Remodeling of gp41-C34 peptide leads to highly effective inhibitors of the fusion of HIV-1 with target cells

Angewandte Chemie - International Edition

Volumn 41, Issue 16, 2002, Pages 2937-2940

  Otaka, Akira ^a   Nakamura, Miki ^a   Nameki, Daisuke ^a   Kodama, Eiichi ^a   Uchiyama, Susumu ^b   Nakamura, Syota ^b   Nakano, Hiroaki ^b   Tamamura, Hirokazu ^a   Kobayashi, Yuji ^b   Matsuoka, Masao ^a   Fujii, Nobutaka ^a  

^a KYOTO UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

Antiviral agents; Drug design; Helical structures; HIV; Peptides

Indexed keywords

CELLS; DISEASES; SOLUBILITY; STABILIZATION; SUBSTITUTION REACTIONS;

HUMAN IMMUNODEFICIENCY VIRUS (HIV);

CHEMICAL ENGINEERING;

ANTIVIRUS AGENT; C 34; GLYCOPROTEIN GP 41; PEPTIDE DERIVATIVE; SC 34 EK; SC 35 EK; UNCLASSIFIED DRUG; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; PEPTIDE FRAGMENT;

AMINO ACID SEQUENCE; ANTIVIRAL ACTIVITY; ARTICLE; CIRCULAR DICHROISM; DRUG EFFECT; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; X RAY ANALYSIS; CHEMISTRY; DRUG DESIGN; HUMAN; MOLECULAR GENETICS; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMINO ACID SEQUENCE; ANTI-HIV AGENTS; DRUG DESIGN; HIV ENVELOPE PROTEIN GP41; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037119022     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-3773(20020816)41:16<2937::aid-anie2937>3.0.co;2-j     Document Type: Article

References (21)