255, H207-H212.
13. Krippeit-Drews P., Morel N. and Godfraind T. (1991) Effect of the endothelium on the membrane potential of smooth muscles of rat aorta. Pflüger's Arch. 419, R128.
14. Palmer R. M. J., Ferrige, A. G. and Moncada S. (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327, 524-526.
15. Pinto A., Abraham N. G. and Mullane K. M. (1986) Cytochrome P-450-dependent monooxygenase activity and endothelial-dependent relaxations induced by arachidonic acid. J. Pharmac. Exp. Ther. 236, 445-451.
16. Rapoport R. M. and Murad F. (1983) Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cyclic GMP. Circ. Res. 52, 352-357.
17. + currents in smooth muscle cells from cerebral arteries. Am. J. Physiol. 267(Cell Physiol., 36), C1589-C1597.
18. Singer H., Saye J. A. and Peach M. (1984) Effects of cytochrome P-450 inhibitors on endothelium-dependent relaxation in rabbit aorta. Blood Vessels 21, 223-230.
19. - secretion across canine tracheal epithelium through cyclo-oxygenase stimulation and cAMP production. Acta Physiol. Scand. 145, 1-6.
20. Tare M., Parkington H. C., Coleman H. A., Neild T. O. and Dusting G. J. (1990) Hyperpolarization and relaxation of arterial smooth muscle caused by nitric oxide derived from the endothelium. Nature 346, 69-71.
21. Taylor S. G. and Weston A. H. (1988) Endothelium-derived hyperpolarizing factor: an endogenous inhibitor released from the vascular endothelium. Trends Pharmacol. Sci. 9, 272-274.
22. Vanheel B., Van de Voorde J. and Leusen I. (1994) Contribution of nitric oxide to the endothelium-dependent hyperpolarization in rat aorta. J. Physiol. 475, 277-284.