The G604S-hERG mutation alters the biophysical properties and exerts a dominant-negative effect on expression of hERG channels in HEK293 cells

Pflugers Archiv European Journal of Physiology

Volumn 456, Issue 5, 2008, Pages 917-928

  Huo, Jianhua ^a   Zhang, Yanmin ^a,d   Huang, Na ^a   Liu, Ping ^a   Huang, Chen ^a   Guo, Xueyan ^b   Jiang, Wenhui ^a   Zhou, Nan ^c   Grace, Andrew ^d   Huang, Christopher L H ^d   Ma, Aiqun ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b SHAANXI PROVINCIAL PEOPLE S HOSPITAL   (China)

^c Xi'an Children's Hospital   (China)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

hERG; Long QT syndrome; Mutation; Patch clamp; Protein trafficking

Indexed keywords

LIPOFECTAMINE; POTASSIUM CHANNEL HERG; PROTEIN SUBUNIT;

ARTICLE; CELL MEMBRANE; CELL STRAIN HEK293; CELLULAR DISTRIBUTION; CHANNEL GATING; CONFOCAL MICROSCOPY; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; VOLTAGE CLAMP; WESTERN BLOTTING;

CELL LINE; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; ION CHANNEL GATING; LONG QT SYNDROME; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; RECOMBINANT FUSION PROTEINS;

EID: 45649084308     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-008-0454-0     Document Type: Article

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