Radiosensitivity is predicted by DNA end-binding complex density, but not by nuclear levels of band components

Radiotherapy and Oncology

Volumn 72, Issue 3, 2004, Pages 325-332

  Ismail, Sheikh M ^a   Buchholz, Thomas A ^a   Story, Michael ^a   Brock, William A ^a   Stevens, Craig W ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Ataxia telangiectasia mutated protein; BRCA1; Prediction; Radiation

Indexed keywords

ANTIBODY; ATM PROTEIN; BRCA1 PROTEIN; BRCA2 PROTEIN; DEOXYRIBONUCLEOPROTEIN; ISOPROTEIN; KU ANTIGEN; NUCLEAR PROTEIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN P53; RAD51 PROTEIN; WERNER SYNDROME PROTEIN;

CONFERENCE PAPER; DNA BINDING; DNA DETERMINATION; DNA HYBRIDIZATION; DNA REPAIR; DNA SEQUENCE; FIBROBLAST; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DNA BINDING; RADIOSENSITIVITY;

BLOTTING, WESTERN; BRCA1 PROTEIN; BRCA2 PROTEIN; CELL LINE, TUMOR; DNA REPAIR; DNA-BINDING PROTEINS; HETEROZYGOTE; HUMANS; NUCLEAR PROTEINS; RADIATION TOLERANCE;

EID: 4644267082     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2004.07.003     Document Type: Conference Paper

References (36)

1. L. Peters, and M. McKay Predictive assays: will they ever have a role in the clinic? Int J Radiat Oncol Biol Phys 49 2001 501 504
2. R.I. Mackay, and J.H. Hendry The modeled benefits of individualizing radiotherapy patients' dose using cellular radiosensitivity assays with inherent variability Radiother Oncol 50 1999 67 75
3. J. Thacker The nature of mutants induced by ionising radiation in cultured hamster cells Mutat Res 160 1986 267 275
4. B.A. Marder, and W.F. Morgan Delayed chromosomal instability by DNA damage Mol Cell Biol 13 1993 6667 6677
5. L.H. Hartwell, and M.B. Kasten Cell cycle control and cancer Science 266 1994 182 188
6. P. Karan DNA double strand break repair in mammalian cells Curr Opin Genet Dev 10 2000 144 150
7. S.A. Nick-McElhinny, C.M. Snowden, and J. McCarville Ku recruits the XRCC4-ligase IV complex to DNA ends Mol Cell Biol 20 2000 2903 2996
8. S.M. Ismail, M. Puppi, and S. Prithivirajsingh Predicting radiosensitivity using DNA end-binding complex analysis Clin Cancer Res 10 2004 1226 1234
9. S.M. Ismail, S. Prithivirajsingh, Y. Nimura, and C.W. Stevens Identification of proteins in the hamster DNA end-binding complex Int J Radiat Biol 80 2004 261 268
10. L.C. Gowen, A.V. Avrutskaya, and A.M. Latour BRCA1 required for transcription-coupled repair of oxidative DNA damage Science 281 1998 1009 1012
11. Q. Zhong, C.F. Chen, and S. Li Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response Science 285 1999 747 750
12. S.K. Sharan, M. Morimatsu, and U. Albrecht Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 Nature (Lond) 386 1997 804 810
13. A.A. Davies, J.Y. Masson, and M.J. McIlwraith Role of BRCA2 in control of the RAD51 recombination and DNA repair protein Mol Cell 7 2001 273 282
14. T.A. Buchholz, X. Wu, and A. Hussain Evidence of haplotype insufficiency in human cells containing a germline mutation in BRCA1 or BRCA2 Int J Cancer 97 2002 557 561
15. R. Scully, J. Chen, and A. Plug Association of BRCA1 with Rad51 in mitotic and meiotic cells Cell 88 1997 265 275
16. J. Chen, D.P. Silver, and D. Walpita Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells Mol Cell 2 1998 317 328
17. T.T. Paull, E.P. Rogakou, and V. Yamazaki A critical role for histone HA2X in recruitment of repair factories to nuclear foci after DNA damage Curr Biol 10 2000 886 895
18. K. Yamane, E. Katayama, and T. Tsuruo The BRCT regions of tumor suppressor BRCA1 and of XRCC1 show DNA end binding activity with multimerizing feature Biochem Biophys Res Commun 279 2000 678 684
19. D. Cortez, Y. Wang, J. Qin, and S.J. Elledge Requirement of ATM-dependent phophorylation of BRCA1 in the DNA damage response to double-strand breaks Science 286 1999 1162 1166
20. D. Blocher, D. Sigut, and M.A. Hannan Fibroblasts for ataxia telangiectasia (AT) and AT heterozygotes show an enhanced level of residual DNA double-strand breaks after low dose-rate γ-irradiation as assayed by pulsed field gel electrophoresis Int J Radiat Biol 60 1991 791 802
21. R. Baskaran, L.D. Wood, and L.L. Whitaker Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation Nature (Lond) 387 1997 516 519
22. Y. Wang, D. Cortez, and P. Yazdi BASC, a super complex of BRCA1-associated protein involved in the recognition and repair of aberrant DNA structures Genes Dev 14 2000 927 939
23. J.D. Dignam, R.M. Lebovitz, and R.G. Roeder Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei Nucleic Acids Res 11 1983 1475 1489
24. C.W. Stevens, T.D. Stamato, and S.K. Mauldin Radiation induced recombination is Ku-80 dependent Radiat Res 252 1999 25 30
25. G.R. Weller, B. Kysela, and R. Roy Identification of a DNA nonhomologous end-joining complex in bacteria Science 297 2002 1686 1689
26. I.S. Ayene, T.D. Stamato, and S.K. Mauldin Mutation in the glucose-6-phosphate dehydrogenase gene leads to inactivation of Ku DNA end binding during oxidative stress J Biol Chem 277 2002 9929 9935
27. J. Sambrook, E.F. Fritsch, and T. Maniatis Molecular cloning: a laboratory manual 1989 Cold Spring Harbor Laboratory Press Cold Spring Harbor, NY
28. D.W. Chan, S.C. Son, and W. Block Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinase J Biol Chem 275 2000 7803 7810
29. H. Wang, J. Guan, and H. Wang Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase Cancer Res 6 2001 8554 8563
30. H. Beamish, P. Kedar, and H. Kaneko Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM J Biol Chem 277 2002 30515 30523
31. S. Banin, L. Moyal, and S. Shieh Enhanced phosphorylation of p53 by ATM in response to DNA damage Science 281 1998 1674 1677
32. K.K. Khanna, K.E. Keating, and S. Kozlov ATM associates with and phosphorylates p53: mapping the region of interaction Nat Genet 20 1998 398 400
33. G. Chen, S.S. Yuan, and W. Liu Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl J Biol Chem 274 1999 12748 12752
34. S.T. Kim, D.S. Lim, and C.E. Canman Substrate specificities and identification of putative substrates of ATM kinase family members J Biol Chem 274 1999 37538 37543
35. K.D. Brown, T.A. Lataxes, and S. Shangary Ionizing radiation exposure results in up-regulation of Ku70 via a p53/ataxia-telangiectasia-mutated protein-dependent mechanism J Biol Chem 275 2000 6651 6656
36. W.S. Dynan, and S. Yoo Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids Nucleic Acids Res 26 1998 1551 1559