Estradiol protects PC12 cells against CoCl2-induced apoptosis

Brain Research Bulletin

Volumn 76, Issue 6, 2008, Pages 579-585

  Jung, Ji Yeon ^a   Roh, Kwang Hoon ^a   Jeong, Yeon Jin ^a   Kim, Sun Hun ^a   Lee, Eun Ju ^a   Kim, Min Seok ^a   Oh, Won Mann ^a   Oh, Hee Kyun ^a   Kim, Won Jae ^a  

^a Chonnam National University   (South Korea)

Author keywords

Akt; Apoptosis; Bcl 2 family; Caspase; CoCl2; Death receptor; Estradiol; Mitochondria

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; COBALT CHLORIDE; CYTOCHROME C; DEATH RECEPTOR; ESTRADIOL; FAS LIGAND; GENOMIC DNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CELL STRAIN; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DNA FRAGMENTATION; DOWN REGULATION; ENZYME ACTIVITY; IN VITRO STUDY; MITOCHONDRION; NEUROPROTECTION; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CASPASE 3; CASPASE 8; CASPASE 9; COBALT; CYTOCHROMES C; DNA FRAGMENTATION; ELECTROPHORESIS, AGAR GEL; ENZYME ACTIVATION; ESTRADIOL; ESTROGENS; FAS LIGAND PROTEIN; MITOCHONDRIA; PC12 CELLS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 46349099581     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2008.04.006     Document Type: Article

References (37)

1. Adams J.M., and Cory S. The Bcl-2 protein family: arbiters of cell survival. Science 281 (1998) 1322-1326
2. Behl C., Skutella T., Lezoualch F., Post A., Widmann M., Newton C.J., and Holsboer F. Neuroprotection against oxidative stress by estrogens: structure-activity relationship. Mol. Pharmacol. 51 (1997) 535-541
3. Cao Y.J., Shibata T., and Rainov N.G. Hypoxia-inducible transgene expression in differentiated human NT2N neurons-a cell culture model for gene therapy of postischemic neuronal loss. Gene Ther. 8 (2001) 1357-1362
4. Chae H.S., Bach J.H., Lee M.W., Kim H.S., Kim Y.S., Kim K.Y., Choo K.Y., Choi S.H., Park C.H., Lee S.H., Suh Y.H., Kim S.S., and Lee W.B. Estrogen attenuates cell death induced by carboxy-terminal fragment of amyloid precursor protein in PC12 through a receptor-dependent pathway. J. Neurosci. Res. 65 (2001) 403-407
5. Chandel N.S., Maltepe E., Goldwasser E., Mathieu C.E., Simon M.C., and Schumacker P.T. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 11715-11720
6. Cimarosti H., Zamin L., Frozza R., Nassif M., Horn A., Tavares A., Netto C., and Salbego C. Estradiol protects against oxygen and glucose deprivation in rat hippocampal organotypic cultures and activates Akt and inactivates GSK-3β. Neurochem. Res. 30 (2005) 191-199
7. Crowder R.J., and Freeman R.S. Phosphatidylinositol-3-kinase and AKT protein kinase are necessary and sufficient for the survival of nerve growth factor sympathetic neurons. J. Neurosci. 18 (1998) 2933-2943
8. Dubal D.B., Shughrue P.J., Wilson M.E., Merchenthaler I., and Wise P.M. Estradiol modulates bcl-2 in cerebral ischemia: a potential role for estrogen receptors. J. Neurosci. 19 (1999) 6385-6393
9. Garcia-Segura L.M., Azcoitia I., and DonCarlos L.L. Neuroprotection by estradiol. Prog. Neurobiol. 63 (2001) 29-60
10. Gollapudi L., Oblinger M.M., and Estrogen. NGF synergistically protect terminally differentiated, ER alpha-transfected PC12 cells from apoptosis. J. Neurosci. Res. 56 (1999) 471-481
11. Green P.S., Bishop J., and Simpkins J.W. 17α-Estradiol exerts neuroprotective effects on SK-N-SH cells. J. Neurosci. Res. 17 (1997) 511-515
12. Green P.S., Gridley K.E., and Simpkins J.W. Estradiol protects against beta-amyloid (25-35) induced toxicity in SK-N-SH human neuroblastoma cells. Neurosci. Lett. 218 (1996) 165-168
13. Green P.S., and Simpkins J.W. Neuroprotective effects of estrogen: potential mechanisms of action. Int. J. Dev. Neurosci. 18 (2000) 347-358
14. 2 in rat neuronal PC12 cells. Nucleic Acids Res. 28 (2000) 2135-2140
15. Hosoda T., Nakajima H., and Honjo H. Estrogen protects neuronal cells from amyloid beta-induced apoptotic cell death. Neuroreport 12 (2001) 1965-1970
16. Huang Y., Ray S., Reed J.C., Ibrado A.M., Tang C., Nawabi A., and Bhalla K. Estrogen increases intracellular p26Bcl-2 to p21Bax ratios and inhibits taxol-induced apoptosis of human breast cancer MCF-7 cells. Breast Cancer Res. Treat. 42 (1997) 73-81
17. 2-induced apoptosis of rat PC12 cells. Neurosci. Lett. 371 (2004) 85-90
18. --ATPase activity, glucose transport, and glutamate transport induced by amyloid beta-peptide and iron. J. Neurosci. Res. 50 (1997) 522-530
19. 2 sensors in hypoxic regulation of tyrosine hydroxylase gene expression. Am. J. Physiol. 274 (1998) 167-174
20. Li H., Zhu H., Xu C.J., and Yuan J. Cleavage of BID by caspase-8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94 (1998) 491-501
21. Linford N.J., and Dorsa D.M. 17beta-Estradiol and the phytoestrogen genistein attenuate neuronal apoptosis induced by the endoplasmic reticulum calcium-ATPase inhibitor thapsigargin. Steroids 67 (2002) 1029-1040
22. Lipton P. Ischemic cell death in brain neurons. Physiol. Rev. 79 (1999) 1431-1568
23. Majewski N., Nogueira V., Bhaskar P., Coy P.E., Skeen J.E., Gottlob K., Chandel N.S., Thompson C.B., Robey R.B., and Hay N. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol. Cell 16 (2004) 819-830
24. Moosman B., and Behl C. The antioxidant neuroprotective effect of estrogens and phenolic compounds are independent from their estrogenic properties. Proc. Natl. Acad. Sci U.S.A. 96 (1996) 8867-8872
25. Moosmann B., and Behl C. The antioxident neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 8867-9972
26. Pike C.J. Estrogen modulates neuronal Bcl-xl expression and β-amyloid-induced apoptosis: relevance to Alzheimer's disease. J. Neurochem. 72 (1999) 1552-1563
27. Qin Z.H., Wang Y., Kikly K.K., Sapp E., Kegel K.B., Aroninn N., and DiFiglia M. Pro-caspase-8 is predominantly localized in mitochondria and released into cytoplasm upon apoptotic stimulation. J. Biol. Chem. 276 (2001) 8079-8086
28. Roth J.A., Feng L., Walowitz J., and Browne R.W. Manganese-induced rat pheochromocytoma (PC12) cell death is independent of caspase activation. J. Neurosci. Res. 61 (2000) 162-171
29. Shimizu S., Eguchi Y., Kamiike W., Matsuda H., and Tsujimoto Y. Bcl-2 expression prevents activation of the ICE protease cascade. Oncogene 12 (1996) 2251-2257
30. Singer C.A., Rogers K.L., and Dorsa D.M. Modulation of Bcl-2 expression: a potential component of estrogen protection in NT2 neurons. Neuroreport 9 (1998) 2565-2568
31. Tang M.X., Jacobs D., Stern Y., Marder K., Schofield P., Gurland B., Andrews H., and Mayeux R. Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet 348 (1996) 429-432
32. Teixeira C., Reed J.C., and Pratt M.A.C. Estrogen promotes hemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells. Cancer Res. 55 (1995) 3902-3907
33. Tsujimoto Y., and Shimizu S. Bcl-2: life-or-death switch. FEBS Lett. 466 (2000) 6-10
34. 2 in rat neuronal PC12 cells. Nucleic Acids Res. 28 (2000) 2135-2140
35. Wilson M., Liu Y., and Wise P.M. Estradiol enhances Akt activation in cortical explant cultures following neuronal injury. Mol. Brain Res. 102 (2002) 49-54
36. Yamaguchi H., and Wang H.G. The protein kinases PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change. Oncogene 20 (2001) 7779-7786
37. Zhang S., and Wang W. Altered expression of Bcl-2 mRNA and Bax in hippocampus with focal cerebral ischemia model in rats. Chin. Med. J. 12 (1999) 608-611