Overexpression of adenovirus-encoded transgenes from the cytomegalovirus immediate early promoter in irradiated tumor cells

Human Gene Therapy

Volumn 8, Issue 17, 1997, Pages 2117-2124

  Tang, D E Chu ^a,b,f   Jennelle, Richard S ^c   Shi, Zhongkai ^a   Garver Jr , Robert I ^a   Carbone, David P ^d   Loya, Francisco ^d   Chang, Cheng Hui ^d,e   Curiel, David T ^a  

^a Gene Therapy Program

^b Dept of Biochem and Molec Genet ^*

^c The University of Alabama at Birmingham   (United States)

^d Simmons Cancer Center

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^f UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYRIC ACID; CANCER VACCINE; GENE PRODUCT; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CANCER RADIOTHERAPY; CELL TYPE; CONTROLLED STUDY; CYTOMEGALOVIRUS; FLOW CYTOMETRY; GENE EXPRESSION; GENE OVEREXPRESSION; GENE THERAPY; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IMMEDIATE EARLY GENE; IRRADIATION; MOUSE; MULTIMODALITY CANCER THERAPY; NONHUMAN; PROMOTER REGION; RADIATION DOSE; TRANSGENE; TUMOR CELL;

EID: 0031581180     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1997.8.17-2117     Document Type: Article

References (5)

1. ADDISON, C.L., BRACIAK, T., RALSTON, R., MULLER, W.J., GAULDIE, J., and GRAHAM, F.L. (1995). Intratumoral injection of an adenovirus expressing interleukin 2 induces regression and immunity in a murine breast cancer model. Proc. Natl. Acad. Sci. USA 92, 8522-8526.
2. ALLAN, D.J. (1992). Radiation-induced apoptosis: Its role in a MAD-CaT (mitosis-apoptosis-differentiation-calcium toxicity) scheme of cytotoxicity mechanisms. Int. J. Radiat. Biol. 62, 145-152.
3. BALEY, P.A., YOSHIDA, K., QIAN, W., SEHGAL, I., and THOMPSON, T.C. (1995). Progression to androgen insensitivity in a novel in vitro mouse model for prostate cancer. J. Steroid Biochem. Mol. Biol. 52, 403-413.
4. BEGOVIC, M., HERBERMAN, R., and GORELIK, E. (1991). Increase in immunogenicity and sensitivity to natural cell-mediated cytotoxicity following in vitro exposure of MCA105 tumor cells to ultraviolet radiation. Cancer Res. 51, 5153-5159.
5. BERGELSON, J.M., CUNNINGHAM, J.A., DROGUETT, G., KURTJONES, E.A., KRITHIVAS, A., HONG, J.S., HORWITZ, M.S., CROWELL, R.L., and FINBERG, R.W. (1997). Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5. Science 275, 1320-1323.