Nuclear export of OLIG2 in neural stem cells is essential for ciliary neurotrophic factor-induced astrocyte differentiation

Journal of Cell Biology

Volumn 166, Issue 7, 2004, Pages 963-968

  Setoguchi, Takao ^a,b   Kondo, Toru ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

AKT; Astrocyte differentiation; CRM1; Nuclear export; OLIG2

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CILIARY NEUROTROPHIC FACTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; HELIX LOOP HELIX PROTEIN; HOE 33342; LEPTOMYCIN B; NEUROFILAMENT PROTEIN; OLIGODENDROCYTE TRANSCRIPTION FACTOR 2; PROTEIN KINASE B; STAGE SPECIFIC EMBRYO ANTIGEN 1; STAT3 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL PROLIFERATION; CELL STRAIN COS7; CONTROLLED STUDY; GENETIC TRANSFECTION; IMMUNOCHEMISTRY; MOTONEURON; MOUSE; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NONHUMAN; NUCLEOCYTOPLASMIC TRANSPORT; OLIGODENDROGLIA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STEM CELL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CELL NUCLEUS; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; CILIARY NEUROTROPHIC FACTOR; CYTOPLASM; KARYOPHERINS; MICE; NERVE TISSUE PROTEINS; NEURONS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STEM CELLS;

ANIMALIA; LAMB;

EID: 4644244652     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200404104     Document Type: Article

References (28)

1. Alonzi, T., G. Middleton, S. Wyatt, V. Buchman, U.A. Betz, W. Muller, P. Musiani, V. Poli, and A.M. Davies. 2001. Role of STAT3 and PI 3-kinase/Akt in mediating the survival actions of cytokines on sensory neurons. Mol. Cell. Neurosci. 18:270-282.
2. Bonni, A., Y. Sun, M. Nadal-Vicens, A. Bhatt, D.A. Frank, I. Rozovsky, N. Stahl, G.D. Yancopouios, and M.E. Greenberg. 1997. Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science. 278:477-483.
3. Cao, Q., R.L. Benton, and S.R. Whittemore. 2002. Stem cell repair of central nervous system injury. J. Neurosci. Res. 68:501-510.
4. D'Alessandro, J.S., J. Yetz-Aldape, and E.A. Wang. 1994. Bone morphogenetic proteins induce differentiation in astrocyte lineage cells. Growth Factors. 11:53-69.
5. Fornerod, M., M. Ohno, M. Yoshida, and I.W. Mattaj. 1997. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell. 90:1051-1060.
6. Fukuda, S., T. Kondo, H. Takebayashi, and T. Taga. 2004. Negative regulatory effect of an oligodendrocytic bHLH factor OLIG2 on the astrocytic differentiation pathway. Cell Death Differ. 11:196-202.
7. Gabay, L, S. Lowell, L.L. Rubin, and D.J. Anderson. 2003. Deregulation of dorsoventral patterning by FGF confers trilineage differentiation capacity on CNS stem cells in vitro. Neuron. 40:485-499.
8. Ghosh-Choudhury, N., S.L. Abboud, R. Nishimura, A. Celeste, L. Mahimainathan, and G.G. Choudhury. 2002. Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription. J. Biol. Chem. 277:33361-33368.
9. Gross, R.E., M.F. Mehler, P.C. Mabie, Z. Zang, L. Santschi, and J.A. Kessler. 1996. Bone morphogenetic proteins promote astroglial lineage commitment by mammalian subventricular zone progenitor cells. Neuron. 17:595-606.
10. Hack, M.A., M. Sugimori, C. Lundberg, M. Nakafuku, and M. Gotz. 2004. Regionalization and fate specification in neurospheres: the tole of Olig2 and Pax6. Mol. Cell. Neurosci. 25:664-678.
11. Hallbergson, A.F., C. Gnatenco, and D.A. Peterson. 2003. Neurogenesis and brain injury: managing a renewable resource for repair. J. Clin. Invest. 112:1128-1133.
12. Hermanson, O., K. Jepsen, and M.G. Rosenfeld. 2002. N-CoR controls differentiation of neural stem cells into astrocytes. Nature. 419:934-939.
13. Hunter, T. 2000. Signaling-2000 and beyond. Cell. 100:113-127.
14. Lei, E.P., and P.A. Silver. 2002. Protein and RNA export from the nucleus. Dev. Cell. 2:261-272.
15. Lu, Q.R., D. Yuk, J.A. Alberta, Z. Zhu, I. Pawlitzky, J. Chan, A.P. McMahon, C.D. Stiles, and D.H. Rowitch. 2000. Sonic hedgehog-regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron. 25:317-329.
16. Lu, Q.R., T. Sun, Z. Zhu, N. Ma, M. Garcia, C.D. Stiles, and D.H. Rowitch. 2002. Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell. 109:75-86.
17. Nakashima, K., M. Yanagisawa, H. Arakawa, N. Kimura, T. Hisatsune, M. Kawabata, K. Miyazono, and T. Taga. 1999. Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. Science. 284:479-482.
18. Nunes, M.C., N.S. Roy, H.M. Keyoung, R.R. Goodman, G. McKhann II, L. Jiang, J. Kang, M. Nedergaard, and S.A. Goldman. 2003. Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain. Nat. Med. 9:439-447.
19. Okano, H. 2002. The stem cell biology of the central nervous system. J. Neurosci. Res. 69:698-707.
20. Rajan, P., D.M. Panchision, L.F. Newell, and R.D. McKay. 2003. BMPs signal alternately through a SMAD or FRAP-STAT pathway to regulate fate choice in CNS stem cells. J. Cell Biol. 161:911-921.
21. Schlessinger, J. 2000. Cell signaling by receptor tyrosine kinases. Cell. 103:211-225.
22. Takebayashi, H., S. Yoshida, M. Sugimori, H. Kosako, R. Kominami, M. Nakafuku, and Y. Nabeshima. 2000. Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3. Mech. Dev. 99:143-148.
23. Takebayashi, H., Y. Nabeshima, S. Yoshida, O. Chisaka, K. Ikenaka, and Y. Nabeshima. 2002. The basic helix-loop-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages. Curr. Biol. 12:1157-1163.
24. Vandromme, M., C. Gauthier-Rouviere, N. Lamb, and A. Fernandez. 1996. Regulation of transcription factor localization: fine-tuning of gene expression. Trends Biochem. Sci. 21:59-64.
25. Yoshida, M., and S. Horinouchi. 1999. Trichostatin and leptomycin. Inhibition of histone deacetylation and signal-dependent nuclear export. Ann. NY Acad. Sci. 886:23-36.
26. Zhou, Q., and D.J. Anderson. 2002. The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. Cell 109:61-73.
27. Zhou, Q., S. Wang, and D.J. Anderson. 2000. Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron. 25:331-343.
28. Zhou, Q., G. Choi, and D.J. Anderson. 2001. The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2. Neuron. 31:791-807.