A possible role of multidrug resistance - Associated protein 2 (Mrp2) in hepatic excretion of PCB126, an environmental contaminant: PBPK/PD modeling

Toxicological Sciences

Volumn 104, Issue 1, 2008, Pages 27-39

  Lohitnavy, Manupat ^a,b   Lu, Yasong ^a   Lohitnavy, Ornrat ^a,b   Chubb, Laura S ^a   Hirono, Shuichi ^c   Yang, Raymond S H ^a  

^a Veterinary Dentistry and Oral Surgery   (United States)

^b NARESUAN UNIVERSITY   (Thailand)

^c KITASATO UNIVERSITY   (Japan)

Author keywords

Carcinogenesis; Disposition; Mrp2; PCB 126; Physiologically based pharmacokinetics; Polychlorinated biphenyls

Indexed keywords

3,3',4,4',5 PENTACHLOROBIPHENYL; CARRIER PROTEIN; GLUTATHIONE TRANSFERASE; LIVER PROTEIN; MULTIDRUG RESISTANCE PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BIOLOGICAL MODEL; BLOOD; CALCULATION; CARCINOGENICITY; CONTROLLED STUDY; DRUG DISPOSITION; EXCRETION; FEMALE; LIVER; MALE; NONHUMAN; PATHOPHYSIOLOGY; PHARMACODYNAMICS; PROTEIN BINDING; QUANTITATIVE ANALYSIS; STRUCTURE ACTIVITY RELATION; TISSUE;

ANIMALS; COMPUTER SIMULATION; ENVIRONMENTAL POLLUTANTS; FEMALE; LIVER; MALE; MODELS, BIOLOGICAL; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; POLYCHLORINATED BIPHENYLS; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 45549108233     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn026     Document Type: Article

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