High-density methylation of p14ARF and P16INK4A in Epstein-Barr virus-associated gastric carcinoma

International Journal of Cancer

Volumn 112, Issue 2, 2004, Pages 273-278

  Sakuma, Kazuya ^a,b   Chong, Ja Mun ^a   Sudo, Makoto ^a,c   Ushiku, Tetsuo ^a   Inoue, Yoko ^a   Shibahara, Junji ^a   Uozaki, Hiroshi ^a   Nagai, Hideo ^b   Fukayama, Masashi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b JICHI MEDICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

Epstein Barr virus; Gastric carcinoma; Methylation; P14; P16; Sequence

Indexed keywords

BISULFITE; PROTEIN P14; PROTEIN P16;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; EPSTEIN BARR VIRUS; FEMALE; HUMAN; HUMAN TISSUE; MALE; METHYLATION; PRIORITY JOURNAL; PROMOTER REGION; STOMACH CARCINOMA; VIRUS INFECTION;

ADULT; AGED; AGED, 80 AND OVER; BASE SEQUENCE; CARCINOMA; DNA METHYLATION; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; GENES, P16; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); STOMACH NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P14ARF;

EID: 4544382189     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.20420     Document Type: Article

References (28)

1. Fukayama M, Chong JM, Kaizaki Y. Epstein-Barr virus and gastric carcinoma. Gastric Cancer 1998;1:104-14.
2. Fukayama M, Hayashi Y, Iwasaki Y, Chong JM, Ooba T, Takizawa T, Koike M, Mizutani S, Miyaki M, Hirai K. Epstein-Barr virus-associated gastric carcinoma and Epstein-Barr virus infection of the stomach. Lab Invest 1994;71:73-81.
3. Fukayama M, Chong JM, Uozaki H. Pathology and molecular pathology of Epstein-Barr virus-associated gastric carcinoma. Curr Top Microbiol Immunol 2001;258:91-102.
4. Chong JM, Fukayama M, Hayashi Y, Takizawa T, Koike M, Konishi M, Kikuchi-Yanoshita R, Miyaki M. Microsatellite instability in the progression of gastric carcinoma. Cancer Res 1994;54:4595-7.
5. Imai S, Koizumi S, Sugiura M, Tokunaga M, Uemura Y, Yamamoto N, Tanaka S, Sato E, Osato T. Gastric carcinoma: monoclonal epithelial malignant cells expressing Epstein-Barr virus latent infection protein. Proc Natl Acad Sci USA 1994;91:9131-5.
6. Esteller M, Corn PG, Baylin SB, Herman JG. A gene hypermethylation profile of human cancer. Cancer Res 2001;61:3225-9.
7. Herman JG, Graff JR, Myöhänen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996;93:9821-6.
8. Kang GH, Lee S, Kim WH, Lee HW, Kim JC, Rhyu MG, Ro JY. Epstein-Barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma. Am J Pathol 2002; 160:787-94.
9. Chong JM, Sakuma K, Sudo M, Ushiku T, Uozaki H, Shibahara J, Nagai H, Funata N, Taniguchi H, Aburatani H, Fukayama M. Global and non-random CpG-island methylation in gastric carcinoma associated with Epstein-Barr virus. Cancer Sci 2003;94:76-80.
10. Osawa, T, Chong JM, Sudo M, Sakuma K, Uozaki H, Shibahara J, Nagai H, Funata N, Fukayama M. Reduced expression and promoter methylation of p16 gene in Epstein-Barr virus-associated gastric carcinoma. Jpn J Cancer Res 2002;93:1195-200.
11. Sudo M, Chong JM, Sakuma K, Ushiku T, Uozaki H, Nagai H, Funata N, Matsumoto Y, Fukayama M. Promoter hypermethylation of E-cadherin and its abnormal expression in Epstein-Barr virus-associated gastric carcinoma. Int J Cancer 2004;109:194-9.
12. Sherr CJ. Cancer cell cycles. Science 1996;274:1672-7.
13. Pomerantz J, Schreiber-Agus N, Liegeois NJ, Silverman A, Alland L, Chin L, Potes J, Chen K, Orlow I, Lee HW, Cordon-Cardo C, DePinho RA. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell 1998;92:713-23.
14. Zhang Y, Xiong Y, Yarbrough WG. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4A locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 1998;92:725-34.
15. Lauren R. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. Acta Pathol Microbiol Scand 1965;64:31-49.
16. INK4A and RASSF1A in human lung cancer cell lines. Oncogene 2002;21:4822-9.
17. Lorincz MC, Schubeler D, Hutchinson SR, Dickerson DR, Groudine M. DNA methylation density influences the stability of an epigenetic imprint and Dnmt3a/b-independent de novo methylation. Mol Cell Biol 2002;22:7572-80.
18. Yoder JA, Walsh CP, Bestor TH. Cytosine methylation and the ecology of intragenomic parasites. Trends Genet 1997;13:335-40.
19. Robertson KD, Ambinder RF, Methylation of the Epstein-Barr virus genome in normal lymphocytes. Blood 1997;90:4480-4.
20. Robertson KD, Manns A, Swinnen LJ, Zong JC, Gulley ML, Ambinder RF. CpG methylation of the major Epstein-Barr virus latency promoter in Burkitt's lymphoma and Hodgkin's disease. Blood 1996;88:3129-36.
21. Tao Q, Robertson KD, Manns A, Hildesheim A, Ambinder RF. The Epstein-Barr virus major latent promoter Qp is constitutively active, hypomethylated, and methylation sensitive. J Virol 1998;72:7075-83.
22. Kwong J, Lo KW, To KF, Teo PML, Johnson PJ, Huang DP. Promoter hypermethylation of multiple genes in nasopharyngeal carcinoma. Clin Cancer Res 2002;8:131-7.
23. Lo KW, Huang DP. Genetic and epigenetic changes in nasopharyngeal carcinoma. Semin Cancer Biol 2002;12:451-62.
24. zur Hausen A, Brink AATP, Craanen ME, Middeldorp JM, Meijer CJLM, van den Brule AJC. Unique transcription pattern of Epstein-Barr virus (EBV) in EBV-carrying gastric adenocarcinomas: expression of the transforming BARF1 gene. Cancer Res 2000;60:2745-8.
25. Chong JM, Sakuma K, Sudo M, Osawa T, Ohara E, Uozaki H, Shibahara J, Kuroiwa K, Tominaga S, Hippo Y, Aburatani H, Funata N, et al. Interleukin-1beta expression in human gastric carcinoma with Epstein-Barr virus infection. J Virol 2002;76:6825-31.
26. Iwakiri D, Eizuru Y, Tokunaga M, Takada K. Autocrine growth of Epstein-Barr virus-positive gastric carcinoma cells mediated by an Epstein-Barr virus-encoded small RNA. Cancer Res 2003;63:7062-7.
27. Kaneko Y, Sakurai S, Hironaka M, Sato S, Oguni S, Sakuma Y, Sato K, Sugano K, Saito K. Distinct methylated profiles in Helicobacter pylori dependent and independent gastric MALT lymphomas. Gut 2003;52:641-6.
28. Kaneda A, Kaminishi M, Yanagihara K, Sugimura T, Ushijima T. Identification of silencing of nine genes in human gastric cancers. Cancer Res 2002;62:6645-50.