Conserved residue Lys574 in the cavity of HIV-1 Gp41 coiled-coil domain is critical for six-helix bundle stability and virus entry

Journal of Biological Chemistry

Volumn 282, Issue 35, 2007, Pages 25631-25639

  He, Yuxian ^a,c,d   Liu, Shuwen ^b   Jing, Weiguo ^a   Lu, Hong ^a   Cai, Dongmei ^a   Darin, Jeekin Chin ^a   Debnath, Asim K ^a   Kirchhoff, Frank ^c   Jiang, Shibo ^a,d  

^a NEW YORK BLOOD CENTER   (United States)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF ULM   (Germany)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HIV-1 GP41 CORE STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS (HIV); IONIC INTERACTIONS; SIX-HELIX BUNDLE (6-HB);

BINDING SITES; CIRCULAR DICHROISM SPECTROSCOPY; GENES; HYDROPHOBICITY; MUTAGENESIS; VIRUSES;

MOLECULAR STRUCTURE;

C PEPTIDE; GLYCOPROTEIN GP 41; LYSINE; MUTANT PROTEIN; N PEPTIDE; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG; HUMAN IMMUNODEFICIENCY VIRUS FUSION INHIBITOR;

ALPHA HELIX; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CIRCULAR DICHROISM; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; ISOTHERMAL TITRATION CALORIMETRY; MUTATIONAL ANALYSIS; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STABILITY; THERMOSTABILITY; VIRUS INFECTIVITY; WILD TYPE; CHEMICAL STRUCTURE; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DESIGN; DRUG EFFECT; GENETICS; HYDROPHOBICITY; METABOLISM; MISSENSE MUTATION; PHYSIOLOGY; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; VIRUS INTERNALIZATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

AMINO ACID SUBSTITUTION; CALORIMETRY, DIFFERENTIAL SCANNING; CIRCULAR DICHROISM; DRUG DESIGN; HIV ENVELOPE PROTEIN GP41; HIV FUSION INHIBITORS; HIV-1; HYDROPHOBICITY; LYSINE; MODELS, MOLECULAR; MUTATION, MISSENSE; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; VIRUS INTERNALIZATION;

EID: 34548481743     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M703781200     Document Type: Article

References (53)

1. Freed, E. O., and Martin, M. A. (1995) J. Biol. Chem. 270, 23883-23886
2. Eckert, D. M., and Kim, P. S. (2001) Annu. Rev. Biochem. 70, 777-810
3. Wyatt, R., and Sodroski, J. (1998) Science 280, 1884-1888
4. Berger, E. A., Murphy, P. M., and Farber, J. M. (1999) Annu. Rev. Immunol. 17, 657-700
5. Lu, M., Blacklow, S. C., and Kim, P. S. (1995) Nat. Struct. Biol. 2, 1075-1082
6. Chan, D. C., Fass, D., Berger, J. M., and Kim, P. S. (1997) Cell 89, 263-273
7. Chan, D. C., Chutkowski, C. T., and Kim, P. S. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 15613-15617
8. Chan, D. C., and Kim, P. S. (1998) Cell 93, 681-684
9. Weng, Y., Yang, Z., and Weiss, C. D. (2000) J. Virol. 74, 5368-5372
10. Weng, Y., and Weiss, C. D. (1998) J. Virol. 72, 9676-9682
11. Wang, S., York, J., Shu, W., Stoller, M. O., Nunberg, J. H., and Lu, M. (2002) Biochemistry 41, 7283-7292
12. Ji, H., Shu, W., Burling, F. T., Jiang, S., and Lu, M. (1999) J. Virol. 73, 8578-8586
13. Cao, J., Bergeron, L., Helseth, E., Thali, M., Repke, H., and Sodroski, J. (1993) J. Virol. 67, 2747-2755
14. Lu, M., Stoller, M. O., Wang, S., Liu, J., Fagan, M. B., and Nunberg, J. H. (2001) J. Virol. 75, 11146-11156
15. Jiang, S., Lin, K., Strick, N., and Neurath, A. R. (1993) Nature 365, 113
16. Wild, C. T., Shugars, D. C., Greenwell, T. K., McDanal, C. B., and Matthews, T. J. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 9770-9774
17. Wild, C., Oas, T., McDanal, C., Bolognesi, D., and Matthews, T. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 10537-10541
18. Kilby, J. M., Hopkins, S., Venetta, T. M., DiMassimo, B., Cloud, G. A., Lee, J. Y., Alldredge, L., Hunter, E., Lambert, D., Bolognesi, D., Matthews, T., Johnson, M. R., Nowak, M. A., Shaw, G. M., and Saag, M. S. (1998) Nat. Med. 4, 1302-1307
19. Dong, X. N., Xiao, Y., Dierich, M. P., and Chen, Y. H. (2001) Immunol. Lett. 75, 215-220
20. Mo, H., Konstantinidis, A. K., Stewart, K. D., Dekhtyar, T., Ng, T., Swift, K., Matayoshi, E. D., Kati, W., Kohlbrenner, W., and Molla, A. (2004) Virology 329, 319-327
21. Jiang, S., Lu, H., Liu, S., Zhao, Q., He, Y., and Debnath, A. K. (2004) Antimicrob. Agents Chemother. 48, 4349-4359
22. He, Y., D'Agostino, P., and Pinter, A. (2003) Vaccine 21, 4421-4429
23. Edelhoch, H. (1967) Biochemistry 6, 1948-1954
24. Shu, W., Liu, J., Ji, H., Radigen, L., Jiang, S., and Lu, M. (2000) Biochemistry 39, 1634-1642
25. Chen, Y. H., Yang, J. T., and Chau, K. H. (1974) Biochemistry 13, 3350-3359
26. Liu, S., Lu, H., Niu, J., Xu, Y., Wu, S., and Jiang, S. (2005) J. Biol. Chem. 280, 11259-11273
27. Santoro, M. M., and Bolen, D. W. (1988) Biochemistry 27, 8063-8068
28. Liu, S., Zhao, Q., and Jiang, S. (2003) Peptides 24, 1303-1313
29. Jiang, S., Lin, K., Zhang, L., and Debnath, A. K. (1999) J. Virol. Methods 80, 85-96
30. Jiang, S., and Debnath, A. K. (2000) Biochem. Biophys. Res. Commun. 270, 153-157
31. Lu, M., Ji, H., and Shen, S. (1999) J. Virol. 73, 4433-4438
32. Chang, D. K., Cheng, S. F., and Trivedi, V. D. (1999) J. Biol. Chem. 274, 5299-5309
33. Bewley, C. A., Louis, J. M., Ghirlando, R., and Clore, G. M. (2002) J. Biol. Chem. 277, 14238-14245
34. Sackett, K., Wexler-Cohen, Y., and Shai, Y. (2006) J. Biol. Chem. 281, 21755-21762
35. Jiang, S., Lin, K., and Lu, M. (1998) J. Virol. 72, 10213-10217
36. Weissenhorn, W., Dessen, A., Harrison, S. C., Skehel, J. J., and Wiley, D. C. (1997) Nature 387, 426-430
37. Liu, J., Wang, S., Hoxie, J. A., LaBranche, C. C., and Lu, M. (2002) J. Biol. Chem. 277, 12891-12900
38. Follis, K. E., Larson, S. J., Lu, M., and Nunberg, J. H. (2002) J. Virol. 76, 7356-7362
39. Korazim, O., Sackett, K., and Shai, Y. (2006) J. Mol. Biol. 364, 1103-1117
40. Weiss, C. D., Levy, J. A., and White, J. M. (1990) J. Virol. 64, 5674 -5677
41. Chen, S. S., Lee, C. N., Lee, W. R., McIntosh, K., and Lee, T. H. (1993) J. Virol. 67, 3615-3619
42. Dubay, J. W., Roberts, S. J., Brody, B., and Hunter, E. (1992) J. Virol. 66, 4748-4756
43. Dimitrov, A. S., Louis, J. M., Bewley, C. A., Clore, G. M., and Blumenthal, R. (2005) Biochemistry 44, 12471-12479
44. Markosyan, R. M., Cohen, F. S., and Melikyan, G. B. (2003) Mol. Biol. Cell 14, 926-938
45. Liu, S., and Jiang, S. (2004) Curr. Pharm. Des. 10, 1827-1843
46. Kilby, J. M., Lalezari, J. P., Eron, J. J., Carlson, M., Cohen, C., Arduino, R. C., Goodgame, J. C., Gallant, J. E., Volberding, P., Murphy, R. L., Valentine, F., Saag, M. S., Nelson, E. L., Sista, P. R., and Dusek, A. (2002) AIDS Res. Hum. Retroviruses 18, 685-693
47. Lalezari, J. P., Eron, J. J., Carlson, M., Cohen, C., DeJesus, E., Arduino, R. C., Gallant, J. E., Volberding, P., Murphy, R. L., Valentine, F., Nelson, E. L., Sista, P. R., Dusek, A., and Kilby, J. M. (2003) AIDS 17, 691-698
48. Eckert, D. M., Malashkevich, V. N., Hong, L. H., Carr, P. A., and Kim, P. S. (1999) Cell 99, 103-115
49. Xu, Y., Lu, H., Kennedy, J. P., Yan, X., McAllister, L. A., Yamamoto, N., Moss, J. A., Boldt, G. E., Jiang, S., and Janda, K. D. (2006) J. Comb. Chem. 8, 531-539
50. Gallo, S. A., Wang, W., Rawat, S. S., Jung, G., Waring, A. J., Cole, A. M., Lu, H., Yan, X., Daly, N. L., Craik, D. J., Jiang, S., Lehrer, R. I., and Blumenthal, R. (2006) J. Biol. Chem. 281, 18787-18792
51. Vaillant, A., Juteau, J. M., Lu, H., Liu, S., Lackman-Smith, C., Ptak, R., and Jiang, S. (2006) Antimicrob. Agents Chemother. 50, 1393-1401
52. Liu, S., Lu, H., Zhao, Q., He, Y., Niu, J., Debnath, A. K., Wu, S., and Jiang, S. (2005) Biochim. Biophys. Acta 1723, 270-281
53. Zhao, Q., Ernst, J. T., Hamilton, A. D., Debnath, A. K., and Jiang, S. (2002) AIDS Res. Hum. Retroviruses 18, 989-997