Light-directed gene delivery by photochemical internalisation

Expert Opinion on Biological Therapy

Volumn 4, Issue 9, 2004, Pages 1403-1412

  Prasmickaite, Lina ^a   Høgset, Anders ^b   Engesæter, Birgit Ø ^a   Bonsted, Anette ^a   Berg, Kristian ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b PCI Biotech AS   (Norway)

Author keywords

Endosomal release; Gene delivery; Gene therapy; Light directed; Photochemical internalisation; Targering

Indexed keywords

ADENOVIRUS VECTOR; BLEOMYCIN; COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR; GELONIN; PARVOVIRUS VECTOR; PEPTIDE NUCLEIC ACID; PHOTOSENSITIZING AGENT; PHTHALOCYANINE ALUMINUM; TETRAPHENYLPORPHINESULFONIC ACID;

CANCER THERAPY; ENDOCYTOSIS; ENDOSOME; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE EXPRESSION ENHANCEMENT; GENE LIBERATION; GENE TARGETING; GENE THERAPY; GENE VECTOR; ILLUMINATION; IN VIVO GENE TRANSFER; IN VIVO STUDY; INTERNALIZATION; LIGHT; LIGHT DIRECTED GENE DELIVERY; MEMBRANE RUPTURE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PHOTOCHEMICAL INTERNALIZATION; REVIEW; TRANSGENE; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANIMALS; DEPENDOVIRUS; ENDOCYTOSIS; ENDOSOMES; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GENES, TRANSGENIC, SUICIDE; GENETIC VECTORS; HUMANS; INDOLES; INTRACELLULAR MEMBRANES; MICE; OLIGONUCLEOTIDES, ANTISENSE; ORGANOMETALLIC COMPOUNDS; PEPTIDE NUCLEIC ACIDS; PHOTOCHEMISTRY; PHOTOSENSITIZING AGENTS; PORPHYRINS; SINGLET OXYGEN; TRANSGENES; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ADENO-ASSOCIATED VIRUS; ADENOVIRIDAE; COXSACKIEVIRUS; PARVOVIRUS;

EID: 4544345133     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.4.9.1403     Document Type: Review

References (66)

1. SOMIA N, VERMA IM: Gene therapy: Trials and tribulations. Nat. Rev. Genet. (2001) 1:91-99. A good introduction to gene therapy.
2. HACEIN-BEY-ABINA S, VON KALLE C, SCHMIDT M et al.: LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science (2003) 302:415-419.
3. CAVAZZANA-CALVO M, THRASHER A, MAVILIO F: The future of gene therapy. Nature (2004) 427:779-781.
4. VERMAIM, SOMIA N: Gene therapy - promises, problems and prospects. Nature (1997) 389:239-242.
5. BALLY MB, HARVIE P, WONG MP et al.: Biological barriers to cellular delivery of lipid-based DNA carriers. Adv. Drug Deliv. Rev. (1999) 38:291-315.
6. POUTON CW, SEYMOUR LW: Key issues in non-viral gene delivery. Adv. Drug Deliv. Rev. (2001) 46:187-203.
7. KIRCHEIS R, WIGHTMAN L, WAGNER E: Design and gene delivery activity of modified polyethylenimines. Adv. Drug Deliv. Rev. (2001) 53:341-358.
8. GREEN NK, SEYMOUR LW: Adenoviral vectors: Systemic delivery and tumor targeting. Cancer Gene Ther. (2002) 9:1036-1042.
9. MEIER O, GREBER UF: Adenovirus endocytosis. J. Gene Med. (2003) 5:451-462.
10. VORBURGER SA, HUNT KK: Adenoviral gene therapy. Oncologist (2002) 7:46-59.
11. BARTLETT JS, WILCHER R, SAMULSKI RJ: Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors. J. Virol. (2000) 74:2777-2785.
12. GREBER UF, WILLETTS M, WEBSTER P, HELENIUS A: Stepwise dismantling of adenovirus 2 during entry into cells. Cell (1993) 75:477-486.
13. LEOPOLD PL, FERRIS B, GRINBERG I et al.: Fluorescent virions: dynamic tracking of the pathway of adenoviral gene transfer vectors in living cells. Hum. Gene Ther. (1998) 9:367-378.
14. ZABNER J, FASSENDER AJ, MONINGERT, POELLINGER KA, WELSH MJ: Cellular and molecular barriers to gene transfer by a cationic lipid. J. Biol. Chem. (1995) 270:18997-19007. An important paper on intracellular barriers for non-viral vectors.
15. PRASMICKAITE L, HØGSET A, TJELLE TE, OLSEN VM, BERG K. Role of endosomes in gene transfeccion mediated by photochemical internalisation (PCI). J. Gene Med. (2000) 2:477-488. A comprehensive study on the role of the endocytic pathway for PCI with non-viral vectors.
16. VARGA CM, HONG K, LAUFFENBURGER DA: Quantitative analysis of synthetic gene delivery vector design properties. Mol. Ther. (2001) 4:438-446.
17. KAMIYA H, AKITA H, HARASHIMA H: Pharmacokinetic and pharmacodynamic considerations in gene therapy. Drug Discov. Today (2003) 8:990-996.
18. OGRIS M, CARLISLE RC, BETTINGERT, SEYMOUR LW: Melittin enables efficient vesicular escape and enhanced nuclear access of nonviral gene delivery vectors. J. Biol. Chem. (2001) 276:47550-47555.
19. WAGNER E, KIRCHEIS R, WALKER GF: Targeted nucleic acid delivery into tumors: new avenues for cancer therapy. Biomed. Pharmacother. (2004) 58:152-161.
20. CURIEL DT: Strategies to adapt adenoviral vectors for targeted delivery. Ann. NY Acad. Sci. (1999) 886:158-171.
21. CRISTIANO RJ: Targeted, non-viral gene delivery for cancer gene therapy. Front. Biosci. (1998) 3:D1161-D1170.
22. NETTELBECK DM, JEROME V, MULLER R: Gene therapy: designer promoters for tumour targeting. Trends Genet. (2000) 16:174-181.
23. VARGA CM, WICKHAM TJ, LAUFFENBURGER DA: Receptor-mediated targeting of gene delivery vectors: insights from molecular mechanisms for improved vehicle design. Biotechnol. Bioeng. (2000) 70:593-605. A good review on receptor-targeted gene vectors and the molecular mechanisms behind them.
24. KIRCHEIS R, WIGHTMAN L, KURSA M et al.: Surface-shielded polycation-based systems targeting reporter and therapeutic genes to distant tumors. Gene Ther. Mol. Biol. (2001) 6:159-167.
25. BARNETT BG, CREWS CJ, DOUGLAS JT: Targeted adenoviral vectors. Biochim. Biophys. Acta (2002) 1575:1-14. A comprehensive review on adenovirus targeting strategies.
26. HAVIV YS, CURIEL DT: Conditional gene targeting for cancer gene therapy. Adv. Drug Deliv. Rev. (2001) 53:135-154.
27. BERG K, SELBO PK, PRASMICKAITE L et al.: Photochemical internalization: a novel technology for delivery of macromolecules into cytosol. Cancer Res. (1999)59:1180-1183. The first paper in which PCI as a concept is presented.
28. HØGSET A, ENGESÆTER BØ, PRASMICKAITE L et al.: Light-induced adenovirus gene transfer, an efficient and specific gene delivery technology for cancer gene therapy. Cancer Gene Ther. (2002) 9:365-371. The first paper demonstrating the PCI effect on adenovirus efficiency.
29. HØGSET A, PRASMICKAITE L, SELBO PK et al.: Photochemical internalisation in drug and gene delivery. Adv. Drug Deliv. Rev. (2004) 56:95-115. A general review on PCI of various types of molecules.
30. BERG K, MOAN J: Lysosomes as photochemical targets. Int. J. Cancer (1994) 59:814-822. Fundamental basis for the development of PCI.
31. MOAN J, BERG K, ANHOLT H, MADSLIEN K: Sulfonated aluminium phthalocyanines as sensitizers for photochemotherapy. Effects of small light doses on localization, dye fluorescence and photosensitivity in V79 cells. Int. J. Cancer (1994) 58:865-870.
32. HØGSET A, PRASMICKAITE L, TJELLE TE, BERG K: Photochemical transfection: a new technology for light-induced, site-directed gene delivery. Hum. Gene Ther. (2000) 11:869-880.
33. SELBO PK, SANDVIG K, KIRVELIENE V, BERG K: Release of gelonin from endosomes and lysosomes to cytosol by photochemical internalization. Biochim. Biophys. Acta (2000) 1475:307-313.
34. HENDERSON BW, DOUGHERTY TJ: How does photodynamic therapy work? Photochem. Photobiol. (1992) 55:145-157.
35. JORI G, SPIKES JD: Photobiochemistry of porphyrins. In: Topics in Photomedicine. Smith KC (Ed.), Plenum Press, New York, USA (1984):183-318.
36. BERG K: Mechanisms of cell damage in photodynamic therapy. In: Fundamental Bases of Phototherapy. Honigsmann H, Jori G, Young A (Eds), OEMF, Milano, Italy (1996):181-207.
37. DOUGHERTY TJ, GOMER CJ, HENDERSON BW et al.: Photodynamic therapy. J. Natl. Cancer Inst. (1998) 90:889-905. A comprehensive review on PDT.
38. MOAN J, PENG Q: An outline of the hundred-year history of PDT. Anticancer Res. (2003) 23:3591-3600.
39. MOAN J, BERG K: The photodegradation of porphyrins in cells can be used to estimate the lifetime of singlet oxygen. Photochem. Photobiol. (1991) 53:549-553.
40. PRASMICKAITE L, HØGSET A, BERG K: Evaluation of different photosensitizers for use in photochemical gene transfection. Photochem. Photobiol. (2001) 73:388-395.
41. PRASMICKAITE L, HØGSET A, SELBO PK et al.: Photochemical disruption of endocytic vesicles before delivery of drugs: a new strategy for cancer therapy. Br. J. Cancer (2002) 86:652-657.
42. HELLUM M, HØGSET A, ENGESÆTER BØ et al.: Photochemically enhanced gene delivery with canonic lipid formulations. Photochem. Photobiol. Sci. (2003) 2:407-411.
43. PRASMICKAITE L, HØGSET A, OLSEN VM et al.: Photochemically enhanced gene transfection increases the cytotoxicity of the herpes simplex virus thymidine kinase gene combined with ganciclovir. Cancer Gene Ther. (2004) 11:514-523. A study demonstrating the PCI effect with a therapeutically relevant gene.
44. WAGNER E, OGRIS M, ZAUNER W: Polylysine-based transfection systems utilizing receptor-mediated delivery. Adv. Drug Deliv. Rev. (1998) 30:97-113.
45. KLOECKNER J, PRASMICKAITE L, HØGSET A, BERG K, WAGNER E: Photochemically enhanced gene delivery of EGF receptor-targeted DNA polyplexes. J. Drug Target. (2004) (In Press).
46. BOUSSIF O, LEZOUALCH F, ZANTA MA et al.: A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl. Acad. Sci. USA (1995) 92:7297-7301.
47. KICHLER A, LEBORGNE C, COEYTAUX E, DANOS O: Polyethylenimine-mediated gene delivery: a mechanistic study. J. Gene Med. (2001) 3:135-144.
48. MOOLTEN FL, WELLS JM: Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors. J. Natl. Cancer Inst. (1990) 82:297-300.
49. N'DOYE A, MERLIN JL, LEROUX A et al.: Enhanced gene transfer and cell death following p53 gene transfer using photochemical internalisation of glucosylated PEI-DNA complexes. J. Gene Med. (2004) 6:884-894. A study demonstrating PCI with a therapeurically relevant gene.
50. NICHOLSON RI, GEE JM, HARPER ME: EGFR and cancer prognosis. Eur. J. Cancer (2001) 37(Suppl. 4):S9-S15.
51. RUSSELL WC: Update on adenovirus and its vectors. J. Gen. Virol. (2000) 81:2573-2604. A comprehensive review on adenovirus and adenoviral vectors.
52. BONSTED A, ENGESÆTER BØ, HØGSET A et al.: Transgene expression is increased by photochemically mediated transduction of polycation-complexed adenoviruses. Gene Ther. (2004) 11:152-160. An interesting study demonstrating the PCI effect on porycation-coated adenovirus.
53. DIETZE A, BONSTED A, HØGSET A, BERG K: Photochemical internalization enhances the cytotoxic effect of the protein toxin gelonin and transgene expression in sarcoma cells. Photochem. Photobiol. (2003) 78:283-289.
54. BRUENING W, GIASSON B, MUSHYNSKI W, DURHAM HD: Activation of stress-activated MAP protein kinases up-regulates expression of transgenes driven by the cytomegalovirus immediate/early promoter. Nucleic Acids Res. (1998) 26:486-489.
55. TANG DC, JENNELLE RS, SHI Z et al.: Overexpression of adenovirus-encoded transgenes from the cytomegalovirus immediate early promoter in irradiated tumor cells. Hum. Gene Ther. (1997) 8:2117-2124.
56. HØGSET A, PRASMICKAITE L, ENGESÆTER BØ et al.: Light directed gene transfer by photochemical internalisation. Curr. Gene Ther. (2003) 3:89-112.
57. LUNA MC, WONG S, GOMER CJ: Photodynamic therapy mediated induction of early response genes. Cancer Res. (1994) 54:1374-1380.
58. ZHUANG S, OUEDRAOGO GD, KOCHEVAR IE: Downregulation of epidermal growth factor receptor signaling by singlet oxygen through activation of caspase-3 and protein phosphatases. Oncogene (2003) 22:4413-4424.
59. WONG TW, TRACY E, OSEROFF AR, BAUMANN H: Photodynamic therapy mediates immediate loss of cellular responsiveness to cytokines and growth factors. Cancer Res. (2003) 63:3812-3818.
60. MARTINDALE JL, HOLBROOK NJ: Cellular response to oxidative stress: signaling for suicide and survival. J. Cell Physiol. (2002) 192:1-15.
61. COWAN KJ, STOREY KB: Mitogen-activated protein kinases: new signaling pathways functioning in cellular responses to environmental stress. J. Exp. Biol. (2003) 206:1107-1115.
62. POOGA M, LAND T, BARTFAI T, LANGEL U: PNA oligomers as tools for specific modulation of gene expression. Biomol. Eng. (2001) 17:183-192.
63. FOLINI M, BERG K, MILLO E et al.: Photochemical internalization of a peptide nucleic acid targeting the catalytic subunit of human telomerase. Cancer Res. (2003) 63:3490-3494.
64. SELBO PK, SIVAM G, FODSTAD Ø, SANDVIG K, BERG K: In vivo documentation of photochemical internalization, a novel approach to site specific cancer therapy. Int. J. Cancer (2001) 92:761-766. The first paper in which PCI is documented in vivo.
65. LUNA MC, FERRARIO A, WONG S, FISHER AM, GOMER CJ: Photodynamic therapy-mediated oxidative stress as a molecular switch for the temporal expression of genes ligated to the human heat shock promoter. Cancer Res. (2000) 60:1637-1644.
66. LUNA MC, CHEN X, WONG S et al.: Enhanced photodynamic therapy efficacy with inducible suicide gene therapy controlled by the grp promoter. Cancer Res. (2002) 62:1458-1461.