Differential gene expression analysis of a known hepatotoxin, N-acetyl-p-amino-phenol (APAP) as compared to its non-toxic analog, N-acetyl-m-amino-phenol (AMAP) in mouse liver

Journal of Toxicological Sciences

Volumn 33, Issue 2, 2008, Pages 163-173

  Priyadarsiny, Priyanka ^a   Khattar, Sunil K ^a   Malik, Renu ^a   Udupa, Venkatesha ^a   Seshaiah, Arigila ^a   Rahman, Shamsur ^a   Shingatgeri, Vyas Madhavrao ^a   Bora, Roop Singh ^a   Saini, Kulvinder Singh ^a  

^a RANBAXY RESEARCH LABORATORIES   (India)

Author keywords

Acetaminophen; Apoptosis; Drug toxicity; Liver injury; Toxicogenomics

Indexed keywords

PARACETAMOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR STRESS RESPONSE; CELLULAR STRESS SIGNAL; DOWN REGULATION; DRUG INDUCED DISEASE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; HISTOPATHOLOGY; LIVER TOXICITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; TOXICOGENETICS; UNINDEXED SEQUENCE; UPREGULATION;

MUS;

EID: 45749117148     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.33.163     Document Type: Article

References (24)

1. Bai, X.C., Deng, F., Liu, A.L., Zou, Z.P., Wang, Y., Ke, Z.Y., Ji, Q.S. and Luo, S.Q. (2002): Phospholipase C-gamma 1 is required for cell survival in oxidative stress by protein kinase C. Biochem. J., 363, 395-401.
2. Beyer, R.P., Fry, R.C., Lasarev, M.R., McConnachie, L.A., Meira, L.B., Palmer, V.S., Powell, C.L., Ross, P.K., Bammler, T.K., Bradford, B.U., Cranson, A.B., Cunningham,M.L.,Fannin, R.D.,Higgins, G.M., Hurban, P., Kayton, R.J., Kerr, K.F., Kosyk, O., Lobenhofer, E.K., Sieber, S.O., Vliet, P.A., Weis, B.K., Wolfinger, R., Woods, C.G., Freedman, J.H., Linney, E., Kaufmann, W.K., Kavanagh, T.J., Paules, R.S., Rusyn, I., Samson, L.D., Spencer, P.S., Suk, W., Tennant, R.J., Zarbl, H., and Members of the Toxicogenomics Research Consortium. (2007): Multi-center Study of Acetaminophen Hepatotoxicity Reveals the Importance of Biological Endpoints in Genomic Analyses. Toxicol. Sci., 99, 326-337
3. Chung, H., Kim, H.J., Jang, K.S., Kim, M., Yang, J., Kim, H.J., Lee, Y.S. and Kong, G. (2006): Comprehensive analysis of differential gene expression profiles on diclofenac-induced acute mouse liver injury and recovery. Toxicol. Lett., 166 , 77-87.
4. Gant, T.W., Baus, P.R., Clothier, B., Riley, J., Davies, R., Judah, D.J., Edwards, R.E., George, E., Greaves, P. and Smith, A.G. (2003): Gene expression profiles associated with inflammation, fibrosis and cholestasis in mouse liver after griseofulvin. EHP Toxicogenomics, 111, 37-43.
5. Hamadeh, H.K., Knight, B.L., Haugen, A.C., Sieber, S., Amin, R.P., Bushel, P.R., Stoll, R., Blanchard, K., Jayadev, S., Tennant, R.W., Cunningham, M.L., Afshari, C.A. and Paules, R.S. (2002): Methapyrilene toxicity: anchorage of pathologic observations to gene expression alterations. Toxicol. Pathol., 30, 470-482.
6. Hassan, H.E., Anwar, K., Macanas-Pirard, P., Crabtree, M., Chow, S.C., Johnson, V.L., Lee, P.C., Hinton, R.H., Price, S.C. and Kass, G.E.N. (2003): Involvement of mitochondria in acetaminophen-induced apoptosis and hepatic injury Roles of cytochrome c, Bax, Bid, and caspases. Toxicol. Appl. Pharmacol., 191, 118-129.
7. Heinloth, A.N., Irwin, R.D., Boorman, G.A., Nettesheim, P., Fannin, R.D., Sieber, S.O., Snell, M.L., Tucker, C.J., Li, L., Travlos, G.S., Vansant, G., Blackshear, P.E., Tennant, R.W., Cunningham, M.L. and Paules, R.S. (2004): Gene expression profiling of rat livers reveals indicators of potential adverse effects. Toxicol. Sci., 80, 193-202.
8. Hsiao, E.C., Koniaris, L.G., Zimmers-Koniaris, T., Sebald, S.M., Huynh, T.V. and Lee, S.J. (2000): Characterization of growth-differentiation factor 15, a transforming growth factor β super-family member induced following liver injury. Mol. Cell. Biol., 20, 3742-3751.
9. Huang, Q., Dunn, R.T., Jayadev, S., DiSorbo, O., Pack, F.D., Farr, S.B., Stoll, R.E. and Blanchard, K.T. (2001): Assessment of cisplatin-induced nephrotoxicity by microarray technology. Toxicol. Sci., 63, 196-207.
10. Huang, Q., Jin, X., Gaillard, E.T., Knight, B.L., Pack, F.D., Stoltz, J.H., Jayadev, S. and Blanchard, K.T. (2004): Gene expression profiling reveals multiple toxicity endpoints induced by hepatotoxicants. Mutat. Res., 549, 147-167.
11. Huby, R. and Tugwood, J.D. (2005): Gene expression profiling for pharmaceutical safety assessment. Expert. Opin. Drug Metab. Toxicol., 1, 247-260.
12. Lakkis, M.M., DeCristofaro, M.F., Ahr, H.J. and Mansfield, T.A. (2002): Application of toxicogenomics to drug development. Expert. Rev. Mol. Diagn., 2, 337-345.
13. Lipshutz, R.J., Fodor, S.P.A., Gingeras, T.R. and Lockhart, D.J. (1999): High density synthetic oligonucleotide arrays. Nature Genet., 21, 20-24.
14. Malik, R., Priyadarsiny, P., Shirumalla, R., Soni, R., Ray, A. and Saini, K.S. (2008): Gene expression profiling of Ovalbumin induced Lung inflammation in a murine model of asthma. J. Investig. Allergol. Clin. Immunol., 8 (2) In press.
15. Pastore, L., Belalcazar, L.M., Oka, K., Cela. R., Lee, B., Chan, L. and Beaudet, A.L. (2004): Helper-dependent adenoviral vector-mediated long-term expression of human apolipoprotein A-I reduces atherosclerosis in apo E-deficient mice. Gene, 327, 153-160.
16. Powell, C.L., Kosyk, O., Ross, P.K., Schoonhoven, R., Boysen, G., Swenberg, J.A., Heinloth, A.N., Boorman, G.A., Cunningham, M.L., Paules, R.S. and Rusyn, I. (2006): Phenotypic anchoring of acetaminophen-induced oxidative stress with gene expression profiles in rat liver. Toxicol. Sci., 93, 213-222.
17. Pradervand, S., Yasukawa, H., Muller, O.G., Kjekshus, H., Nakamura, T., St Amand, T.R., Yajima, T., Matsumura, K., Duplain, H., Iwate, M., Woodward, S.R., Pedrazzini, T., Ross. Jr., J., Firsov, D., Rossier, B.C., Hoshijima, M. and Chien, K.R. (2004): Small proline-rich protein 1A is a gp130 pathway- and stress- inducible cardioprotective protein. EMBO J., 23, 4517-4525.
18. S during apoptotic and necrotic death of mouse liver cells in vivo. Arch. Toxicol., 73, 594-606.
19. Reilly, T.P., Bourdi, M., Brady, J.N., Pise-Masison, C.A., Radonovich, M.F., George, J.W. and Pohl, L.R. (2001): Expression profiling of acetaminophen liver toxicity in mice using microarray technology. Biochem. Biophys. Res. Commun., 282, 321-328.
20. Ruepp, S.U., Tonge, R.P., Shaw, J., Wallis, N. and Pognan. F. (2002): Genomics and proteomics analysis of acetaminophen toxicity in mouse liver. Toxicol. Sci., 65, 135-150.
21. Russel, D.W. (1999): Nuclear orphan receptors control cholesterol catabolism. Cell, 97, 539-542.
22. Salminen, W.F., Voellmy, R. and Roberts, S.M. (1997): Differential heat shock protein induction by acetaminophen and a non-hepatotoxic regioisomer, 3′-hydroxyacetanilide, in mouse liver. J. Pharmacol. Exp. Ther., 282, 1533-1540.
23. Sarkar, K. and Sil, P.C. (2007): Attenuation of Acetaminophen-induced hepatotoxicity in vivo and in vitro by a 43-kD protein isolated from the herb. Toxicol. Mech. Meth., 17, 305-315.
24. Waring, J.F., Ulrich, R.G., Flint, N., Morfitt, D., Kalkuhl, A., Staedtler, F., Lawton, M., Beekman, J.M. and Suter, L. (2004): Interlaboratory evaluation of rat hepatic gene expression changes induced by methapyrilene. Environ. Health Perspect., 112, 439-448.