Structure of an anti-DNA Fab complexed with a non-DNA ligand provides insights into cross-reactivity and molecular mimicry

Proteins: Structure, Function and Genetics

Volumn 57, Issue 2, 2004, Pages 269-278

  Schuermann, Jonathan P ^a   Henzl, Michael T ^b   Deutscher, Susan L ^b   Tanner, John J ^a,b  

^a UNIVERSITY OF MISSOURI   (United States)

^b University of Missouri   (United States)

Author keywords

Anti DNA antibodies; HEPES; Isothermal titration calorimetry; Molecular mimicry; Systemic lupus erythematosus; X ray crystallography

Indexed keywords

4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; AMMONIUM SULFATE; ASPARAGINE; BUFFER; DNA ANTIBODY; DNA BASE; ETHYLENE; HISTIDINE; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN LIGHT CHAIN; LIGAND; PIPERAZINE; SINGLE STRANDED DNA; SULFONIC ACID DERIVATIVE; THYMINE; THYMINE DERIVATIVE; TYROSINE;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; CALORIMETRY; COMPLEMENTARITY DETERMINING REGION; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CROSS REACTION; CRYSTAL STRUCTURE; CRYSTALLIZATION; DNA STRUCTURE; HYDROGEN BOND; HYDROPHOBICITY; IMMUNE RESPONSE; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; MOLECULAR INTERACTION; MOLECULAR MIMICRY; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; SYSTEMIC LUPUS ERYTHEMATOSUS; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

ANTIBODIES, ANTINUCLEAR; ANTIBODY SPECIFICITY; BINDING SITES, ANTIBODY; CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; DNA; IMMUNOGLOBULIN FAB FRAGMENTS; LIGANDS; MODELS, MOLECULAR; MOLECULAR MIMICRY; STEREOISOMERISM; THERMODYNAMICS; TITRIMETRY;

INSERTION SEQUENCES;

EID: 4544339404     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.20200     Document Type: Article

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