Stochastic simulation of hepatic preneoplastic foci development for four chlorobenzene congeners in a medium-term bioassay

Toxicological Sciences

Volumn 73, Issue 2, 2003, Pages 301-314

  Ou, Ying C ^a   Conolly, Rory B ^b   Thomas, Russell S ^c   Gustafson, Daniel L ^d   Long, Michael E ^d   Dobrev, Ivan D ^e   Chubb, Laura S ^e   Xu, Yihua ^f   Lapidot, Smadar A ^e   Andersen, Melvin E ^b   Yang, Raymond S H ^e  

^a GLAXOSMITHKLINE   (United States)

^b CIIT CENTERS FOR HEALTH RESEARCH   (United States)

^c Kalypsos Inc   (United States)

^d UNIVERSITY OF COLORADO   (United States)

^e Veterinary Dentistry and Oral Surgery   (United States)

^f UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Chlorobenzene; Clonal growth model; Liver carcinogenesis; Preneoplastic foci; Simulation

Indexed keywords

1,4 DICHLOROBENZENE; BENZENE DERIVATIVE; CHLOROBENZENE; DIETHYLNITROSAMINE; GLUTATHIONE TRANSFERASE; HEXACHLOROBENZENE; PENTACHLOROETHANE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOASSAY; CELL DIVISION; CELL GROWTH; CELL POPULATION; CELL PROLIFERATION; CELL REGENERATION; CELL SUBPOPULATION; CONTROLLED STUDY; CORRELATION ANALYSIS; GROWTH INHIBITION; LIVER CANCER; LIVER CARCINOGENESIS; LIVER RESECTION; LIVER WEIGHT; MALE; NONHUMAN; PRECANCER; RAT; SENSITIVITY ANALYSIS; STOCHASTIC MODEL; TUMOR GROWTH;

ADMINISTRATION, ORAL; ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; CHLOROBENZENES; CLONE CELLS; COMPUTER SIMULATION; DIETHYLNITROSAMINE; DRUG THERAPY, COMBINATION; FOCAL NODULAR HYPERPLASIA; GLUTATHIONE TRANSFERASE; HEPATECTOMY; LIVER NEOPLASMS; MALE; PRECANCEROUS CONDITIONS; RATS; RATS, INBRED F344;

ANIMALIA; MARTES PENNANTI;

EID: 0038511182     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg078     Document Type: Article

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