A physiologically based pharmacodynamic analysis of hepatic foci within a medium-term liver bioassay using pentachlorobenzene as a promoter and diethylnitrosamine as an initiator

Toxicology and Applied Pharmacology

Volumn 166, Issue 2, 2000, Pages 128-137

  Thomas, R S ^a   Conolly, R B ^a   Gustafson, D L ^a   Long, M E ^a   Benjamin, S A ^a   Yang, R S H ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Cell proliferation; Clonal growth model; Diethylnitrosamine; Glutathione S transferase ; GST P foci; Initiation promotion study; Liver; Liver foci; Medium term bioassay; MVK model; PBPD model; Pentachlorobenzene; Pharmacodynamic model; Two cell model

Indexed keywords

DIETHYLNITROSAMINE; PENTACHLOROBENZENE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOASSAY; CELL DEATH; CELL PROLIFERATION; ENVIRONMENTAL PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; PROMOTER REGION; RAT;

EID: 0034662245     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2000.8959     Document Type: Article

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