Expression and DNA binding activity of the Ku heterodimer in bladder carcinoma

Cancer

Volumn 92, Issue 9, 2001, Pages 2484-2492

  Stronati, Laura ^a   Gensabella, Giuseppe ^a   Lamberti, Claudia ^a   Barattini, Paola ^a   Frasca, Daniela ^a   Tanzarella, Caterina ^b   Giacobini, Stefano ^c   Toscano, Maria Gabriella ^c   Santacroce, Criselda ^c   Danesi, Donatella Tirindelli ^a  

^a ENEA C R CASACCIA   (Italy)

^b ROMA TRE UNIVERSITY   (Italy)

^c FATEBENEFRATELLI HOSPITAL   (Italy)

Author keywords

Bladder carcinoma; DNA binding activity; DNA double strand breaks (DSBs) repair; DNA dependent protein kinase (DNA PK); Ionizing radiation; Ku 70 80

Indexed keywords

KU ANTIGEN; PROTEIN SUBUNIT;

ADULT; AGED; ARTICLE; BLADDER CARCINOMA; CLINICAL ARTICLE; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME ACTIVITY; ENZYME REGULATION; FEMALE; GAMMA RADIATION; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; RADIATION EXPOSURE; TRANSITIONAL CELL CARCINOMA;

AGED; AGED, 80 AND OVER; ANTIGENS, NUCLEAR; BLOTTING, WESTERN; CARCINOMA, TRANSITIONAL CELL; DNA ADDUCTS; DNA HELICASES; DNA PROBES; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RADIATION INJURIES; TUMOR CELLS, CULTURED; URINARY BLADDER NEOPLASMS;

EID: 0035498628     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0142(20011101)92:9<2484::AID-CNCR1598>3.0.CO;2-7     Document Type: Article

References (39)

1. Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap
2. Characterization of the DNA-binding protein antigen recognized from patients with rheumatic disorders
3. Use of monoclonal antibodies for the characterization of the novel DNA-binding proteins recognized by human autoimmune sera
4. Interaction of DNA-dependent protein kinase with DNA and with Ku: Biochemical and atomic force microscopy study
5. Ku polypeptides synthetised in vitro assemble into complexes which recognize ends of double-stranded DNA
6. Ku, a DNA repair protein with multiple cellular functions?
7. Mammalian mutants defective in the response to ionizing radiation-induced damage
8. The DNA-activated protein kinase-DNA-PK
9. DNA-dependent protein kinase
10. DNA-PK: At the cross-roads of biochemistry and genetics
11. HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA multimeric protein complex
12. Analysis of the mechanism of interaction of simian Ku protein with DNA
13. The DNA-dependent protein kinase requirement for DNA ends and association with Ku antigen
14. Ku protein stimulates DNA end joining by mammalian DNA ligase: A direct role for Ku in repair of DNA dsb
15. Human DNA helicase II: A novel DNA unwinding enzyme identified as the Ku autoantigen
16. Functional properties of the separate subunits of human DNA helicase II Ku autoantigen
17. Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II
18. Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids
19. Ku70: A canditate tumor suppressor gene for murine T cell lymphoma
20. Requirement for Ku 80 in growth and immunoglobulin V(D)J recombination
21. Hypersensitivity of Ku80 deficient cell lines and mice to DNA damage: The effects of ionizing radiation on growth, survival and development
22. Gatekeepers and caretakers
23. DNA repair protein Ku80 suppresses chromosomal aberrations ad malignant transformation
24. Analysis of Ku80-mutant mice and cells with deficient levels of p53
25. Regulation of DNA-dependent protein kinase activity in leukemic cells
26. DNA-dependent protein kinase activity correlates with clinical and in vitro sensitivity of chronic lymphocytes to nitrogen mustards
27. The immunohistochemical expression of DNA-PKcs and Ku (p70/p80) in head and neck cancers: Relationships with radiosensitivity
28. DNAPK, the DNA-activated protein kinase, is differentially expressed in normal and malignant human tissues
29. Expression of genes involved in repair of DNA double-strand breaks in normal and tumor tissues
30. Tumor specific modulation of Ku70/80 DNA binding activity in breast and bladder human tumor biopsies
31. On the mechanisms of Ku protein binding to DNA
32. Binding of Ku protein to DNA
33. Cell proliferation and Ku protein expression in ageing humans
34. Double strand break repair
35. DNA end-joining: From yeast to man
36. Tying loose ends: Roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks
37. Menage a trois: Double strand break repair, V(D)J recombination and DNA-PK
38. What to do at an end: DNA double strand break repair