CpG methylation of the major Epstein-Barr virus latency promoter in Burkitt's lymphoma and Hodgkin's disease

Blood

Volumn 88, Issue 8, 1996, Pages 3129-3136

  Robertson, K D ^b   Manns, A ^b   Swinnen, L J ^b   Zong, J C ^b   Gulley, M L ^b   Ambinder, R F ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; CELL PROTEIN; RNA; VIRUS PROTEIN;

ARTICLE; BURKITT LYMPHOMA; CARCINOGENESIS; EPSTEIN BARR VIRUS; HODGKIN DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN SITU HYBRIDIZATION; METHYLATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRUS TRANSCRIPTION;

EID: 0029909374     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.8.3129.bloodjournal8883129     Document Type: Article

References (33)

1. Bourgault I, Gomez A, Gomard E, Levy JP: Limiting-dilution analysis of the HLA restriction of anti-Epstein-Barr virus-specific cytolytic T lymphocytes. Clin Exp Immunol 84:501, 1991
2. Khanna R, Burrows SR, Kurilla MG, Jacob CA, Misko IS, Sculley TB, Kieff E, Moss DJ: Localization of Epstein-Barr virus cytotoxic T cell epitopes using recombinant vaccinia: Implications for vaccine development. J Exp Med 176:169, 1992
3. Murray RJ, Kurilla MG, Brooks JM, Thomas WA, Rowe M, Kieff E, Rickinson AB: Identification of target antigens for the human cytotoxic T cell response to Epstein-Barr virus (EBV): Implications for the immune control of EBV-positive malignancies. J Exp Med 176:157, 1992
4. Levitskaya J, Coram M, Levitsky V, Imreh S, Steigerwaldmullen PM, Klein G, Kurilla MG, Masucci MG: Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1. Nature 375:685, 1995
5. Deacon EM, Pallesen G, Niedobitek G, Crocker J, Brooks L, Rickinson AB, Young LS: Epstein-Barr virus and Hodgkin's disease: Transcriptional analysis of virus latency in the malignant cells. J Exp Med 177:339, 1993
6. Masucci MG, Contreras-Salazar B, Ragnar E, Falk K, Minarovits J, Ernberg I, Klein G: 5-Azacytidine up regulates the expression of Epstein-Barr virus nuclear antigen 2 (EBNA-2) through EBNA-6 and latent membrane protein in the Burkitt's lymphoma line Rael. J Virol 63:3135, 1989
7. Robertson KD, Hayward DJ, Ling PD, Samid D, Ambinder RF: Transcriptional activation of the EBV latency C promoter following 5-azacytidine treatment: Evidence that demethylation at a single CpG site is crucial. Mol Cell Biol 15:6150, 1995
8. Ling PD, Hsieh JJD, Ruf IK, Rawlins DR, Hayward SD: EBNA-2 upregulation of Epstein-Barr virus latency promoters and the cellular CD23 promoter utilizes a common targeting intermediate, CBF1. J Virol 68:5375, 1994
9. Johannsen E, Koh E, Mosialos G, Tong X, Kieff E, Grossman SR: Epstein-Barr virus nuclear protein 2 transactivation of the latent membrane protein 1 promoter is mediated by J kappa and PU.I. J Virol 69:253, 1995
10. Tong X, Drapkin R, Reinberg D, Kieff E: The 62- and 80-kDa subunits of transcription factor IIH mediate the interaction with Epstein-Barr virus nuclear protein 2. Proc Natl Acad Sci USA 92:3259, 1995
11. Grossman SR, Johannsen E, Tong X, Yalamanchili R, Kieff E: The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the J kappa recombination signal binding protein. Proc Natl Acad Sci USA 91:7568, 1994
12. Zimber-Strobl U, Strobl LJ, Meitinger C, Hinrichs R, Sakai T, Furukawa T, Honjo T, Bornkamm GW: Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-J kappa, the homologue of Drosophila Suppressor of Hairless. EMBO J 13:4973, 1994
13. Sam CK, Brooks LA, Niedobitek G, Young LS, Prasad U, Rickinson AB: Analysis of Epstein-Barr virus infection in nasopharyngeal biopsies from a group at high risk of nasopharyngeal carcinoma. Int J Cancer 53:957, 1993
14. Qu L, Rowe DT: Epstein-Barr virus latent gene expression in uncultured peripheral blood lymphocytes. J Virol 66:3715, 1992
15. Barletta JM, Kingma DW, Ling Y, Charache P, Mann RB, Ambinder RF: Rapid in situ hybridization for the diagnosis of latent Epstein-Barr virus infection. Mol Cell Probes 7:105, 1993
16. Frommer M, McDonald LE, Millar DS, Collis CM, Watt F, Grigg GW, Molloy PL, Paul CL: A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc Natl Acad Sci USA 89:1827, 1992
17. Counts JL, Goodman JI: Alterations in DNA methylation may play a variety of roles in carcinogenesis. Cell 83:13, 1995
18. Rowe M, Gregory C: Epstein-Barr virus and Burkitt's lymphoma, in Klein G (ed): Advances in Viral Oncology, vol 8. Tumorigenic DNA Viruses. New York, NY, Raven, 1989, p 237
19. Niedobitek G, Agathanggelou A, Rowe M, Jones EL, Jones DB, Turyaguma, P, Oryema J, Wright DH, Young LS: Heterogeneous expression of Epstein-Barr virus latent proteins in endemic Burkitt's lymphoma. Blood 86:659, 1995
20. Antequera F, Boyes J, Bird A: High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines. Cell 62:503, 1990
21. Baylin SB, Fearon ER, Vogelstein B, de Bustros A, Sharkis SJ, Burke PJ, Staal SP, Nelkin BD: Hypermethylation of the 5′ region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies. Blood 70:412, 1987
22. Allday MJ, Kendu D, Finerty S, Griffin BE: CpG methylation of viral DNA in EBV-associated tumours. Int J Cancer 45:1125, 1990
23. Tesch H, Jucker M, Falk MH, Bornkamm GW, Jones DB, Diehl V: Molecular analysis of Hodgkin's disease-derived cell lines. Hematol Oncol 6:223, 1988
24. Staal SP, Ambinder R, Beschorner WE, Hayward GS, Mann R: A survey of Epstein-Barr virus DNA in lymphoid tissue: Frequent detection in Hodgkin's disease. Am J Clin Pathol 91:1, 1989
25. Gulley ML, Raphael M, Lutz CT, Ross DW, Raab-Traub N: Epstein-Barr virus integration in human lymphomas and lymphoid cell lines. Cancer 70:185, 1992
26. Gulley ML, Eagan PA, Quintanilla-Martinez L, Picado AL, Smir BN, Childs C, Dunn CD, Craig FE, Williams JW Jr, Banks PM: Epstein-Barr virus DNA is abundant and monoclonal in the Reed-Sternberg cells of Hodgkin's disease: Association with mixed cellularity subtype and Hispanic American ethnicity. Blood 83:1595, 1994
27. Pallesen G, Sandvej K, Hamilton-Dutoit SJ, Rowe M, Young LS: Activation of Epstein-Barr virus replication in Hodgkin and Reed-Sternberg cells. Blood 78:1162, 1991
28. Starzl TE, Porter KA, Iwatsuki S, Rosenthal JT, Shaw BW Jr, Atchison RW, Nalesnik MA, Ho M, Griffith BP, Hakala TR, Hardesty RL, Jaffe R, Bahnson HT: Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy. Lancet 1:583, 1984
29. Papadopoulos EB, Ladanyi M, Emanuel D, Mackinnon S, Boulad F, Carabasi MH, Castro-Malaspina H, Childs BH, Gillio AP, Small TN, Young JW, Kernan NA, O'Reilly RJ: Infusions of donor leukocytes to treat Epstein-Barr virus-associated lymphoproliferative disorders after allogeneic bone marrow transplantation. N Engl J Med 33:1185, 1994
30. Rooney CM, Smith CA, Ng CY, Loftin S, Li C, Krance RA, Brenner MK, Heslop HE: Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation. Lancet 345:9, 1995
31. Bird AP: Functions for DNA methylation in vertebrates. Cold Spring Harb Symp Quant Biol 58:281, 1993
32. Doerfler W: The insertion of foreign DNA into mammalian genomes and its consequences: A concept in oncogenesis. Adv Cancer Res 66:313, 1995
33. Farrell PJ: Epstein-Barr Virus, in O'Brien SJ (ed): Genetic Maps - Locus Map of Complex Genomes. Plainview, NY, Cold Spring Harbor Laboratory, 1993, p 1.120