Beneficial effect of an inhibitor of leukocyte elastase (EPI-hNE-4) in presence of repeated lung injuries

Shock

Volumn 22, Issue 2, 2004, Pages 131-136

  Honoré, Stéphanie ^a,b   Attalah, Habiba L ^a   Azoulay, Elle ^a   Soussy, Claude James ^b   Saudubray, François ^c   Harf, Alain ^a,b   Brochard, Laurent ^a,b   Delclaux, Christophe ^a,b  

^a FACULTÉ DE MÉDECINE   (France)

^b HENRI MONDOR HOSPITAL   (France)

^c DEBIOPHARM SA   (Switzerland)

Author keywords

Bleomycin; Compliance; Endotoxin; Neutrophil; Pseudomonas aeruginosa

Indexed keywords

BLEOMYCIN; ELASTASE; ELASTASE INHIBITOR; ENDOTOXIN; ENGINEERED PROTEIN INHIBITOR OF HUMAN NEUTROPHIL ELASTASE 4; LEUKOCYTE ELASTASE INHIBITOR; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMICROBIAL ACTIVITY; ARTICLE; ARTIFICIAL VENTILATION; BACTERIAL PNEUMONIA; BACTERIUM CLEARANCE; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; GRAM NEGATIVE BACTERIUM; HOST RESISTANCE; INFLAMMATION; LEUKOCYTE ACTIVATION; LUNG ALVEOLUS CELL; LUNG CLEARANCE; LUNG COMPLIANCE; LUNG FIBROSIS; LUNG HOMOGENATE; LUNG INJURY; LUNG LAVAGE; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PSEUDOMONAS AERUGINOSA; RAT; RESPIRATORY SYSTEM; STATISTICAL SIGNIFICANCE;

ANIMALS; BLEOMYCIN; CELL MOVEMENT; CYTOKINES; ENDOTOXINS; FIBROSIS; LEUKOCYTE ELASTASE; LUNG; MALE; NEUTROPHILS; PNEUMONIA; PROTEINS; PSEUDOMONAS AERUGINOSA; PULMONARY ALVEOLI; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 13644262277     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.shk.0000126861.77543.d0     Document Type: Article

References (32)

1. Lee WL, Downey GP: Leukocyte elastase: physiological functions and role in acute lung injury. Am J Respir Crit Care Med 164:896-904, 2001.
2. Belaaouaj A, McCarthy R, Baumann M, Gao Z, Ley TJ, Abraham SN, Shapiro SD: Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. Nat Med 4:615-618, 1998.
3. Tkalcevic J, Novelli M, Phylactides M, Iredale JP, Segal AW, Roes J: Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G. Immunity 12:201-210, 2000.
4. Nagai A, Aoshiba K, Ishihara Y, Inano H, Sakamoto K, Yamaguchi E, Kagawa J, Takizawa T: Administration of α1-proteinase inhibitor ameliorates bleomycin-induced pulmonary fibrosis in hamsters. Am Rev Respir Dis 145:651-656, 1992.
5. Mitsuhashi H, Asano S, Nonaka T, Hamamura I, Masuda K, Kiyoki M: Administration of truncated secretory leukoprotease inhibitor ameliorates bleomycin-induced pulmonary fibrosis in hamsters. Am J Respir Crit Care Med 153:369-374, 1996.
6. Taooka Y, Maeda A, Hiyama K, Ishioka S, Yamakido M: Effects of neutrophil elastase inhibitor on bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med 156:260-265, 1997.
7. Steinberg KP, Milberg JA, Martin TR, Maunder RJ, Cockrill BA, Hudson LD: Evolution of bronchoalveolar cell populations in the adult respiratory distress syndrome. Am J Respir Crit Care Med 150:113-122, 1994.
8. Gaudry M, Bregerie O, Andrieu V, El Benna J, Pocidalo MA, Hakim J: Intracellular pool of vascular endothelial growth factor in human neutrophils. Blood 90:4153-4161, 1997.
9. Grenier A, Chollet-Martin S, Crestani B, Delarche C, El Benna J, Boutten A, Andrieu V, Durand G, Gougerot-Pocidalo MA, Aubier M, Dehoux M: Presence of a mobilizable intracellular pool of hepatocyte growth factor in human polymorphonuclear neutrophils. Blood 99:2997-3004, 2002.
10. Jones HA, Schofield JB, Krausz T, Boobis AR, Haslett C: Pulmonary fibrosis correlates with duration of tissue neutrophil activation. Am J Respir Crit Care Med 158:620-628, 1998.
11. Zhang H, Downey GP, Suter PM, Slutsky AS, Ranieri VM: Conventional mechanical ventilation is associated with bronchoalveolar lavage-induced activation of polymorphonuclear leukocytes: a possible mechanism to explain the systemic consequences of ventilator-induced lung injury in patients with ARDS. Anesthesiology 97:1426-1433, 2002.
12. Thrall RS, Swendsen CL, Shannon TH, Kennedy CA, Frederick DS, Grunze MF, Sulavik SB: Correlation of changes in pulmonary surfactant phospholipids with compliance in bleomycin-induced pulmonary fibrosis in the rat. Am Rev Respir Dis 136:113-118, 1987.
13. Azoulay E, Herigault S, Levame M, Brochard L, Schlemmer B, Harf A, Delclaux C: Effect of granulocyte colony-stimulating factor on bleomycin-induced acute lung injury and pulmonary fibrosis. Crit Care Med 31:1442-1448, 2003.
14. Amato MB, Barbas CS, Medeiros DM, Magaldi RB, Schettino GP, Lorenzi-Filho G, Kairalla RA, Deheinzelin D, Munoz C, Oliveira R. Takagaki TY, Carvalho CR: Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med 338:347-354, 1998.
15. Delclaux C, Roupie E, Blot F, Brochard L, Lemaire F, Brun-Buisson C: Lower respiratory tract colonization and infection during severe acute respiratory distress syndrome: incidence and diagnosis. Am J Respir Crit Care Med 156:1092-1098, 1997.
16. Delclaux C, Rezaiguia-Delclaux S, Delacourt C, Brun-Buisson C, Lafuma C, Harf A: Alveolar neutrophils in endotoxin-induced and bacteria-induced acute lung injury in rats. Am J Physiol 273:L104-L112, 1997.
17. Van de Louw A, Jean D, Frisdal E, Cerf C, d'Ortho MP, Baker AH, Lafuma C, Duvaldestin P, Harf A, Delclaux C: Neutrophil proteinases in hydrochloric acid- and endotoxin-induced acute lung injury: evaluation of interstitial protease activity by in situ zymography. Lab Invest 82:133-145, 2002.
18. Delacourt C, Herigault S, Delclaux C, Poncin A, Levame M, Harf A, Saudubray F, Lafuma C: Protection against acute lung injury by intravenous or intratracheal pretreatment'with EPI-HNE-4, a new potent neutrophil elastase inhibitor. Am J Respir Cell Mol Biol 26:290-297, 2002.
19. Jean D, Rezaiguia-Delclaux S, Delacourt C, Leclercq R, Lafuma C, Brun-Buisson C, Harf A, Delclaux C: Protective effect of endotoxin instillation on subsequent bacteria-induced acute lung injury in rats. Am J Respir Crit Care Med 158:1702-1708, 1998.
20. Rezaiguia S, Garat C, Delclaux C, Meignan M, Fleury J, Legrand P, Matthay MA, Jayr C: Acute bacterial pneumonia in rats increases alveolar epithelial fluid clearance by a tumor necrosis factor-α-dependent mechanism. J Clin Invest 99:325-335, 1997.
21. Mercer-Jones MA, Heinzelmann M, Peyton JC, Wickel D, Cook M, Cheadle WG: Inhibition of neutrophil migration at the site of infection increases remote organ neutrophil sequestration and injury. Shock 8:193-199, 1997.
22. Delclaux C, d'Ortho MP, Delacourt C, Lebargy F, Brun-Buisson C, Brochard L, Lemaire F, Lafuma C, Harf A: Gelatinases in epithelial lining fluid of patients with adult respiratory distress syndrome. Am J Physiol 272:L442-L451, 1997.
23. Bachofen M, Weibel ER: Alterations of the gas exchange apparatus in adult respiratory insufficiency associated with septicemm. Am Rev Respir Dis 116:589-615, 1977.
24. Clark JG, Kuhn C 3rd: Bleomycin-induced pulmonary fibrosis in hamsters: effect of neutrophil depletion on lung collagen synthesis. Am Rev Respir Dis 126:737-739, 1982.
25. Thrall RS, Phan SH, McCormick JR, Ward PA: The development of bleomycin-induced pulmonary fibrosis in neutrophil-depleted and complement-depleted rats. Am J Pathol 105:76-81, 1981.
26. Delclaux C, Delacourt C, d'Ortho MP, Boyer V, Lafuma C, Harf A: Role of gelatinase B and elastase in human polymorphonuclear neutrophil migration across basement membrane. Am J Respir Cell Mol Biol 14:288-295, 1996.
27. Adkison AM, Raptis SZ, Kelley DG, Pham CT: Dipeptidyl pepticlase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis. J Clin Invest 109:363-372, 2002.
28. Ishii K, Ito Y, Karagiri H, Matsumoto Y, Kakita A, Majima M: Neutrophil elastase inhibitor attenuates lipopolysaccharide-inducecl hepatic microvascular dysfunction in mice. Shock 18:163-168, 2002.
29. Wickel DJ, Mercer-Jones M, Peyton JC, Shrotri MS, Cheadle WG: Neutrophil migration into the peritoneum is P-selectin dependent, but sequestration in lungs is selectin independent during peritonitis. Shock 10:265-269, 1998.
30. Cantin AM, Woods DE: Aerosolized prolastin suppresses bacterial proliferation in a model of chronic Pseudomonas aeruginosa lung infection. Am J Respir Crit Care Med 160:1130-1135, 1999.
31. Simpson AJ, Wallace WA, Marsden ME, Govan JR, Porteous DJ, Haslett C, Sallenave JM: Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection. J Immunol 167:1778-1786, 2001.
32. Zeiher BG, Matsuoka S, Kawabata K, Repine JE: Neutrophil elastase and acute lung injury: prospects for sivelestat and other neutropr 1 elastase inhibitors as therapeutics. Crit Care Med 30:5281-5287, 2002.