-
1
-
-
33846457870
-
Cancer statistics
-
2007
-
Jemal A., et al. Cancer statistics. 2007. CA Cancer J Clin 57 1 (2007) 43-66
-
(2007)
CA Cancer J Clin
, vol.57
, Issue.1
, pp. 43-66
-
-
Jemal, A.1
-
2
-
-
33947290011
-
Current management of ovarian carcinosarcoma
-
Mano M.S., et al. Current management of ovarian carcinosarcoma. Int J Gynecol Cancer 17 2 (2007) 316-324
-
(2007)
Int J Gynecol Cancer
, vol.17
, Issue.2
, pp. 316-324
-
-
Mano, M.S.1
-
3
-
-
33746895482
-
Advances in mitotic inhibitors for cancer treatment
-
Jiang N., et al. Advances in mitotic inhibitors for cancer treatment. Mini Rev Med Chem 6 8 (2006) 885-895
-
(2006)
Mini Rev Med Chem
, vol.6
, Issue.8
, pp. 885-895
-
-
Jiang, N.1
-
4
-
-
1642401199
-
Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain
-
Ravelli R.B., et al. Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain. Nature 428 6979 (2004) 198-202
-
(2004)
Nature
, vol.428
, Issue.6979
, pp. 198-202
-
-
Ravelli, R.B.1
-
5
-
-
0024513175
-
Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4
-
Pettit G.R., et al. Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4. Experientia 45 2 (1989) 209-211
-
(1989)
Experientia
, vol.45
, Issue.2
, pp. 209-211
-
-
Pettit, G.R.1
-
6
-
-
0642307227
-
Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: magnetic resonance imaging evidence for altered tumor blood flow
-
Stevenson J.P., et al. Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: magnetic resonance imaging evidence for altered tumor blood flow. J Clin Oncol 21 23 (2003) 4428-4438
-
(2003)
J Clin Oncol
, vol.21
, Issue.23
, pp. 4428-4438
-
-
Stevenson, J.P.1
-
7
-
-
0042386700
-
Phase I clinical trial of weekly combretastatin A4 phosphate: clinical and pharmacokinetic results
-
Rustin G.J., et al. Phase I clinical trial of weekly combretastatin A4 phosphate: clinical and pharmacokinetic results. J Clin Oncol 21 15 (2003) 2815-2822
-
(2003)
J Clin Oncol
, vol.21
, Issue.15
, pp. 2815-2822
-
-
Rustin, G.J.1
-
8
-
-
33645732100
-
Phase I clinical evaluation of weekly administration of the novel vascular-targeting agent, ZD6126, in patients with solid tumors
-
Beerepoot L.V., et al. Phase I clinical evaluation of weekly administration of the novel vascular-targeting agent, ZD6126, in patients with solid tumors. J Clin Oncol 24 10 (2006) 1491-1498
-
(2006)
J Clin Oncol
, vol.24
, Issue.10
, pp. 1491-1498
-
-
Beerepoot, L.V.1
-
9
-
-
0036278972
-
Antitumor activity of the novel vascular targeting agent ZD6126 in a panel of tumor models
-
Blakey D.C., et al. Antitumor activity of the novel vascular targeting agent ZD6126 in a panel of tumor models. Clin Cancer Res 8 6 (2002) 1974-1983
-
(2002)
Clin Cancer Res
, vol.8
, Issue.6
, pp. 1974-1983
-
-
Blakey, D.C.1
-
10
-
-
0037096814
-
A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer
-
Dowlati A., et al. A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer. Cancer Res 62 12 (2002) 3408-3416
-
(2002)
Cancer Res
, vol.62
, Issue.12
, pp. 3408-3416
-
-
Dowlati, A.1
-
11
-
-
20044379059
-
Review: tubulin function, action of antitubulin drugs, and new drug development
-
Pellegrini F., and Budman D.R. Review: tubulin function, action of antitubulin drugs, and new drug development. Cancer Invest 23 3 (2005) 264-273
-
(2005)
Cancer Invest
, vol.23
, Issue.3
, pp. 264-273
-
-
Pellegrini, F.1
Budman, D.R.2
-
12
-
-
33646907207
-
Control of the G2/M transition
-
Stark G.R., and Taylor W.R. Control of the G2/M transition. Mol Biotechnol 32 3 (2006) 227-248
-
(2006)
Mol Biotechnol
, vol.32
, Issue.3
, pp. 227-248
-
-
Stark, G.R.1
Taylor, W.R.2
-
13
-
-
0027746003
-
Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase
-
Izumi T., and Maller J.L. Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase. Mol Biol Cell 4 12 (1993) 1337-1350
-
(1993)
Mol Biol Cell
, vol.4
, Issue.12
, pp. 1337-1350
-
-
Izumi, T.1
Maller, J.L.2
-
14
-
-
0033552943
-
Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein
-
Lopez-Girona A., et al. Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein. Nature 397 6715 (1999) 172-175
-
(1999)
Nature
, vol.397
, Issue.6715
, pp. 172-175
-
-
Lopez-Girona, A.1
-
15
-
-
0029417238
-
Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo
-
Blangy A., et al. Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. Cell 83 7 (1995) 1159-1169
-
(1995)
Cell
, vol.83
, Issue.7
, pp. 1159-1169
-
-
Blangy, A.1
-
17
-
-
0032694402
-
BUBR1 phosphorylation is regulated during mitotic checkpoint activation
-
Li W., et al. BUBR1 phosphorylation is regulated during mitotic checkpoint activation. Cell Growth Differ 10 11 (1999) 769-775
-
(1999)
Cell Growth Differ
, vol.10
, Issue.11
, pp. 769-775
-
-
Li, W.1
-
18
-
-
0032846338
-
Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC
-
Chan G.K., et al. Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. J Cell Biol 146 5 (1999) 941-954
-
(1999)
J Cell Biol
, vol.146
, Issue.5
, pp. 941-954
-
-
Chan, G.K.1
-
19
-
-
0035432939
-
Tracing the pathway of spindle assembly checkpoint signaling
-
Gillett E.S., and Sorger P.K. Tracing the pathway of spindle assembly checkpoint signaling. Dev Cell 1 2 (2001) 162-164
-
(2001)
Dev Cell
, vol.1
, Issue.2
, pp. 162-164
-
-
Gillett, E.S.1
Sorger, P.K.2
-
20
-
-
25144513926
-
Mitotic spindle checkpoint inactivation by trichostatin a defines a mechanism for increasing cancer cell killing by microtubule-disrupting agents
-
Dowling M., et al. Mitotic spindle checkpoint inactivation by trichostatin a defines a mechanism for increasing cancer cell killing by microtubule-disrupting agents. Cancer Biol Ther 4 2 (2005) 197-206
-
(2005)
Cancer Biol Ther
, vol.4
, Issue.2
, pp. 197-206
-
-
Dowling, M.1
-
21
-
-
2342635919
-
Cell death by mitotic catastrophe: a molecular definition
-
Castedo M., et al. Cell death by mitotic catastrophe: a molecular definition. Oncogene 23 16 (2004) 2825-2837
-
(2004)
Oncogene
, vol.23
, Issue.16
, pp. 2825-2837
-
-
Castedo, M.1
-
22
-
-
33344476097
-
DNA damage checkpoints in mammals
-
Niida H., and Nakanishi M. DNA damage checkpoints in mammals. Mutagenesis 21 1 (2006) 3-9
-
(2006)
Mutagenesis
, vol.21
, Issue.1
, pp. 3-9
-
-
Niida, H.1
Nakanishi, M.2
-
23
-
-
34247875990
-
Centrosomal localization of DNA damage checkpoint proteins
-
Zhang S., Hemmerich P., and Grosse F. Centrosomal localization of DNA damage checkpoint proteins. J Cell Biochem 101 2 (2007) 451-465
-
(2007)
J Cell Biochem
, vol.101
, Issue.2
, pp. 451-465
-
-
Zhang, S.1
Hemmerich, P.2
Grosse, F.3
-
24
-
-
3042632194
-
The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe
-
Castedo M., et al. The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe. Oncogene 23 25 (2004) 4353-4361
-
(2004)
Oncogene
, vol.23
, Issue.25
, pp. 4353-4361
-
-
Castedo, M.1
-
25
-
-
0041342053
-
Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents
-
Roberti M., et al. Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents. J Med Chem 46 16 (2003) 3546-3554
-
(2003)
J Med Chem
, vol.46
, Issue.16
, pp. 3546-3554
-
-
Roberti, M.1
-
26
-
-
45549089730
-
-
Cao, TM, et al., Stilbene derivatives that are colchicine site microtubule inhibitors have anti-leukemic activity and minimal systemic toxicity. Am J Hematol in press.
-
Cao, TM, et al., Stilbene derivatives that are colchicine site microtubule inhibitors have anti-leukemic activity and minimal systemic toxicity. Am J Hematol in press.
-
-
-
-
27
-
-
0034068601
-
Mitochondrial control of cell death
-
Kroemer G., and Reed J.C. Mitochondrial control of cell death. Nat Med 6 5 (2000) 513-519
-
(2000)
Nat Med
, vol.6
, Issue.5
, pp. 513-519
-
-
Kroemer, G.1
Reed, J.C.2
-
28
-
-
0034284637
-
Mitochondria as the central control point of apoptosis
-
Desagher S., and Martinou J.C. Mitochondria as the central control point of apoptosis. Trends Cell Biol 10 9 (2000) 369-377
-
(2000)
Trends Cell Biol
, vol.10
, Issue.9
, pp. 369-377
-
-
Desagher, S.1
Martinou, J.C.2
-
29
-
-
0343963153
-
Role of oxidative phosphorylation in Bax toxicity
-
Harris M.H., et al. Role of oxidative phosphorylation in Bax toxicity. Mol Cell Biol 20 10 (2000) 3590-3596
-
(2000)
Mol Cell Biol
, vol.20
, Issue.10
, pp. 3590-3596
-
-
Harris, M.H.1
-
30
-
-
2942581328
-
Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain
-
Ricci J.E., et al. Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain. Cell 117 6 (2004) 773-786
-
(2004)
Cell
, vol.117
, Issue.6
, pp. 773-786
-
-
Ricci, J.E.1
-
31
-
-
0000260982
-
Reactive oxygen generation by mitochondria
-
Lemasters J.J., and Neiminen A. (Eds), Kluwer Academic/Plenum Publishers, New York
-
Kowaltowski A.J., and Vercesi A.E. Reactive oxygen generation by mitochondria. In: Lemasters J.J., and Neiminen A. (Eds). Mitochondria in pathogenesis (2001), Kluwer Academic/Plenum Publishers, New York 281-300
-
(2001)
Mitochondria in pathogenesis
, pp. 281-300
-
-
Kowaltowski, A.J.1
Vercesi, A.E.2
-
32
-
-
29144440145
-
Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cells
-
Karimi M., et al. Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cells. J Immunol 175 12 (2005) 7819-7828
-
(2005)
J Immunol
, vol.175
, Issue.12
, pp. 7819-7828
-
-
Karimi, M.1
-
33
-
-
33845192397
-
Potentiation of radiation sensitivity in breast tumor cells by the vitamin D3 analogue, EB 1089, through promotion of autophagy and interference with proliferative recovery
-
Demasters G., et al. Potentiation of radiation sensitivity in breast tumor cells by the vitamin D3 analogue, EB 1089, through promotion of autophagy and interference with proliferative recovery. Mol Cancer Ther 5 11 (2006) 2786-2797
-
(2006)
Mol Cancer Ther
, vol.5
, Issue.11
, pp. 2786-2797
-
-
Demasters, G.1
-
34
-
-
33751232308
-
Chk1-dependent regulation of Cdc25B functions to coordinate mitotic events
-
Loffler H., et al. Chk1-dependent regulation of Cdc25B functions to coordinate mitotic events. Cell Cycle 5 21 (2006) 2543-2547
-
(2006)
Cell Cycle
, vol.5
, Issue.21
, pp. 2543-2547
-
-
Loffler, H.1
-
35
-
-
0033600182
-
Cell-cycle-dependent and ATM-independent expression of human Chk1 kinase
-
Kaneko Y.S., et al. Cell-cycle-dependent and ATM-independent expression of human Chk1 kinase. Oncogene 18 25 (1999) 3673-3681
-
(1999)
Oncogene
, vol.18
, Issue.25
, pp. 3673-3681
-
-
Kaneko, Y.S.1
-
36
-
-
33846636785
-
Chk1 is required for spindle checkpoint function
-
Zachos G., et al. Chk1 is required for spindle checkpoint function. Dev Cell 12 2 (2007) 247-260
-
(2007)
Dev Cell
, vol.12
, Issue.2
, pp. 247-260
-
-
Zachos, G.1
-
37
-
-
0036633164
-
Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells
-
Clark A.S., et al. Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells. Mol Cancer Ther 1 9 (2002) 707-717
-
(2002)
Mol Cancer Ther
, vol.1
, Issue.9
, pp. 707-717
-
-
Clark, A.S.1
-
38
-
-
18544367200
-
Inhibition of phosphorylation of BAD and Raf-1 by Akt sensitizes human ovarian cancer cells to paclitaxel
-
Mabuchi S., et al. Inhibition of phosphorylation of BAD and Raf-1 by Akt sensitizes human ovarian cancer cells to paclitaxel. J Biol Chem 277 36 (2002) 33490-33500
-
(2002)
J Biol Chem
, vol.277
, Issue.36
, pp. 33490-33500
-
-
Mabuchi, S.1
-
39
-
-
0029913172
-
Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway
-
Blagosklonny M.V., et al. Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway. Cancer Res 56 8 (1996) 1851-1854
-
(1996)
Cancer Res
, vol.56
, Issue.8
, pp. 1851-1854
-
-
Blagosklonny, M.V.1
-
40
-
-
33645464650
-
Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein
-
Kotha A., et al. Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein. Mol Cancer Ther 5 3 (2006) 621-629
-
(2006)
Mol Cancer Ther
, vol.5
, Issue.3
, pp. 621-629
-
-
Kotha, A.1
-
41
-
-
33747083495
-
Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1)
-
Tang J., Erikson R.L., and Liu X. Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1). Proc Natl Acad Sci U S A 103 32 (2006) 11964-11969
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.32
, pp. 11964-11969
-
-
Tang, J.1
Erikson, R.L.2
Liu, X.3
-
42
-
-
0036023440
-
Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly(ADP-ribose) polymerase cleavage
-
Nabha S.M., et al. Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly(ADP-ribose) polymerase cleavage. Clin Cancer Res 8 8 (2002) 2735-2741
-
(2002)
Clin Cancer Res
, vol.8
, Issue.8
, pp. 2735-2741
-
-
Nabha, S.M.1
-
43
-
-
33845399894
-
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
-
Lagouge M., et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127 6 (2006) 1109-1122
-
(2006)
Cell
, vol.127
, Issue.6
, pp. 1109-1122
-
-
Lagouge, M.1
-
44
-
-
33749005405
-
Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors
-
Shaked Y., et al. Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors. Science 313 5794 (2006) 1785-1787
-
(2006)
Science
, vol.313
, Issue.5794
, pp. 1785-1787
-
-
Shaked, Y.1
-
45
-
-
45549095866
-
-
Durrant D, et al. cis-3, 4′, 5-trimethoxy-3′-aminostilbene disrupts tumor vascular perfusion without damaging normal organ perfusion. Cancer Chemother Pharmacol in press.
-
Durrant D, et al. cis-3, 4′, 5-trimethoxy-3′-aminostilbene disrupts tumor vascular perfusion without damaging normal organ perfusion. Cancer Chemother Pharmacol in press.
-
-
-
|