Prognostic significance of ataxia-telangiectasia mutated, DNA-dependent protein kinase catalytic subunit, and Ku heterodimeric regulatory complex 86-kD subunit expression in patients with nonsmall cell lung cancer

Cancer

Volumn 112, Issue 12, 2008, Pages 2756-2764

  Xing, Jinliang ^a   Wu, Xifeng ^a   Vaporciyan, Ara A ^a   Spitz, Margaret R ^a   Gu, Jian ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

DNA double strand break; DNA repair; Nonsmall cell lung cancer; Prognosis

Indexed keywords

ATM PROTEIN; DNA DEPENDENT PROTEIN KINASE; KU ANTIGEN; PROTEIN KU80; CELL CYCLE PROTEIN; CELL NUCLEUS ANTIGEN; DNA BINDING PROTEIN; MESSENGER RNA; PROTEIN SERINE THREONINE KINASE; TUMOR SUPPRESSOR PROTEIN;

ADULT; AGED; ARTICLE; CANCER PATIENT; CANCER SURVIVAL; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVE SITE; ENZYME SUBUNIT; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; KAPLAN MEIER METHOD; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; CHEMISTRY; GENETICS; LUNG TUMOR; METABOLISM; MIDDLE AGED; MUTATION; SURVIVAL RATE;

AGED; ANTIGENS, NUCLEAR; CARCINOMA, NON-SMALL-CELL LUNG; CATALYTIC DOMAIN; CELL CYCLE PROTEINS; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; MUTATION; PROGNOSIS; PROTEIN-SERINE-THREONINE KINASES; RNA, MESSENGER; SURVIVAL RATE; TUMOR SUPPRESSOR PROTEINS;

EID: 46049114741     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.23533     Document Type: Article

References (35)

1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin. 2007;57:43-66.
2. Niklinski J, Niklinska W, Laudanski J, Chyczewska E, Chyczewski L. Prognostic molecular markers in non-small cell lung cancer. Lung Cancer. 2001;34(suppl 2):S53-S58.
3. van Gent DC, Hoeijmakers JH, Kanaar R. Chromosomal stability and the DNA double-stranded break connection. Nat Rev Genet. 2001;2:196-206.
4. Khanna KK, Jackson SP. DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet. 2001;27:247-254.
5. Helleday T, Lo J, van Gent DC, Engelward BP. DNA double-strand break repair: from mechanistic understanding to cancer treatment. DNA Repair (Amst). 2007;6:923-935.
6. Lobrich M, Jeggo PA. The 2 edges of the ATM sword: co-operation between repair and checkpoint functions. Radiother Oncol. 2005;76:112-118.
7. Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer. 2003;3:155-168.
8. Ahmed M, Rahman N. ATM and breast cancer susceptibility. Oncogene. 2006;25:5906-5911.
9. Liberzon E, Avigad S, Yaniv I, et al. Molecular variants of the ATM gene in Hodgkin's disease in children. Br J Cancer. 2004;90:522-525.
10. Kim JH, Kim H, Lee KY, et al. Genetic polymorphisms of ataxia telangiectasia mutated affect lung cancer risk. Hum Mol Genet. 2006;15:1181-116.
11. Taylor AM, Metcalfe JA, Thick J, Mak YF. Leukemia and lymphoma in ataxia telangiectasia. Blood. 1996;87:423-438.
12. Grabsch H, Dattani M, Barker L, et al. Expression of DNA double-strand break repair proteins ATM and BRCA1 predicts survival in colorectal cancer. Clin Cancer Res. 2006;12:1494-1500.
13. Yu G, Zhu MH, Zhu Z, Ni CR, Zheng JM, Li FM. Expression of ATM protein and its relationship with p53 in pancreatic carcinoma with tissue array. Pancreas. 2004;28:421-426.
14. Ye C, Cai Q, Dai Q, et al. Expression patterns of the ATM gene in mammary tissues and their associations with breast cancer survival. Cancer. 2007;109:1729-1735.
15. Lieber MR, Ma Y, Pannicke U, Schwarz K. Mechanism and regulation of human non-homologous DNA end-joining. Nat Rev Mol Cell Biol. 2003;4:712-720.
16. Kurimasa A, Ouyang H, Dong LJ, et al. Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis. Proc Natl Acad Sci USA. 1999;96:1403-1408.
17. Gu Y, Jin S, Gao Y, Weaver DT, Alt FW. Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination. Proc Natl Acad Sci USA. 1997;94:8076-8081.
18. Gullo C, Au M, Feng G, Teoh G. The biology of Ku and its potential oncogenic role in cancer. Biochim Biophys Acta. 2006;1765:223-234.
19. Stronati L, Gensabella G, Lamberti C, et al. Expression and DNA binding activity of the Ku heterodimer in bladder carcinoma. Cancer. 2001;92:2484-2492.
20. Hosoi Y, Watanabe T, Nakagawa K, et al. Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer. Int J Oncol. 2004;25:461-468.
21. Lee SW, Cho KJ, Park JH, et al. Expressions of Ku70 and DNA-PKcs as prognostic indicators of local control in nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys. 2005;62:1451-1457.
22. Harima Y, Sawada S, Miyazaki Y, et al. Expression of Ku80 in cervical cancer correlates with response to radiotherapy and survival. Am J Clin Oncol. 2003;26:e80-e85.
23. Komuro Y, Watanabe T, Hosoi Y, et al. The expression pattern of Ku correlates with tumor radiosensitivity and disease free survival in patients with rectal carcinoma. Cancer. 2002;95:1199-1205.
24. Mountain CF. Revisions in the International System for Staging Lung Cancer. Chest. 1997;111:1710-1717.
25. Jiang Y, Liang ZD, Wu TT, Cao L, Zhang H, Xu XC. Ataxia-telangiectasia mutated expression is associated with tobacco smoke exposure in esophageal cancer tissues and benzo[a]pyrene diol epoxide in cell lines. Int J Cancer. 2007;120:91-95.
26. Angele S, Falconer A, Foster CS, Taniere P, Eeles RA, Hall J. ATM protein overexpression in prostate tumors: possible role in telomere maintenance. Am J Clin Pathol. 2004;121:231-236.
27. Waha A, Sturne C, Kessler A, et al. Expression of the ATM gene is significantly reduced in sporadic breast carcinomas. Int J Cancer. 1998;78:306-309.
28. Vandesompele J, De Preter K, Pattyn F, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002;3:research0034.1-0034.11.
29. Bjork-Eriksson T, West C, Nilsson A, et al. The immunohistochemical expression of DNA-PKCS and Ku (p70/p80) in head and neck cancers: relationships with radiosensitivity. Int J Radiat Oncol Biol Phys. 1999;45:1005-1010.
30. Chan DW, Gately DP, Urban S, et al. Lack of correlation between ATM protein expression and tumour cell radiosensitivity. Int J Radiat Biol. 1998;74:217-224.
31. Peng Y, Woods RG, Beamish H, et al. Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM. Cancer Res. 2005;65:1670-1677.
32. Safar AM, Spencer H 3rd, Su X, et al. Methylation profiling of archived non-small cell lung cancer: a promising prognostic system. Clin Cancer Res. 2005;11:4400-4405.
33. Bosken CH, Wei Q, Amos CI, Spitz MR. An analysis of DNA repair as a determinant of survival in patients with non-small-cell lung cancer. J Natl Cancer Inst. 2002;94:1091-1099.
34. Kaina B. DNA damage-triggered apoptosis: critical role of DNA repair, double-strand breaks, cell proliferation and signaling. Biochem Pharmacol. 2003;66:1547-1554.
35. Peretz S, Jensen R, Baserga R, Glazer PM. ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response. Proc Natl Acad Sci USA. 2001;98:1676-1681.