Neutrophil emigration in the skin, lungs, and peritoneum: Different requirements for CD11/CD18 revealed by CD18-deficient mice

Journal of Experimental Medicine

Volumn 186, Issue 8, 1997, Pages 1357-1364

  Mizgerd, Joseph P ^a   Kubo, Hiroshi ^a   Kutkoski, Gregory J ^a   Bhagwan, Sabrina D ^a   Scharffetter Kochanek, Karin ^b   Beaudet, Arthur L ^b   Doerschuk, Claire M ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CD11 ANTIGEN; CD18 ANTIGEN; CROTON OIL; THIOGLYCOLIC ACID;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; DERMATITIS; FLOW CYTOMETRY; INFLAMMATION; LEUKOCYTOSIS; LUNG; MICROSCOPY; MORPHOMETRICS; MOUSE; NEUTROPHIL; NONHUMAN; PERITONEUM; PERITONITIS; PNEUMONIA; PRIORITY JOURNAL; SKIN; SPLENOMEGALY;

ANIMALS; ANTIGENS, CD11; ANTIGENS, CD18; CELL ADHESION MOLECULES; CELL MOVEMENT; DERMATITIS, IRRITANT; EDEMA; LEUKOCYTE-ADHESION DEFICIENCY SYNDROME; LEUKOCYTOSIS; LUNG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHILS; PERITONEUM; PERITONITIS; PNEUMONIA, BACTERIAL; PULMONARY EDEMA; SKIN; SPLENOMEGALY;

EID: 0030731918     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.186.8.1357     Document Type: Article

References (34)

1. Carlos, T.M., and J.M. Harlan. 1994. Leukocyte-endothelial adhesion molecules. Blood. 84:2068-2101.
2. Arfors, K., C. Lundberg, L. Lindbom, K. Lundberg, P.G. Beatty, and J.M. Harlan. 1987. A monoclonal antibody to the membrane glycoprotein complex CD18 inhibits polymorphonuclear leukocyte accumulation and plasma leakage in vivo. Blood. 69:338-340.
3. Doerschuk, C.M., R.K. Winn, H.O. Coxson, and J.M. Harlan. 1990. CD18-dependent and -independent mechanisms of neutrophil adherence in the pulmonary and systemic microvasculature of rabbits. J. Immunol. 114:2327-2333.
4. Bowen, T.J., H.D. Ochs, L.C. Altman, T.H. Price, D.E. Van Epps, D.L. Brautigan, R.E. Rosin, W.D. Perkins, B.M. Babior, S.J. Klebanoff, and R.J. Wedgwood. 1982. Severe recurrent bacterial infections associated with detective adherence and chemotaxis in two patients with neutrophils deficient in a cell-associated glycoprotein. J. Pediatr. 101:932-940.
5. Anderson, D.G., F.C. Schmalsteig, M.J. Finegold, B.J. Hughes, R. Rothlein, L.J. Miller, S. Kohl, M.F. Tosi, R.L. Jacobs, T.C. Waldrop, et al. 1985. The severe and moderate pheno-types of heritable Mac-1, LFA-1 deficiency: their quantitative definition and relation to leukocyte dysfunction and clinical features. J. Infect. Dis. 152:668-689.
6. Buescher, E.S., T. Gaither, J. Nath, and J.I. Gallin. 1985. Abnormal adherence-related functions of neutrophils, monocytes, and Epstein-Barr virus-transformed B cells in a patient with C3bi receptor deficiency. Blood. 65:1382-1390.
7. Weisman, S.J., R.L. Berkow, G. Plautz, M. Torres, W.A. McGuire, T.D. Coates, R.A. Haak, A. Floyd, R. Jersild, and R.L. Baehner. 1985. Glycoprotein-180 deficiency: genetics and abnormal neutrophil activation. Blood. 65:696-704.
8. Hawkins, H.K., S.C. Heffelfinger, and D.C. Anderson. 1992. Leukocyte adhesion deficiency: clinical and postmortem observations. Pediatr. Pathol. 12:119-130.
9. Mulligan, M.S., G.P. Wilson, R.F. Todd, C.W. Smith, O.C. Anderson, J. Varani, T.B. Issekutz, M. Miyasaka, T. Tamatani, M. Miyasaka, et al. 1993. Role of β1, β2 integrins, and ICAM-1 in lung injury after deposition of IgG and IgA immune complexes. J. Immunol. 150:2407-2417.
10. 2-integnn CD18 in the local accumulation of neutrophils in pulmonary and cutaneous inflammation in the rabbit. Am. J. Respir. Cell Mol. Biol. 10:391-398.
11. Kumasaka, T., N.A. Doyle, W.M. Quinlan, L. Graham, and C.M. Doerschuk. 1996. Role of CD11/CD18 in neutrophil emigration during acute and recurrent Pseudomonas aerugi nosa-induced pneumonia in rabbits. Am. J. Pathol. 148:1297-1305.
12. Quin, L., W.M. Quinlan, N.A. Doyle, L. Graham, J.E. Sligh, F. Takei, A.L. Beaudet, and C.M. Doerschuk. 1996. The roles of CD11/CD18 and ICAM-1 in acute Pseudomonas aeruginosa-induced pneumonia in mice. J. Immunol. 157: 5016-5021.
13. Wilson, R.W., C.M. Ballantyne, C.W. Smith, C. Montgomery, A. Bradley, W.E. O'Brien, and A.L. Beaudet. 1993. Gene targeting yields a CD18-mutant mouse for study of inflammation. J. Immunol. 151:1571-1578.
14. Sligh, J.E., Jr., C.M. Ballantyne, S.S. Rich, H.K. Hawkins, C.W. Smith, A. Bradley, and A.L. Beaudet. 1993. Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proc. Nat. Acad. Sci. USA. 90:8529-8533.
15. Bullard, D.C., L. Qin, I. Lorenzo, W.M. Quinlin, N.A. Doyle, R. Bosse, D. Vestweber, C.M. Doerschuk, and A.L. Beaudet. 1995. P-selectin/ICAM-1 double mutant mice: acute emigration of neutrophils into the peritoneum is completely absent but is normal into pulmonary alveoli. J. Clin. Invest. 95:1782-1788.
16. Bullard, D.C., E.J. Kunkel, H. Kubo, M.J. Hicks, I. Lorenzo, N.A. Doyle, C.M. Doerschuk, K. Ley, and A.L. Beaudet. 1996. Infections and deficiency of leukocyte rolling and recruitment in E-/P-selectin mutant mice. J. Exp. Med. 183: 2329-2336.
17. Scharffetter-Kochanek, K., K. Norman, D.C. Bullard, I. Lorenzo, N.P. van Nood, S. Rich, W. Smith, and A.L. Beaudet. 1996. Generation and characterization of a CD18 complete knock-out mouse - new insights in the function of the CD18 molecule? J. Investig. Dermatol. 106:809.
18. Weibel, E.R. 1990. Morphometry: stereological theory and practical methods. In Models of Lung Disease: microscopy and Structural Methods, Volume 47. J. Gil, editor. Marcel Dekker, Inc., New York. 199-252.
19. Mizgerd, J.P., B.B. Meek, G.J. Kutkoski, D.C. Bullard, A.L. Beaudet, and C.M. Doerschuk. 1996. Selectins and neutrophil traffic: margination and Streptococcus pneumoniae-induced emigration in murine lungs. J. Exp. Med. 184:639-645.
20. Conlan, J.W., and R.J. North. 1994. Listeria monocytogenes, but not Salmonella typhimurium, elicits a CD18-independent mechanism of neutrophil extravasation into the murine peritoneal cavity. Infect. Immunol. 62:2702-2706.
21. Schmits, R., T.M. Kundig, D.M. Baker, G. Shumaker, J.J.L. Simard, G. Duncan, A. Wakeham, A. Shahinian, A. van der Heiden, M.F. Bachmann, et al. 1996. LFA-1-deficient mice show normal CTL responses to virus, but fail to reject immunogenic tumor. J. Exp. Med. 183:1415-1426.
22. Coxon, A., P. Rieu, F.J. Barkalow, S. Askari, A.H. Sharpe, U.H. von Andrian, M.A. Arnaout, and T.N. Mayadas. 1996. A novel role for the β2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity. 5:653-666.
23. Lu, H., C.W. Smith, J. Perrard, D. Bullard, L. Tang, S.B. Shappell, M.L. Entman, A.L. Beaudet, and C.M. Ballantyne. 1997. LFA-1 is sufficient in mediating neutrophil emigration in Mac-1 deficient mice. J. Clin. Invest. 99:1340-1350.
24. Winn, R.K., and J.M. Harlan. 1993. CD18-independent neutrophil and mononuclear leukocyte emigration into the peritoneum of rabbits. J. Clin. Invest. 92:1168-1173.
25. Mileski, W., J. Harlan, C. Rice, and R. Winn. 1990. Streptococcus pneumoniae-stimulated macrophages induce neutrophils to emigrate by a CD18-independent mechanism of adherence. Circ. Shock 31:259-267.
26. Issekutz, T.B., M. Miyasaka, and A.C. Issekutz. 1996. Rat blood neutrophils express very late antigen 4 and it mediates migration to arthritic joint and dermal inflammation. J. Exp. Med. 183:2175-2184.
27. Andreoli, S.P., C. Mallett, K. Williams, J.A. McAteer, R. Rothlein, and C.M. Doerschuk. 1994. Mechanisms of polymorphonuclear leukocyte mediated peritoneal mesothelial cell injury. Kidney Int. 46:1100-1109.
28. Liberek, T., N. Topley, W. Luttman, and J.D. Williams. 1996. Adherence of neutrophils to human peritoneal me sothelial cells-role of intercellular adhesion molecule-1. J. Am. Soc. Nephrol. 7:208-217.
29. Nelson, S., W. Summer, G. Bagby, C. Nakamura, L. Stewart, G. Lipscomb, and J. Andresen. 1991. Granulocyte colony-stimulating factor enhances pulmonary host defenses in normal and ethanol-treated rats. J. Infect. Dis. 164:901-906.
30. Lister, P.D., M.J. Gentry, and L.C. Preheim. 1993. Granulocyte colony-stimulating factor protects control rats but not ethanol-fed rats from fatal pneumococcal pneumonia. J. Infect. Dis. 168:922-926.
31. Freeman, B.D., R. Correa, W. Karzai, C. Natanson, M. Patterson, S. Banks, Y. Fitz, R.L. Danner, L. Wilson, and P.Q. Eichacker. 1996. Controlled trials of rG-CSF and CD11b-directed MAb during hyperoxia and E. coli pneumonia in rats. J. Appl. Physiol. 80:2066-2076.
32. Serushago, B.A., Y. Yoshikai, T. Handa, M. Mitsuyama, K. Muramori, and K. Nomoto. 1992. Effect of recombinant human granulocyte colony-stimulating factor (rhG-CSF) on murine resistance against Listeria monocytogenes. Immunology. 75:475-480.
33. Lundblad, R., M.Y. Wang, G. Kvalheim, E. Lingaas, and K. Giercksky. 1995. Granulocyte colony-stimulating factor improves myelopoiesis and host defense in fulminant intra-abdominal sepsis in rats. Shock. 4:68-73.
34. Dunne, J.R., B.J. Dunkin, S. Nelson, and J.C. White. 1996. Effects of granulocyte colony stimulating factor in a non-neutropenic rodent model of Escherichia coli peritonitis. J. Surg. Res. 61:348-354.