Silencing of mouse hepatic lanosterol 14-α demethylase down-regulated plasma low-density lipoprotein cholesterol levels by short-term treatment of siRNA

Biological and Pharmaceutical Bulletin

Volumn 31, Issue 6, 2008, Pages 1182-1191

  Xu, Baoshan ^a   Wang, Chao ^a   Yang, Jie ^a   Mao, Guanping ^a   Zhang, Cheng ^a   Liu, Dan ^a   Tai, Ping ^a   Zhou, Bo ^a   Xia, Guoliang ^a   Zhang, Meijia ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

Cholesterol; Cytochrome P450 lanosterol 14 demethylase; Low density lipoprotein; Low density lipoprotein receptor; RNA interference

Indexed keywords

LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; PROTEIN CYP 1; REGULATOR PROTEIN; SIMVASTATIN; SMALL INTERFERING RNA; STEROL 14ALPHA DEMETHYLASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG MECHANISM; FATTY LIVER; FEMALE; GENE SILENCING; LIPID DIET; LIVER CELL; MOUSE; NONHUMAN; OVULATION; PROTEIN EXPRESSION; RNA INTERFERENCE; SINGLE DRUG DOSE; UPREGULATION;

ACTINS; ANIMALS; BLOTTING, WESTERN; BODY WEIGHT; CHOLESTEROL, DIETARY; CHOLESTEROL, LDL; CUMULUS CELLS; CYTOCHROME P-450 ENZYME SYSTEM; DIET; DOWN-REGULATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FATTY LIVER; FEMALE; GENE SILENCING; LIVER; MICE; OVULATION; OXIDOREDUCTASES; RECEPTORS, LDL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSCRIPTION, GENETIC;

EID: 45749153807     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.31.1182     Document Type: Article

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