Promoter hypermethylation of E-cadherin and its abnormal expression in Epstein-Barr virus-associated gastric carcinoma

International Journal of Cancer

Volumn 109, Issue 2, 2004, Pages 194-199

  Sudo, Makoto ^a,b   Chong, Ja Mun ^a   Sakuma, Kazuya ^c   Ushiku, Tetsuo ^a   Uozaki, Hiroshi ^a   Nagai, Hideo ^c   Funata, Nobuaki ^d   Matsumoto, Yoshiro ^b   Fukayama, Masashi ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF YAMANASHI   (Japan)

^c JICHI MEDICAL UNIVERSITY   (Japan)

^d TOKYO METROPOLITAN KOMAGOME HOSPITAL   (Japan)

Author keywords

E cadherin; Epstein Barr virus; Gastric carcinoma; Methylation

Indexed keywords

CADHERIN; DNA; PROTEIN P16; UVOMORULIN;

ADULT; AGED; ALLELISM; ARTICLE; CANCER GROWTH; CANCER INVASION; CARCINOGENESIS; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE COURSE; DNA METHYLATION; EPSTEIN BARR VIRUS; FEMALE; GENE EXPRESSION REGULATION; GENE MUTATION; GENE SILENCING; GENETICS; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; METABOLISM; METHYLATION; MUTATION; PATHOGENICITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; SINGLE STRAND CONFORMATION POLYMORPHISM; STOMACH CARCINOMA; STOMACH TUMOR; VIROLOGY; VIRUS INFECTION;

ADULT; AGED; AGED, 80 AND OVER; CADHERINS; DISEASE PROGRESSION; DNA METHYLATION; DNA, NEOPLASM; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HERPESVIRUS 4, HUMAN; HUMANS; LOSS OF HETEROZYGOSITY; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MUTATION; NEOPLASM INVASIVENESS; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROMOTER REGIONS (GENETICS); STOMACH NEOPLASMS;

EID: 1242274502     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.11701     Document Type: Article

References (41)

1. Fukayama M, Chong JM, Kaizaki Y. Epstein-Barr virus and gastric carcinoma. Gastric Cancer 1998;1:104-14.
2. Fukayama M, Chong JM, Uozaki H. Pathology and molecular pathology of Epstein-Barr virus-associated gastric carcinoma. In: Takada K, editor. Epstein-Barr virus and human cancer. Berlin: Springer-Verlag, 2001. 91-102.
3. Fukayama M, Hayashi Y, Iwasaki Y, Chong JM, Ooba T, Takizawa T, Koike M, Mizutani S, Miyaki M, Hirai K. Epstein-Barr virus-associated gastric carcinoma and Epstein-Barr virus infection of the stomach. Lab Invest 1994;7:73-81.
4. Chong JM, Sakuma K, Sudo M, Osawa T, Ohara E, Uozaki H, Shibahara J, Kuroiwa K, Tominaga S, Hippo Y, Aburatani H, Funata N, et al. Interleukin β expression in human gastric carcinoma with Epstein-Barr virus infection. J Virol 2002;76:6825-31.
5. Chong JM, Fukayama M, Hayashi Y, Funata N, Takizawa T, Koike M, Muraoka M, Kikuchi-Yanoshita M, Mizuno S. Expression of CD44 variants in gastric carcinoma with or without Epstein-Barr virus. Int J cancer 1997;74:450-4.
6. Sugiura M, Imai S, Tokunaga M, Koizumi S, Uchizawa M, Okamoto K, Osato T. Transcriptional analysis of the Epstein-Barr virus gene expression in EBV-positive gastric carcinoma: unique viral latency in the tumor cells. Br J Cancer 1996;74:625-31.
7. zur Hausen A, Brink AATP, Craanen ME, Middeldrop JM, Meijer CJLM, van den Brule AJC. Unique transcription pattern of Epstein-Barr virus (EBV) in EBV-carrying gastric adenocarcinomas: expression of the transforming BARF1 gene. Cancer Res 2000;60:2745-8.
8. Chong JM, Fukayama M, Hayashi Y, Takizawa T, Koike M, Konishi M, Kikuchi-Yanoshita R, Miyaki M. Microsatellite instability in the progression of gastric carcinoma. Cancer Res 1994;54:4595-7.
9. Kang GH, Lee S, Kim WH, Lee HW, Kim JC, Rhyu MG, Ro JY. Epstein-Barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma. Am J Pathol 2002; 160:787-94.
10. Chong JM, Sakuma K, Sudo M, Ushiku T, Uozaki H, Shibahara J, Nagai H, Funata N, Taniguchi H, Aburatani H, Fukayama M. Global and non-random CpG-island methylation in gastric crcinoma associated with Epstein-Barr virus. Cancer Sci 2003;94:76-80.
11. Osawa T, Chong JM, Sudo M, Sakuma K, Uozaki H, Shibahara J, Nagai H, Funata N, Fukayama M. Reduced expression and promoter methylation of p16 gene in Epstein-Barr virus-associated gastric carcinoma. Jpn J Cancer Res 2002;93:1195-200.
12. Takeichi M. Morphogenetic roles of classic cadherins. Cur Opin Cell Biol 1995;7:619-27.
13. Takeichi M. Cadherin cell adhesion receptors as morphogenetic regulator. Science 1991;251:1451-5.
14. Bracke ME, van Roy FM, Mareel MM. The E-cadherin/catenin complex in invasion and metastasis. In: Gunther U, Birchmeier W, eds. Attempts to understand metastasis formation. Berlin: Springer-Verlag, 1996. 123-61.
15. Shino Y, Watanabe A, Yamada Y, Tanase M, Yamada T, Matsuda M, Yamashita J, Tatsumi M, Miwa T, Nakano H. Clinicopathologic evaluation of immunohistochemical E-cadherin expression in human gastric carcinomas. Cancer 1995;76:2193-201.
16. Shun CT, Wu MS, Lin JT, Wang HP, Houng RL, Lee WJ, Wang TH, Chuang SM. An immunohistochemical study of E-cadherin expression with correlations to clinicopathological features in gastric cancer. Hepato-Gastroenterology 1998;45:944-9.
17. Oka H, Shiozaki H, Kobayashi K, Tahara H, Tamura S, Miyata M, Doki Y, Iihara K, Matsuyoshi N, Hirano S, Takeichi M, Mori T. Immunohistochemical evaluation of E-cadherin adhesion molecule expression in human gastric cancer. Virchows Arch 1992;421:149-56.
18. Becker KF, Atkinson NJ, Reich U, Becker I, Nekarda H, Siewert JR, Hofler H. E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. Cancer Res 1994;54:3845-52.
19. Machado JC, Soares P, Carneiro F, Rocha A, Beck S, Blin N, Berx G, Sobrinho-Simoes M. E-cadherin gene mutations provide a genetic basis of the phenotypic divergence of mixed gastric carcinomas. Lab Invest 1999;79:459-65.
20. Tamura G, Sakata K, Nishizuka S, Maesawa C, Suzuki Y, Iwaya T, Terashima M, Saito K, Satodate R. Inactivation of the E-cadherin gene in primary gastric carcinomas and gastric carcinoma cell lines. Jpn J Cancer Res 1996;87:1153-9.
21. Guilford P, Hopkins J, Harraway J, McLeod M, McLeod N, Harawira P, Taite H, Scoular R, Miller A, Reeve AE. E-cadherin germline mutations in familial gastric cancer. Nature 1998;392:402-5.
22. Wu MS, Shun CT, Wu CC, Hsu TY, Lin MT, Chang MC, Wang HP, Lin JT. Epstein-Barr virus-associated gastric carcinomas: relation to H. pylori infection and genetic alterations. Gastroenterology 2000; 118:1031-8.
23. Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma: 2nd English edition. Gastric Cancer 1998;1:10-24.
24. Lauren P. The two histological main types of gastric carcinoma, diffuse and so-called intestinal-type carcinoma. Acta Pathol Microbiol Scand 1965;64:31-49.
25. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpGislands. Proc Natl Acad Sci 1996;93:9821-6.
26. Kallakury BVS, Sheehan CE, Winn-Deen E, Oliver J, Fisher HAG, Kaufman RP, Ross JS. Decreased expression of catenins (α and β), p120 CTN, and E-cadherin cell adhesion proteins and E-cadherin gene promoter methylation in prostatic adenocarcinomas. Cancer 2001;92:2786-95.
27. Shimoyama Y, Hirohashi S. Expression of E- and P-cadherin in gastric carcinomas. Cancer Res 1991;51:2185-92.
28. Jawhari A, Jordan S, Poole S, Browne P, Pignatelli M, Farthing MJG. Abnormal immunoreactivity of the E-cadherin-catenin complex in gastric carcinoma: relationship with patient survival. Gastroenterology 1997;112:46-54.
29. Berx G, Becker KF, Hofler H, van Roy F. Mutations of the human E-cadherin (CDH1) gene. Hum Mutat 1998;12:226-37.
30. Oda T, Kanai Y, Oyama T, Yoshiura K, Shimoyama Y, Birchmeier W, Sugimura T, Hirohashi S. E-cadherin gene mutations in human gastric carcinoma cell lines. Proc Natl Acad Sci 1994;91:1858-62.
31. Tamura G, Yin J, Wang S, Fleisher AS, Zou TT, Abraham JM, Kong DH, Smolinski KN, Wilson KT, James SP, Silverberg SG, Nishizuka S, et al. E-cadherin gene promoter hypermethylation in gastric carcinomas. J Natl Cancer I 2000;92:569-73.
32. Machado JC, Oliveira C, Carvalho R, Soares P, Berx G, Caldas C, Seruca R, Carneiro F, Sobrinho-Simoes M. E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma. Oncogene 2001;20:1525-8.
33. Oue N, Motoshita J, Yokozaki H, Hayashi K, Tahara E, Taniyama K, Matsusaki K, Yasui W. Distinct promoter hypermethylation of p16(INK4a), CDH1, and RAR-beta in intestinal, diffuse-adherent, and diffuse-scattered type gastric carcinomas. J Pathol 2002;198:55-9.
34. Bender CM, Pao MM, Jones PA. Inhibition of DNA methylation by 5-aza-2′-deoxycytidine suppresses the growth of human tumor cell lines. Cancer Res 1998;58:95-101.
35. Joo YE, Rew JS, Kim HS, Choi SK, Park CS, Kim SJ. Changes in the E-cadherin-catenin complex expression in early and advanced gastric cancers. Digestion 2001;64:111-9.
36. Graff JR, Gabrielson E, Fujii H, Baylin SB, Herman JG. Methylation patterns of the E-cadherin 5′ CpG island are unstable and reflect the dynamic, heterogenous loss of E-cadherin expression during metastatic progression. J Biol Chem 2000;275:2727-32.
37. Rosivatz E, Becker I, Specht K, Fricke E, Luber B, Busch R, Hofler H, Becker KF. Differential expression of the epithelial-mesenchymal transition regulators Snail, SIP1, and Twist in gastric cancer. Am J Pathol 2002;161:1881-91.
38. Rashid MG, Sanda MG, Vallorosi CJ, Rios-Doria J, Rubin MA, Day ML. Posttranslational truncation and inactivation of human E-cadherin distinguishes prostate cancer from matched normal prostate. Cancer Res 2001;61:489-92.
39. Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barrio MG, Portillo F, Nieto MA. The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2000;2:76-83.
40. Batlle E, Sancho E, Franci C, Dominguez D, Monfar M, Baulida J, de Herreros AG. The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2000;2:84-9.
41. Comijn J, Berx G, Vermassen P, Verschueren K, van Grunsven L, Bruyneel E, Mareel M, Huylebroeck D, van Roy F. The two-handed E box binding zinc finger protein SIP1 down regulates E-cadherin and induces invasion. Mol Cell 2001;7:1267-78.