Gene expression profile of ovalbumin-induced lung inflammation in a murine model of asthma

Journal of Investigational Allergology and Clinical Immunology

Volumn 18, Issue 2, 2008, Pages 106-112

  Malik, R ^a   Priyadarsiny, Priyanka ^a,c   Shirumalla, R ^a   Soni, R ^b   Ray, A ^a   Saini, K ^a  

^a RANBAXY RESEARCH LABORATORIES   (India)

^b Premas Biotech Pvt Ltd   (India)

^c ZYDUS RESEARCH CENTRE   (India)

Author keywords

Asthma; Cytokines; Lung; Microarray; Ovalbumin

Indexed keywords

ANTIASTHMATIC AGENT; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; CD14 ANTIGEN; CXCL2 CHEMOKINE; EOTAXIN; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 10 RECEPTOR; INTERLEUKIN 13; INTERLEUKIN 18; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; MACROPHAGE ELASTASE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 3; OVALBUMIN; R 142571; SUPPRESSOR OF CYTOKINE SIGNALING 3; THROMBOCYTE FACTOR 4; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSCRIPTION FACTOR GATA 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CLUSTER ANALYSIS; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; IMMUNE RESPONSE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PROTEIN DEGRADATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

ANIMALS; ANTI-ASTHMATIC AGENTS; ASTHMA; CLUSTER ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; IMMUNITY; LUNG; MICE; MICE, INBRED BALB C; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OVALBUMIN; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 45749084462     PISSN: 10189068     EISSN: 16980808     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Busse WW, Lemanske RF. Asthma. N Engl J Med. 2001;344:350-62.
2. Wilson JW, Li X. The measurement of reticular basement membrane and submucosal collagen in the asthmatic airway. Clin Exp Allergy. 1997;27:363-71.
3. Muro S, Minshall EM, Hamid QA. The pathology of chronic asthma. Clin. Chest Med. 2000;21:225-44.
4. Leong KP, Huston DP. Understanding the pathogenesis of allergic asthma using mouse models. Ann Allergy Asthma Immunol. 2001;87:96-109.
5. Barnes P J, Chung K F, Page CP. Inflammatory mediators of asthma: an update. Pharmacol Rev. 1998;50:515-96.
6. Barnes PJ, Adcock IM. Transcription factors and asthma. Eur Respir J. 1998;12:221-34.
7. Wills-Karp M. Murine models of asthma in understanding immune dysregulation in human asthma. Immunopharmacology. 2000;48:263-8.
8. Garlisi CG, Falcone A, Kung TT, Stelts D, Pennline KJ, Beavis AJ, Smith SR, Egan RW, Umland SP. T-cells are necessary for Th2 cytokine production and eosinophil accumulation in airways of antigen-challenged allergic mice. Clin Immunol Immunopathol. 1995;75:75-83.
9. Peters SP. Heterogeneity in the pathology and treatment of asthma. Am J Med. 2003;115:S49-54.
10. Daheshia M, Tian N, Connolly T, Drawid A, Wu Q, Bienvenu JG, Cavallo J, Jupp R, Sanctis GTD, Minnich A. Molecular characterization of antigen induced lung inflammation in a murine model of asthma. Ann New York Aca Sci. 2002;975:148-59.
11. Follettie MT, Ellis DK, Donaldson DD, Hill VD, DeClercq C, Sypek JP, Dorner AJ, Wills-Karp M. Gene expression analysis in a murine model of allergic asthma reveals overlapping disease and therapy dependent pathways in the lung. Pharmacogen J. 2006:1-12.
12. Rolph MS, Sisavanh M, Liu SM, Mackay CR. Clues to asthma pathogenesis from microarray expression studies. Pharmacol Therapeu. 2006;109: 284-94.
13. Barnes PJ. Transcriptions factors in airway diseases. Lab Invest. 2006:1-6.
14. Barnes PJ, Adcock IM, Ito K. Histone acetylation and deacetylation: importance in inflammatory lung diseases. Eur Repir J. 2005;25:552-63.
15. Barnes PJ, Adcock IM. How do corticosteroids work in asthma. Ann Intern Med. 2003;139:359-70.
16. Barnes PJ and Hansel TT. Prospects for new drugs for chronic obstructive pulmonary disease. Lancet. 2004;364: 985-96.
17. Edwards MR, Kebadze T, Johnson MW, and Johnston SL. New treatment regimes for virus-induced exacerbations of asthma. Pulm Pharmacol Ther. 2006; 19:320-34.
18. Barnes PJ. New drugs for asthma. Nat Rev Drug Discov. 2004;3:831-844.
19. Adcock IM and Ito K. Steroid Resistance in asthma: a major problem requiring novel solutions or a non-issue? Curr Opin Pharmacol. 2004;4:257-62.
20. Zimmermann N, King NE, Laporte J, Yang M, Mishra A, Pope SM, Muntel EE, Witte DP, Pegg AA, Foster PS, Hamid Q, Rothenberg ME. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J Clin Invest. 2003;111:1863-74.
21. Warner RL, Lewis CS, Beltran L, Younkin EM, Varani J, Johnson KJ. The role of metalloelastase in immune complex-induced acute lung injury. Am J pathol. 2001;158:2139-44.
22. Wong CK, Ho CY, Ko FWS, Chan CHS, Ho ASS, Hui DSC , Lam CWK. Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN- ?, IL-4, IL-10 and IL-13) in patients with allergic asthma. Clin Exp Immunol 2001; 125:177-83.
23. Torres R, Picado C, Mora FD. Use of the mouse to unravel allergic asthma: a review of the pathogenesis of allergic asthma in mouse models and its similarity to the conditions in humans. Arch Bronconeumol. 2005;41:141-152.
24. Rankin JA, Picarella DE, Geba GP, Teman UA, Prasad B, DiCosmo B. Phenotypic and physiologic characterization of transgenic mice expression interleukin-4 in the lung: lymphocytic and eosinophillic inflammation without airway hyperreactivity. Proc Natl Acad Sci. 1996;93:7821-5.
25. Lee J, McGarry MP, Farmer SC, Denzler KL, Larson KA, Carrigan PE. Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathogenomic of asthma. J Exp Med. 1997;188:1307-20.
26. Zhu Z, Horner RJ, Wang Z, Chen Q, Geb GP, Wang J. Pulmonary expression of interleukin 13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest. 1999;103:779-88.
27. Kumar RK, Herbert C, Yang M, Koskinen AM, McKenzie AN, Foster P. Role of interleukin-13 in eosinophil accumulation and airway remodeling in a mouse model of chronic asthma. Clin Exp Allergy. 2002;32:1104-11.
28. Cohn L, Horner RJ, Marinov A, Rankin J, Bottomly K. Induction of airway mucus production by T helper 2 (Th2) cells: a critical role for interleukin-4 in cell recruitment but not mucus production. J Exp Med. 1997;186:1737-47.
29. Foster PS, Ming Y, Matthei KI, Young IG, Temelkovski J, Kumar RK. Dissociation of inflammatory and epithelial responses in a murine model of chronic asthma. Lab Invest. 2000; 80:655-62.
30. Cousins DJ, Lee TH, Dontcho ZS. Cytokine co-expression during human Th1/Th2 cell differentiation: Direct evidence for coordinated expression of Th2 cytokines. The Journal of Immunology. 2002;169:2498-506.
31. Frazer KA, Veda Y, Zhu Y, Gifford VR, Garofalo MR, Mohandas N, Martu CH, Palazzolo MJ, Cheng JF, Rubin EM. Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region. Genome Res. 1997;7:495-512.