An updated physiologically based pharmacokinetic model for hexachlorobenzene: Incorporation of pathophysiological states following partial hepatectomy and hexachlorobenzene treatment

Toxicological Sciences

Volumn 91, Issue 1, 2006, Pages 29-41

  Lu, Yasong ^a   Lohitnavy, Manupat ^a   Reddy, Micaela B ^b   Lohitnavy, Ornrat ^b   Ashley, Amanda ^a   Yang, Raymond S H ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b ROCHE BIOSCIENCE   (United States)

Author keywords

Hexachlorobenzene; Medium term liver foci bioassay; PBPK model

Indexed keywords

HEXACHLOROBENZENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING KINETICS; BIOASSAY; BLOOD ANALYSIS; BODY FAT; BODY WEIGHT; CONTROLLED STUDY; DATA ANALYSIS; DIFFUSION; ENVIRONMENTAL EXPOSURE; ERYTHROCYTE; EXPERIMENTAL MODEL; GASTROINTESTINAL TRACT; LIVER CANCER; LIVER METABOLISM; LIVER PARENCHYMA; LIVER WEIGHT; MALE; NONHUMAN; PARTIAL HEPATECTOMY; PATHOPHYSIOLOGY; QUANTITATIVE ANALYSIS; RAT; SCIENTIFIC LITERATURE; SIMULATION; TOXICOKINETICS;

ANIMALS; FEMALE; GLUTATHIONE TRANSFERASE; HEPATECTOMY; HEXACHLOROBENZENE; LIVER; MALE; MODELS, BIOLOGICAL; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; RATS, WISTAR;

ANIMALIA;

EID: 33645815275     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfj133     Document Type: Article

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