NMR-driven discovery of benzoylanthranilic acid inhibitors of far upstream element binding protein binding to the human oncogene c-myc promoter

Journal of Medicinal Chemistry

Volumn 47, Issue 20, 2004, Pages 4851-4857

  Huth, Jeffrey R ^a   Yu, Liping ^a   Collins, Irene ^b   Mack, Jamey ^a   Mendoza, Renaldo ^a   Isaac, Binumol ^a   Braddock, Demetrios T ^c   Muchmore, Steven W ^a   Comess, Kenneth M ^a   Fesik, Stephen W ^a   Clore, G Marius ^d   Levens, David ^b   Hajduk, Philip J ^a  

^a ABBOTT LABORATORIES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRANILIC ACID DERIVATIVE; DNA BINDING PROTEIN; FAR UPSTREAM ELEMENT BINDING PROTEIN; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DRUG DESIGN; GEL MOBILITY SHIFT ASSAY; GENE CONTROL; LIGAND BINDING; NUCLEAR MAGNETIC RESONANCE; ONCOGENE C MYC; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN DOMAIN; SCREENING;

BINDING SITES; COMBINATORIAL CHEMISTRY TECHNIQUES; DNA HELICASES; DNA, SINGLE-STRANDED; DNA-BINDING PROTEINS; DRUG DESIGN; GENES, MYC; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PROMOTER REGIONS (GENETICS); PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; REPETITIVE SEQUENCES, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 4544371672     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0497803     Document Type: Article

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